Zahreni Hamzah
Department of Prosthodontics, Faculty of Dentistry, Universitas Jember

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Evaluasi Radiografik Terhadap Ketinggian dan Densitas Tulang Alveolar Mandibula Setelah Penggunaan Gigi Tiruan Lengkap dengan Tissue Conditioner pada Wanita Pasca Menopause Parnaadji, Rahardyan; Hamzah, Zahreni; Soesetijo, Ady
Journal of Dentistry Indonesia Vol 12, No 2 (2005): August
Publisher : Faculty of Dentistry, University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2606.351 KB) | DOI: 10.14693/jdi.v12i2.868

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The need for women to use a dental prosthesis increases with age. Low estrogen level is characteristic in post menopausal women. In this case, it often related with reduction of density and mandibular alveolar bone height. This study aimed to investigate the differences in density and mandibular alveolar bone height in post-manopausal women wearing complete dentures with tissue conditioner. The clinical observations were conducted on seven persons who had received a new set of complete denture in the Prosthodontic Department of the Dental Hospital of the Dental Faculty in Jember University. Balanced occlusion was used in all dentures, fabricated according to the principles used in the department. Panoramic radiographs had been made for all subjects as the baseline, and two, four, and six months later using dentures with tissue conditione. The data was analyzed by using one-way analysis of variance at the 0.05 level. The conclusion was that there is no significant difference in density and mandibular alveolar bone height of complete denture wearers with tissue conditioner in post-menopausal women.
Pencabutan Gigi yang Irrasional Mempercepat Penurunan Struktur Anatomis dan Fungsi Tulang Alveolar Hamzah, Zahreni; Kartikasari, Nadia
STOMATOGNATIC- Jurnal Kedokteran Gigi Vol 12, No 2 (2015)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Tooth extraction is the most common dental treatment procedure in Indonesia. This is happened due to lack of knowledge and awareness of the effect of tooth extraction. Many patients requested dental extraction for some reason such as do not stand the pain anymore, dental treatment is expensive and long, althought the fact that such cases can still be treated. This condition called irrational extraction. Irrational extraction may cause loss of important componets for bone regeneration such as periodontal ligament stem cells/PDLSC, dental pulp stem cells/DPSC, extracellular matrix/ECM and local growth factor. PDLSC has potential differentiation into osteoblast, fibroblast periodontal ligament, and sementoblast. DPSC induces odontontoblast to form reparative dentin. Local growth factors are important component for hard and soft tissue regeneration. Due to loss of important component for bone regeneration, bone became small, thin, and brittle, which allows bone fracture. The purpose of this review is to explain the effect of irrational extraction on mesenchymal stem cell, periodontal ligament, ECM, and local growth factor. This knowledge is expected to reduce irrational tooth extraction.
THE PROGRESSIVE LOW CHRONIC INFLAMMATION ON ORAL TISSUES IN ELDERLY Hamzah, Zahreni; Indartin, Dyah; Meilawaty, Zahara
UNEJ e-Proceeding 2016: Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UNEJ e-Proceeding

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Abstract

Aging is a normal process, as inevitable biologicalphenomenon. Generally, this process characterizedby a decrease in the ability of resolution,regeneration, and reparation of cell and tissues, So,those cells and tissues cannot function properly andits will grow up and die.(1) WHO reports that thepopulation of elderly people worldwide increases by1.7% annually, whereas the population of peopleaged ≥ 65 years old increases by 2.5%. WHOclassified the elderly based on their chronologic/biologic state in 4 groups: (1) the middle age ranged45-59 years old, (2) the older/elderly age ranged 60-74 years old, (3) the advanced old age ranged 75-90years old, and (4) the very old age over 90 years old.Generally, elders ≥ 65 years old have healthproblems as effects of aging process. That meansthey need to have a special concern about theirhealth condition include in dental care.(2,3)Low, systemic and progressive chronic inflammationin elderly age is called inflammaging. This conditioncan occur as the effects of injury on cells andtissues.(4,5) There are some factors that cause injuryon cells, such as; hypoxia, chemical materials (toxins,drugs), physical agents (mechanical trauma,temperature, sudden changes in atmosphericpressure, radiation, electrical potency), microbiologyagents (virus, microbes, fungi), immune systemdisorder, genetic disorder, or malnutrition. Whenthe cells got injuries, there are some possibilityreactions on cells and tissues, e.g. retrogressivereaction, progressive reaction; and adaptationreaction. The main cause and the response towardsinflammaging that linked to illness are stillunknown.(6)
ROLE OF CHEMOATTRACTANT CHEMOKINE (SDF-1/CXCR4) IN BONE MARROW NICHE Setyowati, Dyah Indartin; Hamzah, Zahreni
UNEJ e-Proceeding 2016: Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UNEJ e-Proceeding

