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Journal : Berkala Ilmu Kedokteran

The difference of Natural Killer cell activities of the people live in the aircraft noise area of Adi Soemarmo Airport Boyolali, Surakarta, Indonesia Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Exposure to noises contributes to a health risk. There is sufficient scientific evidence that noise exposure couldinduce hearing impairment, hypertension and ischemic heart disease, annoyance, sleep disturbances, and decreasedschool performance. Other evidence as changes in the immune system and birth defects is limited. The aims of thisstudy is to find out the difference of Natural Killer (NK) cell activities of the people live in the aircraft noise area ofAdi Sumarmo Airport, Boyolali, Surakarta, Indonesia. The research design was an analytical with a cross sectionalapproach, taking location at the Dibal and Gagak Sipat Villages, Ngemplak Sub district, Boyolali District. The studywas conducted from June 2008 to June 2009. The number of subjects involved was 39. They were divided into 3groups. Group 1 was exposed to 52.17 dB of noise level (13 respondents). Group 2 was exposed to 71.79 dB ofnoise level (13 respondents), and Group 3was exposed to 92.29 dB of noise level (13 respondents). The cytotoxicitiesof NK cells was measured by flowcytometric and using a non-radioactive method. The samples were taken using asimple random sampling. The data were analyzed by Anova followed by Post Hoc Test using LSD test completedwith Homogenous Subsets. The results showed that the activity of NK cells of Group 1, 2 and 3 were 12.50 +3.25%,17.20 3.06%, and 22.33 6.30 %, respectively. The Anova test showed that there was a significantdifference of NK cell activities, in the groups of respondents (p =0.000). In conclusion, there was a significantdifference of the NK cell activities of the people live in the aircraft noise area of Adi Sumarmo Airport, Boyolali,Surakarta, Indonesia.Key words : noise-immune system-flowcytometric-blood mononuclear cells-health risk
Peranan ekskresi amonia oleh ginjal dalam pengaturan keseimbangan asam-basa tubuh Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 9, No 02 (1977)
Publisher : Universitas Gadjah Mada

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Abstract

keywords: garam amonium, kreatinin, ekskresi ammonia
Poland anomaly associated with ocular anomalies Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 01 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A 6-year old boy suffering from Poland anomaly has been reported. The patient showed a complete picture of this malformation which consisted of aplastic greater pectoral muscle and breast on the left side of the chest, as well as oligodactily of the left hand.Other anomalies found were ocular and oral anomalies. The ocular anomalies consisted of hypertelorism, bilateral esotropias due to bilateral abducent palsy, and bilateral optic nerve hypoplasia. Oral anomalies consist of the inability to close the mouth properly and the inability to smile may be due to the defect of oral muscles.Key Words: Poland anomaly - chest anomaly - oligodactily - ocular anomalies - oral anomalies
Congenital cataract: A case report of two sisters Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 18, No 04 (1986)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Two sisters suffering from bilateral congenital zonular cataract have been reported-. Their parents and their one and only sister were perfectly normal. The older sister was 2 years old whereas the younger was 8 months when they were first examined and they immediately underwent discission and evacuation. It was likely that the two cases carried autosomal dominant genes for congenital zonular cataract, either non-penetrant genes or a fresh mutation of the germ cell of one of their parents. In the former the recurrence risk was 50%, whereas in the latter such risk was practically zero. Key Words: congenital zonular cataract - autosomal dominance - non-penetrant gene - fresh mutation - recurrence risk
Genetic counselling Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 15, No 02 (1983)
Publisher : Universitas Gadjah Mada

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Abstract

Genetic counselling is a relatively new medical activity. There.are some conditions that usually need genetic counselling.•The classification of genetic disorders, their mode of inheritance and the method of establishing the diagnosis must be well understood before giving the counselling. The mode of inheritance of genic disorders and some difficulties in the diagnosis need special attention. Chromosomic disorders and embryopathies have been shortly explained ,as well.Finally, a short explanation of prenatal diagnosis, carrier detection and some methods of treating genetics disorders have been proposed so that genetic counselling can be given effectively.Key Words: genetic counselling - genetic disorders - genic disorders - prenatal diagnosis - carrier detection.
