REAKTOR Volume 12, Nomor 2, Desember 2008
Publisher : Dept. of Chemical Engineering, Diponegoro University

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In the laboratory scale, the effect of the concentration of H2SO4 catalyst (1.25-6.25) (% w/w) and the equivalent mol ratio between lauric acid and glycerol (1:1; 1:2.5; 2.5:1) on the synthesis of a-monolaurin has been studied. The a-monolaurin compound has been synthesized from lauric acid and glycerol was done by batch esterification on the free solvent system. The esterification by using 5% H2SO4 catalyst and equivalent mol ratio between lauric acid and glycerol 1:2.5 produced most monolaurin, and dilaurin in amount of 31.14 and 4.42%, respectively. The monolaurin and dilaurin are identified by thin layer chromatography (TLC), infrared spectrophotometer (FTIR), liquid chromatography-mass spectrometer (LC-MS), and Nuclear Magnetic Resonance (NMR) spectrometer. The spectral data of monolaurin was compared to spectral data of standard a-monolaurin.Telah dilakukan penelitian sintesis senyawa a-monolaurin dari asam laurat dan gliserol, dengan konsentrasi katalis H2SO4 (1,25 s.d. 6,25) (% berat) dan perbandingan molaritas reaktan asam laurat terhadap gliserol (1:1; 1:2,5; dan 2,5:1) sebagai parameter. Pada reaksi esterifikasi dengan konsentrasi katalis H2SO4 5%  dan perbandingan molaritas asam laurat terhadap gliserol 1:2,5 dihasilkan senyawa a-monolaurin terbanyak 31,14% sebagai hasil utama dan senyawa a,a’-dilaurin 4,42% sebagai hasil samping sintesis. Kedua senyawa hasil sintesis diidentifikasi dengan kromatografi lapis tipis (KLT), spektrofotometer infra merah (FTIR), spektrometer massa liquid chromatography-mass spectrometer (LC-MS), dan spektrometer resonansi magnetik inti (NMR). Karakteristik senyawa a-monolaurin hasil sintesis dibandingkan  dengan karakteristik a-monolaurin standar.   

The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell

Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

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Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm.

The Synthesis of Quinidine Salicylate Ester Compound

Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 20, No 2 (2018)
Publisher : Research Center for Chemistry - LIPI

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Quinidine a compound isolated from quinine plants, one of the species of quinine plants is (Chincona ledgereriana) From PT SIL Lembang. The purpose of this study was obtain quinidine salicylate ester through esterification reaction. In this study, the synthesis of quinidine ester compound by esterification reaction was conducted. Esterification reaction was conducted by using DCC activator and DMAP catalyst with one carboxylic acid namely salicylate acid producing new compound namely quinidine salicylate, Subsequent Quinidine salicylate was obtained in the form of oil with 97% yield. The compound obtained from the synthesis was then identified using Thin Layer Chromatography continue analyzed using with Spectrophotometer, LC-ESI-MS spectroscopy. Results show that the target compound has been successfully synthesized.

Identification and Characterization of Bacterial Lipase from Plateu Soil in West Java

Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 18, No 02 (2016)
Publisher : Research Center for Chemistry - LIPI

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Lipases are known as glycerol ester hydrolases that catalyze the hydrolysis of triglycerides into free fatty acids and glycerol. Lipases are found in human, animal, plant, and microorganisms. The aim of this research is to identify lipase producers and characterize bacterial lipase from West Java plateau soil. Plateau soil bacteria samples were isolated on lipase screening medium containing Rhodamine B. Olive oil was used as a substrate in screening and production medium bacterial lipases. From 16 bacterial isolate of lipase producers, 14 were identified as Bacillus sp. and the others were identified as Pseudomonas alcaligenes. All isolates were taken into production step to determine their lipase activities. Moreover, top 3 lipase activities out of 16 lipase activities were chosen to find the optimum pH and temperature. Both characterizations showed pH optimum and temperature optimum from each lipase. These optimum condition were used in heat stability characterization for each lipase samples. The result showed that lipase from isolate COK 2 in optimum pH 4 and temperature 50oC was the most stable lipase due to this sample has good and stable activity for 1 to 5 hours incubation time. Lipase sample from isolate COK 2 has good efficiency for lipase productivity in acid condition and high temperature. Results of this investigation could encourage utilization of these activity enhancers for various industrial applications.

