Reti Hindritiani
Departemen Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Padjadjaran-Rumah Sakit Dr. Hasan Sadikin Bandung

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Penurunan Aktivitas Tirosinase dan Jumlah Melanin oleh Fraksi Etil Asetat Buah Malaka (Phyllantus emblica) pada Mouse Melanoma B16 Cell-Line

Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Akumulasi melanin menyebabkan hiperpigmentasi dan bila terdapat pada wajah dapat menimbulkan masalah psikososial. Bahan depigmentasi dari tanaman semakin banyak digunakan. Bahan yang dikembangkan harus efektif menghambat sintesis melanin serta tidak toksik terhadap melanosit. Penelitian ini bertujuan menguji efek fraksi etil asetat buah Phyllanthus emblica (P. emblica) atau buah malaka, terhadap sintesis melanin dengan mengukur jumlah melanin dan aktivitas tirosinase, yang merupakan enzim utama sintesis melanin, secara spektrofotometrik pada kultur sel melanosit mouse melanoma B16 cell-line. Sitotoksisitas diukur dengan metode 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Penelitian dilakukan pada November–Desember 2009 di Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, Korea Selatan. Hasil penelitian menunjukkan aktivitas tirosinase dan jumlah melanin menurun bergantung pada dosis perlakuan berbagai konsentrasi fraksi etil asetat buah P. emblica dengan inhibition concentration (IC) 50 berturutturut 95,63 dan 16,90 μg/mL, serta lethal dose (LD) 50 pada konsentrasi 106,64 μg/mL. Simpulan, fraksi etil asetat buah P. emblica mempunyai potensi sebagai bahan depigmentasi, karena mampu menurunkan sintesis melanin melalui inhibisi aktivitas tirosinase. [MKB. 2013;45(2):118–24]Kata kunci: Aktivitas tirosinase, etil asetat, melanin, Phyllanthus emblicaReduction of Tyrosinase Activity and Melanin Amount by Ethyl Acetate Fraction from Malaka (Phyllanthus emblica) Fruit in Mouse Melanoma B16 Cell-LineMelanin accumulation can lead to hyperpigmentation, and if it occurs on the face can cause psychosocial problem. Depigmenting agents derived from plants are increasingly utilized. Agents being developed have to be effective in inhibiting melanin synthesis and should not be toxic to melanocyte. This study aimed was to examine the effect of ethyl acetate fraction from Phyllanthus emblica (P. emblica) fruit, also known as malaka fruit, towards melanine synthesis, which was measured from the melanin amount and tyrosinase activity, the key regulatory enzyme in melanin synthesis, spectrophotometrically towards melanocytes of mouse melanoma B16 cell-line. The cytotoxic effect towards melanocytes was measured with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. This study was conducted on November−December 2009 in Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, South Korea. The result of this study showed that tyrosinase activity and melanin amount decreased in a dose-dependent manner towards various concentrations of ethyl acetate fraction of P. emblica fruit with inhibition concentration (IC) 50=95.63 and 16.90 μg/mL, respectively and lethal dose (LD) 50 concentration 106.64 μg/mL. In conclusion, ethyl acetate fraction of P. emblica fruit is a potential depigmenting agent, since it can reduce melanin synthesis by inhibition of tyrosinase activity. [MKB. 2013;45(2):119–24]Key words: Ethyl acetate, melanin, Phyllanthus emblica, tyrosinase activity DOI: http://dx.doi.org/10.15395/mkb.v45n2.115

Treatment Evaluation of Melasma Patients in Dr. Hasan Sadikin General Hospital Bandung in period of 2013–2014

Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Melasma is hyperpigmentation of the skin especially located on face exposed to the sunlight. This condition was characterized by brown to gray-brown macula with irregular border. Difficulties in treatment of melasma arise from high tendency for relapse, expensive cost, and high risk of side effects such as erythema, sores, scales, and acne eruption. Study about evaluation of melasma therapy in Dr. Hasan Sadikin General Hospital Bandung have not ever been done before. Therefore, this study was conducted to evaluate therapy of melasma in the Policlinic of Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung.Methods: This study was retrospectively descriptive. Data were obtained from the new melasma patient medical records of Policlinic of Dermatology and Venereology of Dr. Hasan Sadikin General Hospital Bandung in period of January 2013–2014. Sampling method used in this study was total sampling. Treatments of melasma were evaluated by using Melasma Area Severity Index (MASI) score. Collected data were processed and presented in frequency distribution and percentage.Results: The most used topical drugs were combination of hydroquinone and tretinoin, and all of patients received sunblock. Most frequent time interval was two weeks (30.8%). The most common side effect was erythema (10 out of 22). Decreased MASI score was discovered in 48.1% and the most decreased category was mild (14 out of 25). Conclusions: The very common topical drugs used are hydroquinone and tretinoin. The side effect of the treatment is Erythema. The decreased MASI score is mild. [AMJ.2016;3(4):610–5]DOI: 10.15850/amj.v3n4.947

Five Years Data of Clinical and Histopathological Characteristics of Skin Adnexal Tumors in Dr. Hasan Sadikin General Hospital Bandung

Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Abstract

Background: Skin adnexal tumors arise from skin adnexal differentiation. Very limited number of study has been performed on their clinical and histopathological characteristics in Dr. Hasan Sadikin General Hospital. The objectives of this study was to identify the clinical and histopathological characteristic of skin adnexal tumors during the period of 2009 to 2013.Methods: AA descriptive study performed on 79 medical records of patients with skin adnexal tumors at the Department of Anatomic Pathology in Dr. Hasan Sadikin General Hospital Bandung from 2009 to 2013. Data were collected during the period of September to October 2014. The inclusion criteria were medical records containing information on skin adnexal tumors confirmed by histopathological examination results, patient characteristics (age and gender), and the tumor characteristics (size, location, malignancy, type, and histopathological origin). Collected data were processed using computer and presented in tables.Results: This study showed that tumors occured during productive age with male to female ratio was 1.2:1. Most skin adnexal tumors were ≤5 cm in size and were distributed in the head-neck region. Most of the tumors were benign and arised from hair follicle differentiation with pilomatricoma type while the malignant tumors commonly arised from sebaceous gland differentiation with sebaceous carcinoma type.Conclusions: Most skin adnexal tumors occur in productive age with no gender prediclation. They are small in size and are distributed in the cephalic region. Most are benign tumors arising from hair follicle differentiation with some malignant tumors arising from sebaceous gland differentiation. [AMJ.2016;3(4):514–9] DOI: 10.15850/amj.v3n4.933

POTENSI LIMBAH KULIT JERUK NIPIS (Citrus auronfolia) SEBAGAI INHIBITOR TIROSINASE

Indonesian Journal of Pharmaceutical Science and Technology Vol 4, No 2 (2017)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

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Abstract

Hiperpigmentasi merupakan kelainan kulit wajah yang umum terjadi, terutama karena adanya peningkatan melanogenesis, dengan gambaran berupa warna kulit menjadi hitam atau coklat kehitaman. Kelainan ini terdapat pada beberapa macam penyakit kulit diantaranya melasma, melanoderma paska inflamasi, lentigo solaris dan freckles. Salah satu prinsip penanganan hiperpigmentasi yaitu menghambat sintesis melanin yang dapat dilakukan dengan menggunakan agen depigmentasi yang mekanisme kerjanya menghambat aktivitas enzim tirosinase. Penelitian ini bertujuan untuk menguji potensi kulit jeruk nipis sebagai inhibitor tirosinase. Kulit jeruk nipis diektraksi dengan etanol 96 %, identifikasi flavonoid, menghitung flavonoid total, kemudian diuji inhibisi tirosinase menggunakan instrumen microplate reader (ELISA). Hasil penelitian ekstrak kulit jeruk mengandung flavonid, dengan total flavonid totalnya 0,667 % b/b dan inhibition concentration (IC) 50 42,11 mg/mL, Kulit jeruk berpotensi sebagai inhibisi tirosinase.Kata kunci:    Citrus auronfolia, Hiperpigmentasi, IC50, Tirosinase

