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Effect of VCO to leucocyte differential count, glucose levels and blood creatinine of hyperglycemic and ovalbumin sensitized Mus musculus Balb/c HANDAJANI, NOOR SOESANTI; DHARMAWAN, RUBEN
Nusantara Bioscience Vol 1, No 1 (2009): Nusantara Bioscience
Publisher : “Bioscience Community”, School of Graduates, Sebelas Maret University, Surakarta

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Handajani NS, Dharmawan R. 2009. Effect of VCO to leucocyte differential count, glucose levels and blood creatinine ofhyperglycemic and ovalbumin sensitized Mus musculus Balb/c. Nusantara Bioscience 1: 1-8. Chemical medicines and insulin candecrease glucose blood level on hyperglycemic patients with macro vascular side effect. Diabetes and allergy incidences are influencedby quality and quantity of leucocytes. Lauric acid within VCO reports decreased glucose blood level of diabetes and some allergyincidents. The purpose of the study is to know the effect of VCO on glucose blood level, differential leucocytes count and creatinineblood level on hyperglycemic and normoglicemic ovalbumin sensitized mice. Forty five (45) male (mice) of Mus musculus Balb/c withaverage weight of 35 g are divided into 9 groups with 5 repetitions, those are 4 non alloxan groups and 5 alloxan induced hyperglycemicgroups. On 22nd day to 36th day they are sensitize to ovalbumin as allergen. Blood sample was obtained by orbital vena using heparin asanti coagulant in order measuring glucose blood level by GOD method to 6 times, on 1st, 4th, 18th, 22nd, 32nd and 37th days, then aretested by ANOVA followed by DMRT 0.05. On 37th day, differential leucocytes are determined, blood level are counted, and thencompared to normal value. The result of this study were that within differential leucocytes count of hyperglycemic mice, neutrophilepercentage were much lower than the normal value (3.22%), and lymphocyte percentage were much higher than the normal value(94.54%). Consumed 0.003 mL/35 g VCO more 18 days decreased glucose blood level on hyperglycemic mice, decreased basophilepercentage of ovalbumin sensitized mice, normalized neutrophile percentage no increased creatinine blood level.
Decision to Choose Acupuncture Therapy for Degenerative Diseases among the Elderly at Ja’far Medika Hospital, Karanganyar -, Purwanto; Dharmawan, Ruben; Demartoto, Argyo
Journal of Health Promotion and Behavior Vol 1, No 2 (2016)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: Aging process results in biological, physical, and mental changes in the elderly. Degenerative diseases are common in the elderly. They can be treated by pharmacologic or non pharmacologic treatment. Acupuncture therapy potentially can be used as a complementary or alternative therapy to treat degenerative diseases in the elderly. This study aimed to investigate factors that determine the decision to choose acupuncture therapy for the degenerative diseases in the elderly at Ja’far Medika Hospital, Karanganyar, Central Java.SubjectsandMethod: This was a qualitative study with phenomenology approach. This study was conducted at Ja’far Medika Hospital, Karanganyar, Central Java, fromMarch to April 2015. Ten informants were selected for this study by purposive sampling. The data were collected by in-depth interview, observation, and document review.They were validated by source triangulation, and analyzed by Miles and Huberman method.Results: The sample consisted of 5 men and 5 women, aged 53 to 72 years old, with school attainment varying from primary school to university graduate. Job category included farmer, civil servant, and pensioner. The degenerative diseases that were treated by acupuncture therapy including post-stroke, hernia nucleous pulposus, and eyelid disorder.  Internal factors that determined the decision to choose acupuncture were motivation to recover, (religious) belief, and boredom to medical service. External factors that determined the decision to choose acupuncture included the quality of service, family support, trust in the therapist, and hospital image. According to the informants, the acupuncture therapy could help recover their health from the degenerative diseases. Most of them used acupuncture as a complementary treatment.Conclusion: Some internal and external factors determine the decision to choose acupuncture therapy for the degenerative health problem in the elderly. Acupuncture treatment is reported to help recover health in the elderly. Keywords: acupuncture, decision, degenerative disease, elderlyCorrespondence: Purwanto. Masters Program in Public Health, Sebelas Maret University. Email: Purwanto.akp@gmail.com. Mobile: 081393289784.Journal of Health Promotion and Behavior (2016), 1(2): 127-137https://doi.org/10.26911/thejhpb.2016.01.02.08 
Hubungan Kecanduan Online Game dengan Depresi pada Remaja Laki-laki Pengunjung Game Centre di Kelurahan Jebres Ariani, Sofi; Suwito, Djoko; Dharmawan, Ruben
Nexus Pendidikan Kedokteran dan Kesehatan Vol 1, No 1 (2012): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: The number of adolescent boys spending their time in the game center is growing considerably. Previous research revealed that online gaming addiction affected the physical and mental health. This study aims to seek the relationship between online game addiction and depression. Methods: This was a descriptive analytical research with a cross sectional approach. boys were sampled using purposive sampling method, based on inclusion and exclusion criteria. Depression was measured using BDI depression scale, while online game addiction was determined using Young’s questionnaire and Family Intimacy Instrument (CCI). Multiple logistic regression was used to analyse the relationship between online game addiction, depression and family intimacy using SPSS 17.0 for Windows. Results: The results indicated a positive relationship between online game addiction and depression among adolescent boys in Jebres village. Teenagers with online game addiction had 1.61 times greater the risk for depression than adolescent boys without online game addiction, although not statistically significant (OR=1.61; 95% CI=0.30 to 8.69) p=0.581). Result from analysis on family intimacy variable also showed non significant relationship with depression. Adolescent boys with low family intimacy had lower risk for depression (OR=0.44). However, online game addiction showed a greater relationship with depression than low family intimacy. Conclusions: There was a positive relationship between online game addiction and depression among adolescent boys in Jebres village although not statistically significant. The higher the level of addiction to online games, the higher the risk for depression. Keywords: Adolescent, Online game addiction, Depression, Family intimacy.
