Heru Dwi Jatmiko
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PENGARUH BLOK PARAVERTEBRA INJEKSI MULTIPEL TERHADAP NYERI PASCA OPERASI TUMOR PAYUDARA DINILAI DENGAN VISUAL ANALOGUE SCALE

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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ABSTRACTThe effect of multiple injections paravertebral block against postoperative pain breast tumor surgery with Visual Analogue Scale assessedBackground: Breast cancer is the second most frequent cancer ever occured in women after cervical cancer. The number of breast cancer prevalence in Indonesia is 26 for every 100.000. According to the WHO almost 460.000 women died of breast cancer in 2008. Usually breast tumor patients who underwent definitive surgical therapy using the technique of general anesthesia.Objectives: To gain information about the effect of multiple injections paravertebral block on post operative pain in breast tumor surgery with VAS assessed.Methods: This study is an observational analytic with cross sectional approach in 10 breast tumor patients. The surgery on these patients was done by multiple injections paravertebral block anesthesia technique. After that the value of VAS being assessed in recovery room and 24th hours after recovery room. The statistic test of this study using Wilcoxon test (with significance degree p<0,05).Results: VAS value in 24th hour after recovery room (3,5±0,483) is higher than in recovery room (3,3±0,483), but there is no significant difference ( p=0,317).Conclusion: From the results it can be concluded that the multiple injections paravertebra block anesthesia have the effect to postoperative pain breast tumors with VAS assessed in recovery room and 24th hours after recovery room, but there is no significant difference.Keywords: Breast Tumor, Multiple Injection Paravertebral Block, Visual Analogue Scale.

PENGARUH PEMBERIAN ETOMIDATE 0,3 mg/kgBB INTRAVENA TERHADAP AGREGASI TROMBOSIT

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background :Preoperative bleeding is aserious and common problem in surgery. Induction anesthetic agent usage is known for the inhibition of platelet aggregation.Objective :To see the changes of platelet agregation after the injection of Etomidate 0,3mg/kgBM.Method :An experimental study on 20 patients who received general anasthesia. Sample received Etomidate as the induction anesthetic. The speciments are taken before the injection of Etomidate and 5 minutes after injection. All specimens were taken to the Clinical Pathology Laboratory for Platelete Agregation testing. Statistical analyses were performed using paired t-test ( with level of significant is P<0,05).Result :The patients characteristic and variables data to be compared were normally distributed. The changes of platelete agregation after the injection of Etomidate 0,3mg/kgBM is not significant. The platelete agregation before theinjection Etomidate is 73,45 ± 7,33 and the platelete agregation after the injection of Etomidate is 66,07 ± 8,28 with P=0,089.Conclution :Etomidate is unsignificantly changes the platelete agregation.Keywords :Etomidate, ADP, Platelete agregation.

PERBANDINGAN RESPON KARDIOVASKULER ANTARA FENTANIL DAN KLONIDIN PADA TINDAKAN LARINGOSKOPI DAN INTUBASI ENDOTRAKEA

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background: Airway management is an essential skill to be possessed by any anaesthesiologist. Laryngoscopy and endotracheal intubation are the most often way to maintain the airway. However ET intubation often cause an increasing blood pressure, heart rate, and cause arrhytmia. Administration of fentanyl and clonidine before ET intubation can reduce these elated cardiovascular responses.Aim: This study aimed to prove the difference between fentanyl 2 μg/kg intravenous and clonidine 2 μg/kg intravenous administration in reducing the cardiovascular responses due to laryngoscopy and ET intubation.Methods: An observational study with cross-sectional approach. Data were derived from secondary data with total sample of 48 patients which divided into two groups. Group 1 was patient who given fentanyl 2 μg/kg intravenously and Group 2 was given clonidine 2 μg/kg intravenously. Systolic and diastolic blood pressure, mean arterial pressure, and heart rate were recorded before intubation and in the first, third, and fifth minute after intubation.Results: In the first, third, and fifth minute after intubation showed no significant difference in systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate between Group 1 and Group 2 (p > 0,05).Conclusions: There is no significant difference between fentanyl 2 μg/kg intravenous and clonidine 2 μg/kg intravenous administration in reducing the cardiovascular responses due to laryngoscopy and ET intubation.Key words: cardiovascular response, laryngoscopy, ET intubation, fentanyl, clonidine