Mendelisme dalam Oftalmogenetika Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 04 (1988)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Mendelian disorders are genetic diseases caused by a mutant gene or a pair of mutant genes, either dominant or recessive, located in the autosomal or sex-chromosomes.The exact location of several genes in the chromosomes has been established by various rnethods. According to The Edinburgh Conference 1979 the location of 260 genes in the chromosomes has been identified.Based on the nature of the mutant genes (dominant or recessive) and the location of the mutant genes (in the autosomes or sex-chromosomes), Mendelian disorders may be transmitted by:a.autosomal dominant,b.autosomal recessive,c.X-linked dominant,d.X-linked recessive, ande. Y-linked mode of inheritance.Retinoblastoma, macular corneal dystrophies and color blindness are the examples of Mendelian disorders in ophthalmogenetics transmitted by autosomal dominant, autosomal recessive and X-linked recessive mode of inheritance respectively. In addition, a list of other Mendelian disorders affecting the eye have been presented.Key Words: Mendelian disorders - mutant genes - gene location - sex-linked mutant ophthalmogenetics
Genetic syndromes associated with ocular anomalies Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 19, No 02 (1987)
Publisher : Universitas Gadjah Mada

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Abstract

A syndrome is defined as the concurrence or running together of constant patterns of abnormal signs or symptoms. Syndromes can be either genetic or non-genetic in origins. Genetic diseases consist of genic diseases, chromosomic diseases and embryopathies. Genetic syndromes also consist of genic disease syndromes, chromosomic disease syndromes and embryopathic syndromes. Syndromes of genic diseases are caused by pleiotropic mutation of the genes which give rise to multiple (pleiotropic) effects. Syndromes of chromosomic diseases are caused by chromosomal derangement either by the abnormalities of their structure or their number. There are many genetic syndromes associated with ocular anomalies. Geeraets has collected 436 ocular syndromes either genetic and non-genetic in origins, and 49 of 135 recognizable human malformations collected by Smith are also associated with ocular defects. Some important chromosomic syndromes such as tkisomy 21, Patau, Edward, and cri-du-chat syndromes are also associated with ocular anomalies. Key Words: genetic diseases - pleiotropic effects - ocular anomalies - chromosomic syndromes - embryopathies
Cacat Mental Pada Penyakit Kromoson Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 17, No 03 (1985)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Genetic diseases are divided into genic diseases, chromosomic diseases and embryopa shies. There are 23 pairs of chromosomes in each human somatic cell. According to their shape and the location of their centromer, chromosomes are classified into 8 groups, namely group A, B, C, D. E. F and G. Chromosomic diseases are caused by either numerical or structural derangements of chromosomes. Chromosomic diseases cause metabolic disorders during conception until post-natal period. The degree of physical as well as mental disorders depend on the degree of lack or surplus of chromosomic materials. Chromosomic diseases may be lethal. i. e. they can cause spontaneous abortion as well as fetal and neonatal death. Some chromosomic diseases and their IQ scores will be presented here. Special attention will be given to trisomy 13, trisomy 18. trisomy 21, XXX syndrome and XYY syndrome. Key Words : mental defect - chromosomic disease - chromosome classification - IQ score - embryopathies -
