Mira Dewi
Departemen Gizi Masyarakat, Fakultas Ekologi Manusia (FEMA), Institut Pertanian Bogor, Bogor 16680

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RESISTENSI INSULIN TERKAIT OBESITAS: MEKANISME ENDOKRIN DAN INTRINSIK SEL

Jurnal Gizi dan Pangan Vol 2, No 2 (2007): Juli 2007
Publisher : Jurnal Gizi dan Pangan

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Abstract

The number of obese individuals worldwide has reached 2.1 billion and this will lead to explosion of obesity-related morbidity and mortality. Obese individuals will develop re­sistance to celluler action of insulin. The obesity related insulin resistance is the major risk factor of cardiovascular diseases and Type 2 Diabetes Mellitus, the disease which number has reached epidemic proportion. The association between obesity and insulin resistance seem to be cause and effect relation because studies on human and animal has indicated that the increase or decrease of body weight correlates with insulin sensitivity.  Among of many mechanisms proposed, the most often proposed mechanisms are endocrine and cell in­trinsik mechanism. The increase of fatty acid plasma concentration, dysregulation of adi­pokines and ectopic fat storage are proposed to be the endocrin mechanism that lead to obesity related insulin resistance while oxidative stress and mitochondria dysfunction are the cell intrinsic mechanisms that play role to the disease. Understanding the molecular mechanisms of obesity related insulin resistance will provide valuable information to search for interventions that help to prevent or treat Type 2 Diabetes Mellitus and cardiovascular diseases and its related pathologies. Keywords: Obesity, insulin resistance, fatty acid, adipokines, oxidative stress, mitochondria

Mikroenkapsulasi Mineral Besi dan Seng dalam Pembuatan Makanan Tambahan untuk Balita Gizi Kurang

Jurnal Ilmu Pertanian Indonesia Vol 16, No 3 (2011): Jurnal Ilmu Pertanian Indonesia
Publisher : Institut Pertanian Bogor

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As a health problem, prevalence of severe underweight in Indonesia is still high. Riskesdas 2008 indicate that prevalence of severe underweight and underweight in Indonesia are 5.5% and 13.0%, respectively. Effort to overcome that problem are still focused on severe underweight children, so need to anticipate of getting worse of underweight ones of being fell into severe underweight. The aim of this research is to make RUF fortified by encapsulated iron and zinc to overcome underweight balita (under five of age children). First step of this research is making flour from rice, soybean, cassava, sweet potato and taro with proceeded by two kinds of treatment, i.e. physic method (using high temperature and pressure) and soaking in solution of Na2HC03 (1.5% and 2.0%). Drum dryer was applied to dry the ingredient (rice, soybean, cassava, sweet potato and taro) and then milled using disc mill. Microencapsulation of iron and zinc was using arabic gum and maltodextrin (80:20 and 70:30) and concentration of iron or zinc each is 5.0% and 7.5%. Then, assays of stability of microencapsulated iron and zinc, and their bioavailability (in vitro and in vivo). Before mixed with minerals, 12 combinations of flour (3 kinds of tuber x 2 cooking time x 2 concentration of Na2C03) are tested by hedonic test to choose the best preferences of that combination of ingredients of porridge. Based on technical, economical, and technological considerations, and acceptability, mixed of rice, soybean, and sweet potato is selected as based ingredients of porridge. There is no color and odor change or even crystalline forming during more than one month of storing of microencapsulated iron and zinc. Bioavailability (in vitro) of Fe is around 15,48% to 17,05% and Zn is around 6.05% to 6,36%.   Keyword: Ready-to-use food, encapsulated mineral, porridge, underweight balita.