PENGARUH BLOK PARAVERTEBRA INJEKSI TUNGGAL TERHADAP NYERI PASCA OPERASI TUMOR PAYUDARA DINILAI DENGAN VISUAL ANALOG SCALE

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background : general anesthesia oftenly used in breast surgery although it causes 50% post-operative nausea and vomitting incidence. Single injection thoracal paravertebral block can reduce those complications.Aim : This study aims to see the effect of single injection thoracal paravertebral block against Visual analog scale (VAS) in patients who underwent breast surgery.Methods: The design of this research was observational clinical study with cross-sectional approach. The sample consisted of 10 patients who underwent breast surgery with single injection of paravertebral block anesthesia and whose VAS score had been measured in zero hour and 24th hour in Instalasi Bedah Sentral (Central Surgery Installation) RSUP dr. Kariadi Semarang.Results: It was obtained that the VAS score in single injection of paravertebral block anesthesia in 24th hour was lower than the zero hour with average score in zero hour = 3,9 ± 0,2 and average score in 24th hour = 3,7 ± 0,7. The statistic result with wilcoxon test showed that there was no significant difference with p= 0,317.Conclusion: There was a decrease in VAS score at both zero hour and 24th hour in patients who used single injection thoracal paravertebral block.Keywords: Single injection thoracal paravertebral block, VAS score.

PENGARUH BLOK PARAVERTEBRA INJEKSI MULTIPEL TERHADAP KADAR KORTISOL PLASMA PASIEN OPERASI TUMOR PAYUDARA

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Latar Belakang: Blok paravertebra thorakal bilateral sekalipun jarang, juga telah di lakukan secara peri-operatif saat bedah thorakal maupun bedah payudara. salah satu metode blok paravertebra yaitu dengan teknik injeksi multipel. Respon sistemik setelah perlakuan bedah meliputi peningkatan secara umum hormon katabolik seperti katekolamin, kortisol, renin, aldosteron, dan glucagon, yang menyebabkan hiperglikemia, metabolisme protein otot, dan peningkatan lipolisis.Kortisol memiliki unsur penting yang terlibat dalam respon stresss, psikis, trauma, dan respon inflamasi.Tujuan: Membuktikan pengaruh blok paravertebra injeksi multipel terhadap kadar kortisol plasma pre dan post operasi pada pasien yang menjalani operasi tumor payudara.Metode: Desain penelitian ini adalah penelitian Observasional dengan menggunakan rancangan Cross Sectional pada 10 pasien yang menjalani operasi tumor payudara dengan injeksi multipel blok paravertebra yang memenuhi kriteria inklusi dan ekslusi. Kemudian diperiksa kadar kortisol plasma pre operasi dan post operasi. Uji statistik menggunakan uji pair-t test.Hasil: Terjadi perubahan kadar kortisol plasma pre operasi dan post operasi. Rerata kadar kortisol plasma pre operasi 256,55 μg/dl sedangkan post operasi menurun sampai 224,73 μg/dl. Namun sesuai dengan hasil uji statistik di dapatkan perbedaan antara kadar kortisol plasma sebelum dan sesudah operasi adalah tidak bermakna (p=0,061).Simpulan: Terjadi penurunan kadar kortisol plasma pre dan post operasi dengan teknik injeksi multipel blok paravertebra pada pasien operasi tumor payudara. Namun sesuai dengan hasil uji statistik di dapatkan perbedaan yang tidak bermakna.Kata kunci: Injeksi multipel blok paravertebra, Kadar kortisol plasma

