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Antiproliferative Effect of Ethanolic Extract Eugenia uniflora Lam. Leaves on T47D Cells Ismiyati, Nur; Putri, Dyaningtyas Dewi Pamungkas; Kusumastuti, Siska Andrina; Febriansyah, Rifki
Indonesian Journal of Cancer Chemoprevention Vol 3, No 2 (2012)
Publisher : Indonesian Research Gateway

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Abstract

Eugenia uniflora Lam. is one of herbal products developed for anticancer. The aim of the present study was to identify the antiproliferative effect of ethanolic extract of Eugenia Uniflora Lam. leaves (EEU) on breast cancer cell line T47D. This Research was initiated by extracting the active contents of Eugenia uniflora Lam. leaves by maceration with ethanol 96%. The extract was then analyzed by thin layer chromatography (TLC). Cytotoxic assay of EEU was carried out by using MTT assay. Apoptosis phenomenon was observed with double staining using acridine orange-ethidium bromide. EEU showed cytotoxic effct on T47D cells with IC50 value of 65 μg/ml. Moreover, EEU 50 μg/ml and 100 μg/ml induced apoptosis. TLC examination showed that EEU used in this study contain phenolic, flavonoid, and saponin compounds which were suggested to be responsible for antiproliferative effect. Further molecular mechanism underlying EEU antiproliferative effect needs to be done.Keywords : Eugenia uniflora Lam., T47D cells, antiproliferative, apoptosis
Antiproliferative Effect of Ethanolic Extract Eugenia uniflora Lam. Leaves on T47D Cells Ismiyati, Nur; Putri, Dyaningtyas Dewi Pamungkas; Kusumastuti, Siska Andrina; Febriansyah, Rifki
Indonesian Journal of Cancer Chemoprevention Vol 3, No 2 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (711.437 KB) | DOI: 10.14499/indonesianjcanchemoprev3iss2pp370-375

Abstract

Eugenia uniflora Lam. is one of herbal products developed for anticancer. The aim of the present study was to identify the antiproliferative effect of ethanolic extract of Eugenia Uniflora Lam. leaves (EEU) on breast cancer cell line T47D. This Research was initiated by extracting the active contents of Eugenia uniflora Lam. leaves by maceration with ethanol 96%. The extract was then analyzed by thin layer chromatography (TLC). Cytotoxic assay of EEU was carried out by using MTT assay. Apoptosis phenomenon was observed with double staining using acridine orange-ethidium bromide. EEU showed cytotoxic effect on T47D cells with IC50 value of 65 µg/ml. Moreover, EEU 50µg/ml and 100µg/ml induced apoptosis. TLC examination showed that EEU used in this study contain phenolic, flavonoid, and saponin compounds which were suggested to be responsible for antiproliferative effect. Further molecular mechanism underlying EEU antiproliferative effect needs to be done.Keywords: Eugenia uniflora Lam., T47D cells, antiproliferative, apoptosis
Odong-Odong Apoteker: Maskot Baru untuk Sosialisasi GEMACERMAT Wibowo, Andy Eko; Febriansyah, Rifki; Hadning, Ingenida; Utami, Pinasti; Winanta, Aji
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 5, No 3 (2019): Jurnal Pengabdian kepada Masyarakat
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.38569

Abstract

Pharmacist Odong-Odong, Symbols, and Media Branding the Pharmacist's Existence in Indonesian Communities within the framework of the Drug Conscious Smart Society Movement (GEMACERMAT) is a movement based on the deterioration of the pharmacist's image in the last two years due to various cases in Indonesia. The goals of pharmacists odong-odong become symbols of the existence and role of pharmacists in society. The method used is making odong-odong in the form of a pharmacist holding a capsule, turning children's song lyrics into lyrics about basic knowledge of medicine that the public must know and introducing odong-odong as the new mascot of the pharmacists of IAI Bantul Branch members and pharmacists of IYPG members of the Yogyakarta Branch when they organizing community service activities. The result of this community service is that pharmacists odong-odong are created with various children's songs whose lyrics have been changed. The pharmacist odong-odong, was first used by the IAI when conducting antibiotic drug counseling at a healthy walk event in the framework of the 73rd Independence Day of the Republic of Indonesia organized by Karang Taruna Tanuditan Bantul. Odong-odong pharmacists have also been placed in several pharmacies belonging to IYPG member pharmacists. Pharmacists odong-odong become a favorite place for children to play while enjoying a song that contains knowledge about medicine. The songs are expected to enter the subconscious of the community and indirectly educate the use of drugs.Keywords: pharmacist; odong-odong; IYPG; IAI; GEMACERMAT.
Odong-Odong Apoteker: Maskot Baru untuk Sosialisasi GEMACERMAT Wibowo, Andy Eko; Febriansyah, Rifki; Hadning, Ingenida; Utami, Pinasti; Winanta, Aji
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 5, No 3 (2019): Jurnal Pengabdian kepada Masyarakat
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.38569

Abstract

Pharmacist Odong-Odong, Symbols, and Media Branding the Pharmacist's Existence in Indonesian Communities within the framework of the Drug Conscious Smart Society Movement (GEMACERMAT) is a movement based on the deterioration of the pharmacist's image in the last two years due to various cases in Indonesia. The goals of pharmacists odong-odong become symbols of the existence and role of pharmacists in society. The method used is making odong-odong in the form of a pharmacist holding a capsule, turning children's song lyrics into lyrics about basic knowledge of medicine that the public must know and introducing odong-odong as the new mascot of the pharmacists of IAI Bantul Branch members and pharmacists of IYPG members of the Yogyakarta Branch when they organizing community service activities. The result of this community service is that pharmacists odong-odong are created with various children's songs whose lyrics have been changed. The pharmacist odong-odong, was first used by the IAI when conducting antibiotic drug counseling at a healthy walk event in the framework of the 73rd Independence Day of the Republic of Indonesia organized by Karang Taruna Tanuditan Bantul. Odong-odong pharmacists have also been placed in several pharmacies belonging to IYPG member pharmacists. Pharmacists odong-odong become a favorite place for children to play while enjoying a song that contains knowledge about medicine. The songs are expected to enter the subconscious of the community and indirectly educate the use of drugs.Keywords: pharmacist; odong-odong; IYPG; IAI; GEMACERMAT.