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Abstract

Bone marrow is the pioneer for studying stem cells.The basic concept of stem cells obtained by studyinghematopoietic stem cells. Although how theinteraction of HSCs with the local environmentnecessary for the maintenance of stem cells can notbe fully explained ( Compston, 2002; Iwasaki andSuda., 2010). Studies of HSCs aims to study thehabits of these cells in a population of cellscontained in bone marrow . So far little is knownabout the interaction of the bone marrow niche. Thestudy was conducted using a culture system thatlimited done in a sustainable way to prove theinteraction of the bone marrow niche. From theseresults can then be identified subset of osteoblasts (N-Cadherin + CD 45-) that physically attaches to theHSCs in the BM . ( Tong Yin , 2006)Bone marrow consist of hematopoietic cells arewrapped by the bone structure. Hematopoietic cellsdevelop in the bone cavity and retained in the bonemarrow until they have matured, then released intothe vascular system ( Yin and Li , 2006). Most cells ofhaemopoietic can be found next to the endostealsurface of the bone, which layer is primarilyosteoblasts. Osteoblasts is one type of bone cell thatserves to reform or bone formation. HSCs are stemcells that are known to differentiate into osteoclasts.Osteoclasts are the cells of bone that serves to boneresorption. Their physical proximity betweenosteoblasts and which HSCs are parent cellsosteoclasts, as well as the identification of N -Cadherin / β - Catenin adherent complex betweenthe two prove their relationship or communicationbetween these cells. Osteoblast cells not only play arole in bone formation, but as osteoblast niche inthe bone marrow also, contribute to themaintenance of HSCs that are stem cells osteoclasts(Yin and Li , 2006 ; Tong Yin , 2006 ).There are two main types of stem cells areembryonic and adult stem cells . Pluripotentembryonic stem cells derived from the inner cellmass of blastocysts and has the ability to be a threeembryonic germ layers , namely ectoderm ,endoderm , and mesoderm (Li and Xie , 2005). Atbirth, adult stem cells including GSCs and SSCs willoccupy and live in a special microenvironment,called a niche (Li and Sie., 2005)Niche is different depending on the type of tissue ororgan. Structurally niche supported by the cells andtheir interactions molecular signals that preparedand provided to form a microenvironment for stemcells. Niche hypothesis has actually been describedby Scofield in 1978 ( Li and Sie , 2005; Yin and Li ,2006) . Stem cell niche is supported by manysignaling and adhesion molecules involved in theinteraction of the stem cell niche, accounted diversecharacteristics for each niche function ( figure 1 )that is; SDF -1/CXCR4 , SCF/c - Kit, Jagged/Notch,angiopoietin-1/ Tie2 ( Ang-1/Tie2 ), and Ca2 + -sensing receptor ( Yin and Li, 2006). Most studiesconducted to know and understand the molecularmechanisms of interaction and behavior of stemcells. Understanding the interaction and behavior ofstem cells in the bone marrow niche is veryimportant to understand the eventsosteoclastogenesis, especially how osteoclastprecursor cells can be recruited from niche thenmobile until homing (Kollet et al , 2007). Research isusually conducted in diseases associated with theaccumulation of osteoclasts or osteoclast progenitorcells that causes pathological osteolysis , such as ;benign bone tumors and bone metastases cancer (Kollet et al , 2007; Jennifer , 2009).
Saliva as a future potential predictor for various periodontal diseases Hamzah, Zahreni
Dental Journal (Majalah Kedokteran Gigi) Vol 44, No 2 (2011): (June 2011)
Publisher : Faculty of Dental Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v44.i2.p77-81