HUBUNGAN ANTARA ASUPAN ASAM LEMAK TRANS DENGAN PERSEN LEMAK TUBUH DAN STATUS GIZI PADA ORANG DEWASA DI KABUPATEN DAN KOTA BOGOR

Jurnal Gizi dan Pangan Vol 7, No 3 (2012): November 2012
Publisher : Jurnal Gizi dan Pangan

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Abstract

ABSTRACTThe objective of this study was to determine relationship between trans fatty acid intake with percentage of body fat and nutritional status among adults in Bogor rural and urban area. The research was conducted using a cross sectional study. The number of subjects for each region was 48 adults aged 20—65 years which selected purposively. The results showed that most of subjects in urban and rural areas were in categorized as high deficient of energy (0.05) between trans fatty acid intake, adequacy level intakes of energy, total fat, trans fatty acid, and body fat percentage. However there was a significant difference between nutritional status of subjects in rural and urban areas (p0.05), but there was significant correlation between body fat percentages and nutritional status of subjects (p0.05). Terdapat perbedaan yang nyata antara status gizi subjek di wilayah kabupaten dengan wilayah kota (p0.05), akan tetapi terdapat hubungan yang signifikan antara persen lemak tubuh dengan status gizi subjek (p

POLA AKTIVITAS, KONSUMSI PANGAN, STATUS GIZI DAN KESEHATAN ANAK JALANAN DI KOTA BANDUNG

Jurnal Gizi dan Pangan Vol 4, No 2 (2009): Juli 2009
Publisher : Jurnal Gizi dan Pangan

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Abstract

The objective of the research was to analyze activity pattern, dietary consumption, nutritional status and health of street children in Bandung. Cross sectional design was used in this study to elaborate activity pattern, food consumption, nutritional status and health of street children in Bandung. Samples of street children was recruited by purposive sampling from eight NGOs in Bandung with following criterias: 1) 5-18 years old 2) spend time on the street at least four hours a day 3) work for living on the street, commonly as singers, beggars, shoe-polisher, porters etc. The result showed that most of the street children worked as singers, spend 4-8 hours a day and 4-6 days a week. The average energy and protein adequacy level of street children was in light deficit category, iron and vitamin C were in low category and vitamin A was in sufficient category. Almost all of the street children had normal nutritional and health status and good personal hygiene. There was no correlation between activity and duration of street children with nutrition adequacy level. There was no correlation between personal hygiene and nutritional status with health status.             Keywords: street children, nutritional status, health status, pattern activity, food consumption

EFEKTIVITAS PEMBERIAN CGF 40% DALAM MEMPERCEPAT PENINGKATAN TROMBOSIT PADA PENDERITA DEMAM BERDARAH DENGUE

Jurnal Gizi dan Pangan Vol 5, No 3 (2010): November 2010
Publisher : Jurnal Gizi dan Pangan

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Abstract

Aim of this study was to evaluate the effectiveness of CGF 40% in hastening the recuperation, as indicated by reduced length of hospital stay, improvement in clinical status, increase in platelets, and reduction in the hemoconcentration. The study group comprised of 84 consecutive DHF patients, 42 male and 42 female subjects, who were randomized into the control group receiving the WHO standard therapy and the intervention group receiving CGF 40% and the standard therapy. Hemoglobin, hematocrite and thrombocyte counts were taken daily until the subjects were free of the symptoms and signs of DHF, and the thrombocyte count read >100.000. The results were analyzed statistically, student t test and quadratic regression, using SPSS 16 software. The average length of recuperation time in the intervention and control groups were 2.76 days and 4.43 days respectively (p=0.000). Recuperation times of subjects with thrombocyte counts 50,000 of the intervention group (3,09 and 2,37 days) and the control group (4,2 and 4,5 days) were different significantly (p=0.016 and 0.000). When analized specifically in the treatment group, the recuperation time of those with thrombocyte counts 50,000 (3.09 days) with p=0.112. Using quadratic regression, the increase in thrombocytes, reduction in hemoglobin concentrations and hematocrite were faster in the intervention group when compared to the control group, with R2 almost reaching 1. The study disclosed that administration of CGF 40% could reduce the recuperation time and improved the hemoconcentration, which presumably demonstrated the concept of regenerative medicine as indicated by the repairmen of vascular permeability. Key words: Chlorella  Growth  Factors (CGF),  green algae, dengue  fever, and regenerative                   medicine.