AKTIVITAS DEPIGMENTASI FRAKSI N-HEKSANA BUAH MALAKA (PHYLLANTHUS EMBLICA) PADA SEL MELANOSIT MOUSE MELANOMA B16

Indonesian Journal of Applied Sciences Vol 3, No 1 (2013)
Publisher : Universitas Padjadjaran

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Abstract

AbstractInhibitor of melanin synthesis can be used as depigmenting agent to treat skin hyperpigmentation. Herbal depigmenting agents are increasingly utilized due to their character in inhibiting melanin synthesis without causing melanocyte toxicity. This study was aimed to examine depigmenting activity of n-hexane fraction of Phyllanthus emblica fruit by measuring its melanin synthesisinhibition on melanocyte mouse melanoma B16 cell line. Melanin synthesis inhibition was measured spectrophotometrically by counting the melanin and the activity of tyrosinase. The cytotoxicity of n-hexane fraction on melanocytes was measured by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. This study was conducted on November-December2009 at Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, South Korea. The result of this study indicated that melanin count and tyrosinase activity decreased in a dose-dependent manner of n-hexane fraction of P. emblica fruit (IC50 31.68 and 77.92 μg/ml, respectively). The viable cells decreased with increasing concentration ofthe n-hexane fraction of P. emblica fruit (LD50 87.39 μg/ml).Key words: n-hexane fraction, Phyllanthus emblica, depigmenting agent

Successful Combination Therapy of Acne Keloidalis Nuchae

Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 29, No 3 (2017): DESEMBER
Publisher : Faculty Of Medicine Airlangga University

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Abstract

Background: Acne keloidalis nuchae (AKN) is a chronic, inflammatory, idiopathic disorder of hair follicle, characterized by keloidal papules or plaques on the nape and occipital scalp. Various therapies have been reported to treat AKN with various results. Purpose: To observe the efficacy of combination therapy for AKN. Case report: A 19-year-old man presented with multiple pruritic papules, 0.1–0.3 cm in diameter on the nape and occipital area. The histopathological examination revealed neutrophil, eosinophil, and plasma cell infiltration in infundibulum, which was consistent with AKN pathological patterns. Discussion: Combination therapy consisted of 0.025% tretinoin cream, 0.1% mometasone furoate cream, intralesional triamcinolone acetonide 5 mg/ml, and doxycycline 2x100 mg. The improvement was initially observed on 2nd week of follow up, as the lesions had reduced in size and number, and the improvement became more significant on 4th week of follow up. Conclusion: Combination therapy of topical tretinoin, topical and intralesional steroid, and systemic doxycycline shows good result and can be considered in the management of AKN.

Perbandingan Kadar Interleukin-17 Serum Pasien Akne Vulgaris Tipe Papulopustular dengan Komedonal

