Soeharyo Hadisaputro
Bagian Ilmu Penyakit Dalam, Department Epidemiology, Universitas Diponegoro

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Beberapa Faktor yang Berperan Terhadap Keaktifan Kunjungan Lansia ke Posyandu Studi Kasus di Desa Tamantirto Kecamatan Kasihan Kabupaten Bantul Propinsi DIY Lestari, Puji; Hadisaputro, Soeharyo; Pranarka, Kris
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 2 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTFactors influencing elderly visit to elderly community health care (posyandu lansia): Case study in Tamantirto Village, Kasihan, Bantul, DIYBackground: Elderly community health care (ECHC) is the base of holistic-continuous care for the elderly. The number of elderly at Tamantirto Village is 11.3% of the total residents, which has not been accompanied by a high scope of ECHC visit, where 6 of 9 the ECHCs still have the coverage lower than 50%. Purpose of this study is to prove that age, education, occupation, socio economic status, knowledge, attitude, facilities, access, cadre and health workers services, social role and family role can affect elderly people’s visitations to the ECHC.Methods: Study design: observational analytic, case-control approach. The case: elderly as the ECHC members who actively visited, the control: elderly as ECHC members were who did not actively visit ECHC. The sample’s are 52 cases and 52 controls. The quantitative data were gathered by interviews, while the qualitative data by using focus group disscussion.Results: The factors influencing elderly people’s visitations to the ECHC are age of  71 years old (OR:4.6), not working (OR:8.1), good attitude (OR:3), good facilities (OR:5.4), good service of cadres and health workers (OR:6.5) and a good family role (OR:3.2). The factors that do not affect elderly people’s visitations are educational level, socio economic, knowledge, access, and social role ofthe elderly.Conclusion: Characteristics of elderly activity visit ECHC are age of 71 years old, not working, good attitude, good facilities, good service of cadres and health workers and a good family role.Keywords: Elderly community health care, actively visit, influencing factorsABSTRAKLatar belakang: Posyandu lansia merupakan dasar pelayanan yang holistik dan berkesinambungan pada lansia. Jumlah lansia yang cukup banyak di Desa Tamantirto yaitu sebanyak 11,3% dari jumlah penduduk, belum diiringi dengan cakupan kunjungan yang tinggi, dimana 6 dari 9 posyandu masih mempunyai cakupan di bawah 50%. Tujuan penelitian adalah membuktikan bahwa umur, pendidikan, pekerjaan, kondisi sosial ekonomi, pengetahuan, sikap, fasilitas posyandu, akses terhadap posyandu, pelayanan kader dan petugas kesehatan, peran sosial lansia, serta peran keluarga berpengaruh terhadap kunjungan lansia ke posyandu.Metode: Desain penelitian: analitik observasional, pendekatan kasus kontrol. Kasus adalah lansia anggota posyandu (umur 60 tahun) yang aktif melakukan kunjungan ke posyandu. Kontrol adalah lansia anggota posyandu (umur 60 tahun) yang tidak aktifmelakukan kunjungan ke posyandu. Sampel penelitian 52 kasus dan 52 kontrol. Data kuantitatif diperoleh dengan wawancara, data kualitatif dengan diskusi kelompok terarah.Hasil: Faktor yang berpengaruh terhadap keaktifan kunjungan lansia ke posyandu yaitu umur 71 tahun (OR:4,6), tidak bekerja (OR:8,1), sikap yang baik (OR:3), fasilitas yang baik (OR:5,4), pelayanan kader dan petugas kesehatan yang baik (OR:6,5), peran
Sumbangan All-Trans Asam Retinoat (ATRA) Bagi Penyembuhan Periodontitis Praptiwi, Praptiwi; Muis, Siti Fatimah; Hadisaputro, Soeharyo; Suryono, Suryono
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 3 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTAll-trans retinoic acid (ATRA) contribution to periodontitis healingBackground: In inflammation and infection of periodontal ligament i.e periodontitis, collagen fiber is damaged. All-trans retinoic acid (ATRA), metabolite of vitamin A, has potency to depress damage in inflammation. Indonesia with high vitamin A deficiency, facing to delayed recovery of periodontitis. The disease is vastly suffered by common people in this country. The study aimed to know the collagen status of periodontal ligament suffering periodontitis treated with tetracycline and ATRA supplementation.Method: The experimental study using post test only design in 12 adult male Wistar rat was done in 7 days. The animal study were induced periodontitis through Porphyromonas gingivalis inoculation. Tetracycline 90 mg/kg was given, beside ATRA supplementation of 10 mg/kg and 5 mg/kg. Four experimental groups were chosen randomly. Group of periodontitis + tetracycline was the control of the study. The independent variables were ATRA supplementation of those high and low dose. The dependent variable was collagen status. Collagen status consist of degradation and synthesis of collagen, indicated by mRNA MMP-2 and mRNA P1CP respectively. They were measured by reversed transcriptase polymerizing chain reaction and thin layer chromatography. All-trans retinoic acid concentration was measured using high performance liquid chromatography. The dataanalyzed using t-test, Oneway ANOVA, post hoc duncan and least significant differences.Result: In group receiving 10 mg ATRA/kgBB, the ATRA level was highest but the collagen degradation was lower although not significant compared to the low dose ATRA group. In both groups the degradation was significantly lower than the control group (p=0.007). The synthesis of collagen in the low dose ATRA group was higher than the high dose ATRA group and the control group.Conclusion: High dose of ATRA supplementation contribution to less degradation of collagen, but in term of collagen synthesis, low dose ATRA supplementation gives better result.Keywords: ATRA supplementation, collagen degradation, periodontitis ABSTRAKLatar belakang: Pada peradangan dan infeksi kronik ligamentum periodontal yaitu periodontitis, terjadi kerusakan serat kolagen. All-trans asam retinoat (ATRA), metabolit vitamin A, berpotensi menekan kerusakan pada peradangan. Tingginya defisiensi vitamin A di Indonesia, menghambat proses penyembuhan periodontitis yang banyak diderita masyarakat luas. Penelitian bertujuan mengetahui status kolagen ligamentum periodontal periodontitis yang mendapat pengobatan tetrasiklin dan suplementasi ATRA.Metode: Studi eksperimental dengan rancangan post test only pada 12 tikus Wistar jantan dewasa telah dilakukan selama 7 hari. Hewan coba diinduksi periodontitis melalui inokulasi bakteri Porphyromonas gingivalis. Diberikan tetrasiklin 90 mg/kg, juga suplementasi ATRA 10 mg/kg dan 5 mg/kg. Empat kelompok studi dipilih secara acak. Kontrol adalah kelompok sakit + tetrasiklin. Variabel bebas adalah suplementasi ATRA dosis tinggi dan dosis rendah, variabel tergantung adalah status kolagen. Status kolagenmencakup degradasi dan sintesis, berturut-turut dengan petanda mRNA MMP-2 dan mRNA P1CP, diukur menggunakan reverse transcriptase polymerizing chain reaction dan thin layer chromatography. Kadar ATRA diukur dengan high performance liquid chromatography. Data dianalisis dengan uji t, Oneway ANOVA, post hoc Duncan dan least significant differences.Hasil: Pada kelompok yang menerima suplementasi ATRA 10 mg/kgBB kadar ATRA tertinggi, tetapi degradasi kolagennya lebih rendah walau tidak bermakna. Kedua kelompok sumplementasi degradasi kolagennya lebih rendah secara bermakna dibanding kelompok kontrol (p=0,007), dalam sintesis kolagen,kelompok yang mendapat suplementasi ATRA 50 mg/kgBB sintesisnya lebih baik dibanding kelompok yang mendapat ATRA 10 mg/kgBB maupun kelompok kontrol.
Berbagai Faktor Yang Berhubungan Dengan Kejadian Gangguan Fungsi Paru Dalam Ruang Kerja (Studi Kasus Pekerja Industri Rumahan Electroplating di Kecamatan Talang Kabupaten Tegal) Wulandari, Diah Rahayu; Hadisaputro, Soeharyo; Suhartono, Suhartono
JURNAL KESEHATAN LINGKUNGAN INDONESIA Vol 12, No 1 (2013)
Publisher : JURNAL KESEHATAN LINGKUNGAN INDONESIA

