Articles

Found 9 Documents
Search

Secondary acute myeloblastic leukemia after adjuvant chemotherapy and radiotherapy in breast cancer: A case report Hardianti, Mardiah Suci; Kurnianda, Johan; Taroeno-Hariadi, Kartika Widayati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 03 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedScie004603201405

Abstract

A rising number of long-term survivors and potential long-term outcome related to the treatment isone of the most important issue due to the advances of management in cancer. The development ofsecondary malignancy has been reported in a number of cohorts. We present a case of breast cancerpatient developing acute myeloid leukemia (AML)- M5 within a relatively short interval of two and ahalf years from her primary treatment with adjuvant chemotherapy with 4 cycles of doxorubicin andcyclophosphamide, followed by 4 cycles of three weekly paclitaxel (AC-T) and radiotherapy. Whatcould be attributed to the occurrence of secondary leukemia in this patient will be discussed.
Link of Nasopharyngeal Carcinoma and Epstein-Barr Virus Sugiyanto, Sugiyanto; Aryati, Lina; Kusumo, Fajar Adi; Hardianti, Mardiah Suci
Biology, Medicine, & Natural Product Chemistry Vol 7, No 2 (2018)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2018.72.51-55

Abstract

Nasopharyngeal Carcinoma (NPC) is a cancer that occurs in nasopharynx which is associated with Epstein-Barr Virus (EBV). Mutation agents in nasopharyngeal neoplasms occur because of EBV infection. Transformation of B-cells due to EBV causes hormone imbalance in lymphoid cells or nasopharyngeal epithelial tissue. Rates of EBV infection have been shown to be prognostic to NPC. The basic level of EBV DNA can be used for stratification prognosis, with higher titers showing greater disease severity and worse outcomes. With mathematical models, there is a correlation between the increase in Epstein-Barr Virus and the increase in Invasive Carcinoma Cells or increase in Nasopharyngeal Carcinoma Cells.
Telomere and telomerase in hematological disorders Focusing on bone marrow failure syndromes and hematological malignancies Hardianti, Mardiah Suci; Purwanto, Ibnu; Kurnianda, Johan
Acta Interna The Journal of Internal Medicine Vol 4, No 2 (2014): The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/acta interna.16928

Abstract

ABSTRACTWe review the present knowledge of telomeres and telomerase with special attention to their role in hematological disorders especially bone marrow failure syndromes including acquired aplastic anemia and myelodysplastic syndromes, as well as acute and chronic myeloid leukemia. The current understanding on the role of telomere and telomeres dysfunctions in hematological disorders leads us to a better understanding on the pathology of the diseases as well as considering some possibilities to employ the measurement of telomere length and telomere activity in disease prognostication. Several treatment options targeting telomere and telomerase being developed are also reviewed.Keywords: telomere- telomerase- bone marrow failure syndromes- hematological malignancies
Secondary acute myeloblastic leukemia after adjuvant chemotherapy and radiotherapy in breast cancer: A case report Hardianti, Mardiah Suci; Kurnianda, Johan; Taroeno-Hariadi, Kartika Widayati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 03 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedScie004603201405

Abstract

A rising number of long-term survivors and potential long-term outcome related to the treatment isone of the most important issue due to the advances of management in cancer. The development ofsecondary malignancy has been reported in a number of cohorts. We present a case of breast cancerpatient developing acute myeloid leukemia (AML)- M5 within a relatively short interval of two and ahalf years from her primary treatment with adjuvant chemotherapy with 4 cycles of doxorubicin andcyclophosphamide, followed by 4 cycles of three weekly paclitaxel (AC-T) and radiotherapy. Whatcould be attributed to the occurrence of secondary leukemia in this patient will be discussed.
A Stability Mathematical Model of Nasopharyngeal Carcinoma on Cellular Level Sugiyanto, Sugiyanto; Kusumo, Fajar Adi; Aryati, Lina; Hardianti, Mardiah Suci
Biology, Medicine, & Natural Product Chemistry Vol 5, No 2 (2016)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2016.52.61-64

Abstract

This paper discussed the stability of “Tumorigenesis Models” to link between EBV and carcinoma of the nasopharyngeal from normal cell to invasive carcinoma. The review on this case accomplished the previous theorem of equilibrium point on “Tumorigenesis Models”.
Ex vivo Generation of Platelets from Umbilical Cord Blood Hematopoietic Stem Cells with Amniotic Membrane Mesenchymal Stem Cells Support Hardianti, Mardiah Suci
Acta Interna The Journal of Internal Medicine Vol 3, No 1 (2013): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/acta interna.3845

Abstract

Prolonged Survival in a Non-Small Cell Lung Cancer with Brain Metastasis Treated with a Brain Mass Evacuation and Gefi tinib Hardianti, Mardiah Suci; Kurnianda, Johan
Acta Interna The Journal of Internal Medicine Vol 5, No 1 (2015): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/acta interna.22393