Majalah Kedokteran Bandung Vol 48, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Patogenesis akne vulgaris (AV) bersifat multifaktorial dan faktor yang berperan penting adalah inflamasi yang terutama diinduksi oleh reaksi imunologis terhadap Propionibacterium acnes (P. acnes). Bakteri ini dapat ditemukan baik pada lesi inflamasi berupa papula dan pustula, maupun noninflamasi seperti komedo, dengan jumlah P. acnes lebih tinggi pada lesi inflamasi. Secara klinis komedo merupakan lesi noninflamasi, namun secara mikroskopis sudah terjadi inflamasi. P. acnes dapat menginduksi pelepasan sitokin proinflamasi antara lain IL-17. Tujuan penelitian ini adalah membandingkan kadar IL-17 serum antara pasien AV tipe papulopustular dan komedonal. Penelitian ini merupakan penelitian analitik observasional secara potong lintang dengan peserta penelitian masing-masing 12 pasien AV tipe papulopustular dan komedonal derajat dua atau lebih di Poliklinik Dermatologi Kosmetik Departemen Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit Dr. Hasan Sadikin Bandung selama periode Oktober–November 2014. Pada kedua kelompok dilakukan pengambilan darah tepi untuk pengukuran kadar IL-17 serum dengan metode ELISA. Hasil penelitian menunjukkan kadar IL-17 serum rata-rata (SD) pada pasien AV tipe papulopustular adalah 0,65 (1,12) pg/mL, sedangkan pada tipe komedonal adalah 0,46 (0,42) pg/mL, perbedaan tersebut secara statistik tidak bermakna (p=1,000). Simpulan, kadar IL-17 serum pasien AV tipe papulopustular tidak berbeda dibanding dengan AV tipe komedonal menunjukkan bahwa kemungkinan pada lesi komedo sudah terjadi inflamasi. [MKB. 2016;48(3):160–3]Kata kunci: Akne vulgaris, IL-17 serum, tipe komedonal, tipe papulopustular Comparison of Interleukin-17 Serum Level between Papulopustular and Comedonal Types of Acne VulgarisThe pathogenesis of acne vulgaris (AV) is multifactorial and inflammation, which is primarily cause by induction of immunological response to Propionibacterium acnes (P. acnes), is suggested as the main important factor in AV development. These bacteria can be found in the form of papules and pustules in inflammatory lesions and as comedones in noninflammatory lesions, with a higher presentation seen in the inflammatory lesions. Clinically, comedo is a noninflammatory lesion; however, inflammation can be observed microscopically. P. acnes can release proinflammatory cytokines, including IL-17. The aim of this study was to compare the IL-17 serum level between papulopustular type and comedonal type of AV. This study was a cross sectional-analytic observational, conducted at the Cosmetic Dermatology Clinic, Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung during October–November 2014. The participants were AV patients with at least second degree papulopustular (n12) and comedonal types (n12). Blood samples from all subjects were collected and the IL-17 serum levels were measured using ELISA methods. This study showed that the mean (single deviation) IL-17 serum levels in papulopustular and comedonal type of AV were 0.65 (1.12) pg/mL and 0.46 (0.42) pg/mL, respectively, and the difference was not statistically significant (p:1.000). The IL-17 serum level in the papulopustular type is not different from that of the comedonal type of AV in this study, which indicates that the inflammatory events probably had occurred  in comedonal lesions. [MKB. 2016;48(3):160–3]Key words: Acne vulgaris, comedonal type, IL-17 serum level, papulopustular type

Laporan Kasus: Efek Samping Kortikosteroid Topikal Jangka Lama pada Wajah

Syifa'MEDIKA:Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2018): Syifa' Medika
Publisher : Faculty of Medicine University of Muhammadiyah Palembang

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Abstract

Efek samping penggunaan kortikosteroid topikal (KT) jangka panjang antara lain berupa hipertrikosis, telangiektasis, dan dispigmentasi. KT sering digunakan sebagai kombinasi dengan tretinoin dan hidrokuinon untuk terapi melasma, tetapi penggunaannya juga banyak disalahgunakan untuk memutihkan kulit wajah. Tujuan kasus ini untuk melaporkan efek samping penggunaan KT jangka panjang. Dilaporkan dua kasus dengan berbagai efek samping akibat penggunaan KT jangka panjang pada wajah. Pasien yang pertama diduga sudah menggunakan KT selama empat tahun untuk terapi melasma, sedangkan pasien kedua diduga sudah menggunakan KT selama sepuluh tahun untuk mencerahkan kulit wajah. Pemeriksaan fisik kedua pasien didapatkan hipertrikosis, telangiektasis, dan makula eritema pada wajah. Pada pasien pertama terdapat pula makula hipopigmentasi di kedua pipi. Penatalaksanaan kedua pasien ini yaitu menghentikan penggunaan KT, dan diberikan emolien, tabir surya, serta retinoid topikal. Pada pengamatan hari ke-37 didapatkan perbaikan klinis berupa berkurangnya eritema. Penggunaan KT jangka panjang dapat menimbulkan efek samping hipertrikosis, telangiektasis, dan dispigmentasi seperti pada kedua pasien ini. Penggunaan KT harus memperhatikan indikasi dan durasi penggunaan agar efek samping dapat dicegah.

