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STANDARISASI EKSTRAK ETIL ASETAT KAYU SANREGO (Lunasia amara Blanco)

Online Journal of Natural Science FMIPA Vol 2, No 3 (2013): Volume 2 Number 3 (December 2013)
Publisher : Online Journal of Natural Science FMIPA

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Abstract

Lunasia amara Blanco is a popular medicinal plant which is known as aphrodisiac in South Sulawesi Province. Biological activity as antibacterial, anticancer dan antituberculosis were also scientifically reported. This study is to ascertain the safety and quality of the plant extract by standardization procedures mentioned in literature, including specific and non-specific parameters. The result showed that ethyl acetate wood extract of L. amara Blanco, which is brown viscous extract, astringent to the taste and characteristic odor, contain water-soluble extractive matters of 23,95 ± 2,192 %, ethanol-soluble extractive matters of 67,05 ± 3,61 %, water content of 5,33 ± 0,407 %,  total ash content of 0,65 ± 0,199 %, acid-insoluble ash content of 0,58 ±0,225 %, density of 0,7734 ± 0,0016 (5%) and 0,7957 ± 0,0021 (10%), total contaminant number of bacteria and fungus of each < 1 x 104 colony/g, and Pb concentration of 10,59 ± 0,239 mg/kg. Ethyl acetate wood extract of L. amara Blanco has been qualified as standardized extract. Therefore, this study can be a reference for identification and control quality of the extract as a herb-medicine material

ANALISIS LOGAM TIMBAL (Pb) PADA IKAN PETEK (Leiognathus sp.) DAN IKAN TERI (Stelophorus sp.) DI KAWASAN LAUT TELUK PALU SECARA SPEKTROFOTOMETRI SERAPAN ATOM

Online Journal of Natural Science FMIPA Vol 3, No 3 (2014): Volume 3 Number 3 (December 2014)
Publisher : Online Journal of Natural Science FMIPA

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Abstract

Penelitian ini bertujuan untuk mengetahui adanya cemaran logam Timbal (Pb) dan jumlah cemarannya pada spesies ikan Petek dan ikan Teri di kawasan laut Teluk Palu. Metode yang digunakan adalah destruksi kering (dry ashing) kemudian dianalisis secara kualitatif menggunakan pereaksi : (1) KCN ditambah Ditizon 0,005%, (2) Serbuk KI dan (3) Serbuk Na2CO3, serta uji kuantitatif dengan metode Spektrofotometri Serapan Atom pada λmaks 217 nm. Hasil penelitian didapatkan bahwa pada pengujian kualitatif ikan positif mengandung logam timbal (Pb). Hasil pengujian kuantitatif didapatkan kadar rata-rata logam timbal (Pb) adalah : (1) Ikan Petek di lokasi Taman Ria 0,757 mg/kg ; (2) Ikan Petek di lokasi sekitar Muara Sungai Palu 1,752 mg/kg ; (3) Ikan Petek di lokasi sekitar Pantai Talise 0,719 mg/kg ; (4) Ikan Teri di lokasi Taman Ria 1,989 mg/kg ; (5) Ikan Teri di lokasi sekitar Muara Sungai Palu 2,075 mg/kg  dan (6) Ikan Teri di lokasi sekitar Pantai Talise 1,655 mg/kg. Kadar logam timbal (Pb) pada kedua ikan tersebut telah melampaui nilai batas maksimum berdasarkan SNI 7387:2009 yaitu 0,3 mg/kg.

Daya Hambat Infusa Daun Sawo (Manilkara zapota L.) Terhadap Bakteri Escherichia coli

Online Journal of Natural Science FMIPA Vol 4, No 2 (2015): Volume 4 Number 2 (August 2015)
Publisher : Online Journal of Natural Science FMIPA

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Abstract

Penelitian ini bertujuan untuk mengetahui daya hambat infusa daun sawo (Manilkara zapota L.) dalam menghambat pertumbuhan bakteri Escherichia coli sebagai penyebab penyakit diare. Metode ekstraksi yang digunakan yaitu metode infudasi, dengan konsentrasi 25%, 50% dan 75% infusa daun sawo, aquadest sebagai kontrol negatif, dan kloramfenikol sebagai kontrol positif. Dilakukan replikasi sebanyak tiga kali pada setiap kelompok perlakuan. Metode pengujian daya hambat infusa daun sawo menggunakan sumuran pada media yang telah ditanam bakteri. Hasil penelitian menunjukan adanya zona hambat selama 24 jam dan tidak ditemukan zona hambat selama 2x24 jam pada ekstrak daun sawo. Hasil analisa menunjukkan bahwa rata-rata zona hambat yang dihasilkan secara berurutan pada konsentrasi 25%, 50%, dan 75% adalah 14,66 mm, 16,30 mm, dan 19,93 mm. Pada kontrol negatif tidak terbentuk zona hambat, sedangkan  pada kontrol positif rata-rata zona hambat sebesar 38,41 mm. Kesimpulan diperoleh bahwa ekstrak daun sawo dapat menghambat E. coli dengan KHM ekstrak daun sawo pada konsentrasi 25%, namun tidak dapat membunuh E. coli karena tidak ditemukan KBM ekstrak daun sawo terhadap bakteri E. coli.