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Background: electroplating home industry  use chromium as the base material. Chromium is used in the form of hexavalent chromium, which has toxic effects on health.  Electroplating workers exposed chromium through the air into the lungs through inhalation. Objective: Describe the various factors assosiated  to the pulmonary dysfunction  in a workplace at  workers of electroplating home industry . Methods: This study was an observational study with cross sectional approach  on 31 electroplating workers with total sampling of each industry. Vital Lung Capacity Measurements with a spirometer with SpyroAnalyzer type ST-75. Dust levels of Chromium with High Volume Sampler. Results: Results minimal amount of dust in the air of 0.0731 μg/m3, the maximum value of dust concentration in the air is 1.8433 μg/m3 μg/m3 with a mean of 0.774357. Multivariate analysis showed a variable duration of exposure to chromium is the most influential variable on the incidence of pulmonary dysfunction, (p = 0.010) with 95% CI (2.11 to 228.56), odds ratio (Exp B) = 21.97. Conclusion: The factor shown to be associated with pulmonary dysfunction in workers chromium electroplating is a duration of exposure to chromium more than 4 hours a day. Keywords: Electroplating, pulmonary dysfunction, chromium.
The Role of Bamboo Shoot Gigantochloa apus Extract in Decreasing MDA and Increasing IL-10 at The Atherosclerosis Soesanto, Edy; Dharmana, Edi; Hadisaputro, Soeharyo; Muis, Siti Fatimah
Health Notions Vol 3, No 1 (2019): January
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.616 KB) | DOI: 10.33846/hn.v3i1.272