Colour vision and the genetics of colour vision defect Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 03 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Colour vision is one of the visual functions which is very important in daily life. The phenomenon of normal colour vision has been explained briefly in order to understand colour vision defects.The theory of colour vision has been proposed for a long time by Young and Helmholtz. According to this theory there are three kinds of cones in the retina, namely red, green, and blue cones. Each cone has maximum absorbance for red, green, and blue colours respectively, but their absorbance curves overlap each other.The absence of the function of red, green, and blue cones will cause red blindness (pro tanopia) , green blindness (deuteroanopia), and blue blindness (tritanopia) respectively. On the other hand, partial disturbances of red, green, and blue cones give rise to red weakness (protanomaly), green weakness (dcuteroanomaly), and blue weakness (tritoanomaly).The great majority of colour defects are hereditary or genetic diseases. Congenital red and green blindness are X-linked recessive diseases. The location of red and green colour vision genes and their alleles (genes for red and green colour vision defects) are in the end of the long arm of chromosome X. The two genes arc very close to each other. Congenital blue colour defect, on the other hand, is an autosomal recessive disease, and the location of the gene is at the end of the long arm of chromosome 7.Key Words: ophthalmology - colour vision defects - X-linked recessive diseases - autosomal recessive diseases - gene locations
Genetic heterogeneity of retinitis pigmentosa Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 04 (1989)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Genetic heterogeneity is a phenomenon in which a genetic disease can be transmitted by several modes of inheritance. The understanding of genetic heterogeneity is important in giving genetic counselling.The presence of genetic heterogeneity can be explained by the existence of:1.different mutant alleles at a single locus, and2.mutant alleles at different loci affecting the same enzyme or protein, or affecting different enzymes or proteins.To have an overall understanding of genetic heterogeneity, the heterogeneities of chronic hemolytic anemia caused by beta-globin abnormality, chronic hemolytic anemia due to thalassemias, and mucopolysaccharidoses have been chosen as examples.The article is focused on the genetic heterogeneity of retinitis pigmentosa, a kind of retinal hereditary disease. The genetic heterogeneity of retinitis pigmentosa can be known by the facts thata.Retinitis pigmentosa can be either an isolated disease or a part of a certain syndrome.b.Retinitis pigmentosa as isolated disease can be genetic or non-genetic in nature.c. Retinitis pigmentosa as a genetic disease can be transmitted either by autosomal dominant, autosomal recessive, or X-linked recessive genes.The frequency of isolated hereditary retinitis pigmentosa varies between 30% to 50%. Clinically the dominant form is milder than the recessive form. Certain syndromes associated with retinitis pigmentosa which need to be mentioned are Usher syndrome, Laurence-Moon-Bardet-Biedl syndrome, and Kearn-Sayre syndrome.Key Words: genetic heterogeneity - retinitis pigmentosa - genetic disease - hemolytic anemia - Usher syndrome