Pendugaan Masa Simpan Likopen Buah Tomat Afkiran (Lycopersicum esculentum Mill) Tersalut Maltodekstrin dalam Kemasan Kapsul pada Berbagai Suhu Penyimpanan

Online Journal of Natural Science FMIPA Vol 5, No 1 (2016): Volume 5 Number 1 (March 2016)
Publisher : Online Journal of Natural Science FMIPA

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Abstract

Upaya untuk mendapatkan keterangan tentang masa simpan likopen dari buah tomat tersalut maltodekstrin dalam kemasan kapsul dilakukan melalui penyalutan ekstrak likopen dengan maltodekstrin pada berbagai rasio ekstrak likopen terhadap maltodekstrin, dilanjutkan dengan pengemasan dalam kapsul, likopen tersalut maltodekstrin terbaik dilakukan penyimpanan pada suhu 40 dan 50oC. Pengamatan terhadap kerusakan likopen dilakukan setiap 24 jam selama 240 jam. Hasil pengamatan bentuk dan kadar likopen tersalut maltodekstrin menunjukkan bentuk tersalut terbaik terdapat pada rasio likopen/maltodekstrin 1 : 1 atas dasar berat perberat, dan pada rasio tersebut kadar likopen likopen tersalut maltodekstrin 45,47%. Kerusakan likopen tersalut maltodekstrin dalam kemasan kapsul mengikuti reaksi orde nol. Dengan menggunakan asumsi masa kadaluarsa likopen tersalut maltodekstrin dalam kemasan kapsul pada tingkat kerusakan 70 %, diperoleh waktu simpan likopentersalut maltodekstrin dalam kemasan kapsul pada suhu 40 dan 50oC masing-masing 926 hari dan 488 hari. Berdasarkan nilai masa simpan pada suhu 40 dan 50oC tersebut diperoleh faktor percepatan reaksi atau nilai Q10 sebesar 1,9. Dengan menggunakan nilai Q10, diperoleh waktu simpan likopen tersalut maltodekstrin dalam kemasan kapsul pada suhu penyimpanan 20, 25, 30 dan 35oC masing-masing 3.341 hari, 2.427 hari, 1.759 hari dan 1.277 hari.

Mikroenkapsulasi Likopen dari Buah Tomat dengan Metode Penguapan Pelarut

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 5, No 1 (2019): (March 2019)
Publisher : Universitas Tadulako

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Abstract

Lycopene is a carotenoid group easily damaged due to the oxidation process (light, oxygen and temperature) and isomerization during storage. This damage can be minimized by microencapsulation processes. The objective of this study was to develop novel microencapsulation of lycopene extracts from tomato fruit by solvent evaporation method using ethyl cellulose as wall materials and to select the optimum formulation. Three microcapsule formulations were prepared containing the ratio of lycopene and ethyl cellulose (L:ES) of 1:1, 1:2 and 1:3. The morphology of the microcapsules was analysed by optical microscopy and scanning electronic microscopy. The encapsulation efficiency, particle size, recovery yield and moisture content were also examined. The result showed that all microcapsule formula were aggregated and irregular in shape with encapsulation efficiency of 6.13- 19.43%, moisture content of 1,63- 7,52%, recovery yield of 81-98,12% and particle size of 46,2-86µm. Microcapsule with a ratio 1:3 (L:ES) was the most optimum formula based on a maximum encapsulation efficiency than the others

ANALISIS KANDUNGAN MERKURI (Hg) PADA KRIM PEMUTIH WAJAH TIDAK TERDAFTAR YANG BEREDAR DI PASAR INPRES KOTA PALU

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 3, No 1 (2017): (March 2017)
Publisher : Universitas Tadulako

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Abstract

Whitening cream is a mixture of chemicals and other materials to eliminate the the black spots on the skin. The purpose of this research was to determine whether unregistered facial whitening creams that contain mercury (Hg) and to determine the amount of mercury (Hg) levels of the facial whitening creams have circulated in the Inpres Market Palu. There are 10 samples were examined of facial whitening cream by using Purposive Sampling method. The testing of mercury content is divided into two stages first stage is qualitative testing (color test) and the second stage is quantitative testing atomic absorption Spectrophotometry using additional tools MVU (Mercury Vaporizer Unit). The result of the research show that all of 10 the samples contained mercury (Hg) with an average content of each sample A = 67,27 µg/g , B = 5349,47  µg/g, C = 137,49 µg/g, D = 159,25  µg/g, E = 90,22 µg/g, F = 33,61 µg/g, G = 31,87  µg/g, H = 32,36 µg/g, I = 3,63  µg/g and J = 3,52 µg/g.

