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Character, Xanthone Content and Antioxidant Properties of Mangosteen Fruit’s Hull (Garcinia mangostana L.) at Several Fruit Growth Stadia Kurniawati, Ani; Poerwanto, Roedhy; Sobir, ,; Effendi, Darda; Cahyana, Herry
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol 39, No 3 (2011): Jurnal Agronomi Indonesia
Publisher : Bogor Agricultural University

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Abstract

The objective of this study was to evaluate the characteristics of mangosteen fruit’s hull, xanthone content, and antioxidant potential on various stadia of mangosteen fruit development. The experiment  was conducted in September 2006 until July  2008 using randomized complete block design, with three replications at maturation stage i.e. 1, 2, 3, and 4 months after anthesis. The parameters being observed were fruit’s hull characters, xanthone content, and antioxidant capacity.  The results of this study showed that fruit diameter and fruit weight increased until three months after anthesis and then did not change significantly once they entered the process of maturity. Thickness of fruit’s hull differed significantly among maturation stage. The thickness of fruit hull was observed at two months and the highest weight was at three months after anthesis. Xanthone content of mangosteen fruit’s hull at a month up to four months after anthesis did not differ significantly however capacity of antioxidant differed significantly among fruit ages, the IC50 values increased with the increase of fruit maturation.   Keywords: Antioxidant, fruit growth, fruit’s hull, mangosteen, xanthone
Evaluation of Fruit Characters, Xanthones Content and Antioxidant Properties of Various Qualities of Mangosteens (Garcinia mangostana L.) Kurniawati, Ani; Poerwanto, Roedhy; Sobir, ,; Effendi, Darda; Cahyana, Herry
Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Vol 38, No 3 (2010): Jurnal Agronomi Indonesia
Publisher : Bogor Agricultural University

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Abstract

Xanthone in mangosteen fruit hull has antioxidant activities. The objective of this experiment was to determine xanthones content, physical and chemical characters, and antioxidant potentials of several groups of mangosteens qualities. The experiment was carried out in January until August 2008. The research used a randomized complete block design with four replications. The treatments were four physical fruit conditions: large size mangosteens (≥ 100 g), small size mangosteens (min. 50 g), yellow sap dotted fruits, and scabbed fruit. The parameters being observed were physical and chemical characteristics, xanthone content, and radical scavenging activity of mangosteen fruit hull extract. The results demonstrated that the physical condition of fruit significantly affected physical fruit hull characters and chemical fruit characters. Characters of fruit hull, thickness, fresh weight, and dry weight, differed among fruit qualities. The physical condition of fruit hull also significantly influenced total soluble solid and vitamin C content, but did not affect total titrable acid and degree of acidity of the fruits. Fruit hulls of all groups of mangosteen qualities had similar antioxidant properties with the IC50 value of 5.57-6.11 ppm.   Keywords: benzophenone, vitamin C, yellow sap, scab
Antioxidant Activity of Garcinia cf bancana Miq Hartati, Sri; Triyem, .; Cahyana, Herry
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Research Gateway

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Abstract

Guttiferron F and essential oil were isolated from extract  n-hexane of  Garcinia cf bancana  Miq. Antioxidant activity was done by DPPH method to   n-hexane, methanol, ethyl acetate, n-butanol extracts and Guttiferron F, showed activity with IC50 24.5, 22.4, 29.2, 37.6 and 25.8 µg/mL respectively. The structure elucidation of Guttiferon F  based on spectroscopy data of IR, NMR of 1H and 13C.
Sintesis Ramah Lingkungan Senyawa Imina Turunan Vanilin dan 2-Hidroksi Asetofenon Serta Uji Aktivitas Biologi dan Antioksidan Pratiwi, Putri; Cahyana, Herry
Pharmaceutical Sciences and Research (PSR) Vol 2, No 1 (2015)
Publisher : Directorate of Research and Community Engagement, Universitas Indonesia

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Abstract

Eco-friendly synthesis of imine derivative compound from 2-hydroxy acetophenone and vanillin had been conducted by using a method of stirring (with stirrer) in a water solvent. The whole experiment began with the synthesis of imine compounds, followed by purification and characterization of the synthesis products and finally analysis on their biological and antioxidant activities. The experiments showed that imine compounds could be synthesized by a chemical reaction of 4-amino antipirin aqueous solution with 2-hydroxy acetophenone and vanillin at magnetic stirrer speed of 250 and 450 rpm, respectively, which produced product A, (E)-4-(1-(2-hydroxyphenyl) ethylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one and product B, (E)-4-(4-hydroxy-3-(vinyloxy) benzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one. Yield percentage (%) obtained from the synthesis of product A and B were 40.68% and 19.76% respectively. Toxicity and antioxidant activity tests showed that the product B were toxic and more active as an antioxidant than product A. While the antibacterial activity test showed that both products had a response to Staphyllococcus aureus bacteria and Escherechia coli bacteria.  
ISOLASI SENYAWA ANTIOKSIDAN DALAM EKSTRAK HEKSANA KULIT BATANG MANGGIS HUTAN (Garcinia bancana Miq.) Hartati, Sri; Masrukhan, Masrukhan; Cahyana, Herry
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 16, No 1 (2014)
Publisher : Research Center for Chemistry - LIPI

