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24
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Knowledge and attitude of pregnant woman toward umbilical-cord-blood collection

Indonesian Journal of Obstetrics and Gynecology Vol. 34. No 2. April 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

Objective: Stem cell technology from umbilical cord blood (UCB) has developed fast as health services. UCB could be used in many kinds of disease. Private UCB bank has been operated in many places all over Indonesia. There’s a need for research to evaluate the knowledge and attitude of pregnant woman towards the act of collecting UCB.Method: This is a cross-sectional study base on question-naire given to 163 pregnant women in three private hospitals in the Bandung City from September - November 2009. The result was analyzed with Rank-spearman correlation and Kruskal-Wallis chisquare.Result: Most respondent were 20 - 29 years old pregnant women (54.6%), with educational level of strata-1 (S-1) (41.1%), with monthly income within 5 - 10 million rupiah (35.6%). This is the second pregnancy or more (42.9%), with gestational age less than 24 weeks (61.3%) and variative obstetric history (59.5%). The average level of knowledge was poor and attitude scale was uncertain (3.4). There is a significant correlation between age (p = 0.008%; CI 95%), level of education (p = 0.0001; CI 95%) and knowledge. There is a significant correlation between gestational age and attitude (p = 0.003; CI 95%). Respondent’s level of knowledge also has a significant correlation with attitude (τs = 0.421; p = 0.0001; CI 95%).Conclusion: This study described the respondent’s poor knowledge will influence their attitudes toward UCB collection, so it is necessary for disseminating more information on UCB as an effort to get better research result on UCB.[Indones J Obstet Gynecol 2010; 34-2: 97-100]Keywords: knowledge level, attitudes, collecting UCB, pregnant woman, the Bandung city Tujuan: Tujuan: Teknologi sel punca yang berasal dari darah tali pusat (DTP) saat ini berkembang dengan pesat untuk pelayanan kesehatan. DTP ini dapat dipergunakan pada berbagai macam penyakit. Beberapa cabang bank DTP swasta telah beroperasi di Indonesia. Sehingga perlu dilakukan penelitian tingkat pengetahuan dan sikap ibu hamil terhadap pengumpulan DTP. Metode: Dilakukan penelitian survey cross-sectional pada 163 orang ibu hamil di tiga rumah sakit swasta Kotamadya Bandung sejak September - November 2009. Kuisioner berupa kuesioner tertutup.Hasil yang di dapat dianalisis dengan menggunakan uji korelasi Rank-Spearman dan uji chi-kuadrat Kruskal-Wallis. Hasil: Karakteristik terbesar responden berusia 20 - 29 tahun (54,6%), berpendidikan S-1 (41,1%), pendapatan perbulan 5 sampai 10 juta rupiah (35,6%). Kehamilan saat ini adalah kehamilan yang ke-2 atau lebih (42,9%), usia kehamilan kurang dari 24minggu (61,3%) dan riwayat obstetri yang bervariasi (59,5%). Rerata tingkat pengetahuan kurang (50,97%) dan skala sikap raguragu (3,4). Didapatkan hubungan bermakna antara usia (p = 0,008%; CI 95%) dan tingkat pendidikan terhadap tingkat pengetahuan (p = 0,0001; CI 95%). Terdapat hubungan bermakna antara usia gestasi dengan sikap responden (p = 0,003; CI 95%). Tingkat pengetahuan responden juga bermakna secara statistikterhadap sikap responden (τs = 0,42; p = 0,000; CI 95%).Kesimpulan: Penelitian ini menggambarkan tingkat pengetahuan responden yang rendah akan mempengaruhi sikap terhadap pengumpulan DTP, sehingga dibutuhkan penyebaran informasi yang lebih baik lagi mengingat manfaat yang didapat melalui penelitian DTP.[Maj Obstet Ginekol Indones 2010; 34-2: 97-100]Kata kunci: tingkat pengetahuan, sikap, pengumpulan darah tali pusat, ibu hamil, Kotamadya Bandung

Embryo Quality: The Most Critical Factor for Pregnancy Rates after day-2, day-3, and day-5 of Embryo Transfer