Penurunan Aktivitas Tirosinase dan Jumlah Melanin oleh Fraksi Etil Asetat Buah Malaka (Phyllantus emblica) pada Mouse Melanoma B16 Cell-Line

Majalah Kedokteran Bandung Vol 45, No 2 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Akumulasi melanin menyebabkan hiperpigmentasi dan bila terdapat pada wajah dapat menimbulkan masalah psikososial. Bahan depigmentasi dari tanaman semakin banyak digunakan. Bahan yang dikembangkan harus efektif menghambat sintesis melanin serta tidak toksik terhadap melanosit. Penelitian ini bertujuan menguji efek fraksi etil asetat buah Phyllanthus emblica (P. emblica) atau buah malaka, terhadap sintesis melanin dengan mengukur jumlah melanin dan aktivitas tirosinase, yang merupakan enzim utama sintesis melanin, secara spektrofotometrik pada kultur sel melanosit mouse melanoma B16 cell-line. Sitotoksisitas diukur dengan metode 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Penelitian dilakukan pada November–Desember 2009 di Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, Korea Selatan. Hasil penelitian menunjukkan aktivitas tirosinase dan jumlah melanin menurun bergantung pada dosis perlakuan berbagai konsentrasi fraksi etil asetat buah P. emblica dengan inhibition concentration (IC) 50 berturutturut 95,63 dan 16,90 μg/mL, serta lethal dose (LD) 50 pada konsentrasi 106,64 μg/mL. Simpulan, fraksi etil asetat buah P. emblica mempunyai potensi sebagai bahan depigmentasi, karena mampu menurunkan sintesis melanin melalui inhibisi aktivitas tirosinase. [MKB. 2013;45(2):118–24]Kata kunci: Aktivitas tirosinase, etil asetat, melanin, Phyllanthus emblicaReduction of Tyrosinase Activity and Melanin Amount by Ethyl Acetate Fraction from Malaka (Phyllanthus emblica) Fruit in Mouse Melanoma B16 Cell-LineMelanin accumulation can lead to hyperpigmentation, and if it occurs on the face can cause psychosocial problem. Depigmenting agents derived from plants are increasingly utilized. Agents being developed have to be effective in inhibiting melanin synthesis and should not be toxic to melanocyte. This study aimed was to examine the effect of ethyl acetate fraction from Phyllanthus emblica (P. emblica) fruit, also known as malaka fruit, towards melanine synthesis, which was measured from the melanin amount and tyrosinase activity, the key regulatory enzyme in melanin synthesis, spectrophotometrically towards melanocytes of mouse melanoma B16 cell-line. The cytotoxic effect towards melanocytes was measured with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. This study was conducted on November−December 2009 in Department of Biochemistry and Diabetes Research Centre, Chonbuk National University Medical School, South Korea. The result of this study showed that tyrosinase activity and melanin amount decreased in a dose-dependent manner towards various concentrations of ethyl acetate fraction of P. emblica fruit with inhibition concentration (IC) 50=95.63 and 16.90 μg/mL, respectively and lethal dose (LD) 50 concentration 106.64 μg/mL. In conclusion, ethyl acetate fraction of P. emblica fruit is a potential depigmenting agent, since it can reduce melanin synthesis by inhibition of tyrosinase activity. [MKB. 2013;45(2):119–24]Key words: Ethyl acetate, melanin, Phyllanthus emblica, tyrosinase activity DOI: http://dx.doi.org/10.15395/mkb.v45n2.115

