Articles

PENGARUH KONSENTRASI KATALIS DAN PERBANDINGAN MOLARITAS REAKTAN PADA SINTESIS SENYAWA Widiyarti, Galuh; Hanafi, Muhammad
REAKTOR Volume 12, Nomor 2, Desember 2008
Publisher : Dept. of Chemical Engineering, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1051.582 KB) | DOI: 10.14710/reaktor.12.2.90-97

Abstract

In the laboratory scale, the effect of the concentration of H2SO4 catalyst (1.25-6.25) (% w/w) and the equivalent mol ratio between lauric acid and glycerol (1:1; 1:2.5; 2.5:1) on the synthesis of a-monolaurin has been studied. The a-monolaurin compound has been synthesized from lauric acid and glycerol was done by batch esterification on the free solvent system. The esterification by using 5% H2SO4 catalyst and equivalent mol ratio between lauric acid and glycerol 1:2.5 produced most monolaurin, and dilaurin in amount of 31.14 and 4.42%, respectively. The monolaurin and dilaurin are identified by thin layer chromatography (TLC), infrared spectrophotometer (FTIR), liquid chromatography-mass spectrometer (LC-MS), and Nuclear Magnetic Resonance (NMR) spectrometer. The spectral data of monolaurin was compared to spectral data of standard a-monolaurin.Telah dilakukan penelitian sintesis senyawa a-monolaurin dari asam laurat dan gliserol, dengan konsentrasi katalis H2SO4 (1,25 s.d. 6,25) (% berat) dan perbandingan molaritas reaktan asam laurat terhadap gliserol (1:1; 1:2,5; dan 2,5:1) sebagai parameter. Pada reaksi esterifikasi dengan konsentrasi katalis H2SO4 5%  dan perbandingan molaritas asam laurat terhadap gliserol 1:2,5 dihasilkan senyawa a-monolaurin terbanyak 31,14% sebagai hasil utama dan senyawa a,a’-dilaurin 4,42% sebagai hasil samping sintesis. Kedua senyawa hasil sintesis diidentifikasi dengan kromatografi lapis tipis (KLT), spektrofotometer infra merah (FTIR), spektrometer massa liquid chromatography-mass spectrometer (LC-MS), dan spektrometer resonansi magnetik inti (NMR). Karakteristik senyawa a-monolaurin hasil sintesis dibandingkan  dengan karakteristik a-monolaurin standar.   
SINTESIS ANALOG UK-3A : 6-HIDROKSI-N-FENILNIKOTINAMIDA DAN 6-HIDROKSI-N- FENILPIKOLINAMIDA DAN UJI SITOTOKSISITAS SECARA IN VITRO TERHADAPSEL KANKER MURINE LEUKEMIA P388 Febriyanti, Lilis; Hanafi, Muhammad; Hayun, Hayun
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.583

