Arta Farmawati
Department of Biochemistry Faculty of Medicine Universitas Gadjah Mada

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Emping Garut (Maranta arundinacea Linn) sebagai Makanan Ringan dan Kadar Glukosa Darah, Angiotensin II Plasma serta Tekanan Darah pada Penderita Diabetes Mellitus Tipe 2 (DMT2) Novitasari, Dwi; Sunarti, Sunarti; Farmawati, Arta
MEDIA MEDIKA INDONESIANA 2011:MMI Volume 45 Issue 1 Year 2011
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACTConsumption of crispy arrowroot (Maranta arundinacea Linn), blood glucose and angiotensin II level, and blood pressure in type 2 diabetesBackground: The mortality of DM caused by cardiovascular complication is about 75% can be reduce by using food with lowglycemic index. The level of fiber consumption on DM sufferers is low (12.08±3.80 gr/day). Crispy arrowroot has 14 glycemic index. The purpose of this study is to know the influence of crispy arrowroot giving to the fasting plasma glucose, angiotensin II rate and blood pressure and also to study the correlation between angiotensin II and blood pressure before and after the giving of crispy arrowroot.Method: This research used quasi-experimental design of pre and post test one group design, the subjects were 14 DMT2 female sufferers (35 to 60 years old), the length of suffering from DM was 1 year, and used insulin therapy. The giving of crispy arrowroot was 20 gr/day for four weeks. The determination of fasting blood glucose rate used colorimetry, angiotensin II rate used ELISA sandwich method and blood pressure used spignomanometer. The data analysis used paired t test and regression test.Results: Consumption of crispy arrowroot does not increase fasting blood sugar (p=0.551), or decrease angiotensin II (p=0.550), and systolic-diastolic blood pressure (psystolic=0.518; pdiastolic=0.216). Conclusion: Crispy arrowroot of 20 g/day for 4 weeks does not give any benefit to DM type 2 patients.Keywords: Crispy arrowroot, blood glucose, angiotensin II, hypertensionABSTRAKLatar belakang: Angka kematian penderita DM karena komplikasi kardiovaskular sekitar 75%. Upaya mengurangi komplikasi tersebut dapat menggunakan makanan dengan indeks glikemik rendah. Tingkat konsumsi serat penderita DM relatif rendah yaitu sekitar 12,08±3,80 gr/hari. Umbi garut mempunyai indeks glikemik 14 sehingga dapat digunakan sebagai makanan fungsional penderita DM. Tujuan penelitian untuk mengkaji pengaruh pemberian makanan ringan emping garut terhadap kadar glukosa darah puasa (GDP), angiotensin II dan tekanan darah serta mengkaji hubungan antara angiotensin II dan tekanan darah sebelum dan setelah pemberian emping garut pada penderita DMT2.Metode: Penelitian menggunakan desain kuasi eksperimental pre and post test one group design, subyek penelitian 14 wanita (35-60 tahun) penderita DMT2, lama DM 1 tahun dan menggunakan insulin. Emping garut sangrai 20 gr/hari diberikan pagi dan sore hari selama 4 minggu. Pengukuran GDP menggunakan metode kolorimetri, angiotensin II ditentukan menggunakan metode ELISA sandwich dan tekanan darah menggunakan spignomanometer. Analisis data menggunakan uji paired t test dan uji regresi.Hasil: Pemberian emping garut tidak meningkatkan GDP (p=0,551) dan tidak menurunkan kadar angiotensin II (p=0,550), serta tekanan sistolik dan diastolik (psistolik=0,518; pdiastolik=0,216).Simpulan: Pemberian emping garut sangrai 20 gr/hari selama 4 minggu pada penderita DM tidak menunjukkan manfaat.
Polimorfisme Gen Ferroportin (FPN1) Q248H dan Karakteristik Sosial Ekonomi Ibu Hamil dengan Anemia di Surakarta Istiqomah, Nor; Dewi, Vitria Sari; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Pena Medika Jurnal Kesehatan Vol 4, No 1 (2013): Pena Medika Jurnal Kesehatan, Vol.4 No.1 Desember 2013
Publisher : Fakultas Ilmu Kesehatan Universitas Pekalongan

