Yulia Ismail
Alumny Doctoral-Study Program of Medical Science, Graduate School, Universitas Airlangga

Published : 4 Documents
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Comparation Between Operative and Conservative Therapy of Spondylitis Tuberculosis in Hasan Sadikin Hospital Bandung Nataprawira, Heda Melinda; Rahim, Agus Hadian; Dewi, Mia Milanti; Ismail, Yulia
Journal of the Indonesian Medical Association Vol. 60 No. 7 July 2010
Publisher : Journal of the Indonesian Medical Association

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Abstract

Spondylitis tuberculosis (TB) most commonly affects thoracal and lumbal vertebrae. Clinical manifestations are insidious and not specific so that the patient usually presents in advanced disease. Destruction in the corpus results in gibbus formation. Anti tuberculous drugs and conservative treatment remain the cornerstone therapy for spondylitis TB. However, operative treatment must be considered if the child presents with severe deformity or developing and deterioration of neurological deficit. We reported two children diagnosed as spondylitis TB with different management in each cases in addition to antituberculosis treatment. In the first case, a nine-year-old girl came to the hospital with chief complaint of painless lump at the lumbar region and weakness of the limbs. There was no neurological deficit so we performed spinal orthoses. While surgery was performed in the second case with posterior approach, a sixyear- old boy who came to the hospital with chief complaint of painless lump and neurological deficit. With appropriate procedure, both cases showed good results in follow-up.Keywords: Spondylitis tuberculosis, surgery, spinal orthoses
Differences of Serum Ferritin Levels in Children with Thalassemia Major after Deferiprone and Deferoxamine Iron Kelator Administration Ismail, Yulia; Reniarti, Lelani; Hilmanto, Dany
Journal of the Indonesian Medical Association Vol. 60 No. 11 November 2010
Publisher : Journal of the Indonesian Medical Association

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Abstract

Routine serum ferritin examination was used to evaluate response of iron chelator in thalassemia major. Iron chelator which was widely used were deferoxamne (DFO) and deferiprone (DFP). Iron loading in thalassemia major patients continued despite iron chelation therapy, so effective and continue iron chelator agent was needed. This study was aimed to know the difference of ferritin serum levels after DFO and DFP therapy in 6, 12, and 18 months. A cross sectional study was performed between May and August 2009 in Hasan Sadikin General Hospital Bandung. Forty eight children with thalassemia major were analyzed. There were statistical differences between DFO or DFP administration (Factor-A) with serum ferritin level (p=0.002) and between 6, 12, 18 months administration time (Factor-B) with serum ferritin level (p<0.001). Interaction between both factors was not significantly different (p=0.645). In conclusion, type and administration time of iron chelator effect in serum ferritin level.Keywords: deferiprone, deferoxamine, ferritin, thalassemia major
ANALYSIS OF HIV SUBTYPES AND CLINICAL STAGING OF HIV DISEASE/AIDS IN EAST JAVA Ismail, Yulia; Soetjipto, Soetjipto; Wasito, Eddy; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012)
Publisher : Institute of Topical Disease

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Abstract

Human Immunodeficiency Virus type 1 (HIV-1) known to cause Acquired Immune Deficiency Syndrome (AIDS) disease are divided into several subtypes (A, B, C, D, F, G, H, J, K) and Circulating Recombinant Form (CRF). Different characteristics of subtype of the virus and its interaction with the host can affect the severity of the disease. This study was to analyze HIV-1 subtypes circulatingin HIV/AIDS patients from the East Java region descriptively and to analyze its relationship with clinical stadiums of HIV/AIDS. Information from this research was expected to complement the data of mocular epidemiology of HIV in Indonesia. This study utilited blood plasma from patients who had been tested to be HIV positive who sected treatment to or were reffered to the Intermediate Care Unit of Infectious Disease (UPIPI) Dr. Soetomo Hospital Surabaya from various area representing the East Java regions. Plasma was separated from blood samples by centrifugation for use in the the molecular biology examination including RNA extraction, nested PCR using specific primer for HIV gp120 env gene region, DNA purifying, DNA sequencing, and homology and phylogenetic analysis. Based on the nucleotide sequence of the HIV gp120 env gene, it was found that the most dominant subtypes in East Java were in one group of Circulating Recombinant Form (CRF) that is CRF01_AE, CRF33_01B and CRF34_01B which was also found in Southeast Asia. In the phylogenetic tree, most of HIV samples (30 samples) are in the same branch with CRF01_AE, CRF33_01B and CRF34_01B, except for one sample (HIV40) which is in the same branch with subtype B. HIV subtypes are associated with clinical stadiums (disease severity) since samples from different stages of HIV disease have the same subtype.
ANALYSIS OF HIV SUBTYPES AND CLINICAL STAGING OF HIV DISEASE/AIDS IN EAST JAVA Ismail, Yulia; Soetjipto, Soetjipto; Wasito, Eddy; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012)
Publisher : Institute of Topical Disease

Show Abstract | Original Source | Check in Google Scholar | Full PDF (140.202 KB)

Abstract

Human Immunodeficiency Virus type 1 (HIV-1) known to cause Acquired Immune Deficiency Syndrome (AIDS) disease are divided into several subtypes (A, B, C, D, F, G, H, J, K) and Circulating Recombinant Form (CRF). Different characteristics of subtype of the virus and its interaction with the host can affect the severity of the disease. This study was to analyze HIV-1 subtypes circulatingin HIV/AIDS patients from the East Java region descriptively and to analyze its relationship with clinical stadiums of HIV/AIDS. Information from this research was expected to complement the data of mocular epidemiology of HIV in Indonesia. This study utilited blood plasma from patients who had been tested to be HIV positive who sected treatment to or were reffered to the Intermediate Care Unit of Infectious Disease (UPIPI) Dr. Soetomo Hospital Surabaya from various area representing the East Java regions. Plasma was separated from blood samples by centrifugation for use in the the molecular biology examination including RNA extraction, nested PCR using specific primer for HIV gp120 env gene region, DNA purifying, DNA sequencing, and homology and phylogenetic analysis. Based on the nucleotide sequence of the HIV gp120 env gene, it was found that the most dominant subtypes in East Java were in one group of Circulating Recombinant Form (CRF) that is CRF01_AE, CRF33_01B and CRF34_01B which was also found in Southeast Asia. In the phylogenetic tree, most of HIV samples (30 samples) are in the same branch with CRF01_AE, CRF33_01B and CRF34_01B, except for one sample (HIV40) which is in the same branch with subtype B. HIV subtypes are associated with clinical stadiums (disease severity) since samples from different stages of HIV disease have the same subtype.