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Introduction: Bamboo shoot Gigantochloa apus extract has antioxidant compounds that act as lipid peroxidation inhibitors and reduce free radical formation so that it can be used as an anti-inflammatory and anti-oxidative stress in the atherosclerosis. Aim: Knowing the effect of bamboo shoot Gigantochloa apus extract in reducing MDA levels and IL-10 increasing levels in rabbits given atherogenic diet. Methods: This experiment used randomized pre-test and post-test with control group design, in 24 New Zealand White rabbits divided into 4 groups randomly. MDA and IL-10 levels were examined by the ELISA method. Results and conclusion: Bamboo shoot Gigantochloa apus extract can reduce MDA levels and increase IL-10 levels significantly in accordance with increasing doses. The increase of MDA levels in the control group with all treatment groups was different (p = 0.0001), and between the treatment groups and other treatment groups there were also differences (p
RISK FACTORS OF CATARACT IN TYPE 2 DIABETES MELITUS Fauzi, Ahmad; Hadisaputro, Soeharyo
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

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Background: One of Diabetes Melitus (DM) complication to the eye that may result as visual disturbances and blindness is cataract. According to The Framingham Eye Study and the Health and Nutrition Examination Survey shows that patient with DM before age of 65 years is easier 3-4x to get cataract and 2x easier than the age after 65 years compared to non DM. The research about risks factors for diabetic cataract in type 2 DM in Indonesia is rare, so that it is necessary to do the research about these risk factors. Method: This study involves observational analytic study with case control study design. Subject of the case is type 2 DM with cataract (73 people) and type 2 DM without cataract as control (73 people) at Dr. Kariadi Hospital Semarang. Then data followed retrospectively about risk factors that influence incidence of cataract in type 2 DM. The stages of analysis used in this study is univariate analysis, bivariate analysis and multivariate analysis. The statistics test used in multivariate analysis is Multiple Logistic Regression. Result: The multivariate analysis shows that 5 years Duration of DM or longer (P=0,002) and Trigliserida value ≥150 mg/dl (P=0,015) are the risks factors for cataract in type 2 DM. Conclusion: 5 years duration of DM or longer and trigliserida value ≥150 mg/dl are factors that proven as risk factors for cataract in type 2 DM. [Juke Unila 2014; 4(8):173-179]
Kadar Oksidan yang Tinggi Sebagai Faktor Risiko Terjadinya Hemolisis pada Neonatus Sepsis R, Kamilah Budhi; Aminullah, Asril; Hadisaputro, Soeharyo; Soemantri, Ag; Suhartono, Suhartono
Sari Pediatri Vol 14, No 3 (2012)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp14.3.2012.198-204