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Background: Iron deficiency anemia in pregnancy remains an important health problem in Indonesia. Ferroportin (FPN1) is one of important gene in iron metabolism encodes ferroportin for iron absorption, release, and recycle inside the body. The polymorphism of FPN1 Q248H alters negative charge of the amino acid sequence positively, hence influenced its ubiquitination and degradation. Beside of that, the high prevalence of anemia not only caused by genetics, nutrition, physiology of each pregant women, but also demographic factor and sosio-economic burden of family. This research will study the polymorphism of ferroportin Q248H and demographic character in pregnant women in Surakarta. Methods: The study using descriptive analytic case-control approach. The data used were from questionaire and blood sampling whose counted for screening anemia in private laboratorium. Pregnant women who had intention and had 10-25 week in pregnant were selected to be research subject.  FPN1 Q248H polymorphism were determined using PCR-RFLP method. Analysis Chi-square dan Independent t-test used to conclude the relationship between each variable to anemic state of pregnant women in Surakarta. A p<0.05 was considered as significant. The study using decriptive analytic design method. Results: Prevalence of anemia in Surakarta is 25.7% with 80.7% have mild anemia. There was no varian in FPN1 Q248H. Majority of pregnant women in group of anaemia have demographic character like 20-25 old, multigravid, last education in High School, housewife, their income range from Rp 500.000,00 to Rp 1.000.000,00, and consume Fe tablet. The bivariat analysis show no statistical significancy of parity, maternal age, education, income, and comsumption of iron tablet to state of anaemia (p>0.05). Conclusions: The FPN1 Q248H polymorphism was not a risk factor for iron deficiency anemia in pregnant women, likewise socio-economic factors had no significant role to incidence of anemia in Surakarta. Keywords: Anemia in pregnancy, Ferroportin (FPN1) Q248H polymorphism, Socio-Economic
Raja Bandung Banana (Musa paradisiacaL.cv Raja Bandung) Prevents Increased Systolic Blood Pressure in Rats Given Acute Stress Test Anindyah, Dina Septari; Farmawati, Arta
International Journal of Public Health Science (IJPHS) Vol 4, No 1: March 2015
Publisher : Institute of Advanced Engineering and Science

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The relationships between stress and hypertension have been evaluated. Heightened blood pressure (BP) reactions to acute stress have been implicated in cardiovascular disease’s development. Consumption of fruit or vegetables lowering BP. This study aimed to evaluate the effect of Raja Bandung Banana (Musa paradisiacaL. cv Raja Bandung) on blood pressure after acute restraint stress and forced swim test.Twenty male Sprague dawley rats were divided into 4 groups (A,B,C,D) and adapted for 3 days. At 4th day, groups were administered 2 g/200gBw AIN-93M, then exposed to acute restraint (1hour), except group A. After restraint, A&B received water, C received diazepam 0,5mg/kgBW, and D received banana 2,52 g/200gBW. One hour later, the forced swim test was carried out (45 minutes). Blood pressure was measured 1 hour after swim. Result showed,mean of blood pressure significantly increased after treatment (p<0,01) all groups. But, the increasing of blood pressure in C and D group was lower than unrestraint (A) and control (B) group. There was significant difference of blood pressure between control (A&B) and intervention group (C&D), but no significant difference between C and D. Thisresults indicate that Raja Bandung Banana can prevent increased blood pressure on acute stress condition as effective as diazepam.  
Efek minuman kombinasi maltodekstrin dan vitamin C terhadap VO2maks atlet sepak bola Puspaningtyas, Desty Ervira; Sudargo, Toto; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 12, No 1 (2015): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