Abstract

The incidence of brain metastasis (BM) is reported to be increase about 20-40% over the last few years in patients with non-small-cell lung cancer (NSCLC).1 The use of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in NSCLC patients with BM, especially those harboring EGFR mutations have been reported.
Prognostic Value Of Chemotherapy-Induced Neutropenia In Metastatic Colorectal Cancer At Rsup Dr Sardjito Yogyakarta Qomaruzzaman, Muhammad Ihsan; Kurnianda, Johan; Hardianti, Mardiah Suci
Acta Interna The Journal of Internal Medicine Vol 6, No 1 (2016): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.27006

Abstract

Background: Colorectal cancer is the third largest incidence of cancer in the world and is the third most common cause of death in women and men . Five-year overall survival (OS) in colorectal cancer who have undergone metastasis was 10 % . Hematologic toxicity may be a marker of biological activity of cytotoxic drug on various types of cancer . Neutropeniaafter chemotherapy known to be associated with increased patient survival .Objective : To establish whether chemotherapy-induced neutropenia is predictive of better outcome in patients with metastatic colorectal cancer (mCRC).Methods: This research was a case-control study. Subjects were patients with metastatic colorectal cancer in the Cancer Instalation Center Tulip RSUP dr. Sardjito who meet the inclusion and exclusion criteria. Data were analyzed by bivariate analysis using chi square test and multivariate analysis with logistic regression.Results: Neutropenia present in 26 patients (32.5%) of the total 80 patients of the study. Neutropenia were significantly affect OS ( p = 0.001 and OR 7.73, 95% CI: 2.51-23.80). Multivariate logistic regression analysis showed neutropenia and the number of metastases affect OS with p <0.001 and p <0.003.Conclusion: Neutropenia occurring during the two first lines of chemotherapy for metastases colorectal cancer is associated with better survival. Variables that affect OS is the number of metastases and incidence of neutropenia after chemotherapy.
[PHS5] Dampak Volume Berita Figur Publik dan Peringatan Hari Kanker terhadap Volume Pencarian Kanker di Indonesia: Studi Analisis Google Trend Setiawan, Syahru Agung; Hardianti, Mardiah Suci
Berita Kedokteran Masyarakat (BKM) Vol 35, No 4 (2019): Proceedings the 5th UGM Public Health Symposium
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tujuan: Jumlah pengguna internet di Indonesia saat ini cukup gemuk yang berpotensi menjadi target promosi kesehatan baru di era digital. Aplikasi Google Trend memungkinkan untuk mendapatkan data lebih cepat untuk mempelajari tren pencarian informasi kesehatan oleh masyarakat. Sebagai bentuk ketertarikan kami terhadap kesadaran publik mengenai kanker, kami mempelajari fluktuasi minat publik tentang pencarian kanker dan seberapa kuat pengaruh dari berita figur publik serta kampanye hari kesadaran kanker di Indonesia.Metode: Volume pencarian kanker, berita kanker yang dialami figur publik, dan hari kesadaran kanker dilacak dari tahun 2018 hingga trimester pertama tahun 2019 melalui Google trend. Tren dianalisis menggunakan korelasi, regresi berganda, dan korelasi silang.Hasil: Dilaporkan peningkatan tren volume pencarian kanker secara linier di Indonesia (R = 0,379; p <0,002) dengan korelasi kuat terhadap pencarian figur publik (r = 0,752; p = <0,001) namun korelasi lebih rendah terhadap hari kesadaran kanker (r = 0,296; p = 0,017). Terjadi beberapa lonjakan yang relatif bersamaan baik pada tren pencarian kanker dan figur publik. Analisis multivariat menunjukkan dampak signifikan dari figur publik, tren sekuler, dan hari kesadaran kanker terhadap pencarian kanker di Indonesia (R2 = 0,646; p <0,001). Penelitian ini membuktikan pengaruh kuat dari berita figur publik terhadap minat pengguna internet mengenai kanker meskipun terjadi sementara dan mendadak. Dampak tersebut berlangsung sekitar 4 minggu dengan pencarian tokoh masyarakat mendahului 1 minggu dari kuatnya pencarian kanker. Efek lebih lemah namun positif dari hari kesadaran kanker menunjukkan perlunya perbaikan terhadap intervensi ini.Kesimpulan: Dibandingkan dengan kampanye kanker, berita tokoh masyarakat akan lebih 'meledakkan' pencarian informasi kanker secara signifikan namun berlangsung sementara, sehingga disarankan pemangku kepentingan dapat memaksimalkan 'periode emas' ini untuk menyuguhkan dan memasifkan konten kanker yang informatif dan terpercaya sekaligus sebagai upaya melawan hoax mengenai kanker.