Irianiwati Irianiwati
Department of Pathology of Anatomy, Faculty of Medicine, University of Gadjah Mada
Articles
6
Documents
Molecular subtypes and clinicopathological features of breastcancer

Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 01 (2013)
Publisher : Universitas Gadjah Mada

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Abstract

Breast cancer is a heterogeneous disease with regard to morphological spectrum, clinical presentation and response to therapy. Based on immunohistochemistry detection of estrogen receptor, progesterone receptor, Her-2 status, proliferation rate and clusters of basal gene expression, breast cancers can be classified into luminal A, luminal B, basal-like/triple negative, and Her-2 positive. It was suggested that there was a close relationship between molecular subtypes and clinicopathological features of breast cancer, as they are very important to predict prognosis and therapeutic implications. Keywords: molecular subtypes - breast cancer- clinicopathological features -heterogeneity –theraputicimplications  

The role of tumor-associated macrophages in breast cancer

Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Interaction of Tumor-Associated Macrophages (TAMs) with tumor cells gives insights into tumor progression andinto a novel therapeutic strategy. In papillary thyroid cancer, patients with tumors containing TAMs had a betterprognosis than patients without TAMs . In prostatic cancer, the reduced of total TAMs can be used as a novelprognostic marker. In melanoma maligna, high number of TAMs was statistically significant associated with poorresponse to treatment . In breast cancer progression, the role of TAMs is still unclear.Key words: tumor-associated macrophages - breast cancer – angiogenesis - tumor progression - prognosis

The basal membrane destruction in benign prostatic hyperplasia, prostatic intraepithelial neoplasma, and prostatic adenocarcinoma. A study on basal membrane type IV collagens

Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Universitas Gadjah Mada

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Abstract

Basal membrane (BM), a selective permeable membrane is mainly composed of type IV collagen. A tumor invasion, therefore, may only occur if this membrane is destroyed by an active process of tumor producing proteolytic enzymes. It has been found that prostatic intraepithelial neoplasia (PIN) is a prostatic premalignant lesion. Although both benign prostate hyperplasia (BPH) and prostatic adenocarcinoma required an androgenic hormone for their growth, the correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinoma should be clarified. This can be studied by observing the continuity of periacinair BM. In order to understand the correlation among prostatic lesions, the BM continuity of 40 paraffin block specimens (15 BPH, 11 PIN, and 14 Prostatic adenocarcinomas) were studied. The BM of these specimens were stained immunohistochemically with MoAB anti human Type IV collagens. The periacinair BM continuity was scored 0-5. The Spearmans correlation test was used to analyze their possible relationship.The result shows that there is a significant correlation between the degree of destruction of basal membranes and BPH, PIN, and Prostatic adenocarcinomas (r = 0.898; p<0.05). In conclusion, based on periacinair BM des-truction, there is a positive correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinomas.Key words : collagen type IV - prostatic adenocarsinoma - prostatic intrapithelial neoplasia - benign prostate hyperplasia - basal membrane

THE INFLUENCE OF NIFEDIPINE INDUCTION TO GINGIVAL EPITHELIAL CELL PROLIFERATION (in vivo study in rat)

Journal of Dentistry Indonesia Vol 11, No 1 (2004): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

It is well known that nifedipine administration in hypertensive patients results in gingival hyperplasia. The aim of this study was to study the pattern of nifedipine-induced gingival hyperplasia, based on morphometric and histogical changes as well as on PCNA (Proliferating Cell Nuclear Antigen) expression in the gingival epithelium. In total, 36 male Sprague Dawley rats at the age of 6-8 weeks were divided into nine experimental groups and three control groups. Each animal received daily DMSO (dimethyl sulfoxide) via oral intubation at a dosage of 0 (for control groups), 15, 30, or 60 mg/kg (experimental groups) of body weight for 7, 21 or 42 days. After the animals were sacrificed, impression of the lower gingival tissue was taken to measure mesio-distal distance, labio-lingual distance and papilla height. The number of blood vessels and the thickness of gingival epithelium were assessed from hematoxylin and eosin stained sections. Proliferative activity of the epithelial cells was determined by immunohistochemical analysis using PCNA monoclonal antibody. Significant increase in the mesio-distal and labio-lingual distance of the lower gingival tissue was detected morphometrically (p<0.05). There were more blood vessels in the experimental groups than in the control groups, however there was no specific pattern based on the dosage or duration of nifedipine administration. On the other hand, significant differences were found in the gingival epithelial thickness and proliferative activity between the experimental and the control groups. PCNA-positive cells were observed in basal and suprabasal layers, but nearly none in lamina propria.

The role of tumor-associated macrophages in breast cancer

Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Original Source | Check in Google Scholar

Abstract

Interaction of Tumor-Associated Macrophages (TAMs) with tumor cells gives insights into tumor progression andinto a novel therapeutic strategy. In papillary thyroid cancer, patients with tumors containing TAMs had a betterprognosis than patients without TAMs . In prostatic cancer, the reduced of total TAMs can be used as a novelprognostic marker. In melanoma maligna, high number of TAMs was statistically significant associated with poorresponse to treatment . In breast cancer progression, the role of TAMs is still unclear.Key words: tumor-associated macrophages - breast cancer – angiogenesis - tumor progression - prognosis

The basal membrane destruction in benign prostatic hyperplasia, prostatic intraepithelial neoplasma, and prostatic adenocarcinoma. A study on basal membrane type IV collagens

Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 01 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Original Source | Check in Google Scholar

Abstract

Basal membrane (BM), a selective permeable membrane is mainly composed of type IV collagen. A tumor invasion, therefore, may only occur if this membrane is destroyed by an active process of tumor producing proteolytic enzymes. It has been found that prostatic intraepithelial neoplasia (PIN) is a prostatic premalignant lesion. Although both benign prostate hyperplasia (BPH) and prostatic adenocarcinoma required an androgenic hormone for their growth, the correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinoma should be clarified. This can be studied by observing the continuity of periacinair BM. In order to understand the correlation among prostatic lesions, the BM continuity of 40 paraffin block specimens (15 BPH, 11 PIN, and 14 Prostatic adenocarcinomas) were studied. The BM of these specimens were stained immunohistochemically with MoAB anti human Type IV collagens. The periacinair BM continuity was scored 0-5. The Spearmans correlation test was used to analyze their possible relationship.The result shows that there is a significant correlation between the degree of destruction of basal membranes and BPH, PIN, and Prostatic adenocarcinomas (r = 0.898; p<0.05). In conclusion, based on periacinair BM des-truction, there is a positive correlation between the degree of destruction of basal membranes and BPH, PIN, and prostatic adenocarcinomas.Key words : collagen type IV - prostatic adenocarsinoma - prostatic intrapithelial neoplasia - benign prostate hyperplasia - basal membrane