Synthesis and cytotoxicity assay using Brine Shrimp Lethality Test of Cinchonidine Isobutyrate Ester

Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 19, No 1 (2017)
Publisher : Research Center for Chemistry - LIPI

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This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. Cinchonidine is predicted to have anticancer activity. Synthesized ester was aimed to gain higher lipophilicity. Higher lipophilicity makes it easier for the compund to pass through cell membrane. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. BSLT result showed that cinchonidine isobutyrate ester had LC50 value of 75.16 ppm which was more toxic than cinchonidine that had LC50 value of 99.2 ppm. It was proved that higher lipophilicity could increase pharmacology activity


Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 1 (2016): WISUDA FEBRUARI 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Tourism is one of the new industries which are able to accelerate economic growth and employment, boosting incomes, living standards and to stimulate other productive sectors. This prompted the Department of Culture and Tourism Rokan Hulu to create the attraction Airpanas Hapanasan with the aim to increase the budget and make the area one of the leading tourist attraction in the province of Riau. In increasing the number of visitors needed an effective marketing strategy to create attraction. The aim of this study was to determine how the marketing strategy undertaken by the Department of Culture and Tourism Rokan Hulu in increasing tourist arrivals area and outside the region. In addition, this study also aims to mengetehaui factors supporting and inhibiting factors in the implementation of marketing strategies.This study used qualitative research methods. Subjects in this study consisted of seven people and data collection techniques are grouped into three sections, namely; in-depth interviews, observation, and documentation. This study uses data analysis interactive model of Miles and Hubermen, using a technique that checks the validity of the data through the extension of participation and triangulation.Results of this study show that the marketing strategy of Culture and Tourism Rokan Hulu is decisive segmentation, perform targeting, promotion through print media and online media. Supporting factors in conducting marketing strategy is the attraction Airpanas Hapanasan an asset in the regions, the object of Hapanasan Airpanas tourists are also breeding butterflies, childrens playground as well as outbound, and the location of Rokan Hulu directly adjacent to West Sumatra. Inhibiting factor is the lack of cooperation with a third party / private sector in managing attractions Airpanas Hapanasan the minimnnya intensity of promotion by local governments in promoting attractions Airpanas Hapanasan the professionalism, knowledge in promoting regional tourism is still minimal and competition attractions same become an obstacle to the government in promoting the tourist attraction.Jom

Characterization of Ethanol Extract from Katumpangan Air Herbs (Peperomia pellucida L. Kunth

Biopropal Industri Vol 6, No 2 (2015)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

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Peperomia pellucida L. Kunth known as “Katumpangan Air” is a potential medicinal plants used traditionally for uric acid, rheumatic, headache, stomachache, antimicrobial. This study aims to establish  the non-specific  and specific parameters of ethanol extract from Katumpangan air (EKA). EKA was collected from three different growth places: South Tangerang (6.833%), Bogor (7.8%) and Yogyakarta (13.125%). The results show that organoleptic extract characterization from three places were same: thick, blackish green brown, bitter and have a characteristic odor. The average content of water-soluble compounds was within range 7.39-13.29%, ethanol-soluble 15.33-16.68%, flavonoid total 3.807-4.244%. The range of moisture content was 12.25-16.34%, ash total 1.21-2.78%, acid insoluble ash 0.19-1.62%, drying shrinkage 21.62-24.98%, specific gravity 1.0010-1.0034 g/mL for the non-specific parameter. Microbial contamination testing results 0.61x103-1.13x103 coloni/g, the contaminant testing mold/yeast 0.1x102-1.7x102 coloni/g, while lead metal 0.15-0.18 mg/kg, cadmium 0-0.11 mg/kg and arsenic <0.005µg/kg.


Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 2: WISUDA OKTOBER 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Many social networking sites can be a place to share information and with interesting features but it also can become a means of getting a lot of friends to arrive to find a mate. Internet sites such as Twitteer, Friendster, Hi5, Myspace, YouTube, Blogger and many more. Facebook is a social networking website that is now increasing in popularity and the number of members increased sharply in a short time.The main task of the student is learning and studying, because adolescence is a time of transition that is eager to note, facebook is a website that can make teens more expressive highlight himself, his desire, and profile. Thus these students will continue to play facebook that disturbed his homework and make the time taken up by a lot by playing these sites.The concept of the theory that the researchers use a communication model Stimulus - Response. To determine the stimulus arising from a sale effectively, required knowledge of the factors that influence a person to receive, consider the information and make a decision to buy the products offeredThis research is a quantitative research. To measure the force between two variables, namely social media facebook as an independent variable and learning motivation of students as the dependent variable, used simple regression, or often called simple regression.From t test results obtained value for the variable t¬test Social Media facebook3.900 (greater than ttabel 1.984), and pvalue of 0.000 <0.05), the results of this study indicate that social media facebook affect student learning motivation FISIP Riau University ,Keywords: Social Media and Motivation

Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes from Neesia altissima

Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

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Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.