INTERVENSI ISOFLAVON KEDELAI TIDAK BERPENGARUH TERHADAP STATUS INFLAMASI DAN IMUNITAS PADA REMAJA DENGAN KEGEMUKAN

Jurnal Gizi dan Pangan Vol 5, No 1 (2010): Maret 2010
Publisher : Jurnal Gizi dan Pangan

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Abstract

Overweight/obesity is a condition that has been proven to be interrelated with chronic inflammation and compromised immune system due to disregulation of adipocytokine. The aim of the present study was to evaluate the effect of soy isoflavone on the markers of inflammation and immunity of overweight or obese teenagers. Eighteen overweight or obese teenagers, 9 boys and 9 girls each sex were randomized to one of three  intervention groups; 0 ml, 150 ml and 300 ml soy milk, equal to 0 g, 25 g and 50 mg isoflavone everyday for 30 days. The data collected were food consumption, plasma isoflavone concentration, plasma IL6 as indicator of inflammation, and lymphocyte and NK cell count as indicator of immunity. The study showed that nutrient intake of samples were still relatively low. The soy milk intervention significantly increased plasma isoflavone concentration, but not significantly had contribution to the plasma IL6 concentration and lymphocyte and NK cell count. Several kind of food consumed by samples had contribution to the plasma isoflavone concentration, and lymphocyte count. Based on the results, it was suggested that soy isoflavone intervention does not affect the inflammation status and immunity of overweight/obese teenagers.   Key words: Overweight/obesity, teenagers, soy isoflavone, inflammation, immunity

NUTRIENTS INTAKE AND NUTRITIONAL STATUS OF STREET CHILDREN IN BANDUNG

Jurnal Gizi dan Pangan Vol 5, No 3 (2010): November 2010
Publisher : Jurnal Gizi dan Pangan

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Abstract

The objectives of this research were to analyze food habits and nutrients intake, and health and nutritional status of street children. The research was carried out in the City of Bandung, West Java; Indonesia. A sample of 324 street children was selected randomly. The sample consisted of 232 boys and 92 girls. The data obtained from questionnaires. Means, standard deviation, frequency and proportion were calculated with a combination of software applications:  Microsoft Excel and Statistical Analysis System. The result showed the level of consumption adequacy did not meet the recommended dietary allowances i.e. with the shortage of 10-15%, this is an indication that the street children should be aware of their daily food consumption. The most common diseases suffered by the respondents were acute respiratory infections (ARI) (47%). In addition, 22.7 % and 18.4 % of them suffered from diarrhoea and skin diseases, respectively. Blood haemoglobin status of street children shows that the incidence of anemia was 29.3%. Based on the classification of nutritional status, 42.7% and 80.4 % of street children were underweight and stunted, respectively. Key words: nutrients intake, nutritional status, street children

NILAI INDEKS GLIKEMIK BEBERAPA JENIS PENGOLAHAN JAGUNG MANIS (Zea mays saccharata Sturt)

Jurnal Gizi dan Pangan Vol 6, No 1 (2011): Maret 2011
Publisher : Jurnal Gizi dan Pangan

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Abstract

The implementation of glycemic index can be used as basis for selecting carbohydrate food source to enhance and or to maintain health. The objective the following study was to analyze the glycemic indices of sweet corn with three different cooking methods.  Glycemic index values of boiled, sauted and grilled sweet corn were 41.22, 31.08 and 55.31 respectively. Based on those results, grilled sweet corn was classified as food with medium glycemic index, whereas both of boiled and sauted sweet corn were classified as food with low glycemic index. Key words: glycemic index, sweet corn

HUBUNGAN STATUS GIZI DAN TEKANAN DARAH DENGAN KADAR C-REACTIVE PROTEIN DARAH PADA SUBJEK DISLIPIDEMIA

Jurnal Gizi dan Pangan Vol 8, No 1 (2013): Maret 2013
Publisher : Jurnal Gizi dan Pangan