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Background: VO2max is one of win determiner in a game. Athletes receive training to improve technical skills, tactical skills, and physiology functions that can support the improvement of VO2max, so they can improve their achievement. Maltodextrin and vitamin C can be used as an ingredient for beverage products which can improve VO2max.Objective: To assess the effect of maltodextrin and vitamin C combination drink on VO2max in soccer athletes.Method: Type of this study was experimental design with the same subject design. The study was conducted from January 2014 until June 2014 at Culinary Laboratory Universitas Gadjah Mada (UGM) and Stadium of Universitas Negeri Yogyakarta (UNY). Subjects of this study were 14 soccer players coming from Universitas Negeri Yogyakarta (UNY). Every subject had to fulfill the inclusion and exclusion criteria, and the subjects were chosen by purposive sampling. In the first treatment, subjects received the combination drink―a drink with a composition 15% of maltodextrin and 250 mg of vitamin C in 300 mL. After 6 days washout period, subjects received 300 mL plain water. Drinks were given 30 minutes before VO2max test. VO2max test method used in this study was yo-yo intermittent recovery test level 2 (IR-2).Results: VO2max when subjects consumed maltodextrin and vitamin C combination drink was significantly lower than VO2max when athletes consumed plain water (p=0,0000).Conclusion: Maltodextrin and vitamin C combination drink was less effective than plain water to enhance VO2max.
Effect of exercise on lipid peroxidation in student soccer players Puspaningtyas, Desty Ervira; Afriani, Yuni; Mahfida, Silvi Lailatul; Kushartanti, Wara; Farmawati, Arta
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Training is conducted to improve physiological functions that can support improvementof cardio-respiratory function (O2max). However, intensive training can lead to oxidativestress, which can contribute to health problems. The purpose of this study was to evaluatethe effect of training on serum lipid peroxidation levels in student soccer players. Thestudy was pre-experimental study with a one-shot case design conducted in April 2014.Twelve student soccer players from UGM who chosen by purposive sampling and metthe inclusion and exclusion criteria were involved in the study. Each subject receivedtraining in the form of O2max measurements using the yo-yo intermittent recovery test.Plasma malondialdehyde (MDA) levels were measured using the thiobarbituric acidmethod 30 min after O2max measurement. Pearson correlation was used to analyzethe correlation between O2max and plasma MDA levels. The mean age of subject was19.25?1.06 years old. Subjects had normal nutritional status (body mass index 20.99? 1.65) with mean body weight of 58.13?3.76 kg and mean height of 166.2?3.40cm. The mean O2max score was 49.56?0.61 mL/kg/min. The mean plasma MDA levelwas 4.32?2.09 ?mol/L. There was no significant correlation between O2max and plasmaMDA levels (p=0.7717). In conclusion, training does not negatively impact oxidativestress conditions in student soccer players.
Pengaruh pemberian kecambah kacang hijau (Phaseolus radiatus (L.)) terhadap kadar malondealdehid (MDA) plasma dan jaringan hati tikus Sprague Dawley yang diberi pakan lemak tinggi Novidiyanto, Novidiyanto; Farmawati, Arta; Lestari, Lily Arsanti
Jurnal Gizi Klinik Indonesia Vol 13, No 2 (2016): Oktober
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

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Background: High-fat diet increases the levels of fat, especially cholesterol and triglycerides that cause hyperlipidemia. Polyunsaturated fatty acids are very easily oxidized by free radicals reactive oxygens species (ROS) called lipid peroxidation, to produce compounds that malondialdehyde (MDA), is toxic and can damage plasma membrane and liver tissue. Mung bean sprouts are known to contain antioxidants which act to inhibit lipid peroxidation process.Objective: Determine the effect of mung bean sprouts to the level of plasma MDA and liver tissue of rats with high-fat diets.Method: This research is an experimental study with an only post-test design with the control group. Thirty-five male Sprague-Dawley rats were divided into 5 groups. Group K1 received fed standard; K2 received high-fat diet without mung bean sprouts. Group P1 received high-fat diet and mung bean sprouts dose of  0.5 mL/gBW. Group P2 received high-fat diet and mung bean sprouts dose of 1 mL/gBW. Group P3 received high-fat diet and vitamin E doses of 23 IU. All group were treated for 28 days. Analysis of MDA plasma and liver tissue performed after treatment.Results: Group K1 has plasma MDA levels of 1.17 ± 0.14 nmol/mL Mean MDA plasma level in the group K1 Group of K1 Mean MDA plasma level in the group K2 (39.7±0.19 nmol/mL) was higher than the group of K1 (1,17±0,14 nmol/mL), group P1 (2.94±0.09 nmol/mL), group P2 (1.73±0.08 nmol/mL) and group P3 (1.53±0.07 nmol/mL). Group K1 has liver tissue MDA Levels of 1,64±0,11 nmol/g. Mean MDA liver tissue level in the group of K2 (4.90±0.29 nmol/g) was higher than the group of P1 (3.68±0.45 nmol/g), group P2 (2.27±0.10 nmol/g), and group P3 (2.01±0.11 nmol/g).Conclusion: Level of MDA plasma and liver tissue of rat in group P1 and P2 was lower than a level of MDA plasma and liver tissue of rat in group K1, but higher than the level of MDA plasma and liver tissue of rat in group P3. There was a very strong correlation between the level of MDA plasma and liver tissue of rat was given the mung bean sprouts and high-fat diet.
Pencegahan hipertensi dan penebalan dinding aorta dengan pemberian kecambah kacang hijau (Phaseolus radiatus (L)) pada tikus putih Sprague Dawley Hadi, Novian Swasono; Farmawati, Arta; Ghozali, Ahmad
Jurnal Gizi Klinik Indonesia Vol 12, No 3 (2016): Januari
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