Abstract

The Novel compound of analog UK-3A defined as HF-1 (6-hydroxy-N-phenylnicotinamide) and HF-2 (6-hydroxy-N-phenylpicolinamide)was successfully synthesized by amidation reaction of aromatic carboxilyc acids and primary amine by adding the activator of DCC (dicyclohexylcarbodiimide), catalyst DMAP (4-dimethyl aminopyridine, and DMSO (dimethyl sulfoxide) as the solvent. Reaction run for 24 hours in 55oC. Result shows yield of HF-1 as much as 52%, and for HF-2 is 16%. The analogue compounds structure of UK-3A were characterized by spectrophotometer FT-IR, LCMS, and NMR. Citotoxicity assay against Murine Leukemia cells of HF-1 and HF-2 by MTT (3-(4,5-dimethylltiazo-2-yl-) 2,5-diphenyltetrazolium bromide) assay. The result of bioassay showed IC50(inhibitory concentration)value 71 µg/mL and 63 µg/mL for HF-1 and HF-2 respectively. It informed that the analogue compounds have lower activity than UK-3A compound which has IC50 value 38 µg/mL.
STRATEGI KOMUNIKASI PEMASARAN DINAS KEBUDAYAAN DAN PARIWISATA KABUPATEN ROKAN HULU DALAM MENINGKATKAN KUNJUNGAN WISATA PADA OBJEK WISATA AIRPANAS HAPANASAN Hanafi, Muhammad; Lubis, Evawani Elysa
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 1 (2016): WISUDA FEBRUARI 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Tourism is one of the new industries which are able to accelerate economic growth and employment, boosting incomes, living standards and to stimulate other productive sectors. This prompted the Department of Culture and Tourism Rokan Hulu to create the attraction Airpanas Hapanasan with the aim to increase the budget and make the area one of the leading tourist attraction in the province of Riau. In increasing the number of visitors needed an effective marketing strategy to create attraction. The aim of this study was to determine how the marketing strategy undertaken by the Department of Culture and Tourism Rokan Hulu in increasing tourist arrivals area and outside the region. In addition, this study also aims to mengetehaui factors supporting and inhibiting factors in the implementation of marketing strategies.This study used qualitative research methods. Subjects in this study consisted of seven people and data collection techniques are grouped into three sections, namely; in-depth interviews, observation, and documentation. This study uses data analysis interactive model of Miles and Hubermen, using a technique that checks the validity of the data through the extension of participation and triangulation.Results of this study show that the marketing strategy of Culture and Tourism Rokan Hulu is decisive segmentation, perform targeting, promotion through print media and online media. Supporting factors in conducting marketing strategy is the attraction Airpanas Hapanasan an asset in the regions, the object of Hapanasan Airpanas tourists are also breeding butterflies, childrens playground as well as outbound, and the location of Rokan Hulu directly adjacent to West Sumatra. Inhibiting factor is the lack of cooperation with a third party / private sector in managing attractions Airpanas Hapanasan the minimnnya intensity of promotion by local governments in promoting attractions Airpanas Hapanasan the professionalism, knowledge in promoting regional tourism is still minimal and competition attractions same become an obstacle to the government in promoting the tourist attraction.Jom
Characterization of Ethanol Extract from Katumpangan Air Herbs (Peperomia pellucida L. Kunth Angelina, Marissa; Amelia, Puteri; Irsyad, Muchammad; Meilawati, Lia; Hanafi, Muhammad
Biopropal Industri Vol 6, No 2 (2015)
Publisher : Balai Riset dan Standardisasi Industri Pontianak