PENGARUH INJEKSI TUNGGAL BLOK PARAVERTEBRA TERHADAP KADAR KORTISOL PLASMA PASIEN OPERASI TUMOR PAYUDARA

MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Latar Belakang: Teknik anestesi yang digunakan dalam bedah payudara saat ini telah mengalami perkembangan dengan menggunakan anestesi regional. Anestesi regional injeksi tunggal blok paravertebra menjadi inovasi baru yang dikembangakan pada pasien operasi tumor payudara. Blok paravertebra dinyatakan dapat mengurangi reaksi efek samping maupun menurunkan respon stress tubuh pasien seperti kortisol plasma.Tujuan: Penelitian ini bertujuan untuk membuktikan pengaruh injeksi tunggal blok paravertebra yang menyebabkan penurunan kadar kortisol plasma pasien operasi tumor payudara.Metode: Desain penelitian ini adalah observasional dengan menggunakan analitik Cross sectional pada catatan medik 10 pasien yang menjalani operasi dengan teknik anestesi injeksi tunggal blok paravertebra yang memenuhi criteria inklusi dan ekslusi. Kemudian dibandingkan kadar konsentrasi kortisol plasma pada sebelum operasi (preoperasi) maupun pasca operasi (postoperasi). Uji statistic mengguakan uji pair-t test.Hasil: Penggunaan teknik injeksi tunggal blok paravertebra pada pasien bedah tumor payudara yang dilihat pengaruhnya melalui kadar konsentrasi kortisol plasma sebelum operasi (preoperasi) dengan rerata 258,34 ± 0,91 maupun pasca operasi (postoperasi) dengan rerata 234,01 ± 0,84 mengalami penurunan. Akan tetapi penurunan yang terjadi pada seluruh sampel tidak mengalami penurunan yang cukup significant. Rerata kadar konsentrasi kortisol plasma diuji dengan menggunakan uji statistic paired t- test mendapatkan hasil p>0,05 yaitu p=0,163. Sehingga penurunan kadar konsentrasi kortisol plasma pasien sebelum operasi (preoperasi) dengan pascaoperasi (postoperasi) memperoleh hasil yang tidak bermakna.Kesimpulan: injeksi tunggal blok paravertebra menyebabkan penurunan kadar konsentrasi kortisol plasma pascaoperasi (postoperasi) pada pasien bedah tumor payudara yang kurang significant. Sehingga mendapatkan hasil yang tidak bermakna.

KARAKTERISTIK DASAR PASIEN SEPSIS YANG MENINGGAL DI ICU RSUP DR.KARIADI SEMARANG PERIODE 1 JANUARI – 31 DESEMBER 2014

JURNAL KEDOKTERAN DIPONEGORO Vol 4, No 4 (2015): MEDIA MEDIKA MUDA
Publisher : Jurusan Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro

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Background: Sepsis is a leading cause of admission and death in ICU. It is important to know the basic characteristics of sepsis patients who die in ICU as an information to improve the comprehensive management of sepsis.Aim: The purpose of this study is to describe the basic characteristics of sepsis patients who died in Dr.Kariadi General Hospital ICU from January 1st – Desember 31st 2014.Methods: The study design is a descriptive study. Data were collected from medical record of sepsis patients who died in ICU from January 1st – Desember 31st 2014.Results: The majority of 77 patients suffered from sepsis who died in ICU were females (53.2%), 32 patients (41.5%) were in <44 years old age group, 32 patients (41.5%) already had sepsis on ICU admission, 57 patients (74%) were admitted in ICU for less than 7 days. The most frequent microorganisms found in blood cultures were Staphylococcus aureus and Staphylococcus haemolyticus (3 cases each). The source of infection of 58 patients (75.3%) were lungs. Twenty two patients (28.5%) had 20-24 APACHE II score range. Twenty cases (19.5%) had pneumonia as comorbid. The most medical intervention given to patients was mechanical ventilator (67.9%). The most common antibiotics used were ceftriaxone (43.4%).Conclusion: Most frequent microorganisms found in blood cultures of sepsis patients in ICU were Staphylococcus aureus and Staphylococcus haemolyticus. The most frequent source of infection were lungs. The most frequent APACHE II were in 20-24 score range. The most frequent comorbid was pneumonia. The most frequent medical intervention was mechanical ventilator installation. The most frequent antibiotic used were ceftriaxone.

