Articles

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KLT DENSITOMETRI Sugihartini, Nining; Fudholi, Achmad; Pramono, Suwidjiyo; Sismindari, .
PHARMACIANA Vol 2, No 1: Mei 2012
Publisher : PHARMACIANA

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Abstract

KLT Densitometri adalah salah satu metode yang banyak digunakan untuk penetapan kadar bahan aktif. Salah satu bahan aktif tersebut adalah epigalokatekin galat dalam ekstrak teh hijau yang banyak digunakan dalam produk krim. Metode tersebut perlu divalidasi untuk membuktikan hasil pengukuran mendekati kadar yang sesungguhnya. Tujuan penelitian ini ingin membuktikan bahwa metode KLT Densitometri yang digunakan akan memberikan linieritas, ketelitian, ketepatan yang memenuhi persyaratan serta mengetahui nilai LOD(Limit if Detection) dan LOQ (Limit of Quantitation). Penelitian menggunakan kadar 600, 1800 dan 3000 ?g dengan replikasi 3 kali untuk mengetahui ketelitian (berdasarkan nilai CV) dan ketepatan (berdasarkan nilai perolehan kembali). Linieritas diketahui dengan menghitung nilai r pada kurva hubungan antara kadar dan luas area kromatogram yang selanjutnya persamaan kurva baku digunakan untuk menghitung LOD dan LOQ. Hasil penelitian menunjukkan bahwa metode yang digunakan memenuhi persyaratan liniearitas dengan nilai r=0,98. Nilai CV untuk kadar 600, 1800 dan 3000 ug masing-masing 8,18%; 3,19% dan 1,53% dan perolehan kembali masing-masing 88,10%; 99,65% dan 111,33%. Nilai LOD adalah 827,01 ?g/ml dan LOQ adalah 2756,69 ?g/ml.
EVALUASI TINGKAT KESESUAIAN STANDAR AKREDITASI TERHADAP PELAYANAN FARMASI DAN STRATEGI PERBAIKAN DENGAN METODE HANLON DI RSUD KABUPATEN BIMA Bimmaharyanto.s, Dedent Eka; Fudholi, Achmad; Widodo, Gunawan Pamudji
Jurnal Ilmiah Mandala Education (JIME) Vol 3, No 2 (2017): Jurnal Ilmiah Mandala Education (JIME)
Publisher : Lembaga Penelitian dan Pendidikan Mandala

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Abstract

Getting maximal service represent dream all society especially receiver of service of  the hospital  including in pharmacy installation. Patient got many problems because service not yet fulfilled standard. To fulfill requirement of patient, pharmacy installation have to this research accredit  to know storey level according to seven accreditation standard to service of pharmacy in RSUD Sub Province Bima and repair strategy with Hanlon method.  This Research use instrument of quizioner  Depkes and special informan interview counted 15 informan and people lock counted 3 people. Subject at this research is all officer in concerned and have important role in pharmacy Installation RSUD Sub Province Bima. Conducted by assessment seven standard  later then compared to between informan with result of observation,  afterwards analyzed by strategy development by using Hanlon method. Result of Research of show there are difference of result assessment of standard accredit between officer of pharmacy Installation that is ( 58,75%) with research that is  ( 55%). From seventh of accreditation standard, nothing that fulfill accreditation standard (< 60%), result  strategy development with Hanlon method is Facility and equipments, repair of facilities and basic facilities of Pharmacy administration  management and, immediately do function KFT . Evaluation and quality control, require to make pharmacy program written  and also SK about meeting schedule .Philosophy   and  target, SK about policy of pharmacy service  from  Hospital head. Policy and procedure, making SOP and policy written  about management of provisions of pharmacy . Development of education program and staff,  done by education program and periodical training in IFRS. STAF and head, existence of staff pharmacy performance evaluation and orientation to officer of Installation Pharmacy
Evaluasi Kualitas Hidup dengan Kuesioner EQ-5D pada Pasien Kanker Serviks Rawat Inap Sebelum dan Setelah Kemoterapi Suwendar, Suwendar; Fudholi, Achmad; Andayani, Tri Murti; Sastramihardja, Herri S
Indonesian Journal of Clinical Pharmacy Vol 6, No 1 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.998 KB) | DOI: 10.15416/ijcp.2017.6.1.1

