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ÉCRITURE FÉMININE: Reconstructing Social Identity and Recontextualizing the Scripture Hanafi, M.
JOURNAL OF INDONESIAN ISLAM Vol 4, No 2 (2010)
Publisher : State Islamic University (UIN) of Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (124.485 KB) | DOI: 10.15642/JIIS.2010.4.2.438-445

Abstract

Book Review:Book title:Women, Islam and Everyday Life: Renegotiating Polygamy in Indonesia Author:Nina NurmilaNo. of Pages:xvii + 197Year:2010Publisher:Routledge, London and New York
PENGEMBANGAN KURIKULUM PERGURUAN TINGGI AGAMA ISLAM Hanafi, M.
Islamuna: Jurnal Studi Islam Vol 1, No 2 (2014)
Publisher : Madura State Islamic Institute (Institut Agama Islam Negeri (IAIN) Madura)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (737.682 KB) | DOI: 10.19105/islamuna.v1i2.572

Abstract

Pengembangan kurikulum Pendidikan Agama Islam adalah suatu proses kegiatan penyusunan, pelaksanaan, penilaian dan penyempurnaan kurikulum pendidikan agama Islam. Ada empat asas dalam pengembangan kurikulum yaitu asas filosofis, sosiologis, organisatoris dan psikologis. Selain itu, terdapat empat pendekatan dalam pengembangan kurikulum di antaranya, yaitu pendekatan subjek akademik, pendekatan humanistic, pendekatan teknologi, dan pendekatan rekonstruksi social. Untuk mening-katkan mutu PTAI, maka kurikulum yang diterapkan perlu terus dikembangkan dengan memperhatikan asas-asas pengembangan kurikulum di atas. Pengembangan kurikulum PTAI harus berbasis kompetensi, agar lulusannya memiliki kompetensi handal sesuai bidang garapannya.
UJI AKTIVITAS PENGHAMBATAN ENZIM A-GLUKOSIDASE DAUN KALANCHOE PINNATA PERS. Efizal, Efizal; Soemiati, Atiek; Hanafi, M.; Dwiyanti, Indah
Pharmaceutical Sciences and Research (PSR) Vol 4, No 1 (2007)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2040.868 KB) | DOI: 10.7454/psr.v4i1.3812

Abstract

The study of inhibitory activity against the a-glucosidase enzyme of Kalanchoe pinnata Pers. leaves has been carried out. In vitro, the methanol extract, n-hexane fraction, ethyl acetate fraction and methanol-water (1:1) fraction inhibited a-glucosidase enzyme activities with IC50 value 72.8, 982.6, 194.6 and 293.8 ug/mL, respectively. In vivo, the study was conducted in normal ddY mice by using oral glucose tolerance test. The administration of methanol extract dose 0.5, 1.0 g/kg of body weight and ethyl acetate fraction dose 1.0 g/kg of body weight can suppress the blood glucose level at 30 min significantly (p<0.05) if compared with control after oral administration of sucrose (3 g/kg of body weight), and their activity were similar with acarbose 0.01 g/kg of body weight (p>0.05).
ISOlASI DAN ELUSIDASI SENYAWA KIMIA DARI KULIT POHON Garcinia tetrandra PIERRE Kosela, Soleh; B. Kardono, leonardus; Hanafi, M.
Jurnal Kimia Terapan Indonesia Vol 10, No 1-2 (2000)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3414.945 KB) | DOI: 10.14203/jkti.v10i1-2.178

Abstract

A preliiminary study was carried out to isolate theconstituents of the stem bark of Garcinia tetran dra Pierre(Guttiferae). Several species of this family had been known asmedicinal herb, some other contain bioactive constituents andnovel compounds. The isolation were carried out by macerationin n-hexane where crude extract was purified usingchromatographic technique on SIG60 coloumn and n- hexane ethylacetate as eluents by gradient. Two pure compunds werefound and their molecular structures were determined on thebasis of combined spectroscopic methods UV, IR, 1H-NMR, l3C-NmR and MS and comparison with literature. The compouridhad been identified as xanton, 15-hydroxy-20, 21, 22, 23-tetramethyl-3H,11H-dipyrano (3, 2-a ; 2. 3-i) xanten-17-one(A), known as Thwaitesixanton and a triterpene as Hopenol - a(Hop-(22) (29)-en 3-0 ol) (B).
ISOLATION AND ANTIBACTERIAL TEST OF GARLIC OIL T. Karossi, A.; Hanafi, M.; Sutedja, L.
Jurnal Kimia Terapan Indonesia Vol 3, No 2 (1993)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3252.499 KB) | DOI: 10.14203/jkti.v3i2.271

Abstract

Garlic oil is known to have medicinal effect on hypertension, heart desease, anemia and various infections. The active principles are reported to be allicin, diallil disulfide, allilpropyl disulfide, scorduun, selenium and germanium in addition to the presence of anticoagulant, anuhaemolytic and arulthrombotic agents. The methods applied for isolation and other conditions during the isolation affect the yield or the compositions of the oil, for instance with steam distillation the allicin will decompose whereas extraction at room temperature will yield oil with allicin as the main component. In the present study isolation was conducted by extraction with ethylacetate or ethanol and the oil obtained was tested for their antibacterial capacity. Tests against Staphylococcus aureus, Bacillus cereus and Escherichia coli indicated that the isolated oil were active. On the other hand, commercial garlic extract (KGE) and garlic oil capsule (GOC) gave negative test. This may have been due to either insufficient concentration. of the biologically active component present in the commercial drugs or different method of extraction process. investigation with thin layer chromatography (TLC) of the drugs On silica gel plate ustngn-hexane and ethyl acetate as eluents showed six components in the GOC and none in KGE whereas for the isolated oil 13 components were identified with iodine vapour. Although the oils indicated antibacterial activity, it is somehow less active compared with oxytetracycline which is used as reference.
QSAR STUDY OF XANTHONE DERIVATIVES AS ANTI PLASMODIAL AGENTS Amanatie, Amanatie; Jumina, Jumina; Mustofa, Mustofa; Hanafi, M.; Armunanto, Ria
Indonesian Journal of Chemistry Vol 10, No 3 (2010)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (177.856 KB) | DOI: 10.22146/ijc.21443