Etomidat Menurunkan Kadar Gula Darah Pasca Induksi Anestesi

Jurnal Anestesiologi Indonesia Vol 3, No 2 (2011): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan terapi Intensif

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Backgrounds: The apperehensiveness of etomidate that causing hypoglicemia becomed problem. A rapid onset of action, a low cardiovascular risk profile, and less likely to cause a significant drop in blood pressure provide etomidate choose an anesthetic induction drug.Objectives: To proved the usage effects of etomidate that causing decrement of blood glucose level.Method: Pretest posttest controlled group design on 40 patients who are undergoing surgery with general anesthesia, divided into two groups (n =20), group E2 and E4, which received etomidate 0,2 mg/kgbw and 0,4 mg/kgbw respectively. Each groups was examined its blood glucose 3 times, before 2 hours and 6 hours after unduction. All data in E2 an E4 were analyzed by paired T-test and wilcoxon rank sum test.Results: Blood glucose of E2 were significantly different P=0,05 between before. And 2 hours after intervention 106, 95 ± 15, 453 mg/dl -96, 40 ± 14, 966mg/dl ; between 2 hours and 6 hour after intervention P= 0, 016; 96,40 ± mg/dl-99,35 ± 15,938 mg/dl; between before 6 hours after intervention P= 0.041 ; 102,60 ± 12,696 mg/dl – 98,25 ± 19,878 mg/dl. However, there were no significant differences between E2 and E4 in decreasing blood glucose on 2 hours P = 0,550; 96, 40 ±14, 966 mg/dl – 99, 35 ± 15, 938 mg/dl and 6 hours after intervention P = 0, 104; 108, 85 ± 27, 238 mg/dl – 98, 25 ± 19, 878 mg/dl. Statistically, etomidate could cause decrement on blood glucose, both in group E2 and E4 but stil in normal border or clinically insignificant.Conclusions: etomidate 0,2 mg/kgbw (E2) and 0,4 mg/ kg bw (E4) were statistically significant in decreasing blood glucose on 2 hours and 6 hours after induction.Keywords : Etomidate, adrenal suppresion, blood glucose.ABSTRAKLatar belakang: Kekhawatiran etomidat menyebabkan hipoglikemi menjadi masalah. Onset aksi cepat, profil kardiovaskuler rendah dan kurang signifikan menyebabkan penurunan tekanan darah membuat etomidat menjadi pilihan obat anestesi induksi yang cukup baik.Tujuan: membuktikan pengaruh pemberian etomidat dalam menyebabkan penurunan kadar gula darah.Metode: merupakan penelitian pretest postest controlled design pada 40 pasien yang menjalani operasi dengan anestesi umum, dibagi menjadi dua kelompok (n=20), kelompok1,etomidat 0,2 mg/kg ( E2) dan kelompok 2, 0, 4 mg/ kg ( E4). Masing- masing kelompok diperiksa kadar gula darah sebelum 2 jam dan 6 jam sesudah induksi. Uji statistik pair T-test dan Wilcoxon rank sum test terhadap E2 dan E4.Hasil: pada E2 terdapat perbedaan bermakna P= 0,05 antara sebelum dan 2 jam sesudah perlakuan 106, 95 ± 15, 453 mg/dl – 96, 40 ± 14, 966 mg/ dl ; 2 jam dan 6 jam sesudah perlakuan P= 0, 016 ; 96, 40 ±14, 966 mg/dl – 108, 85 ± 27, 238 mg/dl. Sedangkan pada E4 terdapat perbedaan bermakna P= 0, 041 baik sebelum dan 2 jam sesudah 102,60n± `12, 696 mg/dl – 99, 35 ± 15, 938 mg/dl ; sebelum dan 6 jam sesudah perlakuan P= 0, 041; 99, 35 ± 15, 938 mg/dl – 98, 25 ±± 19, 878 mg/dl. Tetapi tidak terdapat perbedaan bermakna antara E2 dan E4 dalam menyebabkan penurunan kadar gula darah baik 2 jam P= 0, 550 ; 96, 40 ± 14, 966 mg/ dl- 99, 35 ± 15, 938 mg/ dl, maupun sesudah 6 jam pemberian P= 0, 104 ; 108, 85 ± 27, 238 mg/ dl – 98, 25 ± 19, 878 mg/dl. Secara statistik etomidat menurunkan kadar gula darah baik pada E2 maupun pada E4 tetapi masih dalam batas normal atau secara klinik tidak bermakna.Kesimpulan: etomidat 0, 2 mg/dl (E2) dan 0, 2 mg/ dl (E4) secara statistik bermakna menurunkan kadar gula darah pada 2 jam dan 6 jam sesudah induksi