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Latar belakang. Sepsis merupakan penyebab utama morbiditas dan mortalitas neonatus. Penyebab hemolisis pada neonatos meliputi: fisiologis, proses imun, stres oksidatif, aktivasi komplemen, kelainan eritrosit, enzim hemolisin. Penyebab hemolisis pada neonatus sepsis belum banyak diteliti. Tujuan. Membuktikan bahwa kadar oksidan (MDA) yang tinggi sebagai faktor risiko terjadinya hemolisis pada neonatus sepsis.Metode. Penelitian di RS Dr. Kariadi, Semarang tahun 2009, desain observasional prospektif dengannested case – controlpada 94 neonatus sepsis terdiri 47 kelompok kasus (hemolisis positif ) dan 47 kontrol (hemolisis negatif ). Diagnosis sepsis ditegakkan dengan kriteria SIRS (systemic inflammatory response syndrome)1 atau lebih, gejala klinik, pemeriksaan laboratorium atau penunjang lain. Hemolisis ditegakkan dengan metode indeks retikulosit >3, hari ke-1 dan ke-3. Pemeriksaan faktor risiko kadar MDA, GPx dengan metode spektrofotometri, vitamin C dengan metode colorimetric assay, vitamin E dengan metode ELISA, hemolisin dengan kultur darah media agar darah. Uji hipótesis menggunakan Chi-square, OR (95% Cl), Mantel-Haenszeldan regresi logistik.Hasil. Kejadian hemolisis pada neonatus sepsis 49%. Kadar MDA kelompok kasus (5,3±2,06) lebih tinggi bermakna dibanding kelompok kontrol (3,3±1,27) p=0,0001. Analisis bivariat, kadar MDA tinggi (>2,90 ng/dL) merupakan faktor risiko hemolisis pada neonatus sepsis (OR 11,6; 95% CI 2,5-54,1) Analisis multivariat, kadar MDA tinggi (> 2,90 ng/dL) dengan memperhitungkan interaksi GPx (OR 5,16; 95%CI 1,22-21,86), vitamin E (OR 5,77; 95%CI 1,49-22,26) dan vitamin C (OR 11,26:2,38-53:30) merupakan faktor risiko kejadian hemolisis pada neonatus sepsis. Hemolisin belum dapat dibuktikan Kesimpulan. Kadar oksidan (MDA) yang tinggi (>2,90 ng/dL), merupakan faktor risiko terjadinya hemolisis pada neonatus sepsis.
STUDI EFFEKTIVITAS KEFIR BENING DAN MENIRAN (Philanthus niruri) TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA HEWAN TIKUS WISTAR HIPERGLIKEMIA DIINDUKSI STREPTOZOTOCIN ., Judiono; Hadisaputro, Soeharyo; Djokomoeljanto, RRJ; Laksono, Budi; W, Theophilus
GIZI INDONESIA Vol 33, No 2 (2010): September 2010
Publisher : PERSATUAN AHLI GIZI INDONESIA

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EFFECTIVITY STUDY OF PLAIN KEFIR AND MENIRAN (PHILANTUS NIRURI) ON BLOOD GLUCOSE LEVELS ON HYPERGLYCEMIA WISTAR RATS INDUCED STREPTOZOTOCINTraditional medicines and functional foods used for diabetes therapy increased in Indonesia. Bioactive components play an important role in decreasing blood glucose. The study aims to prove the effectiveness of plain kefir and Meniran (Philanthus niruri) to decrease blood glucose levels in wistar rats with streptozotocin-induced hyperglycemia. The study design was randomized pre – post test control group. A number of 60 male rats aged 2.5-3 months, 150-250 g were made hyperglycemia by induced streptozotocin (STZ) 40 mg / kg berat badan. The hyperglycemic rats were grouped into: (1) treated with 0.76 UI insulin /day, (2) treated with 3.6 mL plain kefir /day, (3) treated 2.7 mL meniran / day, (4) positive control group of hyperglycemic rats, and (5) negative control group (standard diet ad libitum). The ratswere given feed refers to the AIN 93. Fasting glucose levels before and after treatment were measured by Super (Glucocard II) enzimatic method. The results showed that body weight increased in all treatments, except meniran, however the increaments were not differ significantly. Changes in body weight of insulin group were 13.800 + 16.104 g, kefir treatment amounted to 13.812 + 21.294, and meniran increased about 18.394 + 16.225. Changes in blood glucose in the insulin group about -118.571+55.815 mg/dL, kefir treatment at -102.875+60.454, while meniran group -66,625+37,784. In contrast, the positive control group tended to increase glucose levels. Conclusion In vitro, plain kefir and meniran potentially lowered blood glucose levels. However, kefir showed lowered glucose level better than meniran. Futher research needs to study bio- molecular mechanisms of the decline in the future.Key words: diabetes mellitus, meniran, plain kefir, streptozotocin (STZ), hyperglycemic rat
EFFECT OF CONSUMING RED SPINACH (AMARANTHUS TRICOLOR L) EXTRACT ON HEMOGLOBIN LEVEL IN POSTPARTUM MOTHERS Muliani, Resty Himma; Soejoenoes, Ariawan; Suherni, Titi; Hadisaputro, Soeharyo; Mashoedi, Imam Djamaluddin
Belitung Nursing Journal Vol 3, No 4 (2017): July-August 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.931 KB) | DOI: 10.33546/bnj.156