Hubungan antara Kecerdasan Emosi dengan Kecemasan dalam Menghadapi Ujian Nasional 2012 pada Siswa SMA Hapsari, Atika Puspita; Susilohati, Mardiatmi; Dharmawan, Ruben
Nexus Pendidikan Kedokteran dan Kesehatan Vol 2, No 1 (2013): Nexus Pendidikan Kedokteran & Kesehatan
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Anxiety can be experienced by students, especially during preparation for the national examination. Brain performance in learning among students with high anxiety will more likely to degrade. Anxiety can further cause emotion disturbance, sleeping interference, appetite and physical fitness decrease, hence increasing the possibility of failing the final exam. These problems can be anticipated by early identification, regulation, and management of the emotion disturbance. This study aimed to determine the relationship between emotional quotient with anxiety among high school students preparing the national examination. Methods: This was a cross-sectional study using descriptive and analytical approach. The study was conducted at SMA Negeri 1 Tanjung, Brebes, and purposively sampled 12th grade students in 2011/2012 school year. EQ scores were measured using EQ scale, while anxiety scores were measured using TMAS scale. Data were processed using SPSS 17.0 for Windows. Results: Of 287 eligible samples, only 51 students met the inclusion criteria. Analysis from Pearson’s product moment correlation showed an r value of -0,681 (p< 0.001). Conclusions: There was a negative relationship between emotional quotient with anxiety among students of SMA Negeri 1 Tanjung, Brebes preparing the 2012 national examination. Keywords: Emotional Quotient, Anxiety, High School National Examination
Pengaruh Ekspresi Emosi Keluarga terhadap Frekuensi Kekambuhan Pasien Skizofrenia di Rumah Sakit Jiwa Daerah Surakarta Prihandini, Irene Yunita; Sudiyanto, Aris; Dharmawan, Ruben
Nexus Kedokteran Klinik Vol 1, No 2 (2012): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Schizophrenia is a severe disease, with basic personality disorder, distortion the proccess of thought, sometimes have the feeling that he/she was being controlled by external powers, peculiar delusions, disturbing perception, and an affect which does not correspond to the actual situation. In Schizophrenia patients, there are degradation in the field of employment, socialization, and self-care function. Thus, the patient requires caregiver who could take care of him/her, especially when the disease is relapse. Methods: This research is analitical observational by its character with the case control study approach that held between June up to July 2012 in Rumah Sakit Jiwa Daerah Surakarta. It used purposive sampling by divide it into two inclusion criterisa, the caregiver inclusion criteria were (1) Schizophrenia patients family that accompany the patient in the Rumah Sakit Jiwa Daerah Surakarta (2) Schizophrenia patients family that live in the same house with the patient (3) Patient that currently 20-60 years old (4) Voluntarily become respondent in this research and have agreed the informed consent sheet, whereas the inclusion criteria for the schizophrenia patients was (1) relapse patient (2) no reccurrence patient. The sample fulfill (1) identity & informed consent sheet (2) emotion expression quesioner. There are 60 sample and analyzed by pearson test and paired sampel t-test with SPSS 17.0 program for windows. Results: According to the result, we have known that the significance level is 0.004 so (which is 0.004<0.01/0.05) the decision is to accept the hypothesis which was stated that there is a significant connection between the emotion expression with the frequency of recurrence Schizophrenia patients in Rumah Sakit Jiwa Daerah Surakarta. The average difference between the groups of high emotional expression and low emotional expression, t arithmetic (3.826 > t table 1.76) so that H0 could be rejected. Therefore, there is also significant difference in recurrence between the groups of high emotional expression and the low emotional expression. While r calculation in this research is 0.058, so the alternative hypothesis (Ha) which was stated that there is significant positive connection between the Emotional Expression (EE) with the frequency of reccurrence Schizophrenia Patients in Rumah Sakit Jiwa Daerah Surakarta is accepted. Thus, naught hypothesis (Ho) which was stated that there isnt significant positive between the family emotional expression (EE) and the frequency of recurrence is rejected. The direction of both variables is positive, that is if Schizophrenia patients family emotional expression is high then the frequency of recurrence must be high too, vice versa. Conclusions: The higher family emotional expression (EE) then the frequency of recurrence is must be higher too, vice versa.   Key words: Emotional Expression, Frequency of Recurrence 