STUDI ETNOFARMASI SUKU DONDO KECAMATAN DONDO KABUPATEN TOLITOLI SULAWESI TENGAH

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 2 (2015): (October 2015)
Publisher : Universitas Tadulako

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Abstract

This study aims to inventory and to record plants and their parts used as medicine by Dondo Tribe in Dondo Subdistrict, Tolitoli Regency, Central Sulawesi. This research is a descriptive study using qualitative methods and snowball sampling technique through open-ended interviews to 4 informants using questionnaire. The results showed that 56 plant species divided into 32 familia were used as medicine. The most widely used plant was from Euphorbiaceae family as much as 11%. Parts of plant which were used included leaf, petiole, stem, bark, flower, fruit, seed, rhizomes, tuber, and herb. Part of plant widely used was the leaf with percentage of utilization as much as 62%. The people of Dondo Tribe in Tolitoli District use the plants for treatment of illness, recovery, and maintenance of health. The methods of processing included decocting, mashing, roasting, burning, squeezing, and brewing the parts of the plant. The ways of using included drinking, eating, chewing, smearing, dropping, affixing/compressing, attaching, and rubbing the plant preparations on the sore spot as well as inhaling the fumes, and mixing it with water for bathing

KAJIAN ETNOFARMASI ETNIK BUNGKU DI KECAMATAN BUNGKU TENGAH KABUPATEN MOROWALI PROVINSI SULAWESI TENGAH

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 2, No 2 (2016): (October 2016)
Publisher : Universitas Tadulako

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Abstract

This study aims to find out and to inventory the types and parts of plants as well as to dig up information about ways of their utilization as remedy used by Bungku people “To Bungku”. It was conducted from August to December 2015 in Bungku Subdistrict, Central Bungku, Morowali Regency, Central Sulawesi. This research is a descriptive study using qualitative methods and snowball sampling technique on 12 informants through data collection by questionnaire. Results of this etnopharmacy study revealed that there were 62 species of medicinal plants divided into 34 familia. The most widely used plants came from familia Euphorbiaceae, Fabaceae and Zingiberaceae, each was as many as 8%. Parts of plant including roots, stems, leaves, flowers, fruits, seeds and bulbs were used in accordance with their function. Leaves were the ones used with the highest percentage (50%). Bungku people used medicinal plants to treat diseases such as kidney stone, diabetes, hemorrhoids, diarrhea, abscess, candidiasis, gout, cancer, hypertension, hypercholesterolemia, dyspepsia, cough, abdominal pain, malaria, hematuria, skin inflammation, headache, fever, bronchitis, dysentery, asthma, stroke, gallstones, urinary tract infections, broken bones, nail-punctured, wound ulcers, burns, hepatitis, appendicitis. Ways of the utilization were very diverse such as boiling then drinking the decoction; crushing then rubbing on the necessary skin; attaching to the body; squeezing then drinking the juice; and heating on the fire. Processing by boiling has the largest percentage, as much as 54%

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU BUTON DI KECAMATAN BINONGKO, KABUPATEN WAKATOBI, SULAWESI TENGGARA

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Vol 1, No 2 (2015): (October 2015)
Publisher : Universitas Tadulako

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Abstract

Herbal plant ethno pharmacy study in Butonse has been coducted from January to april2014 in Binongko Sub-districtm Wakatobi Regency of South East Sulawesi. This research aimed tofind out various species and plant organs used, kinds of diseases healed, and the way to use the herbalplants by Butonese in Binongko Sub-district. This was a descripive research using qualitativemethod.The sample was taken through snowball technique with 17 informans by using questiomnaire.Based on the research result, it was obtained 53 species of plants and divided into 35 families thatused as medicine.The most used plants were family of Euphorbiaceae of 6 species. It was found 3kinds of unique plants used such as tali putri, daun picah, and kayu kuda. The organs used were leaf,fruit, stem, tuber, root, rhozome. Latex, flower, stem skin, and wood skin. The most used plant’sorgan was the leaves of 56%. The wey is by boiling, pounding, chewing, squeezing, slicing, smearing,burning, dropping, soaking, consuming directly, gratting, attachng, and having smoke. The most wayused is by boiling and pounding for 34% each.

Uji Aktivitas Antibakteri Ekstrak Serbuk Gergaji Kayu Eboni (Diospyros celebicaBakh.) Terhadap Bakteri Staphylococcus aureus dan Escherichia coli

Biocelebes Vol 12, No 1 (2018)
Publisher : Biocelebes

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Abstract

Ebony (Diospyros celebica Bakh.) is one of the beneficial plants from ebenaceae, especially in traditional medicine. The sawdust extract containing chemical compounds such as tannins, saponins and terpenoids. This research were aimed to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) also to identified the active compounds from sawdust extracts of D. celebica Bakh. against Staphylococcus aureus and Escherichia coli. The Research methods include extraction using maceration method by ethanol 96%. MIC and MBC determination using dilution and diffusion methods. The Results showed that MIC value of S.aureus and E. coli were 6% and 7%, respectively. While MBC value of S. aureus and E. coli were 12% and 13%, respectively. Identification of chemical compounds were determined by Thin Layer Chromatography (TLC) bioautography method by 10% H2SO4 and anisaldehid-sulfuric acid reagent spray. There were two chemichal compounds that produced, saponin and terpenoid.