JURNAL ILMU BUDAYA JIB Volume 5, No 1 Januari - Juni 2017
Publisher : Universitas Hasanuddin

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Teachers are professional educators with the primary task of educating, teaching, guiding, directing, training, assessing, and evaluating learners in early childhood education, primary education, and secondary education. Professional is a work or activity undertaken by a person and becomes a source of income of his life that requires expertise, skill or skill that meets certain quality or norm standards and requires professional education. As a profession, thecompetence that must be possessed by a teacher, namely personality competence, pedagogic competence, professional competence, and social competence. Teachers have a strategic role in the field of education, even other adequate educational resources are often meaningless if not accompanied by adequate teacher quality. Likewise, the opposite happen, if the quality teacher is poorly supported by other supporting resources are adequate, can also cause less optimal performance. In other words, teachers are at theforefront of improving the quality of education services and outcomes. In many cases, the quality of the education system as a whole is related to the quality of teachers. To that end, improving the quality of education should be done through efforts to improve the quality of teachers character. The professionalism of a teacher must be framed in character education, because to educate the character of the learner can only be done by a teacher of character. So,educating characters must be character, because the most effective way of educating is to set an example.Key words: Professionalism, character education, teachers, pedagogic systems, learners

Co-Authors . Hariyanti Abdul Mun’im Achmadi, Suminar A Andini Sundowo Aoki, Chie Arry Yanuar Asih, Puji Budi Setia Atiek Soemiati Atiek Sumiati, Atiek Berna Elya Efrina, D Endang Saepudin, Endang Eva Vaulina YD Evawani Elysa Lubis Evi Triwulandari Fatmawaty Fatmawaty, Fatmawaty Fauzi Febrianto Ferbianto, Fauzi Galuh Widiyarti HAK HOTTA Hanifah Nuryani Lioe Hariyanti Hariyanti Harjono Harjono Husniati, - Ika Mustika Iqmal Tahir Irwan Iftadi Jamilah Abbas Jemi, Renhart Jumina Jumina Kanzaki, Mamoru Ken Ichi Fujita, Ken Ichi Khanifudin, Ahmad Kozo, Shibata Kurnia Sofyan Laksana, Yanotama T Lia Meilawati Linar Zalinar Udin, Linar Zalinar Lotulung, Puspa D.N Lotulung, Puspa Dewi MAGGY THENAWIDJAJA SUHARTONO Maksum Radji Mario Mario Marissa Angelina Megawati Megawati Minarti Minarti Mochammad Chasani Muchammad Irsyad, Muchammad Muhammad Ghozali Ngadiman Ngadiman Nina Artanti Nuraini, Lutviasari Nurjaya, Intan Ponco Iswanto Prasasty, Vivitri Dewi Prasasty, Vivitri Dewi Pratiwi, Rosa Dewi Prima, Sylvia Rizky Primahana, Gian Primahana, Gian Puspa D Lotulung, Puspa D Puteri Amelia, Puteri Rahmaniyah Dwi Astuti Rina Andriyani Rina Hidayati Pratiwi Rita Kartika Sari Rosmalena, Rosmalena Rosmalena, Rosmalena Salahuddin Salahuddin Santy Rahmawati Sari, Rita K Soedarmono, Pratiwi Sofa Fajriah Soleh Kosela Sri Hartati Sri Mursiti Sugara, Taufan H Sugiwati, Sri Suminar S Achmadi Suprapto, Irma Herawati Suwandl, B. Syafrudin, Din Syahbudin, Zaitun Syahrul Aiman Teni Ernawati Tun Tedja Irawadi Vienna Saraswaty, Vienna Wahyudi Priyono Soewarso Wasrin Syafi, Wasrin Wasrin Syafii Winata, Vinella Yasir ", Yasir Yoshinosuke Usuki, Yoshinosuke Yulia Anita