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Journal : Jurnal Medika Veterinaria

The Effect of Propofol on Onset and Sedation in Diabetic Mellitus Rat (Rattus norvegicus)

Jurnal Medika Veterinaria Vol 8, No 2 (2014): J. Med. Vet.
Publisher : UNIVERSITAS SYIAH KUALA

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Abstract

This research aimed to examine the time of onset and sedation on diabetic mellitus (DM) rat (Rattus norvegicus) by propofol. This study used 8 female wistar rats 2-3 months old and 150-200 grams of bodyweight, fed with standard feed and water ad libitum. Samples were divided into two groups. Group 1 (KI) as a control group was injected intraperitoneally with aloxan solvent and group 2 (KII) was injected intraperitoneally with 150 mg/kg bodyweight aloxan. Blood glucose was checked 10 days after aloxan injection, DM was categorized if the blood glucose over 150 mg/dl. All rats were injected intravenously with propofol 1% with the dose of 10 mg/kg bodyweight. Onset and sedation time was counted using stopwatch after propofol injection. The result showed that mean (±SD) of onset on KI and KII were 1.39±0.49 and 8.64±1.23 seconds, consecutively and they were significantly different at P<0.01. Whilst mean (±SD) of sedation KI and KII were 12.12±1.47 minutes and 7.62±1.61 minutes, respectively. The onset and sedation time of KI was significantly different from KII P<0.01. The conclusion of this research was DM affects time of onset and sedation when wistar strain rats were anesthetized by 1% propofol.Key words: rats, diabetic mellitus, propofol, onset, sedation

EFEK PENGGUNAAN KETAMIN-XILAZIN DAN PROPOFOL TERHADAP DENYUT JANTUNG DAN PERNAFASAN PADA ANJING JANTAN LOKAL (Canis familiaris) (Effect of Ketamine-Xylazine and Propofol on Heart Rate and Breathing Frequency of Local Male Dog (Canis familiaris))

Jurnal Medika Veterinaria Vol 10, No 1 (2016): J. Med. Vet.
Publisher : Universitas Syiah Kuala

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Abstract

The purpose of this study was to determine the effect of using ketamine-xylazin and propofol on heart rate and breathing in local male dogs (Canis familiaris). Six male dogs with average body weight ±2-3 kg were divided into 2 treatment groups, each group was subcutaneously injected with of atropine sulfate at dose of 0.04 mg/kg as premedication prior to anesthetic administration. The first group (K1) was intravenously injected with anesthetic combination of ketamine-xylazine at dose of 5.5 mg/kg and 1 mg/kg, respectively. The second group (K2) was given propofol at dose of 6.6 mg/kg intravenously. The heart rate and breathing were directly calculated using stethoscope and stopwatch with 10 minutes interval. Data were analyzed statistically using analysis of variance (Anova) with split-splot design and if there is a difference between the two groups followed by least significant difference test (LSD). The administration of ketamine-xylazin (K I) significantly (P<0.05) increase the respiratory frequency compared to propofol administration (K2). The interaction between time and precise observation of K1 and K2 on 30 minute observation (W3) showed significant differences (P<0.05). While on other time observations did not reveal any differences in the interaction between time and observation (P>0.05). It can be concluded that there is no difference effects of given ketamine-xylazin and propofol against heart rate on local male dogs. But there was difference effect of administration ketamine-xylazin and propofol on respiratory frequency on local male dogs.

