Lia Dewi Juliawaty
Natural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132

Published : 8 Documents
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Journal : Indonesian Journal of Chemistry

FLAVANONES FROM THE WOOD OF Morus nigra WITH CYTOTOXIC ACTIVITY Ferlinahayati, Ferlinahayati; Syah, Yana Maolana; Juliawaty, Lia Dewi; Hakim, Euis Holisotan
Indonesian Journal of Chemistry Vol 13, No 3 (2013)
Publisher : Universitas Gadjah Mada

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Abstract

Two flavanone derivatives, norartocarpanone (1) and euchrenone a7 (2) had been isolated for the first time from the methanol extract of the wood of Morus nigra. The structures of these compounds were determined base on spectral evidence, including UV, IR, and NMR. The first compound also confirmed by comparison with the reported data. Cytotoxic properties of these compounds were evaluated against murine leukemia P-388 cells. Euchrenone a7 (2) was found more cytotoxic than norartocarpanone (1) with their IC50 7.8 and 12.7 mg/mL respectively.
Antibacterial Activity of Germacrane Type Sesquiterpenes from Curcuma heyneana Rhizomes Diastuti, Hartiwi; Syah, Yana Maolana; Juliawaty, Lia Dewi; Singgih, Marlia
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

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Abstract

The isolation of terpenoids from C. heyneana rhizomes and their antibacterial activity have been conducted. The terpenoids were isolated by using vacuum liquid chromatography and radial chromatography. The structures of the compounds were determined based on spectroscopic data (1H-NMR, 13C-NMR (1D and 2D)). The antibacterial activity was carried out by using microdilution method and evaluated against eight bacteria. Three germacrane type sesquiterpenes have been isolated from C. heyneana rhizhomes and were identified as germacrone, dehydrocurdione, and 1(10),4(5)-diepoxygermacrone. Germacrone showed highest antibacterial activity against P. aeruginosa with MIC values of 15.6 µg/mL and MBC values 31.2 µg/mL. Dehydrocurdione showed highest antibacterial activity against B. subtilis with MIC values of 31.2 µg/mL and MBC values of 31.2 µg/mL. However, 1(10),4(5)-diepoxygermacrone showed a weak antibacterial activity.
RESVERATROL DIMERS FROM STEM BARK OF Hopea gregaria AND THEIR CYTOTOXIC PROPERTIES Sahidin, Sahidin; Hakim, Euis Holisotan; Syah, Yana Maolana; Juliawaty, Lia Dewi; Achmad, Sjamsul Arifin; Bin Din, Laily; Latip, Jalifah
Indonesian Journal of Chemistry Vol 8, No 2 (2008)
Publisher : Universitas Gadjah Mada

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Abstract

Six resveratrol dimers have been isolated from the stem bark of H. gregaria, ampelopsin A (1), balanocarpol (2), ε-viniferin (3), hopeafuran (4), heimiol A (5), and parviflorol (6). The structures of these compounds were determined based on spectroscopic evidence such as UV, IR, 1-D, 2-D NMR and comparison with the reported data. These compound inventions are strengthen conclusion that Hopea tends to produce resveratrol dimers. Biological activity of those compounds against murine leukemia P-388 cells showed that ε-viniferin (3) is the most active compound with IC50 value 5.1 ± 0.3 μg/mL.   Keywords: H. gregaria, resveratrol dimers, murine leukemia P-388 cells