Abstract

Background: There are many diagnostic biomarkers have been found in saliva. Saliva contains a wide variety of proteins, including bacteria and products, enzymes, inflammatory mediators and host response modifiers, products of tissue breakdown. Purpose: The purpose of the study was studied current development of diagnostic biomarkers in saliva that will lead to the development of simple and accurate diagnostic tools for periodental disease. Reviews: Specifically, the salivary biomarkers divided for three aspects of periodontitis i.e. inflammation, collagen degradation and bone turnover, correlated with clinical features of periodontal disease. The diagnostic biomarkers is in saliva, such as enzyme, immunoglobulin, cytokines, bacteria and bacterial products, hormones. For the past two decades, oral health researchers have been developing salivary diagnostic tools to monitor oral diseases. Conclusion: The indicators of acute periodontitis can detect with ß-glucuronidase and AST, IL-1β, and MMP-8, whereas indicators for chronic periodontitis can detect with ALP. The indicators for collagen degradation and bone turnover suggest ICTP, fibronectin fragments, and osteonectin. The indicators of severity of periodontitis especially can be predict by B. forsythus.Latar belakang: Banyak biomarker telah ditemukan dalam saliva. Saliva terdiri dari berbagai protein unik meliputi bakteri dan produk bakteri, enzim, mediator inflamasi dan modifikasi respon host (immunoglobulin, sitokin), produk kerusakan jaringan (telopeptida kolagen, osteokalsin, proteoglikan, fragmen fibronectin). Tujuan: Mengkaji biomarker dalam saliva untuk pengembangan metode diagnostik sederhana dan akurat untuk penyakit periodontal. Tinjauan Pustaka: Secara khusus, biomarker saliva pada periodontitis dibagi dalam tiga aspek yaitu inflamasi, dan degradasi kolagen serta pergantian tulang. Biomarker diagnostik dalam saliva, meliputi enzim, imunoglobulin, sitokin, bakteri dan produk-produk bakteri, hormon. Selama dua dekade terakhir, para peneliti kesehatan mulut telah mengembangkan alat diagnostik melalui saliva yang tepat untuk memonitor beberapa penyakit periodontal. Kesimpulan: Indikator periodontitis akut dapat dideteksi dengan β-glucuronidase dan AST, IL-1β,dan MMP-8, whereas indikator untuk periodontitis kronis dapat dideteksi dengan ALP. Indikator untuk degradasi kolagen dan penggantian tulang dideteksi melalui ICTP, fibronectin fragments, dan osteonectin. Sedang indikator untuk keparahan periodontitis terutama dapat diprediksi melalui B. forsythus.
The benefits of information system of water pollution at Bedadung river towards oral and dental health of the community Ernanda, Heru; Hamzah, Zahreni; Setyowati, Dyah I.; Handayani, Ary TW.; Indriana, Tecky
Journal of Dentomaxillofacial Science Vol 3, No 2 (2018)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v3i2.738

Abstract

Objective: The purpose of creating the river water pollution information systems related to oral and dental health community is to facilitate the analysis of diseases caused by water pollution.Material and Methods: The Environment-based Health Management Information System based on GIS is based on real data of Bedadung River-Jember Regency, East Java, Indonesia includes the location of the dumping points, photo dumping points, the area of garbage accumulation, and tooth and mouth disorders that arise due to contamination of river water, which is associated with community dental and oral health data that taken by survey.Results: Through the Environmental Health Information System information can be displayed about the environment and the dental and oral status of the population around the Bedadung river.Conclusion: The use of the Environment-Based Health Management Information System is very important to help support the governments decision to prevent the spread and severity of community diseases caused by river water pollution, reduce morbidity and mortality, and reduce the burden of government financing to treat diseases and disability integrated in an integrated manner.
[RETRACTED] IMPACT PSYCHOLOGICAL AND PSYCHO-PHYSICAL WORK DISTRESS ON TOOTH MOBILITY IN RAT MODEL (ARTICLE RETRACTED FROM IBSC PROCEEDING) Hamzah, Zahreni; Putra, Suhartono Taat; STP, Elyana Asnar
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Retracted under author request.