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Abstract

Antioksidan adalah suatu senyawa yang dapat menangkap radikal bebas. Salah satu sumber anti oksidan alami adalah dari tumbuh-tumbuhan. Dalam usaha pencarian antioksidan baru, telah dilakukan identifikasi senyawa antioksidan dari ekstrak n-heksana kulit batang Garcinia bancana Miq dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH). Metode isolasi dilakukan dengan cara  kombinasi kromatografi (Kromatografi kolom vacum, kromatografi kolom gravitasi, kromatografi lapis tipis  sentrifugal dan kromatografi lempeng tipis)  Penentuan struktur molekul berdasarkan analisis data spektroskopi UV-VIS, IR, LC-MS, NMR proton dan karbon. Dari  hasil isolasi didapatkan suatu senyawa isoprenil bezofenon dengan bobot molekul 466,22 dan  rumus molekul C28H34O6 dengan nama IUPAC 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil) bisiklo (3.3.1) non-3-ene-2,9-dione atau disebut bacanone yang diduga senyawa baru. Dari proses isolasi juga ditemukan senyawa atsiri b- caryophyllene, α-humulene dan b-cadinene serta stigmasterol. Hasil uji aktivitas antioksidan ekstrak n-heksana dan hasil isolat murni menunjukkan IC50 berturut-turut 17,78 ppm dan 12,79 ppm dimana pembanding kuersetin adalah 9,90 ppm.Kata kunci:  Garcinia bancana, antioksidan, DPPH, 3-(3,4-dihidroksibenzoil)-4-hidroksi-8-8-dimetil-1,7-bis(3-metilbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone. Antioxidants are compounds that can capture free radicals. One source of natural antioxidant is from plants. On searching  for new antioxidant, identification of antioxidant compound of the n-hexane extract of the stem bark of Garciniabancana Miq was done by  1.1-diphenyl-2-pikrilhidrazil (DPPH) method. Isolation active compound were done by combination of chromatographic methods (Flash column chromatography, gravitation column chromatography, cetrifugal thin layer chromatography and thin layer chromatography) .Determination of molecular structure by analysis spectroscopic data of UV-VIS, IR, LC-MS, NMR proton and carbon.Isolation results were      isophrenyl bezophenon with molecular weight 466.22 and the molecular formula is C28H34O6 IUPAC name 3 - (3,4-dihydroxybenzoil)-4-hydroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enyl) bicyclo (3.3.1) non-3-ene-2,9-dione or named bacanone wich is suspected as a new compound. From the isolation were also found of known volatile compounds b - caryophyllene, α-humulene and b-cadinene and stigmasterol. The test results of antioxidant activity of  n-hexane extract and pure compound  showed IC50 respectively 17.78 ppm and 12.79 ppm which comparison with  quercetin is 9.90 ppm. Key words :  Garcinia bancana Miq., antioxidant, DPPH, 3-(3,4-dihydroxybenzoil)-4-hidroxy-8-8-dimethyl-1,7-bis (3-methylbut-2enil)bisiklo(3.3.1)no-3-ene-2,9-dione, bacanone.
Antioxidant Activity of Garcinia cf bancana Miq Hartati, Sri; Triyem, Triyem; Cahyana, Herry
Indonesian Journal of Cancer Chemoprevention Vol 1, No 2 (2010)
Publisher : Indonesian Society for Cancer Chemoprevention

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Abstract

Guttiferron F and essential oil were isolated from extract n-hexane of Garcinia cf bancana Miq. Antioxidant activity was done by DPPH method to  n-hexane, methanol, ethyl acetate, n-butanol extracts and Guttiferron F, showed activity with IC50  24.5, 22.4, 29.2, 37.6 and 25.8 µg/mL respectively. The structure elucidation of Guttiferon F  based on spectroscopy data of IR, NMR of 1H and 13C.Keywords: Antioxidant, Garcinia  cf bancana Miq., Essential oil and  Guttiferon-F.