Indonesian Journal of Obstetrics and Gynecology Vol. 34. No. 4. October 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

Objective: To determine the most critical factor on day-2, day-3, and day-5 of embryo transfer in correlation with pregnancy rates.Method: This research is a retrospective study in Aster Fertility Clinic, IVF program- Dr. Hasan Sadikin Hospital, Bandung, Indonesia. One hundred ninety five women enrolled in an IVF program conducted from March 2006 through November 2009 at the Aster Fertility Clinic. Effect of embryo-transfer day and any other factors (including quality of embryo, oocyte quantity, difficulty of embryo transfer technique, and blood or mucus contamination on the catheter) on pregnancy rate in IVF.Results: The mean age of the pregnant group was 34.65 (SD = 3.91), and the mean of the infertility period was 7.25 years (SD = 3.54). There were no siginificant differences in pregnancy rates in the day-2, day-3, and day-5 groups. The most critical factor influencing pregnancy was the total score for the quality of embryos [p = 0.001; OR (CI 95%) = 1.94 (0.91 - 4.08)]. Otherwise, the day of embryo transfer, oocyte quantity, and difficulties in embryo transfer did not affect the pregnancy rate (p > 0.05).Conclusion: Our study suggests that the total score for the quality of the embryos was the most critical factor for the success rate of pregnancy rather than the day of embryo transfer, oocyte quantity, difficulty of embryo transfer technique, or contamination of blood and mucus on the catheter.[Indones J Obstet Gynecol 2010; 34-4: 175-9]Keywords: day of embryo transfer, in vitro fertilization, quality of embryo total score, oocytes quantity, catheter contaminationTujuan: Untuk menentukan faktor yang terpenting pada keberhasilan kehamilan setelah transfer embrio hari ke-2, ke-3 dan ke-5.Metode: Penelitian ini adalah studi retrospektif di klinik Fertilitas Aster, Program IVF- Rumah Sakit Dr. Hasan Sadikin, Bandung, Indonesia. Penelitian ini melibatkan seratus sembilan puluh lima perempuan yang mengikuti program IVF sejak Maret 2006 hingga Nopember 2009. Efek dari waktu (hari) transfer embrio dan faktorfaktor lainnya (termasuk kualitas embrio, jumlah oosit, kesulitan dalam teknik transfer embrio, dan kontaminasi darah atau mukus dalam kateter) terhadap angka keberhasilan kehamilan pada IVF.Hasil: Rata-rata usia perempuan hamil pada penelitian ini 34,65 (SD = 3,91), dan rata-rata periode infertilitas 7,25 (SD = 3,54). Tidak terdapat perbedaan bermakna pada angka kebehasilan kehamilan setelah transfer embrio baik pada hari ke-2, -3 dan -5. Faktor terpenting yang mempengaruhi keberhasilan kehamilan adalah skor total dari kualitas embrio [p = 0,001; OR (CI 95%) = 1,94 (0,91 - 4,08)]. Dilain fihak, waktu transfer embrio, jumlah oosit, kesulitan dalam teknik transfer embrio tidak mempengaruhi kebehasilan kehamilan (p > 0,05).Kesimpulan: Hasil studi kami menunjukkan bahwa faktor terpenting yang mempengaruhi keberhasilan kehamilan adalah skor total dari kualitas embrio dibandingkan dengan waktu transfer embrio, jumlah oosit, kesulitan dalam teknik transfer embrio, atau kontaminasi darah dan mukus dalam kateter.[Maj Obstet Ginekol Indones 2010; 34-4: 175-9]Kata kunci: hari setelah transfer embrio, fertilisasi in vitro, skor total dari kualitas embrio, jumlah oosit, kontaminasi kateter

Uji Fungsional dan Karakteristik Sel Punca Hematopoetik Hasil Isolasi dari Darah Tali Pusat Manusia Menggunakan Metode Modifikasi Unpad- Aster

Majalah Kedokteran Bandung Vol 43, No 4 (2011)
Publisher : Fakultas Kedokteran, Universitas Padjadjaran