Granisetron, Kombinasi Metoklopramid dan Deksametason Terhadap Mual Muntah Paska Laparatomi

Jurnal Anestesiologi Indonesia Vol 2, No 3 (2010): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan terapi Intensif

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Backgroud: Post-operative Nausea and Vomitus (PONV) is commonly unsatisfy experienced by patient after surgical procedures with general anesthesia. Laparatomy is one among high risk groups for PONV. Objective: The aim of this study to compare the efficacy between granisetron 1 mg and combination metoclopramide 10 mg and dexamethasone 8 mg in preventing PONV after laparatomy. Methods: This research was a clinical trial stage 1 in 48 patients undergoing laparatomy surgery by general anesthesia. All patients were observe the 6 hours fasting period before induction of anesthesia. Patient randomly divided in to two group. Group I treatme nt with granisetron that given 30 to 60 minutes before end operation. Group II treatment with metoclopramide 10 mg and dexamethasone 8 mg, that dexamethasone given before induction of anesthesia and metoclopramide administration 30 to 60 minutes before end operation. All patient were observe the nausea and vomiting 24 hours post operative. Results: There was no significant difference for patient characterictics data distribution between two group before treatment. There was no significant difference to decr ease nausea and vomiting after laparatomy between two groups. Patient who had received intravenous 1 mg granisetron incidence nausea-vomiting was 83,3 % while patient who had received the combination 10 mg metoklopramid and 8 mg dexamethasone incidence nau sea—vomiting was 75%. Conclusion: There was no antiemetics which fully effective to exceed post operative nausea and vomitus. Combination 10 mg metoclopramide and 8 mg dexamethasone has similar effect like 1 mg granisetron on prevent Post -operative Nausea and Vomitus but higher adverse effects.Keywords : nausea, vomiting, granisetron, metoclopramide, dexamethasone, laparatomyABSTRAKTujuan: Penelitian ini bertujuan untuk membandingkan efektifitas antara granisetron 1 mg dan kombinasi metoklopramid 10 mg dengan deksametason 8 mg dalam mencegah mual muntah paska laparatomi. Metode: Penelitian ini merupakan penelitian tahap I pada 48 penderita yang menjalani laparatomi dengan anestesi umum. Semua penderita dipuasakan 6 jam sebelum dilakukan induksi anestesi. Pasien secara random dibagi menjadi dua kelompok. Kelompok I diberikan granisetron 30 sampai 60 menit sebelum operasi selesai. Dan kelompok II diberikan deksametason sebelum induksi anestesi dan metoklopramid 30 sampai 60 menit sebelum operasi selesai. Semua pasien diamati kejadian mual muntah paska operasi selama 24 jam. Hasil: Didapatkan perbedaan tidak bermakna pada distribusi karakteristik pasien antara kedua kelompok sebelum perlakuan. Hasil uji statistik menunjukkan terdapat perbedaan yang tidak bermakna kejadian mual muntah paska laparatomi pada kedua kelompok. Dimana pasien yang diberikan granisetron 1 mg didapatkan kejadian mual muntah sebesar 83,3 % sedangkan pasien yang diberikan kombinasi metoklopramid 10 mg + deksametason 8 mg didapatkan angka kejadian mual muntah sebesar 75%. Simpulan: Tidak ada antiemetik yang mampu sepenuhnya mencegah mual muntah paska operasi. Pemberian kombinasi metoklopramid 10 mg + deksametason 8 mg mampu mengurangi resiko mual muntah paska operasi yang hampir sama efektifnya dengan granisetron 1 mg dengan efek samping lebih banyak.Kata kunci : mual, muntah, granisetron, metoklopramid, deksametason, laparatomi

Hubungan Kadar Midazolam Plasma Ibu Dan Bayi Dengan Kondisi Fisik Serta Waktu Persalinan Pada Pasien Sectio Caesaria Yang Mendapat Premedikasi Midazolam Intravena