Abstract

Kualitas hidup merupakan salah satu acuan keberhasilan dari upaya pengobatan termasuk kemoterapi pada pasien kanker. Pasien kanker yang menjalani kemoterapi dapat mengalami perubahan pada kualitas hidupnya. Tujuan penelitian ini adalah untuk menilai kualitas hidup pasien kanker serviks dengan menggunakan kuesioner EQ-5D sebelum dan setelah mendapatkan kemoterapi. Penelitian ini merupakan penelitian non-eksperimental bersifat analitik menurut perspektif pasien dengan teknik pengumpulan data secara prospektif. Subjek penelitian adalah pasien kanker serviks rawat inap kelas 3 yang memenuhi kriteria inklusi. Penelitian dilakukan di RSUP Dr. Hasan Sadikin Bandung. Data yang digunakan adalah data pasien dari bulan Juni sampai Desember 2015. Penelitian dilakukan dengan menggunakan kuesioner EQ-5D. Selanjutnya dilakukan perhitungan persentase permasalahan pasien, nilai indeks EQ-5D (utility) dan nilai EQ-5D VAS. Nilai utility dan EQ-5D VAS dianalisis secara statistik dengan uji Wilcoxon (α=5%) untuk melihat terjadinya perubahan kondisi yang bermakna sebelum dan setelah kemoterapi. Hasil menunjukkan bahwa setelah kemoterapi siklus pertama, persentase masalah kemampuan berjalan/bergerak dan kegiatan yang biasa dilakukan mengalami peningkatan, rasa sakit/ tidak nyaman dan rasa cemas/depresi mengalami penurunan, sedangkan perawatan diri tidak mengalami perubahan. Berdasarkan hasil uji statistik, setelah kemoterapi siklus pertama, nilai utility dan EQ-5D VAS mengalami peningkatan dan menunjukkan peningkatan bermakna (nilai T hitung masing-masing 2,0 dan 4,5) pada pasien stadium I.  
The effect of Curing Process in Acetic Acid on the Gelatin Properties of Blingon Goat Skin Said, Muhammad Irfan; Triatmojo, Suharjono; Erwanto, Yuny; Fudholi, Achmad
JURNAL ILMU DAN TEKNOLOGI PETERNAKAN Vol 3, No 2 (2014)
Publisher : Fakultas Peternakan Universitas Hasanuddin

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Abstract

Bligon goat is a cross between Kacang with Ettawah goat.  The skin of Bligon goat contains collagen protein compounds that have the potential to be processed into gelatin. Curing process is necessary to improve the properties of gelatin both quantitative and qualitative.  The purpose of this study was to identification of the best process time and level of acetat acid as curing materials of Blingon goat skin.  The skin of male Bligon goat age  ±1.5-2.5 years of old and acetic acid (CH3COOH 0.5 M) were used as material.  The experiment was run according to completely randomized design (CRD) with factorial pattern of 2x3 and three replications for each treatment.  Two processing time (48 and 96 hours) as first factor and three concentrations levels of acetic acid (3, 6 and 9%, v/v) as the second factor.   The data were analyzed by analysis of variance.  Yields, gel strength and viscosity were used as parameters. The results of this study showed that the processing time up to 96 hours and level of concentration up to 9% significantly affected (P&lt;0.01 ) gel strength, but no significantly on the yields and viscosity. The combination of processing time of 96 hours with concentration level of 3% gave the best results compared to others.
ANALISIS KINERJA INSTALASI FARMASIRUMAH SAKIT X PURWOKERTODITINJAU DARI PERSPEKTIF CUSTOMER BALANCED SCORECARD “KETERJARINGAN PASIEN” Suryanegara, Fithria Dyah Ayu; Satibi, Satibi; Fudholi, Achmad
Jurnal Ilmiah Farmasi Vol 10, No 1 (2013): Jurnal Ilmiah Farmasi
Publisher : Jurnal Ilmiah Farmasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol10.iss1.art4