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Background: Postpartum mothers are susceptible to anemia, due to loss of blood count during labor. Postpartum anemia causes uterine subinvolution which causes postpartum hemorrhage, facilitates puerperium infection, decreases breastfeeding and easy mamae infection. One alternative to prevent anemia in postpartum is to consume vegetables with high iron one red spinach. Red spinach is one of the non-heme iron sources needed to synthesize hemoglobin.Objective: To determine the effect of red spinach in increasing the levels of hemoglobin in postpastum mothers.Methods: This was a quasy experiment with pretest posttest with control group design in October-December 2017 at the Community Health Center of PONED Tarub, Tegal regency. Thirty postpartum mothers were included using purposive sampling, which 15 assigned in each group. Blood sampling and examination were performed in each respondent. Paired and Independent t-test were done for data analysis.Results: The results of the 14-day intervention of given red spinach extract showed that there was a significant increase of hemoglobin level (1.25 g / dL) with p-value 0.047.Conclusion: There is a significant effect of consuming red spinach extract (amaranthus tricolor L.) on the increase of  hemoglobin level in postpartum mother. It is recommended that midwives could apply this intervention and cooperate with agriculture and food processing in order to produce red spinach extract that increases hemoglobin, hematocrit and erythrocytes levels.
EFFECT OF PSYCHOEDUCATION ON ANXIETY IN PATIENTS WITH CORONARY HEART DISEASE Sulistiyo, Yuli; Santoso, Bedjo; Shobirun, Shobirun; Hadisaputro, Soeharyo; Latifah, Leni; Endang Pujiastuti, Rr Sri
Belitung Nursing Journal Vol 3, No 6 (2017): November-December 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (249.405 KB) | DOI: 10.33546/bnj.303

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Background: Cardiovascular heart disease still remains high in Indonesia. Various interventions have been implemented as an effort to deal with cardiovascular disease. However, little is known about intervention to reduce anxiety in patients with cardiovascular disease although anxiety is related to angina attack in this patient. Psychoeducation is considered effective in decreasing anxiety.Objective: To examine the effect of psychoeducation in decreasing anxiety in patients with coronary heart disease (CHD) at the General Hospital of Semarang.Methods: This was a quasy experimental design with pretest posttest control group design. The study was conducted in the inpatient wards of the General Hospital of Semarang on January 17 until March 8, 2017. Fifty-six respondents were recruited using consecutive sampling, with 28 assigned in the experiment and control group. Hamilton Anxiety Rating Scale (HARS) was used to measure anxiety levels. Paired t-test and Independent t-test were used for data analysis.Results: Paired test showed that there was a statistically significant effect of psychoeducation on anxiety level in the experiment group with p-value 0.001 (<0.05), and significant effect of given a brochure of CHD on the anxiety level in the control group with p-value 0.001 (<0.05). Independent t-test showed a statistically significant difference of anxiety level after intervention in the experiment and control group with p-value 0.001 (<0.05). The mean anxiety level in the experiment group (22.46) was lower than the mean anxiety level in the control group (41.54).Conclusion: Psychoeducation is effective in reducing anxiety levels in patients with CHD. It is suggested that psychoeducation can be used as one of nursing intervention in an effort to reduce anxiety in patients with CHD. 
THE IMPACT OF HONEY ON CHANGE IN NUTRITIONAL STATUS IN CHILDREN WITH POOR NUTRITION Harmiyati, Harmiyati; Soejoenoes, Ariawan; Wahyuni M, Sri; Aristiati, Kun; Hadisaputro, Soeharyo
Belitung Nursing Journal Vol 3, No 2 (2017): March-April 2017
Publisher : Belitung Nursing Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.728 KB) | DOI: 10.33546/bnj.71

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Background: Toddlers are vulnerable groups to malnutrition. Thus, to maintain their nutritional status is needed. Honey is considered having health benefits that might increase the nutritional status in children. However, little is known about the impact of honey on nutritional change in Sumbawa. Objectives: The aim of this study is to analyze the effect of honey on changes in nutritional status in children with poor nutrition in the area of the Health Center of Lopok, Sumbawa IndonesiaMethods: This study employed a quasi experiment design with pretest-posttest with control group. The total sample in this study were 60 children recruited by simple random sampling, divided into 2 groups, namely 30 children in intervention group and 30 children in control group. The sampling technique used simple random sampling. Data were analyzed using Mann Whitney and linear regression test. Results: Findings showed that there were significant mean differences between the intervention and control group in term of weight (intervention 1.316; control 0.903), height (intervention 1.586; control 1.030), weight-for-height (W/H) z-score (intervention 0.713; control 0.595), weight-for-age (W/A) z-score (intervention 0.717; control 0.531), and height-for-age (H/A) z-score (intervention 0.847; control 0.423) with p-value < 0.05.Conclusion: There was a significant effect of honey on changes in nutritional status in children with poor nutrition. It is suggested that health providers may use honey to deal with children under nutrition to increase their appetite and change their nutritional status.