Hubungan kecanduan online game dengan kecemasan pada remaja pengunjung game centre di Kelurahan Jebres Surakarta Putri, Asri Sukawati; Suwito, Djoko; Dharmawan, Ruben
Nexus Kedokteran Klinik Vol 2, No 2 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Perfection graphics technologies in online gaming becomes allure for players, especially for adolescents. Some previous studies have claimed that online gaming addiction can affect the physical and psychological players, one of which may cause anxiety. This study aims to prove the relationship between addiction to online games with anxiety. Methods: This is a descriptive analysis research with a cross sectional approach. Subjects were adolescents game centre visitor in the Jebres Village . The samples are adolescents of the age 12-21 years old. Samples were taken purposively sampling. Data collection techniques using the TMAS anxiety scale, the scale of online gaming addiction questionnaires and Family Intimacy Instrument. Data scores online gaming addiction, anxiety and family intimacy were analyzed with multiple logistic regression analysis model. Result : This research obtained 35 young males. The results of multiple logistic regression analysis showed that there is a positive relationship between online game addiction and anxiety in adolescents in the Village Jebres. Adolescents with online gaming addiction have a risk 2.86 times greater for anxiety than adolescents without online gaming addiction p = 0.212. (OR: 2.86 CI 95% 0.55 s / d 14.91). The results of this analysis also showed an association between family intimacy and anxiety. Adolescents with low family intimacy had 0.51 times the risk for anxiety with p = 0.440 (OR = 0.51). However, online gaming addiction pose a greater risk of experience anxiety than the risks posed by families with low intimacy. Conclusion : There is relationship between online game addiction and anxiety. The higher the level of adolescent addiction to online games, the higher the risk for anxiety. Keywords : adolescent, online game addiction, anxiety, family intimacy
Hubungan antara Kecemasan dengan Masa Menopause pada Wanita Harnani, Kharisma Setya; Indrayanto, Yoseph; Dharmawan, Ruben
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background : Menopause is the transition of the reproductive period to the nonreproductive period which happens in women due to the decreased levels of the esterogen and progesterone hormones. There are several symptoms during the menopause period such as physical symptoms, somatic disorders, sexual disorders, and physical disorders. This research aims to describe the relation between anxiety and menopause in women. Methodology : This research is observational analytic research with cross sectional approach. This research was conducted in Posyandu Lansia Dahlia RW XIX Nusukan, Posyandu Lansia RW XIV Nusukan, and Posyandu Lansia Pucangsawit. The samples of this research are the women who had no menstrual period for 1-2 years, women ≥ 40 years old which are not in menopause period yet (control), women with unpathological menopause, L-MMPI scores with “NO” answers < 10, and the women who are able to be the respondents to fill in and accept the informed consent. This research employs the purposive random sampling technique in which samples are selected based on the characteristics of the research inclusion and exclusion. The dependent variable in this research is menopause and the independent variable is anxiety. The subject of the research filled (1) the curriculum vitae and informed consent, (2) L-MMPI questionnaire to checked the respondent’s truthfulness in filling the questionnaire, (3) TMAS questionnaire to found out the anxiety scores. The data which were obtained  are 60 respondents, then the data were analyzed using Chi Square (x2) then Coeficient Contingency (C). Result : Based on the data analysis, p = 0.01 was obtained from α = 0.05 which means p < 0.05 and the relation is 0.317. Conclusion : Statistically, there is significant relation with weak correlation between anxiety and menopause period in women.   Keywords : Menopause, Anxiety 
Hubungan antara Penerimaan Diri dengan Kecemasan pada Wanita Menopause Dewanti, Dyah Mustikaningtyas; Indrayanto, Yoseph; Dharmawan, Ruben
Nexus Kedokteran Komunitas Vol 2, No 3 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Anxiety of menopausal women may appear because they have to adjust to the aging process. Anxiety will become pressure and burden if she always thinks negatively. Self-acceptance is the ability of individuals to accept themselves which is characterized by self-confidence and self-appreciation. Self-acceptance can reduce the possibility of a person to think of anything that can stimulate anxiety. This study aims to determine the relation between self-acceptance and anxiety of menopausal women. Method: This research was observational analytic study with cross-sectional approach by using purposive random sampling technique. This research was conducted from March to April 