Abstract

IFRS X Purwokerto merupakan salah satu rumah sakit pemerintah sebagai pelayanan publik. Pengelolaan keuangan IFRS X Purwokerto dikelola dengan sistem Badan Layanan Umum. Persentase pasien memiliki dampak terhadap pendapatan rumah sakit. Persentase pasien adalah salah satu pengukuran perspektif pelanggan pada metode balanced scorecard. Desain penelitian yang digunakan adalah studi kasus deskriptif. Data kuantitatif diperoleh dari dokumen penerimaan rawat jalan pada Desember 2008, dan dari data administrasi rumah sakit. Data kualitatif diperoleh dari wawancara dengan Kepala Departemen Farmasi Rumah Sakit X Purwokerto. Data kuantitatif dianalisis sebagai rata-rata persentase pasien yang dihadapi, dan data kualitatif adalah deskriptif analisis. Hasil menunjukkan rata-rata persentase pasien yang ditemui pada pasien rawat jalan IFRS X Purwokerto adalah 71,84%. Kepala Departemen Farmasi Rumah Sakit X Purwokerto mengatakan untuk mengoptimalkan persentase pasien perlu kerjasama semua segmen, dari stakehoulders (direktur dewan rumah sakit X Purwokerto dan pemerintah), dan perbaikan terus-menerus dari proses internal IFRS X Purwokerto.
PENGARUH ENKAPSULASI EKSTRAK DAUN MURBEI (Morus alba L.) TERHADAP TEKANAN DARAH ARTERI PADA TIKUS Aminah, Siti; Suwaldi, Suwaldi; Fudholi, Achmad; Wahyono, Wahyono
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1042.062 KB) | DOI: 10.14499/mot-TradMedJ19iss3pp149-155

Abstract

Rutin dan kuersetin merupakan senyawa golongan flavonoid yang terkandung dalam ekstrak daun murbei (Morus alba L.) dan mempunyai pengaruh  dalam sistem kardiovaskuler. Pada penelitian ini diteliti pengaruh enkapsulasi ekstrak daun murbei terhadap tekanan darah arteri,. Ekstrak dibuat secara remaserasi dengan menggunakan penyari etanol 95%. Kandungan rutin dan kuersetin didalam ekstrak ditentukan dengan menggunakan Kromatografi Cair Kinerja Tinggi (KCKT). Enkapsulasi  dilakukan terhadap 0,25% ekstrak,  menggunakan kitosan  0,5mg/mL  dan TPP 1mg/mL. Karakterisasi dilakukan terhadap ukuran partikel, efisiensi enkapsulasi dan Spektroskopi Infra Merah-Fourier Transform. Ekstrak dengan dosis 1g/kg berat badan dan ekstrak terenkapsulasi dengan dosis 1,313g/kg berat badan kemudian diberikan   secara per oral pada tikus normotensif maupun tikus hipertensif, selanjutnya diukur tekanan darah arteri dan frekuensi denyut jantung dengan menggunakan Coda Non-Invasive Blood Pressure System. Hasil menunjukkan bahwa kadar rutin dan kuersetin dalam ekstrak adalah (0,87±0,138) mg/g  dan (4,427±0,065) mg/g.  Kitosan-TPP dengan perbandingan 0,5:1  membentuk partikel dengan ukuran antara  25,11–45,21nm  dan  efisiensi enkapsulasi  (76,14±2,29) % pada enkapsulasi ekstrak daun murbei. Ekstrak daun murbei dan ekstrak daun murbei terenkapsulasi dapat menurunkan tekanan darah  arteri.
Influence of learning and growth toward internal business processes: case studies on Departement of Hospital Pharmacy in DIY ., Satibi; Fudholi, Achmad; Kusnanto, Hari; ., Jogiyanto
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 3, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.147 KB) | DOI: 10.14499/indonesianjpharm0iss0pp238-250

Abstract

Hospital Pharmacy have revenue contribution to the Hospital reached 40-60%,  thus  becoming  one  of  the  hospital  revenue  center.  However  hospital pharmacy  services  in  Indonesia  are  still  many  shortcomings,  is  considering several  constraints  such  as  the  ability  of  pharmaceutical  workers,  the  limited ability  of  hospital  management,  hospital  management policies,  and  limited knowledge of the relevant parties of hospital pharmacy services. Such conditions must be efforts to change with the development of learning and growth factors, because  these  factors  (human  capital,  organizational  capital  and  information capital)  and  that  effective  management  is  a  source  of  sustainable  competitive advantage. The research objective is to determine the relationship and influence of learning and growth to the internal business processes in Hospital Pharmacy. Kind  of  research  is  non-experimental  research  is  associative.  Research  tool includes a questionnaire indicators of learning andgrowth, and internal business processes.  The  subjects  was  the  head  of  hospital  pharmacy  in  the  hospital region  of  Daerah  Istimewa  Yogyakarta  (DIY).  Sample  size  was  35  hospital.  In addition  to  sending  questionnaires,  random  interviews  will  be  conducted  on several  hospital  pharmacies  to  enrich  the  results  of  the  survey  questionnaire. The  data  was  analyzed  by  correlation  and  linear  regression  to  determine  the relationship  and  influence  the  learning  and  growth  factors  to  the  internal business  processes  in  hospital  pharmacy.  Results  obtained  from  statistical calculations  with  95%  confidence  show  that  there  is a  strong  relationship between  the  organizational  culture  against  internal business  processes  with  r value of 0.981 with a contribution of 96.20% of theorganizational capital of the sustainability  of  the  internal  business  processes  in  Hospital  pharmacy  in Yogyakarta  Special  Region.  There  is  not  significant relationship  between  the human  capital  against  internal  business  processes.   There  is  not  significant relationship between the information capital against internal business processesKey words:learning and growth, internal business processes, the hospital pharmacy 
Formula optimization of sustained-release ibuprofen tablet using simplex lattice design with mixture of caragenan, calsium sulphate, and PVP-K30 Hadinugroho, Wuryanto; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 22 No 4, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (332.915 KB) | DOI: 10.14499/indonesianjpharm0iss0pp300-305