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Abstract

Peperomia pellucida L. Kunth known as “Katumpangan Air” is a potential medicinal plants used traditionally for uric acid, rheumatic, headache, stomachache, antimicrobial. This study aims to establish  the non-specific  and specific parameters of ethanol extract from Katumpangan air (EKA). EKA was collected from three different growth places: South Tangerang (6.833%), Bogor (7.8%) and Yogyakarta (13.125%). The results show that organoleptic extract characterization from three places were same: thick, blackish green brown, bitter and have a characteristic odor. The average content of water-soluble compounds was within range 7.39-13.29%, ethanol-soluble 15.33-16.68%, flavonoid total 3.807-4.244%. The range of moisture content was 12.25-16.34%, ash total 1.21-2.78%, acid insoluble ash 0.19-1.62%, drying shrinkage 21.62-24.98%, specific gravity 1.0010-1.0034 g/mL for the non-specific parameter. Microbial contamination testing results 0.61x103-1.13x103 coloni/g, the contaminant testing mold/yeast 0.1x102-1.7x102 coloni/g, while lead metal 0.15-0.18 mg/kg, cadmium 0-0.11 mg/kg and arsenic <0.005µg/kg.
PENGARUH PENGGUNAAN MEDIA SOSIAL FACEBOOK TERHADAP MOTIVASI BELAJAR MAHASISWA FISIP UNIVERSITAS RIAU Hanafi, Muhammad; ", Yasir
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 3, No 2: WISUDA OKTOBER 2016
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Many social networking sites can be a place to share information and with interesting features but it also can become a means of getting a lot of friends to arrive to find a mate. Internet sites such as Twitteer, Friendster, Hi5, Myspace, YouTube, Blogger and many more. Facebook is a social networking website that is now increasing in popularity and the number of members increased sharply in a short time.The main task of the student is learning and studying, because adolescence is a time of transition that is eager to note, facebook is a website that can make teens more expressive highlight himself, his desire, and profile. Thus these students will continue to play facebook that disturbed his homework and make the time taken up by a lot by playing these sites.The concept of the theory that the researchers use a communication model Stimulus - Response. To determine the stimulus arising from a sale effectively, required knowledge of the factors that influence a person to receive, consider the information and make a decision to buy the products offeredThis research is a quantitative research. To measure the force between two variables, namely social media facebook as an independent variable and learning motivation of students as the dependent variable, used simple regression, or often called simple regression.From t test results obtained value for the variable t¬test Social Media facebook3.900 (greater than ttabel 1.984), and pvalue of 0.000 <0.05), the results of this study indicate that social media facebook affect student learning motivation FISIP Riau University ,Keywords: Social Media and Motivation
Bioactivity of Antibacterial Compounds Produced by Endophytic Actinomycetes from Neesia altissima Pratiwi, Rina Hidayati; Hanafi, Muhammad; Artanti, Nina; Pratiwi, Rosa Dewi
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (71.575 KB) | DOI: 10.11594/jtls.08.01.07

Abstract

Identification of alternate bioactive compounds isolated from microbial endophytes from plants may lead to better solution against antibiotic resistance. Main objective of this research is to determine the bioactivity of antibacterial compounds produced by endophytic actinomycetes, which was isolated from stem bark of Neesia altissima Bl. at Halimun Salak Mount. Detection of bioactive compounds was assayed using Thin Layer Chromatography (TLC) by employing bioautography. Bioactivity was assayed using crude extract against five microorganisms using agar diffusion methods. Tetracycline was used as a positive control. The result of antibacterial activity from endophytic actinomycetes isolate revealed that the bioactive compounds were effective in inhibiting the growth of bacteria Bacillus cereus (1.25 mm), Salmonella typhimurium (5.75 mm), and Shigella flexneri (4.37 mm). Bioactivity of ethyl acetate extract from bioactive compounds of endophytic actinomycetes has an antibacterial activity against bacteria Bacillus cereus (13.00 mm) and Staphylococcus aureus (15.90 mm), at a concentration of 250,000 ppm. Each of TLC fraction was able to inhibit growth of B. cereus at a minimum concentration of 10,000 ppm. In conclusion, the bioactive compounds produced by endophytic actinomycetes can have inhibitory effect towards B. cereus. The category of that compounds are narrow spectrum. The bioactive compound isolated from endophytic actinomycetes may have other implications such as anticancer, antifungal, and antioxidant.
MEMBANGUN PROFESIONALISME GURU DALAM BINGKAI PENDIDIKAN KARAKTER hanafi, Muhammad
JURNAL ILMU BUDAYA JIB Volume 5, No 1 Januari - Juni 2017
Publisher : Universitas Hasanuddin