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Abstract

Metode isolasi sel-sel mononuklear/mononuclear cells (MNCs) dari darah tali pusat (DTP) manusia secara konvensional menghasilkan tingkat kontaminasi sel eritrosit yang sangat tinggi. Oleh karena itu, tujuan penelitian ini adalah menilai perbedaan viabilitas dan kontaminasi sel eritrosit dalam populasi MNC DTP pada modifikasimetode isolasi yang kami kembangkan. Penelitian ini juga bertujuan untuk menguji fungsi dan karakteristik populasi MNCs dari DTP manusia sebagai dasar pembangunan bank darah tali pusat di Indonesia. Penelitian dilakukan di Departemen Obstetri dan Ginekologi RS Dr. Hasan Sadikin Bandung periode Januari–Oktober 2010. Isolasi MNCs dengan metode modifikasi (dinamakan modifikasi Unpad-Aster) yang menghasilkan 5,1x106 sel/mL memiliki tingkat kontaminasi sel eritrosit yang lebih rendah dibandingkan dengan metode konvensional. Morfologi sel yang dibiakkan dalam medium unrestricted somatic stem cells (USSCs) tampak seperti sel-sel yang adheren (menempel di dasar), berbentuk sel spindle, dengan cluster of differentiation-90 (CD-90) (antigen leukosit) dan cluster of differentiation-105 (CD-105) yang positif serta dapat berdiferensiasi menjadi sel neuron dan adiposit; sedangkan morfologi untuk cord blood-derived multipotent progenitor cells (CB-MPCs) tampak seperti sel-sel fibroblas dengan cluster of differentiation-45 (CD-45) (antigen hematopoetik) yang positif serta dapat berdiferensiasi menjadi sel neuron. Disimpulkan bahwa metode modifikasi Unpad-Aster memberikan tingkat kontaminasi eritrosit yang lebih rendah dibandingkan dengan metode konvensional. Sel mononuklear yang berasal dari darah tali pusat ini dapat berdiferensiasi menjadi sel-sel neuron dan adiposit. [MKB. 2011;43(4):171–7].Kata kunci: Darah tali pusat (DTP), diferensiasi, karakterisasi, modifikasi Unpad-Aster, sel mononuklearFunctional Test and Characteristic of Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood Using Unpad-Aster’s Modified MethodThe conventional method of mononuclear cells (MNCs) isolation from human umbilical cord blood (UCB) yielded high erythrocyte contamination level. Therefore, the aim of this study was to assess the differences of cell viability and erythrocyte contamination on the population of UCB MNCs in our modified isolation method. This study was also aimed to test the function and characteristic of human MNCs derived from UCB as the basis for the development of UCB banking in Indonesia. The study was conducted in Department of Obstetry and Ginecology >RS Dr. Hasan Sadikin Bandung in period of January–October 2010. The modified isolation method (namely Unpad Aster’s modification) yielded 5.1x106 MNC cell/mL has lower erythrocyte contamination level than conventional method. The morphology of MNCs cultured in unrestricted somatic stem cells (USSCs) medium looked like adhered cells (attached at the surface of culture flask), spindle-shaped cells with positive luster of ifferentiation-90 (CD-90) (leukocyte antigen) and cluster of differentiation-105 (CD-105) and could differentiate into neuronal cells and adipocytes. While the morphology of cord blood-derived multipotent progenitor cells (CB-MPCs) looked like fibroblast cells with positive cluster of differentiation-45 (CD-45) (antigen hematopoietic) and could differentiate into neuronal cells. In conclusions, the Unpad-Aster’s modified isolation method gives lower level of erythrocyte contamination compared with conventional method. Mononuclear cells derived from UCB could differentiate into neuronal cells and adipocytes. [MKB. 2011;43(4):171–7].Key words: Characteristic, differentiation, mononuclear cells (MNCs), umbilical cord blood, Unpad-Aster modification

Modifikasi Metode Isolasi Sel Endotel Pembuluh Darah Otak (EPDO) Tikus: Teknik Dasar Kultur Sel Primer di Bidang Neurosains