Abstract

Xanthones and their derivatives have been reported to exhibit inhibitory activities towards Plasmodium falciparum. To provide deep insight into the correlation between inhibitory activities and structures of xanthones, linear regression method was employed to establish QSAR models for 16 xanthone derivatives that have diverse structures. The accuracy and predictive power of the proposed QSAR model were verified by semi empirical PM3 method, optimation, and validation. The result showed that the best model is model 3 i.e. Log 1/IC50 = Σ (-1.446)qO(7)+ (-8.775)q.C(12) + (-10.592)qC(13) + 1,979; Y = PRESS = 1.124192.
SYNTHESES AND CYTOTOXICITY ASSAY OF ANALOGUES OF UK-3A, A NOVEL FROM Streptomyces sp. 517-02 Anita, Yulia; Hanafi, M.; Arifin, S.
Teknologi Indonesia Vol 36, No 3 (2013)
Publisher : LIPI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jti.v36i3.211

Abstract

UK-3A is a minor compound from the mycelium of Streptomyces sp.517-02 and had been isolated. It has IC50 38 ?g/mL against P388 Murine Leukemia cells. Products of UK-3A analogues were assigned the name A and B compounds. These compounds were prepared from L-serine methyl ester-HCl as starting material and synthesized by amidation and esterifi cation. The products were determined by TLC, FT-IR, MS and NMR instruments. Theoverall yield was compounds A 95.63% and B 87.10%. The in vitro anticancer activities of compounds A and B against the same Leukemia cells and found to have IC50 46.5?g/mL and 15.4?g/mL, respectively. The compound B exhibited higher inhibitory activity than UK-3A.
Identifikasi Senyawa dari Ekstrak Air Rimpang Bangle (Zingiber cassumunar Roxb.) HARTATI, SRI; MEGAWATI, MEGAWATI; ARTANTI, NINA; L., MEILYAWATI; HANAFI, M.
JURNAL ILMU KEFARMASIAN INDONESIA Vol 11 No 2 (2013): JIFI
Publisher : Fakultas Farmasi Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.458 KB)

Abstract

Dalam studi pendahuluan pencarian senyawa marker dari sediaan bahan baku fitofarmaka tumbuhan obat ekstrak air bangle (Zingiber casumunar Roxb.) telah ditemukan tiga senyawa yaitu (E)-4-(3’,4’-dimetoksifenil)but-3-en-1-il-asetat (1), (E)-4-(3’,4’-dimetoksifenil)but-3-en-1-1-ol (2) dan 2-metoksi-8-(3,4-dimetoksifenil)-1,4-naptokuinon (3). Metode isolasi dilakukan dengan cara partisi dan kombinasi teknik kromatografi. Senyawa murni yang diperoleh dianalisis dengan metode spektroskopi RMI proton dan karbon satu dan dua dimensi, kromatografi cair–spektroskopi massa dan spektrofotometri infra merah
SINTESIS XANTON DARI ASAM 2-PHENOXYBENZOIC ACID SEBAGAI BAHAN DASAR OBAT MALARIA BARU Amanatie, Amanatie; Jumina, Jumina; Mustofa, Mustofa; Hanafi, M.
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 15, No 2 (2013)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4345.116 KB) | DOI: 10.14203/jkti.v15i2.108

Abstract

Synthesis of xanthone was conducted from the raw material of 2-phenoxybenzoic acid through acid-catalyzed-cyclization. The product was characterized using UV- Vis, 1 13 d FT-IR, H-NMR, C-NMR, an LC-MS Cyclization of 2-phenoxybenzoic acid using sulfuric acid catalyt gave xanthone in 86.11 % yield. These compounds as the basis of new malaria drugs.Keywords 2-phenoxybenzoic acid, Synthesis, Xanthone, Characterized.
ANTICANCER ACTIVITIES OF SECONDARY METABOLITES PRODUCED BY TAXUS ENDOPHYTIC FUNGUS PHOMOPSIS CHIMONANTHI Sri, A. Desak Gede; Raymond, J. p.; Harmastini, Harmastmi; Kardono,, L.B. S.; Hanafi, M.; Meiyanto, E.
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 13, No 1 (2011)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3233.791 KB) | DOI: 10.14203/jkti.v13i1.125

Abstract

Secondary metabolite by the Taxus endophytic fungus strain Tse3 culture obtained from the West Java Forest has been produced. Production of secondary metabolite had done by aerobic fermentation for 7 days, 3(fC, 120 rpm in PDB (potato dextrose broth) media. The broth of fermentation was extracted by ethyl acetate. Various concentrations of the ethyl acetate extract in (0- 800) mcg/mL were prepared and test against T47D cancer cell line. Cytotoxic test has be done by MTTmethod. ICso value of ethyl acetate extract was 3 mcg/mL. The result of fungus identification by morphology and molecular 18S rRNA was Phomopsis chimonanthi.Key words: Phomopsis chimonanthi, fermentation, isolation, cytotoxicity, identification, taxus