Nur Haryono
National Cardiovascular Center Harapan Kita. Department of Cardiology and Vascular Medicine Faculty of Medicine, Universitas Indonesia.

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Correlation Between Arterial Stiffness and Plasma Endothelin-1 Concentration in Man with Obesity Kosasih, Adrianus; Lilyasari, Oktavia; Gunawan, Richard Indra; Librantoro, dr; Haryono, Nur; Sunu, Ismoyo
Jurnal Kardiologi Indonesia Vol. 28 NO.4 Juli 2007
Publisher : Indonesian Heart Association

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Abstract

Background. Obesity is associated with increase arterial stiffness and elevated plasma endothelin-1 concentration. However, there is still conflicting data regarding the effect of obesity on arterial stiffness and plasma endothelin-1 concentration.Objective. The purpose of the current study was to assess this effect and analyze whether there was correlation between arterial stiffness indices and plasma endothelin-1 concentration.Methods. The design of the study was cross sectional study that compare and correlate arterial stiffness and plasma endothelin-1 concentration between obesity group (n=40) and normoweight group (n=40). Obesity was defined as body mass index = 25 kg/m2. Arterial stiffness was assessed by measuring carotid-femoral pulse wave velocity (PWV) dan β stiffness index (β) non-invasively using ultrasound method. Endothelin-1 was measured by ELISA.Results. There was no significant difference regarding PWV between obesity and normoweight group (mean ± SD: 809.44 ± 137.77 versus 850.96 ± 211.60 cm/s, p=NS), but β was significantly higher in obese group (8.79 ± 3.15 versus 7.28 ± 1.96, p=0.012). PWV and β correlated significantly with age (PWV: r=0.446, p<0.001, β : r=0.354, p=0.001), but only β correlated with body mass index (r=0.282, p=0.011) and waist circumference (r=0.312, p=0.005). There was no significant difference between obesity and normoweight group regarding plasma endothelin-1 concentration (0.94 ± 0.26 versus 0.95 ± 0.18pg/dl, p=NS). There are no significant  correlations  between PWV/β andplasma endothelin-1 concentration.Conclusions. These findings suggest that the effect of obesity on arterialstiffness is not uniformly seen  throughout all arterial region. Obesity impact on carotid artery is greater than its impact on aorta, and this impact on arterial stiffness is not mediated by endothelin-1.
Predictive Value of Terminal QRS Distortion in Anterior Wall Acute Myocardial Infarction Masrul, dr; Setianto, Budhi; Haryono, Nur
Jurnal Kardiologi Indonesia Vol.28 No.3 Mei 2007
Publisher : Indonesian Heart Association

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Abstract

Background. The initial ECG at patients with Acute Coronary Syndrome, especially STEMI can predict size of infarction, response to reperfusion therapy and long term prognosis. A new classification, the QRS distortionhave increased mortality rates and larger infarct size and less limitation of their infarct size by thrombolytic therapy. QRS distortion is the emergence of J point = 50% of R wave in leads with qR configuration (I, aVL, V4-V6), or disappearance of the S wave in leads with Rs configuration (V1-V3).Methods and results. This study is cohort-retrospective to patients with anterior IMA treated by thrombolytic at National Cardiovascular Centre – Harapan Kita, Jakarta, Indonesia, during January 2003 – September 2004,that fulfill inclusion and exclusion criterias. They were divided into two group, with QRS distortion (+) and without QRS distortion (-); each group consist of 30 patients. Correlation between the two groups were analyzed by t test, chi-square test, Mann Whitney u test and logistic regression.Patients age range is 40 – 69 years, and mostly man. There is no difference between baseline characteristic in the two groups, except cholesterol LDL which is higher in the group with QRS distortion. Patients with QRS distortion have a higher tendency of thrombolytic therapy failure compare to patients without QRS distortion, (p=0,003). As the consequence they also have a higher rate of arrhythmia events, low ejectionfraction and re-hospitalization due to congestive heart failure.Conclusions. The prognosis of patients with anterior IMA associated with QRS distortion is worse than without QRS distortion.
Case report of secondary hypertension due to renal artery stenosis in young patient Saragih, Wendy M.; Sulistiowati, Siska; Haryono, Nur; Siswanto, Bambang B.; Hersunarti, Nani; Soesanto, Amiliana M.
Medical Journal of Indonesia Vol 23, No 2 (2014): May
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (792.088 KB) | DOI: 10.13181/mji.v23i2.666

Abstract

Secondary hypertension is rare to occur, but should become suspicion in young age. Secondary hypertension must be appropriately diagnosed and treated. Renal artery stenosis is one of many causes of secondary hypertension. The aim of this case report is to describe diagnosis, pathophysiology and management of secondary hypertension due to renal artery stenosis in young patient. A 17 year old man with symptom of shortness of breath was diagnosed with hypertension stage 3 on his medical examination at Pasar Rebo Hospital, Jakarta. Abdominal CT scan examination revealed bilateral renal artery stenosis. Percutaneous transluminal angiography (PTA) of left renal artery was performed at National Cardiovascular Centre Harapan Kita. Stent was placed succesfully and the blood pressure was normalized.