Perbandingan Kadar Interleukin-17 Serum Pasien Akne Vulgaris Tipe Papulopustular dengan Komedonal

Majalah Kedokteran Bandung Vol 48, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Patogenesis akne vulgaris (AV) bersifat multifaktorial dan faktor yang berperan penting adalah inflamasi yang terutama diinduksi oleh reaksi imunologis terhadap Propionibacterium acnes (P. acnes). Bakteri ini dapat ditemukan baik pada lesi inflamasi berupa papula dan pustula, maupun noninflamasi seperti komedo, dengan jumlah P. acnes lebih tinggi pada lesi inflamasi. Secara klinis komedo merupakan lesi noninflamasi, namun secara mikroskopis sudah terjadi inflamasi. P. acnes dapat menginduksi pelepasan sitokin proinflamasi antara lain IL-17. Tujuan penelitian ini adalah membandingkan kadar IL-17 serum antara pasien AV tipe papulopustular dan komedonal. Penelitian ini merupakan penelitian analitik observasional secara potong lintang dengan peserta penelitian masing-masing 12 pasien AV tipe papulopustular dan komedonal derajat dua atau lebih di Poliklinik Dermatologi Kosmetik Departemen Ilmu Kesehatan Kulit dan Kelamin Rumah Sakit Dr. Hasan Sadikin Bandung selama periode Oktober–November 2014. Pada kedua kelompok dilakukan pengambilan darah tepi untuk pengukuran kadar IL-17 serum dengan metode ELISA. Hasil penelitian menunjukkan kadar IL-17 serum rata-rata (SD) pada pasien AV tipe papulopustular adalah 0,65 (1,12) pg/mL, sedangkan pada tipe komedonal adalah 0,46 (0,42) pg/mL, perbedaan tersebut secara statistik tidak bermakna (p=1,000). Simpulan, kadar IL-17 serum pasien AV tipe papulopustular tidak berbeda dibanding dengan AV tipe komedonal menunjukkan bahwa kemungkinan pada lesi komedo sudah terjadi inflamasi. [MKB. 2016;48(3):160–3]Kata kunci: Akne vulgaris, IL-17 serum, tipe komedonal, tipe papulopustular Comparison of Interleukin-17 Serum Level between Papulopustular and Comedonal Types of Acne VulgarisThe pathogenesis of acne vulgaris (AV) is multifactorial and inflammation, which is primarily cause by induction of immunological response to Propionibacterium acnes (P. acnes), is suggested as the main important factor in AV development. These bacteria can be found in the form of papules and pustules in inflammatory lesions and as comedones in noninflammatory lesions, with a higher presentation seen in the inflammatory lesions. Clinically, comedo is a noninflammatory lesion; however, inflammation can be observed microscopically. P. acnes can release proinflammatory cytokines, including IL-17. The aim of this study was to compare the IL-17 serum level between papulopustular type and comedonal type of AV. This study was a cross sectional-analytic observational, conducted at the Cosmetic Dermatology Clinic, Dermatology and Venereology, Dr. Hasan Sadikin General Hospital Bandung during October–November 2014. The participants were AV patients with at least second degree papulopustular (n12) and comedonal types (n12). Blood samples from all subjects were collected and the IL-17 serum levels were measured using ELISA methods. This study showed that the mean (single deviation) IL-17 serum levels in papulopustular and comedonal type of AV were 0.65 (1.12) pg/mL and 0.46 (0.42) pg/mL, respectively, and the difference was not statistically significant (p:1.000). The IL-17 serum level in the papulopustular type is not different from that of the comedonal type of AV in this study, which indicates that the inflammatory events probably had occurred  in comedonal lesions. [MKB. 2016;48(3):160–3]Key words: Acne vulgaris, comedonal type, IL-17 serum level, papulopustular type