Friska Jifanti
Department of Dermatology, Hasanudin Medical Faculty, Makassar

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Studi Retrospektif Lupus Eritematosus di Subdivisi Alergi Imunologi Bagian Ilmu Kesehatan Kulit dan Kelamin RSUP dr. Wahidin Sudirohusodo Makassar Periode 2005-2010 Jifanti, Friska; Mappiasse, Alwi
Majalah Kesehatan Pharmamedika Vol.2 No.2 2010
Publisher : Majalah Kesehatan Pharmamedika

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Abstract

Lupus eritematosus  (LE) adalah penyakit  jaringan konektif yang ditandai dengan adanya auto antibodi melawan beberapa sel (autoimun). Kelainan kulit merupakan manifestasi klinis  yang paling umum setelah artritis dan belum pernah ada laporan atau publikasi mengenai studi retrospektif LE di RSUP Dr. Wahidin Sudirohusodo  Makassar.  Tujuan penelitian ini adalah untuk mengetahui gambaran umum penyakit LE yang meliputi distribusi kasus baru, kelompok usia, jenis kelamin, tipe LE , kelainan yang ditemukan berdasarkan  kriteria ARA, dan data pemeriksaan penunjang. Penelitian ini dilakukan secara retrospektif dengan mengambil data-data dari rekam medik penderita baru lupus eritematosus di RSUP Dr. Wahidin Sudirohusodo  Makassar selama 5 tahun, mulai Juni 2005- Mei 2010. Dalam kurun waktu mulai 2005-2010 diperoleh data jumlah kunjungan baru LE sebanyak 12 kasus. Pada studi ini tahun 2009 ditemukan 5 pasien (41,6%) yang merupakan kasus  LE terbanyak. Terdapat kunjungan terbanyak pada pasien wanita yaitu 10 kasus (83%) dibandingkan pasien laki-laki sebanyak 2 kasus (17%). Berdasarkan kelompok umur, penderita baru LE paling banyak berada dikelompok usia 41-50 tahun (50%). Berdasarkan tipe LE, yang terbanyak adalah tipe  lupus eritemasosus diskoid (LED) yaitu sebanyak 7 pasien (58,3%). Berdasarkan kelainan yang ditemukan dengan menggunakan  kriteria ARA (American Rheumatism Association) yang paling banyak adalah eritema fasial sebanyak 8 pasien (25,8%). Berdasarkan data pemeriksaan laboratorium, didapatkan pemeriksaan laju endap darah merupakan pemeriksaan terbanyak yang mengalami peningkatan yaitu sebanyak 6 pasien (31,6%) dan hanya 2 pasien (10,5%) yang dilakukan  pemeriksaan histopatologi. Disimpulkan bahwa kasus LE terbanyak ditemukan tahun 2009 dengan jenis LED dan berdasarkan kriteria ARA paling banyak dijumpai adalah eritema fasial.
COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE BETWEEN HOUSEHOLD AND NONHOUSEHOLD CONTACT OF LEPROSY Arsyad, Yuniarti; Jifanti, Friska; Amiruddin, Muhammad Dali; Anwar, Anis Irawan; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 1 (2012)
Publisher : Institute of Topical Disease

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Abstract

Leprosy stills a public health problem in West Sulawesi which has a Case Detection Rate (CDR) around 43.69/100.000 population. Household contacts of leprosy are a high risk group to be infected, due to droplet infection mode of transmission of the disease. A nose swab examination and serological study was conducted to detect exposure of M. leprae of people who live in leprosy endemic area. Detection of M. leprae in the nasal cavity will represent the exposure rate from outside and the measurement of specific antibody is represented the result of exposure to the immune system. Two group of inhabitants (30 household contacts of leprosy and 30 nonhousehold contacts) were involved in the study. They live in Banggae district, a leprosy endemic area of Majene Regency, West Sulawesi. Sixty nose swab samples and sixty capillary blood samples from the same invidividuals of the two groups were collected and sent to Leprosy laboratory of the Institute of Tropical Disease, Airlangga University Surabaya. A Polymerase Chain Reaction (PCR) was performed to the nose swab samples for detection of M. leprae. The blood samples were examined serologically to measure the level of anti PGL-1 antibody. PCR examination of nose swab samples showed 1/30 positive result in the household contact group and also 1/30 positive result in non-household contact of leprosy (statistically no significant difference, p > 0.05). Serological study showed higher sero-positive result in the household contact group (15/30 or 50%) compared to non-household contact (11/30 or 36%), but statistical calculation revealed no significant difference between the two groups (p > 0.05) on sero-positive results of leprosy. It is concluded that household and non-household contact in leprosy have the same risk to be affected by the disease. The term of household and non-household contact need to be redefined. The possible role of exposure from the environment was also discussed, especially from non-human resource of M. leprae.
COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE BETWEEN HOUSEHOLD AND NONHOUSEHOLD CONTACT OF LEPROSY Arsyad, Yuniarti; Jifanti, Friska; Amiruddin, Muhammad Dali; Anwar, Anis Irawan; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 1 (2012)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1081.524 KB) | DOI: 10.20473/ijtid.v3i1.192

Abstract

Leprosy stills a public health problem in West Sulawesi which has a Case Detection Rate (CDR) around 43.69/100.000 population. Household contacts of leprosy are a high risk group to be infected, due to droplet infection mode of transmission of the disease. A nose swab examination and serological study was conducted to detect exposure of M. leprae of people who live in leprosy endemic area. Detection of M. leprae in the nasal cavity will represent the exposure rate from outside and the measurement of specific antibody is represented the result of exposure to the immune system. Two group of inhabitants (30 household contacts of leprosy and 30 nonhousehold contacts) were involved in the study. They live in Banggae district, a leprosy endemic area of Majene Regency, West Sulawesi. Sixty nose swab samples and sixty capillary blood samples from the same invidividuals of the two groups were collected and sent to Leprosy laboratory of the Institute of Tropical Disease, Airlangga University Surabaya. A Polymerase Chain Reaction (PCR) was performed to the nose swab samples for detection of M. leprae. The blood samples were examined serologically to measure the level of anti PGL-1 antibody. PCR examination of nose swab samples showed 1/30 positive result in the household contact group and also 1/30 positive result in non-household contact of leprosy (statistically no significant difference, p > 0.05). Serological study showed higher sero-positive result in the household contact group (15/30 or 50%) compared to non-household contact (11/30 or 36%), but statistical calculation revealed no significant difference between the two groups (p > 0.05) on sero-positive results of leprosy. It is concluded that household and non-household contact in leprosy have the same risk to be affected by the disease. The term of household and non-household contact need to be redefined. The possible role of exposure from the environment was also discussed, especially from non-human resource of M. leprae.