Majalah Kedokteran Bandung Vol 42, No 4 (2010)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Metode konvensional isolasi sel endotel pembuluh darah otak (EPDO) masih tergolong sulit, sehingga upaya mendapatkan populasi murni sel ini adalah tantangan. Pada penelitian ini dilakukan isolasi endotel dari tikus Wistar dan mencit C57/Bl6, berdasarkan protokol the care and use of laboratory animals, Universitas Gunma, Jepang. Modifikasi metode isolasi adalah menggunakan gradasi bovine serum albumin (BSA), bukan Dextran-70 yang umumnya dipakai, untuk memisahkan sel EPDO yang bersatu menjadi sel EPDO tunggal. Penelitian ini dilakukan di laboratorium sel kultur, Universitas Padjadjaran bekerjasama dengan Universitas Gunma, Jepang, Januari 2008–Juni 2009. Uji hasil isolasi dan karakteristik sel EPDO dilakukan dengan teknik imunofloresen. Ekspresi tight junction ZO-1, menunjukkan sel EPDO membentuk selapis sel utuh, rapat, tidak bertumpuk dan kompak, sesuai dengan karakteristik dinding EPDO. Fenotip sel EPDO dikonfirmasi dengan acethylated LDL, faktor von Willebrand dan CD31. Penghancuran kapiler dengan collagenase/dispase masih menghasilkan populasi sel yang terkontaminasi perisit. Kontaminasi dimurnikan dengan menggunakan puromycin, tingkat pemurnian sel EPDO mencapai 98,3%. Simpulan, teknik modifikasi berhasil mengisolasi sel EPDO tikus dan mencit, tanpa melakukan intervensi genetik. Puromycin dapat digunakan untuk memurnikan sel EPDO. [MKB. 2010;42(4):161–8].Kata kunci: Metode modifikasi isolasi sel EPDO, pembuluh sawar otak, teknik pemurnian Isolation Modified-Method of Mouse-Brain Microvessel Endothelial Cells: Primary Cell Culture Technique in NeuroscienceIsolation method to obtain pure BMVECs is hard to be done consistently and remains a challenge. In this study, we isolated BMVECs from Wistar rat and C57/Bl6 mouse from Japan SLC. All procedures performed according to guidelines for the care and use of laboratory animals of Gunma University, Japan. The modification of isolation method was using bovine serum albumin (BSA) gradation, not Dextran-70 in which generally used, to separate clusters of BMVECs into single cell. This study was done at Universitas Padjadjaran, in colaboration with Gunma University, Japan, January 2008–June 2009. Further,characteristic and purification results were proven by imunofluorescene staining. The results showed that staining of tight junction, ZO-1, formed a monolayer, tightly packed, non-overlapping and contact-inhibited BMVECs, as expected for a vessel wall endothelial. ECs phenotype confirmed by acethylated LDL, von Willebrand and CD31. The digestion of capillaries generated contaminating pericytes. Contamination was purified using puromycin and the results considered satisfactory (98.3%). In conclusion, our modification procedure allows the isolation of primary rat and mouse BMVECs, which form an endothelial-like monolayer in few days. Puromycin can be used for purification of primary rat and mouse BMVECs. [MKB. 2010;42(4):161–8].Key words: Blood brain barrier, isolation modified-method of mouse-BMVECs, purification methods DOI: http://dx.doi.org/10.15395/mkb.v42n4.30

-Conglycinin Content Obtained from Two Soybean Varieties Using Different Preparation and Extraction Methods

HAYATI Journal of Biosciences Vol 18, No 1 (2011): March 2011
Publisher : Bogor Agricultural University, Indonesia

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Abstract

Soybean is a good source of protein. It has two major fractions, b-conglycinin (7S) and glycinin (11S). b-conglycinin’s function was known to suppress food intake, and this effect may be due to stimulating endogenous cholecystokinin (CCK) release. The aims of this study were to determine the highest content of total b-conglycinin and b-conglycinin sub unit-b level obtained from two varieties of soybean i.e. Wilis and Detam 1 varieties using different preparation and extraction methods. These two soybean varieties were prepared into tempeh. Then the seed and tempeh were extracted using Deak and Panthee methods. There were six extracts analysed using sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS PAGE) and coomassie brilliant blue (CBB) staining. The result was shown that Detam variety and raw seed contained the highest total b-conglycinin level. And Panthee method was the best method for extraction of total b-conglycinin, while Deak method was the best method for extraction of b-conglycinin subunit-b.

