Lia Dewi Juliawaty
Natural Product Research Group, Department of Chemistry, Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132

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Journal : ALCHEMY Jurnal Penelitian Kimia

Antibacterial Activity of Germacrone Sesquiterpene from Curcuma Xanthorrhiza Rhizomes Diastuti, Hartiwi; Syah, Yana Maolana; Juliawaty, Lia Dewi; Singgih, Marlia
ALCHEMY Jurnal Penelitian Kimia Vol 12, No 2 (2016): Alchemy Jurnal Penelitian Kimia
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

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Abstract

The aim of this research was to isolate and indentify the terpenoid compound from Curcuma xanthorrhiza rhizomes and its antibacterial activity. Isolation was carried out by using vacuum liquid chromatography and centrifugal chromatography. The structure was determined by NMR spectroscopy (1H-NMR, 13C-NMR 1D and 2D), then compare with data from literatures. Antibacterial test was carried out by using  microdillution methods and evaluated against eight bacteria. They are Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysentriae and Vibrio cholerae. The result showed that the isolate was a white crystal which was indetified as germacron-type sesquiterpene. Germacron have highest activity againts P. aeruginosa, MIC 15.6 µg/mL and MBC 31.2 µg/mL.