Co-Authors . Amiruddin . Rusli A. A. R, Muhammad Taufik Abdul Rahim Abdul Rohman Afif Bintoro Agung, Putra Sunan Ahmad Fali Oklilas Ahmad Heryanto, Ahmad Ahmad Siswantara, Ahmad Ajib Susanto Al Azhar Alexander A. S. Gunawan, Alexander A. S. Alexander Richard, Alexander Alfian Noor Alimuddin Alimuddin Aman Sentosa Panggabean Amiruddin Amiruddin An Nisa, Redda Andayani, Ratih Diah Anderes Gui, Anderes Andy Andy Antonius Surbakti Antoro, Marwin Didik Ariusmedi, Ariusmedi Arman Sayuti Arneliwati, Arneliwati Arsindho, Yoarga Asdi Agustar Asmayanti, Andi Nur Atmoko, Doni Prio Azhari Azhari Badillah, Clara Fin Bayhakki Bayhakki, Bayhakki budianto panjaitan Bukhory, M Ilham Al Daniel Daniel Day, Diasttri Wahyu Rahmah DENI NOVIANA Deris Stiawan Desvita, Yenny Dewi Fatma Dewi, Tri Isyani Tungga Dian Masyitha Effendi Effendi Eka Srimulyati, Eka Eko Harry Susanto Elsavira, Radhika Erina Erina Erlina, Junia Etriwati, . Eva Marliana, Eva Eviliony, Eviliony Fadillah Irwansyah, Fadillah Fathra Annis Nauli Fauzi, Maulidya Hafsari febriyanti, eka Firman, H Fitri, Yanuari Eka Florensa Rosani Purba Frastantie, Dilla Frengky, Frengky Gaanty Pragas Maniam, Gaanty Pragas Gunanti Gunanti, Gunanti Gunawan Wibisono Hamdan Hamdan Hamdan, Suhaivi Hamdani Hamdani Harison, Alya Nathasya Hariyani, Fifi Hasneli, Yesi Henri D. Henri, Henri D. Hidayat Asta, Hidayat Hidayat Hidayat Hutabarat, Utami Maulina Hutagalung, Sandi Christopher Ibnu Utomo Ichsan, Tahayati Imam Imam Irawan W Kusuma, Irawan W Isna’im, Isna’im Jendrius Jendrius Jimmy G. Jimmy, Jimmy G. Jumaini, Jumaini Khoiri, Kms. M. Shofuan Kiyatmoko, Tomi Konadi, Alfian Krisman Krisman, Krisman Kurniawan, Rizal Eko Kusuma, Afif Yuda Kusuma, Irawan W. Laili, Miftachul Larasati, Indah Kurnia Laraswati, Yeni Lavintang, Mutiara Lazuardi, Auzan Leo Satya Phangestu, Leo Satya Ligaya Ita Tumbelaka Maharani, Anizza Dyah Kartika Mardiana Mardiana Marinda, Hening Ayu Maulia, Rahmi Maulizar, Ria Mokhamad Fakhrul Ulum Monita Olivia morow, meutya silviana Muhammad Fachrurrozi Muhammad Fajri Muhammad Syaipul Hayat Mulyadi Adam, Mulyadi Mustafa Sabri Muttaqien Muttaqien, Muttaqien Nainggolan, Maria Sonya Nauli Nastiti, Mahardika Niniarty Z. Djamal, Niniarty Z. Nirwana, Nirwana Noor Hindryawati, Noor Nora Vera Amanda, Nora Vera Noviyanti, Dea Sella Nunuk Hariani Soekamto Nuraedah Nuraedah Nurchayati, Sofiana Nurjanah, Laras Azrisa Nurul Huda Nuzul Asmilia Pasuluran, Nirwanto Permana, I Pratiwi, Noviara Sindi Prima, Benny Putra, I Gusti Agung Ngurah Arphan Eka Putra, Sandra Utama Putri, Arum Cantika RAHMAT GUNAWAN Rahmawati Rahmawati Ramadhana, Cut Erika Ramalis, T R Ramandhan, Akbar Ramandhan, Akbar Ramandhan Reza Firsandaya Malik Rilla Gantino Rinidar Rinidar, Rinidar Riri Novayelinda Robert Faber Rosmiati Rosmiati Rossi Passarella rusita rusita Rusli Rusli Rustaman, N Y Safitroh, MHD. Ali Saktioto Saktioto, Saktioto salomo, Salomo Salomo, Salomo Saparudin Saparudin Sari, Reny Pamela Sariningrum, Arlita Sarmayanta Sembiring Satria, Neti Sella, Nur Sembiring, Anatasya Sikumbang, Dinda Jasmal Sinta, Dwi Siti Anisatur Rofiqah, Siti Anisatur Siti Rahmalia Sitra, Elian Sofyan, Suhikma Sri Angky Soekanto Sri Maryani Sudirman Sudirman Sugandi Yahdin Sugito Sugito Suib Awrus Sunit Hendrana Susanto, Ari Murti Susilawati, Tri Susita, Farida Sutarno Sutarno Syafitri, Syafitri Syafruddin Syafruddin Syahadat, Rachmat Syakbaniah Syakbaniah, Syakbaniah Syarief, Firman T Armansyah, T tasmi, cut nila Tasruddin Tasruddin, Tasruddin Teuku Reza Ferasyi Thoha Firdaus, Thoha Tjodi Harlim Tresna Soemardi, Tresna Triva Murtina Lubis Ulfa, Ruvida Umbu, Dany Usman Malik Utami, Ghiena Rifka Utari, Heta Vivi Oktaviani Wahdana Kusuma Sari, Wahdana Kusuma Wahid Gunarto, Wahid Wasisto Utomo Widodo Budiharto Widya Sari Wijanarto Wijanarto Winni Astuti, Winni Wisdiarman, Wisdiarman Woferst, Rismadefi Wolfgang Straka Wong Foek Tjong Wongso, Calista Wulandari Saputri, Wulandari Yanuar Yanuar, Yanuar Yulia Irvani Dewi YUNALDI, HEFRI Yurika, Yurika Yusmeri, Yusmeri Zoelkaranain, M Dicky Zuhendri, Zuhendri Zulfan Saam Zulkarnaen Zulkarnaen Zulnuraini, Zulnuraini Zuraidawati Zuraidawati, Zuraidawati