Abstract

Ibuprofen is one of non steroid anti inflammatory drug (NSAID), derivated propionic  acid  often  use  rheumatoid  therapy.  Frequented  using  can  make unpleasant  of  patient,  solution  for  this  problem  by  sustained  release  ibuprofen tablet design. This experiment aim is find out the optimized formula of sustained release  ibuprofen  tablet  with  hardness  of  ≥  4  kgf,  brittleness  of  ≤  1  %,  and 0.7-0.9 mg/minutes ibuprofen rate out by using mixture of carrageenan, calcium sulphate  and  PVP-K30.  This  formula  use  ibuprofen  as  400  mg,  the  mixture  of carrageenan, calcium sulphate and  PVP-K30  as  12 mg,  so  tablet total  weight  is 600  mg,  the  mixture  total  weight  is.  The  proportion  was  optimized  by  using simplex  lattice  design  special  cubic  model.  There  are  seven  formula  in  this design  (each  three  formula  consist  of  100  %,  three  formula  consists  of  two  as 50 % : 50 % and last formula mixture three component as 33.33 % of each) to get  coefficient  of  equation  Y  =  a(A)+b(B)+c(C)+ab(A)(B)+ac(A)(C)+bc(B)(C)+ abc(A)(B)(C).  Based  of  each  optimized  parameter  equation  is  got  contour  plot and  combined  to  superimposed  contour  plot,  so  the  optimized  formula  can  be found.  Based  of  superimposed  contour  plot  is  mixture  carrageenan:calcium sulphate:PVP-K30 comperation of optimized formula sustained release ibuprofen tablet are  0.347  :  0.233  :  0.420  to  find out  the optimized  formula  of sustained release  ibuprofen  tablet  with  the  hardness  as  5.71;  brittleness  as  0.28;  and ibuprofen  rate  out  as  0.79.  The  most  dominant  increase  factor  on  hardness  is calcium sulphate, on brittleness is carrageenan and on ibuprofen rate out is PVPK30.  About  interaction,  the  most  hardness  is  calcium  sulphate-PVP-K30,  the most  brittleness  and  ibuprofen  rate  out  is  carrageenan-calcium  sulphate-PVPK30.Key words:carrageenan, calcium sulphate, PVP-K30, ibuprofen.
Ibuprofen salt production and its application in tablet dosage form Hadisoewignyo, Lannie; Fudholi, Achmad; Muchalal, M.
INDONESIAN JOURNAL OF PHARMACY Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.59 KB) | DOI: 10.14499/indonesianjpharm0iss0pp141-150

Abstract

Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the poor flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt form of ibuprofen which has better solubility in water.Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method.The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199.9 °C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the. Sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.Key words: sodium ibuprofen, ibuprofen, dissolution.
Studi on the in vitro release of ibuprofen from xanthan gum matrix combined with a crosslinking agent Hadisoewignyo, Lannie; Fudholi, Achmad
INDONESIAN JOURNAL OF PHARMACY Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.107 KB) | DOI: 10.14499/indonesianjpharm0iss0pp133-140