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Abstract

ABSTRACTThe objective of this study was to analyze the association of nutritional status (Body Mass Index, waist circumference, waist-hip ratio, and body fat mass) and blood pressure with inflammation status which was assessed by blood C-reactive protein level in dyslipidemic subjects. The study design was cross sectional survey involving 81 dyslipidemic subjects in Bogor. The study showed that there were significant correlations between BMI, waist-hip ratio, body fat mass, and diastolic blood pressure with blood CRP level (p<0.05). In conclusion, the higher percentage of over nutritional status, body fat mass, and diastolic blood pressure, the higher status of inflammation.Keywords: blood pressure, body fat mass, C-reactive protein, dyslipidemia, nutritional statusABSTRAKTujuan penelitian ini adalah untuk menganalisis hubungan status gizi berdasarkan Indeks Massa Tubuh (IMT), lingkar pinggang, rasio lingkar pinggang pinggul dan persen lemak tubuh serta tekanan darah dengan status inflamasi yang ditentukan dengan kadar C-reactive protein (CRP) darah pada subjek dislipidemia. Desain penelitian adalah survei potong lintang, melibatkan 81 subjek penderita dislipidemia di wilayah Kota dan Kabupaten Bogor. Hasil penelitian menunjukkan bahwa terdapat hubungan signifikan antara IMT, rasio lingkar pinggang pinggul, persentase lemak tubuh, serta tekanan darah diastolik dengan kadar CRP darah (p<0.05). Disimpulkan bahwa pada subjek penderita dislipidemia, semakin tinggi persentase status gizi lebih, massa lemak tubuh, dan tekanan darah diastolik semakin tinggi pula status inflamasinya.Kata kunci: C-reactive protein, dislipidemia, massa lemak tubuh, status gizi, tekanan darah

ASUPAN KALSIUM, STATUS GIZI, TEKANAN DARAH DAN HUBUNGANNYA DENGAN KELUHAN SENDI LANSIA DI PANTI WERDHA BANDUNG

Jurnal Gizi dan Pangan Vol 8, No 1 (2013): Maret 2013
Publisher : Jurnal Gizi dan Pangan

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Abstract

ABSTRACTThe objective of this study was to determine the relationship of calcium intake, nutritional status, and blood pressure to joint pain among elderly in nursing homes in Bandung. The study design was cross-sectional study. Subjects were consisted of 12 elderly men and 69 elderly women from four nursing homes in Bandung. Most subjects had joint pain (59.3%), hypertension (30.9%), and were overweight (39.5%). There was no significant relationship between frequency of consumption of calcium food sources and nutritional status, blood pressure, joint pain, and the level of joint pain (p>0.05). There was no significant relationship between joint pain and the level of joint pain with blood pressure and nutritional status.Keywords: blood pressure, calcium, elderly, joint pain, nutritional statusABSTRAKPenelitian ini bertujuan untuk mengetahui hubungan asupan kalsium, status gizi, dan tekanan darah terhadap keluhan sendi pada lansia di Panti Werdha Kota Bandung. Desain penelitian ini adalah cross-sectional. Subjek terdiri atas 12 lansia pria dan 69 lansia wanita dari empat panti werdha di Kota Bandung. Sebagian besar subjek mempunyai keluhan sendi (59.3%), hipertensi (30.9%), dan status gizi overweight (39.5%). Tidak terdapat hubungan yang signifikan antara frekuensi konsumsi pangan sumber kalsium dengan status gizi, tekanan darah, keluhan sendi, dan tingkat keluhan sendi (p>0.05). Tidak terdapat hubungan yang signifikan antara keluhan sendi dan tingkat keluhan sendi dengan tekanan darah dan status gizi.Kata kunci: kalsium, keluhan sendi, lansia, status gizi, tekanan darah*