Sri Hastini
Center for Development of Radioisotope and Radiopharmaceutical, National Nuclear Energy Agency, Kawasan PUSPIPTEK Serpong, Tangerang, 15314

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EVALUASI PROSES PRODUKSI RADIOISOTOP Sm-153 DAN SEDIAAN RADIOFARMAKA Sm-153 EDTMP Kadarisman, Kadarisman; Hastini, Sri; Tahyan, Yayan; Abidin, Abidin; Hafid, Dadang; Lestari, Enny
Jurnal Radioisotop dan Radiofarmaka Vol 9 (2006): jurnal PRR 2006
Publisher : Jurnal Radioisotop dan Radiofarmaka

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Abstract

EVALUASI PROSES PRODUKSI RADIOISOTOP Sm-153 DAN SED1AAN RADIOFARMAKA Sm-153 EDTMP. Telah dilakukan percobaan proses produksi radioisotop Sm-153 dan proses penandaan sediaan radiofarmaka Sm-153 EDTMP, yang bertujuan untuk mengevaluasi proses produksi radioisotop Sm-153 dan sediaan radiofarmaka Sm-153 EDTMP di Pusat Radioisotop dan Radiofarmaka, BATAN. Dalam percobaan ini mencakup penyiapan bahan sasaran Sm2O3, pelarutan pasca irradiasi, penetapan konsentrasi radioaktivitas isotop Sm-153, kemurnian radionuklida, proses penandaan senyawa EDTMP, penetapan kemurnian radiokimia dan pH. Dalam percobaan ini diperoleh produk radioisotop Sm-153 dengan radioaktivitas total antara 2845,83 mCi s/d 36963,31 mCi atau dengan konsentrasi radioaktivitas antara 474,30 mCi/ml sampai dengan 6160,55 mCi/ml) berbentuk larutan SmCl3yang masing-masing mempunyai volume 6,0 ml, kandungan samarium 5,76 mg/ml dan dengan kemurnian radionuklida dari produk radioisotop Sm-153 adalah 100 %. Semua produk sediaan radiofarmaka Sm-153 EDTMP memenuhi syarat konsentrasi radioaktivitas, kandungan Sm, kemurnian radiokimia dan pH. Konsentrasi radioaktivitas sediaan radiofarmaka Sm-153 EDTMP minimum 37,50 mCi/ml dan yang terbesar 283,50 mCi/ml, sebanyak 8 buah larutan mempunyai pH 7,5, sedangkan yang lainnya ( 2 buah larutan ) mempunyai pH sebesar 8,5. Kemurnian radiokimia sediaan raiofarmaka Sm-153 EDTMP berkisar antara 90,00 % sampai dengan 98,76 %. Kata Kunci : Evaluasi, Radioisotop, Radiofarmaka, Sm-153, Sm-153 EDTMP EVALUATION OF RADIOISOTOPE PRODUCTION PROCESS OF Sm-153 AND Sm-153 EDTMP RADIOPHARMACEUTICALS. Experiments on the process of Sm-153 radioisotope and labeling of Sm-153 EDTMP radiopharmaceuticals were carried out, as a purpose for evaluation of Sm-153 radioisotope and Sm-153 EDTMP process production in Center for Radioisotope and Radiopharmaceuticals, National Nuclear Energy Agency. This experiments included preparation of Sm2O3target, dissolution of post irradiation, determination of radioactivity concentration of Sm-153 radioisotope, radionuclide purity, EDTMP labeling, determination of radiochemicals purity and pH. In these experiments the total radioactivity Sm-153 product is about 2845.83 mCi to 36963,31 mCi, or with the radioactivity concentration between 474,30 mCi/ml and 6160,55 mCi/ml in the SmCl3solution form. The volume is 6.0 ml, the samarium content is 5.76 mg/ml and the radionuclide purity of Sm-153 is 100 %. All of the Sm-153 EDTMP radiopharmaceuticals product are fullfilled requirements the radioactivity concentration, Sm content, radiochemical purity and pH. The radioactivity concentration of Sm-153 EDTMP radiopharmaceuticals is 37,50 mCi/ml(minimum) to 283,50 mCi/ml (highest). The pH 7.5 were 8 products, and the rest are pH 8.5. Radiochemical purity of Sm-153 EDTMP are round about 90.00 % to 98,76 %. Key Words : evaluation, radioisotope, radiopharmaceutical, Sm-153, Sm-153 EDTMP
PRODUCTION OF 11 C-METHIONINE BY CYCLOTRON AVF JAERI Hastini, Sri
Indonesian Journal of Chemistry Vol 2, No 1 (2002)
Publisher : Universitas Gadjah Mada

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At the Takasaki-site of JAERI, an AVF cyclotron has been constructed for advanced radiation technology research. The cyclotron produces extracted beams particularly light and heavy ions of proton as well as deutron. Target chamber is available for production of 11CO2 a positron emitter radioisotope, by bombardment of proton from nitrogen gas as a target, by 14 N (p,a) 11C reaction. The use of incident energy on target was estimated to be 11 MeV for primary proton energy of 20 MeV and the beam current was 0,1 m A and the irradiation time was 10 minutes for production of 11CO2 and the yield was about 30 MBq (EOB)and for irradiation time 15 minutes and the beam current was 1 mA for production of 11C-Methionine, the yield was about 70 MBq (EOB). Remotely operated automatic and semiautomatic processing systems are used for the production of the 11 C-Methionine agent and the radiochemical purity of the product obtained was determined by High Performance Liquid Chromatography (HPLC) with cation exchange column was LC 10 AD MERCK LICHROSPHER 100 RP-18 and the mobile phase was 10 mM ammonium phormmate, the mean of retention time was 1,815 minutes and the radiochemical purity to be more than 90 %. The product was used for plant studies and visualized by PETIS (Positron Emission Tracer Imaging System)   Keywords: cyclotron, Positron emitter, 11C-Methionine.