Jurnal Anestesiologi Indonesia Vol 2, No 1 (2010): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan terapi Intensif

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Background: Routine midazolam premedication is given in spinal anesthesia because very useful to give sedation, amnesia, decrease anxiety so that the patients’ hemodynamic is more stabile. To date, midazolam premedication for Cesarean section is still controversial because can depress nenonate respiratory. It is because data about the pharmacology of transplacental is still limited. In Cesarean section didn’t have bad effect to neonate. This study want to add information about transplacental pharmacology so that analysis the relation of blood plasma midazolam level of mother and baby with physical condition and time of labor. Objective: To prove the relation of blood plasma midazolam level of mother and baby with physical condition and time of labor. Method: There were 15 sample who fulfilled inclusion and exclusion criteria. Patient was injected with 0,02 mg/kgBW intravenous midazolam premedication just before spinal anesthesia (± 2 minute). After the umbilical cord cut, the maternal blood sample and umbilical vein blood sample was taken. The level of midazolam plasma was measured by HPLC. Statistic Corelation was analyzed using Person. Result: The aged of mother had positive significant correlation with blood plasma midazolam level of mother (r=0,932 ; =0,000) and baby ( r=0,578 ; =0,024 ). The aged of pregnancy had negative significant correlation with mother blood plasma midazolam level ( r= -0,648 ; = -0,009 ). The weight of the baby had negative significant correlation with baby blood plasma midazolam level ( r= -0,954 ; =0,000 ). Time of labour have negative significant correlation with blood plasma midazolam level of mother ( r= - 0,760; =0,001 ) and the baby (r= -0,558 ; = -0,031 ). Conclusion: There is relation of blood plasma midazolam level of mother and baby with physical condition and time of labor.Keywords : Midazolam, Spinal Anesthesia, Sectio CaesariaABSTRAKLatar belakang: Premedikasi midazolam rutin diberikan pada anestesi spinal karena sangat bermanfaat untuk memberikan efek sedasi, amnesia, menghilangkan kecemasan. Premedikasi midazolam untuk pasien section caesaria masih kontroversial karena ditakutkan terjadinya depresi napas neonatus. Hal ini karena informasi farmakologi transplasenta masih langka. Pada penelitian sebelumnya menyatakan dosis 0,02mg/kgbb iv aman bagi bayi. Penelitian ini bermaksud menambah informasi mengenai studi farmakokinetika yaitu menganalisis hubungan kadar midazolam plasma ibu dan bayi dengan kondisi fisik dan lamanya persalinan. Tujuan : Membuktikan adanya hubungan kadar midazolam plasma ibu dan bayi dengan kondisi fisik serta waktu persalinan. Metode : Ruang lingkup penelitian adalah Anestesiologi dan Farmakologi. Sample sebanyak 15 orang yang telah melalui kriteria inklusi dan eklusi Pasien diberi premedikasi midazolam dosis 0,02 mg/kgbb iv sesaat sebelum dilakukan anestesi spinal (± 2 menit). Setelah bayi lahir dipotong tali pusat, maka diambil arah vena maternal dan diambil sampel darah vena umbilikali Kadar midazolam plasma diukur menggunakan HPLC. Analisa statistik korelasi dengan pearson. Hasil : Usia ibu mempunyai hubungan bermakna positif dengan kadar midazolam plasma ibu (r=0,932 ; =0,000) dan bayi (r=0,578 ; =0,024). Usia kehamilan mempunyai hubungan bermakna negatif dengan kadar midazolam plasma ibu (r= -0,648 ; = -0,009). Berat badan bayi mempunyai hubungan bermakna negatif dengan kadar midazolam plasma bayi (r= -0,954 ; =0,000). Waktu persalinan mempunyai hubungan bermakna negatif dengan kadar midazolam plasma ibu (r= - 0,760 ; =0,001) maupun bayi (r= -0,558 ; = -0,031). Kesimpulan : Ada hubungan kadar midazolam plasma ibu dan bayi terhadap kondisi fisik serta waktu persalinan.Kata kunci : Midazolam, Anestesi Spinal, Sectio Caesaria