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Background: Lifestyle changes with high-fat food consumption is one of the factors the risks of cardiovascular diseases like of coronary heart disease and atherosclerosis. A healthy diet and a balanced diet and consume foods that contain lots of antioxidants is one of the effective ways to prevent hyperlipidemia. Mung bean sprouts have properties that neutralize free radicals cause Hyperlipidemia and cardiovascular diseases because it is an antioxidant compound.Objective: The aim of this study was to determinate the effect of mung bean sprouts (Phaseolus radiatus (L)) to blood pressure and histopathology aorta of Sprague-Dawley male rats.Method: The type of study was experimental research using pre-post test controlled group design for blood pressure variable and post test only controlled group design histopathology aorta. The thirty-five of Sprague-Dawley male rats was eight weeks divided into 5 groups. The first group was given standard diet, group 2 was given a hight fat diet, the third group was given a high-fat diet and mung bean sprout 0,67 gram, group 4 was given a high-fat diet and mung bean 1,34 gram, and group 5 was given a high-fat diet and vitamin E doses of 23 IU.Results: Result of this study showed that after 4 weeks of treatment, increased in blood pressure systole in the given of  high fat diet higher than group who were given a high fat diet and mung bean sprout and also on group who were given high fat diet and vitamin E, but there is no difference effect a decrease in blood pressure between the provision of mung bean sprouts and vitamin E (p>0,05). Statistical analysis to thick the wall the aorta show the similarity meaningful in all the treatment group, it can be said that overall thick the wall the aorta in this research is not different.Conclusion: A dose of mung bean sprout 0,67 g is optimal doses in preventing a rise in blood pressure and prevent alterations histopathology Sprague-Dawley male rats.
Asupan Cairan dan Vitamin C dengan Tingkat Kecemasan pada Atlet Sepak Bola di Yogyakarta Afriani, Yuni; Puspaningtyas, Desty Ervira; Mahfida, Silvi Lailatul; Kushartanti, Wara; Farmawati, Arta
Media Ilmu Keolahragaan Indonesia Vol 7, No 2 (2017): December 2017
Publisher : Universitas Negeri Semarang

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Tujuan penelitian ini untuk melihat hubungan asupan cairan dan vitamin C dengan kondisi kecemasan atlet sepak bola. Penelitian ini merupakan penelitian observasional, desain cross-sectional, dilakukan bulan Mei-Juni 2014 di Stadion Universitas Negeri Yogyakarta (UNY) Indonesia. Subjek penelitian ini adalah 10 atlet sepak bola dari UGM dan 11 atlet sepak bola dari UNY. Data asupan cairan dan vitamin C dilihat dengan wawancara menggunakan form SQFFQ. Kondisi kecemasan atlet diukur dengan kuesioner kecemasan yang dimodifikasi dari State-Trait Anxiety Inventory (STAI). Data dianalisis menggunakan software statistik. Hasil : Rata-rata asupan cairan pada atlet sepak bola UGM adalah 2.930,92 1.249,26 ml. Asupan vitamin C pada atlet sepak bola UGM adalah 112,33 212,38 mg. Skor kecemasan dari atlet sepak bola UGM adalah 26,9 7,18. Tidak ada hubungan yang signifikan pada asupan cairan dan vitamin C dengan kecemasan pada atlet UGM (p>0,05). Sedangkan rata-rata asupan cairan pada atlet sepak bola UNY adalah 3.250,32 1.055,53 ml. Asupan vitamin C atlet adalah 19,93 12,9 mg. Rata-rata skor kecemasan dari atlet sepak bola UNY adalah 26,18 2,52. Tidak ada hubungan yang signifikan pada skor kecemasan dengan asupan cairan dan vitamin C pada atlet sepak bola UNY (p>0,05). Tidak ada hubungan yang signifikan pada asupan cairan dan vitamin C dengan skor kecemasan atlet sepak bola di Yogyakarta.The aims of the reseach is correlation between fluid intake and vitamin C with anxiety condition of soccer athletes in Yogyakarta is the objects of this study.This was an observational study with cross-sectional design. This research was conducted on May-June 2014 at Yogyakarta State University Stadium (UNY) Indonesia. The subjects of this study were 10 soccer athletes from UGM and 11 soccer athletes from UNY. Data of fluid intake and vitamin C were seen by interview using SQFFQ form. The athletes anxiety condition was measured by a modified anxiety questionnaire from the State-Trait Anxiety Inventory (STAI). Data were analyzed using statistical software.Result: The average fluid intake in UGM soccer athletes is 2,930.92 1,249.26 ml. Vitamin C intake in UGM soccer athletes is 112.33 212.38 mg. Anxiety score from UGM soccer athletes is 26.9 7.18. There was no significant association between fluid intake and vitamin C with anxiety in UGM athletes (p> 0.05). While the average fluid intake in soccer athletes of UNY is 3,250.32 1055,53 ml. Vitamin C intake of athletes was 19.93 12.9 mg. The average anxiety score of a soccer athletes of UNY is 26.18 2.52. There was no significant association in anxiety scores with fluid intake and vitamin C in soccer athletes of UNY (p> 0.05).There is no significant correlation of fluid intake and vitamin C with anxiety scores of soccer athletes in Yogyakarta.
Pemberian minuman kombinasi maltodekstrin dan vitamin C terhadap mood negatif dan VO2 maks atlet sepak bola Afriani, Yuni; Hadjam, Noor Rochman; Farmawati, Arta
Jurnal Gizi Klinik Indonesia Vol 13, No 4 (2017): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