Co-Authors A Mushawwir Taiyeb A. Rachman Ibrahim, A. Rachman A. Rusilowati Abdul Haris Nasution, Abdul Haris Abrar Ridwan Abul Walid Achmadi Priyatmojo Adhistia Amelia, Adhistia Adhitya Angga Wijaya, Adhitya Angga ADISAPUTRA, MIMIN K. Aditya Marianti Adityas Normalita, Adityas Afina Murtiningrum, Afina Agus Cahyono Ahmad Fudholi Al Irsyad, M. Indra Ali, Majid Khan Bin Majahar Alvianto, Wibi Ardi Ambar Kusumandari Amelia Hani Saputri, Amelia Hani Amsari, Uli Andreas Priyono Budi Prasetyo, Andreas Priyono Budi Ani Rusilowati Anita Madiana Dewi, Anita Madiana Anwar Efendi Any Wuryaningrum, Any Ardin Ardin, Ardin Ari Pani Desvina Ari Pani Desvina Ari Probandari Arif Hidayat Arif Wibowo Arif Widiyatmoko, Arif Arini, Affita Nur Arisyanto, Prasena Artensena, Trian Arum, Agnes Yustika Wulan Aryanti Indah Jaya Asadillah Hadi As’ari, Asadillah Hadi Ashar Ashar Astuti, Andi Arie Aswandi Aswandi, Aswandi Awan, Meiseti Azizah, Fatya Badrun Badrun Bahiyah, Lumiyatun Bambang Sugiantoro Bambang Sulistyo Barano SS Meteray, Barano SS Basri, Novysa Bhisma Murti Brilliansya, Wempy Budi Yulianto Cahyati, Ani Chandra Lesmana, Chandra Choiril Anwar, Choiril Danang Parikesit Daniel Sutopo Pamungkas, Daniel Sutopo Danoedoro Danoedoro Darmawi Bayin Daulay, Mushoddik Deny Dwi Hartomo, Deny Dwi Dewi Wulandari Dharmansyah, Eddy Dhimas Wiratmoko, Dhimas Diah Kartika Sari Dian Armanto Didik Purwadi Dilaga, Ahmad Prasetya Dimyati, Ratih Dewanti Dimyati, Ratih Dewanti Dita Primashanti Koesmadi Djuwita Amin Mahmud Dona Fitriawan Donal, Donal Dulbahri Dulbahri, Dulbahri Dwi Oktaviana, Dwi Dyah Pratamawati, Dyah Edi, Sukiswo Supeni Effendi Effendi Effendy, Suhardi Eka Fitriani Eka Rosanti Eko Haryono Eko Pujiono Eko Sugiharto Eko Wahyuni, Eko Endang Sri Markamah, Endang Sri Endang Wara Suprihatin Suprihatin, Endang Wara Suprihatin Erna Budhiarti Nababan F. EKA SAFITRI, F. EKA Fahrudin Indra Buana Falah, Syarifatul Farhana Mohd Razali, Nur Farzand Abdullatif Fatimah Azzahrah Fauzan Wibawa, Fauzan Fauzi, Muhamad Irfan Ferdian, Rizky Fitriani Fitriani Frananda, Hendry Fuad Abd. Rachman, Fuad Fuad Abd. Rachman, Fuad Abd. Fuad Abdurachman, Fuad Gandes Nurseto, Gandes Gunawan Nusanto, Gunawan Gunawan Pamudji Widodo Hadadi, Oki Hadian Hadiyah, Hadiyah Hakim Zulkarnain, Hakim Hardianti, Meliana Harini, Latifah Aulia Haryono Haryono Haryono Supriyo Haryono Umar Hasanuddin, H Hestiarini, Aprisa Rian Hidayah, Husnul Hidayat, Willy hidayat Hidayati Hidayati Himawati, Azizah Himayah, Shafira Hudaya, Yudi Fatwa Husna Arifah, Husna I.S, Rifdian Ian Yulianti, Ian Imam Barnadib Imam Sujadi Indah Setyowati, Indah Indrawati, Like Inmarlinianto Inmarlinianto, Inmarlinianto Inna Latifa Rahmawati, Inna Latifa Ipung Permadi Iqbal Iqbal Ira Alia Maerani Irchami Putriningtyas, Irchami Irham Irham Irianto, Rifdian Irsyad, M. Indra al Isa Akhlis Ishaq, Sunaryo Isis Rachmadi, Isis Ismail Sriyanto, Ismail Ismanto Ismanto Ismet Ismet, Ismet Isnain Dhartaredjasa Iwan Purnawan Jamilah Jamilah Janah, Anisa Furtakhul Jati Utomo Dwi H Jejem Mujamil, Jejem Joko Lianto Buliali Joko Santoso Joko Sutarto Junus, Nursyamsi Kamaruddin Kamaruddin Kartinaty, Tietyk Kastam Syamsi Khan Bin Majahar Ali, Majid Khumaedi Khumaedi, Khumaedi Kresno Kresno, Kresno Krismiyanti, lufia Kumala Andriani, Riski Widya Kurniawan Yudhi Nugroho, Kurniawan Yudhi Kus Prihantoso Krisnawan Kusmawaty, Dewi Kustiyo Kustiyo, Kustiyo Kuswadi, Kuswadi Langlang Handayani Lestari, Nartini Liliana Liliana Lilies Lilies Linda Dwi Setyowati, Linda Dwi Lukman Lukman M. Djahir Basir, M. Djahir Magita Novita Sari, Magita Novita Mahardhika, Hendy Maharsi, Endah Dwi Maliasih, Maliasih Maman Suryaman Mandini, Gity Wulang Mandoza, Defri Marhadi Saputro, Marhadi Martanto, Rochmat Masayu Nurhayati, Masayu Masluchah, Indah Matsun Matsun, Matsun Maulana Istu Pradika Metan, Yosefina Miftakhus Sholikhah, Miftakhus Mochammad Maksum Machfoedz, Mochammad Maksum Mohammad Hakimi Mokhamad Taufik, Mokhamad Muchtadi Muchtadi, Muchtadi Mudhofir, Faiz Muhammad Ali Imron Muhammad Askari Zakariah Muhammad Dimyati, Muhammad Muhammad Hakimi Muhammad Kamal Muhammad Masykuri Muhammad Merlis, Muhammad Muhammad Zainuddin Lubis Muhammad, Fan Naa Na Muliati Muliati, Muliati Mulyono, Tedjo Murbangun