Abstract

Ibuprofen is non-steroidal anti-inflammatory drugs that is often used so frequently in a day that is can cause the patient to forget to take it. Besides it may cause gastro intestinal disturbances, which increase with the frequent of use. Many studies have been undertaken to obtain ibuprofen controlled release systems. Based on this, this study is done to find out the in vitro release kinetic of ibuprofen from xanthan gum matrix combined with a crosslinking agent, that is locust bean gum or calcium sulphate.In this research there were six formulas sustained release ibuprofen tablet that was made by the same compression pressure. Formula I, II and III used matrix combination of xanthan gum and locust bean gum (1:½, 1:1, 1:1½), while formula IV, V and VI used matrix combination of xanthan gum and calcium sulphate (1:½, 1:1, 1:1½). Afterward, the physical and release characteristics of the tablet were examined.The results showed that the compactibility of matrix combination of xanthan gum and locust bean gum was different from the matrix combination of xanthan gum and calcium sulphate. Combination of xanthan gum and locust bean gum and also calcium sulphate as crosslinking agent can influence the physical properties and the release profile of tablet.Key words: ibuprofen, xanthan gum, locust bean gum, calcium sulphate, dissolution, sustained release tablet.
Co-Authors . Sismindari A. Kharis Nugroho, A. Kharis Abdul Rohman Agatha Budi Susiana Lestari Agus Siswanto Akhmad Kharis Nugroho Anitawati, Enggar Anwarudin, Wawang Ardiningtyas, Bondan Ardiningtyas, Bondan Aris Perdana Kusuma, Aris Perdana Ayu, Fithria Dyah Bambang Suryadi, Bambang Basu Swastha Dharmmesta Bimmaharyanto.s, Dedent Eka Budi, Samuel Carolien, Ivonie Daulay, Eliza Hanum Devi, Andika Purnama Dewi Setyaningsih Diah Ayu Puspandari, Diah Ayu Dinaryanti, Pratiwi Drastiana, Friska Effendi Abustam Eka Deddy Irawan Endarti, Dwi Endarti, Dwi Erlianti, Karina Erna Prawita Setyowati Fithria Dyah Ayu Suryanegara, Fithria Dyah Ayu Gede Bayu Suparta Gozali, Mu’min Gunawan Pamudji Widodo Hari Kusnanto Hartati Hartati Hayatus Sa`adah, Hayatus Herri S Sastramihardja, Herri S Herri S. Sastramihardja Heru Sasongko HINRICHS, WOUTER L.J. Ika Ratna Hidayati, Ika Ratna Iwan Dwiprahasto Jogiyanto ., Jogiyanto Jogiyanto, Jogiyanto Kencanasari, Tiekha Lannie Hadisoewignyo Liza Pratiwi, Liza Lolok, Nike Herpianti M. Muchalal Marasabessy, Hadija Marchaban ., Marchaban Marchaban Marchaban, Marchaban Meilanda, Rastria MUDJAHID, ROCHMAT Muhammad Irfan Said Muhammad Ridwan Ningsih, Andriyani Ningsih, Andryani Nining Sugihartini Nugroho, A Kharis Nugroho, Edy Prasetyo Nurmainah Nurmainah Oktavia Eka Puspita, Oktavia Eka Oviani, Gusti Ayu P., I Gusti Ngurah Agung Windra W. Parina, Ana Bella Purnamasari, Vina Puspandari, Dyah Ayu Puung, Florensia Kurnia R. A. Oetari, R. A. R., Wirdah Wati Resti, Adestria Resti, Adestria Rizellia, Rizellia Ronny Martien S, Hilda S., Hilda Sahlani, Suci Paramitasari Sampurno Sampurno Samsubar Saleh Saputri, Laras Tri Sardjiman . Sarie, Lamlay Sarifudin, Barbara Azalya Sarifudin, Barbara Azalya Satibi ., Satibi Satibi Satibi Sirait, Septilina Melati Sismindari Sismindari Siti Aminah Sri Hartati Yuliani Sudibyo Martono Suena, Ni Made Dharma Shantini Suharjono Triatmojo Sumarni Sumarni suwaldi suwaldi Suwendar Suwendar Suwidjiyo Pramono SUWIJIYO PRAMONO Swastiandari, Gabriela Larasati Swastiandari, Gabriela Larasati T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman, T.N. Saifullah Tedjo Yuwono Tri Murti Andayani Tri Yulianti, Tri Triana Hertiani Trisnawati, Komang Tuko, Eirene Copalcanty Tuko, Eirene Copalcanty Tuti Sri Suhesti, Tuti Sri Wahyono Wahyono Wuryanto Hadinugroho Yosi Bayu Murti Yuni Erwanto Yuny Erwanto Zubaydah, Wa Ode Sitti