Medical Social Informatics Application of Human Computer Interface for Traumatic Brain Injury in the Rural Area

Jurnal Kedokteran Maranatha Vol 11, No 2 (2012)
Publisher : Universitas Kristen Maranatha

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Abstract

Medical social informatics is a framework to solve public health problems by using the information technology based on the public needs. In the field of neurosurgical services as part of public health, traumatic brain injury (TBI) is common in Indonesia. Roughly, 200 neurosurgeons in Indonesia are working for 250 million population. Most of them are working in the big city so that TBI in the rural and disaster area cannot be treated properly. To support the treatment of TBI during the absence of a neurosurgeon, we have developed a TBI supported information system focussing on the TBI graphic user interface (GUI). This system can be employed by general surgeons, doctors and nurses under a neurosurgeon’s distant guidance. The human-computer simulation was performed using Lenovo T500 with finger touched mouse keyboard and Lenovo X201 with pen-tablet ThinkPad. A patient admitted to the emergency room was the candidate on this simulation. Data were assessed and recorded in the system simultaneously by nurses, doctors and general surgeons after they login according to their qualification. The speed of data comprehending and data entry was almost similar on both types of computer; however, the particular tablet PC was found more convenient and faster. Under neurosurgeon guidance, the paramedics were competent to provide early treatment, to stabilize the patient’s condition and to perform minimal surgical intervention for saving patient’s threatened life. Therefore, this system is expected to be useful for the rural and disaster area that has no neurosurgeon.

A New Beginning For Majalah Kedokteran Bandung (MKB) in 2019

Majalah Kedokteran Bandung Vol 50, No 4 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

[no abstract available]

Histological Description of Meningeal and Periosteal Dural Layers at the Porus of Internal Acoustic Canal in the Vestibular Schwannoma

International Journal of Integrated Health Sciences VOL 1, NO 1, July (2013)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To study the transformation point of meningeal and periosteal dural at the porus of internal acoustic canal (IAC) in order to verify the different thickness of meningeal and periosteal dura in vestibular schwannomas (VS). Methods: Three IAC cadaver specimens and ten samples of VS patients from porus were obtained and analyzed. Samples were stained by using Masson trichrome technique after cutting in 6 micron of thickness. The samples were then observed under light microscopes to understand the meninges pattern in the IAC. Results: The meningeal dura is becoming thin at the porus and disappears at the meatal portion to form epineurium. However, the periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick and forms a pseudo-capsule in the middle of meatus, known as perineurium. The residual nerve filament was compressed by the tumor parenchyma. Between the tumor and nerve interface, three or more perineureal layers are seen. The perineurium in the cisternal portion was consistently loose and forms the tumor and arachnoid nerve interface. Almost all the nerve filaments are displaced to the tumor periphery near the pseudocapsule. In contrast, the periosteal dural of VS is becoming thin and disappear nearby the middle of meatal portion. This changing site establishes “meningo-periosteal ring” of VS because of the encircling nearby the porus. Conclusions: In IAC, the meningeal dural becomes thin. The periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick, joins perineurium and forms pesudocapsule near the porus, but the periosteal dura disappeared. This changing point is called meningo-periosteal ring.     Keywords: Meningeal,  periosteal, porus, vestibular schwannomasDOI: 10.15850/ijihs.v1n1.104

Penatalaksanaan emergensi pada trauma oromaksilofasial disertai fraktur basis kranii anterior

Majalah Kedokteran Gigi Indonesia Vol 3, No 2 (2017): August
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