2013 at Posyandu Dahlia RW XIX Nusukan, Posyandu RW XIV Nusukan and Posyandu Pucang Sawit. The number of sample was 35 menopausal women who were appropriate to the inclusion criteria. The sampling of this research are the women who had menopause for 1-2 years, women with unpathological menopause, L-MMPI scores with “NO” answers <10, and the women who are able to be the respondents to fill in and accept the informed consent. The subject of the research filled (1) informed consent (2) curriculum vitae form (3) L-MMPI questionnaire to evaluate the respondent’s truthfulness in answering questionnaire (4) Berger’s Self-Acceptance Scale questionnaire to find out the self-acceptance score (5) Taylor Manifest Anxiety Scale questionnaire to find out the anxiety score. Data were analyzed using Pearson Product Moment correlation test through SPSS 17.00 for Windows. Result: Based on the data analysis, p = 0.0001 (p < 0.05) and Pearson correlation value (r) = -0.627. Conclusion: There is a strong negative correlation between self-acceptance and anxiety of menopausal women. Keywords: self-acceptance, anxiety, menopausal women  
Hubungan Ibu Hamil Perokok Pasif dengan Kejadian Ketuban Pecah Dini Dithyana, Icha; Soetrisno, .; Dharmawan, Ruben
Nexus Kedokteran Klinik Vol 3, No 1 (2014): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Premature Rupture of Membranes (PROM) is most important issues commonly encountered. Premature rupture of membranes can cause some complications for both mother and fetus and may increase maternal morbidity and mortality. The prevalence of smoking in Indonesia increase every year and 85.4% current smokers smoke in the home where their family members live with them, thus threatening the health and safety of the environment. This research aimed to analyze the correlation between pregnant passive smoker and premature rupture of membrane. Methode : This research is observational analytic research using case control approach. Total of 60 samples were selected with a fixed - disease sampling, are all expectant mothers and maternity patients at the RSUD Dr. Moewardi. Data were collected by interview and medical record. The data which is got then analyzed by the program Statistic Products and Service Solution (SPSS) for Windows Release 17.0 with the use of statistic test Chi Square. Result: There is a significant correlation between pregnant passive smoker and premature rupture of membrane where the results obtained by using statistical test Chi Square is p = 0.02 and OR= 3.5. Conclusion: Pregnant passive smoker is 3.5 times more risky for experiencing premature rupture of membrane than non-passive smoker. Keywords: Pregnant passive smoker, Premature Rupture of Membrane (PROM) 
Pengaruh Ekstrak Bengkuang (Pachyrhizus erosus) terhadap Kadar Kolesterol Total Darah Tikus Putih (Rattus norvegicus) yang Diberi Diet Tinggi Lemak Tunikasari, Atma Sanggani; Suhanantyo, .; Dharmawan, Ruben
Nexus Biomedika Vol 3, No 1 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Background : Cardiovascular disease is the leading cause of disability and death in the world. High levels of blood cholesterol becoming a risk factor in atherosclerosis is the leading cause of cardiovascular disease. Yam Bean contains flavonoids, isoflavones, phenols, and saponins which have an effect of antihyperlipidemia. This study aimed to determine the effect of Yam Bean (Pachyrhizus erosus) extract on blood total cholesterol level of rats (Rattus norvegicus) with a high fat diet. Methods : This research was an experimental laboratoric research using the post test only with control group design. The research subject were 30 male white rats, Sprague Dawley strain, 2 months old, and their weights were about 130-240 gram. The subjects were arranged into 6 groups. The whole groups were adapted for 7 days. All groups except normal control, were administered high fat diet 2 ml/200 gram BW/day for 21 days. The positive control group was administered 0.18 mg/200 g BW/day of simvastatin and the negative control group was administered 2.00 ml/200 g BW/day of distilled water. While the first, second and third treatment groups were consecutively administered 70 mg, 140mg and 210 mg/200 g BW/day of Yam Bean extracts. On the 22nd day, the blood samples of the subjects were taken from pre-orbital plexus for measurement of cholesterol levels. Then, the data were analyzed using One-way ANOVA test and Least Significance Difference test (LSD). Results : The One-way ANOVA test showed a significant difference in blood total cholesterol level among six groups (p = 0.001). Post Hoc Test showed a significant difference among two groups, except the third treatment group which had the same result and the normal control groups (p = 0.335). Conclusion : Yam Bean (Pachyrhizus erosus) extract had effect to decrease the blood total cholesterol levels of rats. Keywords : Yam Bean (Pachyrhizus erosus) extract, total  cholesterol levels, white rats.