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Background: Stress during the match can influence the change of mood and performance of athletes. Physical exercise can improve the ability of physiologically and psychologically, but lead to fatigue, dehydration and hypoglycemia. Maltodextrin has a lower osmolarity to improve emotional and performance. Vitamin C as a cofactor of neurotransmitters can support the performance of athletes.Objective: This study aimed to determine the effectiveness of a combination drinks of maltodextrin and vitamin C on mood and the correlation with VO2 max of football athletes.Method: This research is a quasi experimental with same subject design. The subjects were 14 University state of Yogyakarta football athlete. Subjects received a drink of 15% maltodextrin and 250 mg of vitamin C in 300 ml given 30 minutes before and 5 minutes after the performance test using yo-yo intermittent test continued by physical exercise. Measurement of mood would be done in 3 times; before cardiorespiratory test, 5 minutes after physical exercise, and 15 minutes after drink.Results: There are significant changes after consuming a combination of maltodextrin and vitamin C on the confusion (p<0.05), while components of anger, fatigue, depression, tension and vigor (p>0.05). There are significant changes after consuming plain water on fatigue and tension (p<0.05), while anger, confusion, depression, and vigor (p>0.05). There are no significant differences in every components of mood between two treatments. There is a correlation between anger and confusion with cardiorespiratory after consuming a combination of maltodextrin and vitamin C.Conclusion: Maltodextrin and vitamin C has the potential effect to improve the mood condition and have a correlation with VO2 Max improvement in football athletes.
Polimorfisme gen ferroportin (FPN1) -1355 G/C sebagai faktor risiko anemia defisiensi besi pada ibu hamil Istiqomah, Nor; Umarghanies, Sarah Safira; Farmawati, Arta; Sadewa, Ahmad Hamim; Soesilo, Yuliana Heri; Damayanti, Kusumadewi Eka; Indarto, Dono
Jurnal Gizi Klinik Indonesia Vol 9, No 4 (2013): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, Fakultas Kedokteran UGM

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Background: According to WHO data, prevalence of anemia pregnancy in Indonesia is 44.3%, it’s higher than world prevalence (41.8%). Ferroportin (FPN1) is one of important iron exsporter for iron absorption, release, and recycle inside the body. The varian of FPN1-1355 G/C in promoter region, leads to increased of ferroportin expression and iron export, increased cellular iron needs, overexpression of soluble transferrin receptor (sTfR), decrease hemoglobin (Hb) and erythrocyte indices that manifest to iron deficiency anemia (IDA).Objective: This research will study the frequency of FPN1-1355 G/C polymorphism as a risk factor of IDA in pregnant women in Indonesia.Method: The research design was a case and control study. Blood samples were taken from 26 pregnant women with anemia and 48 pregnant women without anemia. FPN1-1355G/C polymorphism were determined using PCR-RFLP method. sTfR and ferritin level were measured with ELISA. Hemoglobin, erythrocyte indices, and sTfR level were compared among genotype group, then statistically analyzed using independent sample t-test and one way ANOVA. Bivariat analysis of Pearson test was conducted to analyze correlation between level of blood Hb and ferritin in pregnant women (p<0.05).Results: FPN1-1355 G/C polymorphism with frequency in pregnant women with IDA and in pregnant women with anemia non IDA were 100% and 95.2%, respectively (p=0.710; OR=1.600; 95%CI: 0.296-8.653). The mean of Hb level and erythrocyte indices in subjects carrying C allele were lower than subjects carrying only G allele although Hb level is not significantly different (p>0.05). The sTfR and hepcidin level in subjects carrying C allele were higher than subjects carrying only G allele (p<0.05). Conclusion: In this study the FPN1 gene promoter -1355 G/C polymorphism was not a risk factor for anemia, but it was a risk factor for iron deficiency anemia in pregnant women.