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Abstract

Teachers are professional educators with the primary task of educating, teaching, guiding, directing, training, assessing, and evaluating learners in early childhood education, primary education, and secondary education. Professional is a work or activity undertaken by a person and becomes a source of income of his life that requires expertise, skill or skill that meets certain quality or norm standards and requires professional education. As a profession, thecompetence that must be possessed by a teacher, namely personality competence, pedagogic competence, professional competence, and social competence. Teachers have a strategic role in the field of education, even other adequate educational resources are often meaningless if not accompanied by adequate teacher quality. Likewise, the opposite happen, if the quality teacher is poorly supported by other supporting resources are adequate, can also cause less optimal performance. In other words, teachers are at theforefront of improving the quality of education services and outcomes. In many cases, the quality of the education system as a whole is related to the quality of teachers. To that end, improving the quality of education should be done through efforts to improve the quality of teachers character. The professionalism of a teacher must be framed in character education, because to educate the character of the learner can only be done by a teacher of character. So,educating characters must be character, because the most effective way of educating is to set an example.Key words: Professionalism, character education, teachers, pedagogic systems, learners
The Model of Learning Design based on Islamic Multicultural Education to Prevent Conflicts of Behavior Syahbudin, Zaitun; Hanafi, Muhammad
Jurnal Pendidikan Islam Vol 3, No 2 (2017): Jurnal Pendidikan Islam
Publisher : The Faculty of Tarbiyah and Teacher Training associated with ASPII

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (399.048 KB) | DOI: 10.15575/jpi.v3i2.1279

Abstract

This paper presents the form of multicultural conflict at SMA (Sekolah Menengah Atas/Senior High School) Kartini Regency of Rokan Hilir Riau, the supporting and inhibiting factors in application of the multicultural curriculum and design of learning model for multicultural-based PAI (Pendidikan Agama Islam /Islamic Education) to put down the conflicts among students. The research was a research and development (R&D) with qualitative approach. Research and development were conducted up to hypothetical phase. The research subjects were the teachers of PAI, Chemistry, and PKN (Pendidikan Kewarganegaraan/Civic Education). Each of subject teacher was one person, and the number of participating students were 34 people. Data collection technique was conducted by observation, interview, questionnaire, and documentation. Qualitative data processing encompassesed data collection, reduction, presentation, and verification. Based on the research results, there were conflicts at SMA Kartini caused by individual differences, interest differences, cultural and social changes. The supporting factor in application of multicultural curriculum was that all stakeholders at SMA Kartini still have tolerant attitude which can be developed and directed and the teachers at SMA Kartini have inclusive attitude. Meanwhile, the inhibiting factors in application of multicultural curriculum at SMA Kartini were the minimum facilities and infrastructure, lack of information services, and lack of supervision towards students.     
Antiviral effect of Archidendron pauciflorum leaves extract to hepatitis C virus: An in vitro study in JFH-1 strain Hartati, Sri; Aoki, Chie; Hanafi, Muhammad; Angelina, Marissa; Soedarmono, Pratiwi; Hotta, Hak
Medical Journal of Indonesia Vol 27, No 1 (2018): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.399 KB) | DOI: 10.13181/mji.v27i1.2189

Abstract

Background: Hepatitis C virus (HCV) is a leading cause of chronic liver diseases. Drug resistance to the regimen is also increasing. Hence, there is a need for new anti-HCV agents that are less toxic and more efficacious. The aim of this study is to evaluate the  possibility of A. pauciflorum extracts can be a antiviral drug.Methods: Huh-7it cells were infected with the HCV genotype 2a strain JFH-I in the presence of methanol extracts of Archidenron pauciflorum. The methanol extract further partition used n-hexane, ethyl acetate, n-butanol, and water showed in which butanol extracts exerted the strongest IC50 (6.3 g/ml). Further, the butanol fraction was fractionated and yielded into 13 fractions.Results: The methanol extract of the leaves of A. pauciflorum exhibited concentration dependent inhibition against the JFH1 strain of HCV genotype 2a with an IC50 is 72.5 μg/ml. The butanol fraction exhibited the highest anti-HCV activity with an IC50 is 6.3 μg/ml. The butanol fraction was fractionated which yielded 13 fractions. Fractions 5 and 13 exhibited high anti-HCV activities with IC50 is 5.0 μg/ml and 8.5 μg/ml and a time-of-addition study demonstrated that fraction 5 inhibited viral infection at the post-entry step, whereas fraction 13 primarily inhibited the viral entry step.Conclusion: The extract A. pauciflorum can be used as a herbal-based antiviral drug.
The Synthesis of Cinchonine Tiglat Ester Compound and Cytotoxic Test Against MCF-7 Breast Cancer Cell Khanifudin, Ahmad; Primahana, Gian; Prima, Sylvia Rizky; Lotulung, Puspa Dewi; Hanafi, Muhammad
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v19i2.354