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Abstract

Emergency management of oromaxillofacial trauma with anterior cranial base fracture. Oromaxillofacial trauma with cranial base fracture is a case that is quite commonly found in the ER of Oral and Maxillofacial Surgery Department at Dr. Hasan Sadikin General Hospital Bandung. Emergency management aims to take any appropriate action, prevent complications, and consult to other departments involved. A man aged 28 years came with bleeding from the mouth due to a motorcycle accident approximately 6 hours before admission to the hospital. Physical examination showed facial asymmetry, bilateral periorbital edema and hematoma, rhinorrhea, and stitches in labiomental area. Intraoral examination showed maxillary, palatal, parasymphisis, dentoalveolar fractures, lacerated wound on the upper lip, lower lip, palate, gingival, difficulty in opening the mouth, and malocclusion of the teeth. Immediate and rapid surgical and maxillofacial surgical emergency was performed with minimal maxillary intervention, aiming to prevent persistent spontaneous cerebrospinal fluid leak, and prevent infection. The management of soft tissue and hard tissue injury is by reduction, fixation and immobilization of fractures, management of pain and administration of antibiotics. In conclusion, the emergency management of oromaxillofacial trauma with cranial base fracture is promptly and rapidly carried out with minimal intervention.ABSTRAKTrauma oromaksilofasial disertai fraktur basis kranii merupakan kasus yang cukup banyak ditemukan di Instalasi Gawat Darurat Bedah Mulut dan Maksilofasial RSUP Dr. Hasan Sadikin Bandung. Penatalaksanaan emergensi bertujuan untuk melakukan tindakan yang tepat, mencegah komplikasi, serta konsultasi kepada bagian lain yang terkait. Seorang laki- laki usia 28 tahun datang dengan keluhan perdarahan dari mulut akibat kecelakaan motor kurang lebih 6 jam sebelum masuk rumah sakit. Pemeriksaan fisik ditemukan wajah asimetris, edema dan hematoma pada regio periorbita bilateral, terdapat rhinorrhea, serta bekas jahitan pada regio labiomental. Pemeriksaan intra oral tampak fraktur pada daerah maksila, palatum, parasimfisis, fraktur dentoalveolar, vulnus laserasi pada bibir atas, bibir bawah, palatum, gingiva, kesulitan membuka mulut, dan maloklusi gigi geligi. Tindakan emergensi bedah mulut dan maksilofasial dilakukan segera dan cepat dengan minimal intervensi pada rahang atas bertujuan untuk mencegah kebocoran cairan serebro spinal persisten, dan mencegah terjadinya infeksi. Manajemen luka jaringan lunak dan jaringan keras, melakukan reduksi, fiksasi dan imobilisasi fraktur, manajemen nyeri serta pemberian antibiotik. Penatalaksanaan emergensi pada trauma oromaksilofasial disertai fraktur basis kranii dilakukan segera dan cepat dengan minimal intervensi.

Anterior Interhemispheric Approach for Olfactory Groove Meningioma

International Journal of Integrated Health Sciences VOL 4, NO 2, September (2016)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To evaluate the surgical technique with bifrontal interhemispheric approach for total removal of tumor in olfactory groove meningioma (OGM). Methods: This study described a case of a 38-year-old woman with bilateral blindness, anosmia, and behaviour changes. Imaging studies show a tumor mass in midfrontal base. Surgery using a bifrontal interhemispheric approach was performed and total removal was achieved and postoperative computed tomography (CT) scan was performed to confirm the result. Histopathological findings established a diagnosis of meningioma.Results: A coronal skin incision behind the hairline was utilized. The scalp was elevated, taking care to reserve the vascularized pericranium medial to the linea temporalis of each side, and preserving the 2 supraorbital nerves. Eight burr holes were used, with the two initial holes made on each side of the orbitotemporal region, and the other four holes at the midline. A bifrontal craniotomy was performed. The tumor was first detached from its attachment with bipolar cautery and debulked. During this step, the main tumor feeder arteries from the anterior and posterior ethmoidal artery were interrupted, and the tumor devascularized. Total tumor removal through surgical intervention was achieved and confirmed by head CT-scan postoperatively.Conclusions: This case report supports the suitability of the bifrontal interhemispheric approach for OGM resection with additional radiation therapy.Keywords: Anterior interhemispheric approach, olfactory groove meningioma DOI: 10.15850/ijihs.v4n2.838