Nuswowati Murti BS, Sigit Heru Murti, Murti Musdalifah, Ana Musthafa, Mariyam Fazleena Nengah Suparta, Nengah Ni Komang Tri Paramityaningrum, Ni Komang Tri Nika Bellarinatasari Nikmah, Syafridatun Ninik Lukiana Nirbaya, Eryaya Nisaa, Arifatun Novi Susetyo Adi, Novi Susetyo Noviani, Yusida Nugraha, Erika Sulistya Nur Mohammad Farda Nuraini Dwi Astuti Nurdjanah Hamid, Nurdjanah Nurhadi, Imam Nurhalim Nurhalim, Nurhalim nurlailis saadah, nurlailis Nursida Arif Opim Salim Sitompul Ova Emilia P, Nurani Panjaitan, Sriwidya Hotmaria pargaulian siagian siagian, pargaulian siagian Perdani, Ambika Putri Phillips, David Prabang Setyono Prabowo, Anggun Pramaditya Wicaksono, Pramaditya Pramuharti, Marlita Pramuwardani, Ida Pratiwi Oktaviani, Pratiwi Prihatini, Luciana Intan Priyo Widodo, Priyo Projo Danoedoro Puji Rahayu Putra, Bhima Andhika Putut Marwoto Qadriathi Dg Bau Rachman, Fuad Abd Rahardjo, Pentardi Rahmadiah, Sari Rahmadini, Nafisa Syahida Rahmi Susanti Rakanita Dyah Ayu Kinesti, Rakanita Dyah Ayu Ramdhan, Herry Muhammad Ratih Dewanti Dimyati, Ratih Ratih Kumala Sari, Ratih Kumala Raymundus Parulian Sihotang Rendani, Feby Reni Wijayanti Restu Lanjari Restuningrum, Ayu Retnadi Heru Jatmiko Retno Winarni Ria Mardiana Yusuf Ridwan, Mohd. Rika Subarniati Rinawati, Sulis Rini Dorojati, Rini Riyadi Riyadi Rizka Maulina, Dhoriyah Vataty Rizki Annisa Rizky, Kurniawan ROEKMOWATI ROEKMOWATI, ROEKMOWATI Rohmaniyah, Rohmaniyah Rolly Intan Ronggo Sadono Ruata, Isabella Christy Ruseno Arjanggi Ryan Permana S., Rifdian I. Sadiman Sadiman Sagaf Faozata Adzkia, Sagaf Faozata Sakuri, Sakuri Sani M. Isa Sania Mariant Sari, Sania Mariant Sanjiwana Arjasakusuma, Sanjiwana Santika Santika Sapitri Sapitri, Sapitri Saputra, Gilang Surya Saputri, Aneng Dewi Saputri, Sucilia Sari, Yulvia Sartika Sartika Sehah Sehah Seno Darmanto Septi Andriani, Septi Serom, Serom Setiaji Setiaji, Setiaji Setyasih, Astin Dwi Sigit Heru Murti, Sigit Heru Siti Handayani Siti Mardliya, Siti Slamet Hariyadi Sobron Y Lubis, Sobron Sofianty, Sri Sofyan Djamil Sopaheluwakan, Ardhasena Sopian, Kamaruzzaman Sopian, Kamaruzzaman Sri Budiastuti Sri Endayani, Sri Sri Iswidayati Sri Mulyani Endang Susilowati, Sri Mulyani Endang Sri Rum Giyarsih Sri Sumarni Sri Yatmihatun St. Budi Waluya St. Y. Slamet Subawi, Handoko Sudarmin Sudarmin Sudjoko, Rifdian Sugito Sugito Suhadi Lili Sujarwata Sujarwata, Sujarwata Sukristiyanti Sukristiyanti, Sukristiyanti Sukwardjono, Sukwardjono Sulistyo, Bambang Sulistyowati, Elina Endang Sumardiyono Sumardiyono Sumendap, Priscillia Sunarno Sunarno Sunartini Sunartini, Sunartini Sunarto Sunarto Sunyoto Eko Nugroho, Sunyoto Eko Suparman Suparman Supartono Supartono Supriyadi Supriyadi Sutikno Sutikno Suwarta Suwarta Suyono Suyono syakir syakir Tatang Suhery, Tatang Taufik Hery Purwanto Thomas Thomas Tiarma Simanihuruk, Tiarma Tirtaningsih, Munaisra Tri Titisari, Anastasia Dewi Tjetjep Rohendi Rohidi, Tjetjep Rohendi Totok Gunawan Totok Sumaryanto Florentinus, Totok Sumaryanto Totok Sumaryanto, Totok Tri Wahyuningtyas, Tri Triyanto Triyanto Tulus Tulus Udi Utomo Ukiman, Ukiman Umul Aiman Useng, Daniel Utantyo Utantyo, Utantyo Utari, Tria Utin Desy Susiaty, Utin Desy Utomo, Setio Utomo, Wasito Vidiastuti, Ririn Wadiyo Wadiyo, Wadiyo Wafrotur rohmah, Wafrotur Wahidah, Nazilatul Wahjoedi Wahjoedi Wahyu Lestari wahyuni wahyuni Wahyuningrum, Febryanti Wantoro Wantoro, Wantoro Wardani, Anestia Widya Wasida, Maria Rosadalima Waterman Sulistyana B, Waterman Sulistyana Wenang Anurogo, Wenang Wibowo, Eko Yulianto Widodo J. Pudjirahardjo Widodo, Agung Mulyo Wihantoro Wihantoro Wintolo, Marhento Wiyanto Wiyanto Wiyatmi Wiyatmi Yahya Yahya Yendra, Rado Yendra, Rado Yudianto Sujana Yunita Sari Zakariah, Muhammad Zarnzani Zarnzani, Zarnzani Zulaiha Zulaiha, Zulaiha Zulfahmi, Muhammad Nofan