Abstract

Cinchonine is a type of cinchona alkaloid compound commonly found and/or isolated from Cinchona sp. plant. It is commonly used to treat malaria, and can potentially be used against cancer cells. In this particular study, cinchonine ester derivatives were extracted through esterification processs. Synthesized esther is aimed to gain higher lipophilicity of cinchonine so that makes it easier to pass through cell membrane. Esterification was done using DCC activator as well as DMAP catalyst with tiglic acid used to create cinchonine tiglat. Subsequent cinchonine tiglat was obtained in the form of oil with 25,28% yield. The compound obtained from the synthesis was the analyzed using LC-ESI-MS and 1H-NMR spectroscopy instrumentation. Results show that the target compound has been successfully synthesized. Its cytotoxic ability against MCF-7 breast cancer cells was tested using the Alamar Blue method. Results concluded that cinchonine tiglat ester compound has a viable cytotoxic activity with IC50 value of 1.22 ppm.
Co-Authors . Hariyanti Abdul Mun’im Achmadi, Suminar A Ade Chandra Iwansyah Andini Sundowo Aoki, Chie Arry Yanuar Asih, Puji Budi Setia Atiek Soemiati Atiek Sumiati, Atiek Berna Elya Efrina, D Endang Saepudin, Endang Eva Vaulina YD Evawani Elysa Lubis Evi Triwulandari Fatmawaty Fatmawaty, Fatmawaty Fauzi Febrianto Febriyanti, Lilis Ferbianto', Fauzi Galuh Widiyarti HAK HOTTA Hanifah Nuryani Lioe Hariyanti Hariyanti Harjono Harjono Hayun Hayun, Hayun Husniati, - Ika Mustika Iqmal Tahir Irwan Iftadi Jamilah Abbas Jemi, Renhart Jumina Jumina Kanzaki, Mamoru Ken Ichi Fujita, Ken Ichi Khanifudin, Ahmad Kozo, Shibata Kurnia Sofyan Laksana, Yanotama T Lia Meilawati Lilik Kustiyah Linar Zalinar Udin, Linar Zalinar Lotulung, Puspa D.N Lotulung, Puspa Dewi MAGGY THENAWIDJAJA SUHARTONO Maksum Radji Mario Mario Marissa Angelina Megawati Megawati Minarti Minarti Mochammad Chasani Muchammad Irsyad, Muchammad Muhammad Ghozali Muhammad Rizal Martua Damanik Ngadiman Ngadiman Nina Artanti Nuraini, Lutviasari Nurjaya, Intan Ponco Iswanto Prasasty, Vivitri Dewi Pratiwi, Rosa Dewi Prima, Sylvia Rizky Primahana, Gian Primahana, Gian Puspa D Lotulung, Puspa D Puteri Amelia, Puteri Rahmaniyah Dwi Astuti Rina Andriyani Rina Hidayati Pratiwi Rita Kartika Sari Rosmalena, Rosmalena Salahuddin Salahuddin Santy Rahmawati Sari, Rita K Soedarmono, Pratiwi Sofa Fajriah Soleh Kosela Sri Hartati Sri Mursiti Sugara, Taufan H Sugiwati, Sri Suminar S Achmadi Suprapto, Irma Herawati Suwandl, B. Syafrudin, Din Syahbudin, Zaitun Syahrul Aiman Teni Ernawati Tun Tedja Irawadi Vienna Saraswaty, Vienna Wahyudi Priyono Soewarso Wasrin Syafi, Wasrin Wasrin Syafii Winata, Vinella Yasir ", Yasir Yoshinosuke Usuki, Yoshinosuke Yulia Anita