Selamat Budijitno
Staf Pengajar Bagian Bedah FK Undip Semarang

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HUBUNGAN KARAKTERISTIK (USIA DAN JENIS KELAMIN) DAN KADAR TRIGLISERIDA SERUM DENGAN KEJADIAN KARSINOMA KOLOREKTAL DI RSUP DR. KARIADI SEMARANG Kurahmawati, Anis; Mughni, Abdul; Budijitno, Selamat; Yudhanto, Eka
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background: Colorectal carcinoma ranked as 4th of the most deadliest cancer worldwide and 5th in Indonesia. The earlier research suggested that there was an association between age, sex, serum triglycerides levels, and the incidence of colorectal carcinoma. This study aimed to find out the association between characteristic (age and sex) and serum triglycerides leves with the incidence of colorectal carcinoma in Kariadi Hospital.Method: This was a case-control study. The samples were divided into two groups, the case and the control group. The case group included the patients was diagnosed with colorectal carcinoma in any stages between 2009-2011 while the control group included those who had the other diseases in digestive system. After selected by simple random sampling, the number of eligible samples according to the inclusion criterias was 30 for case and 78 for control. The Chi-Square and logistic regression test was used to analyse the data.Result: The Chi–Square test for serum triglycerides levels show that the value of p=0,312, with OR:1,643 (95% CI=0,642-4,326). For age logictic regression show that the value of significancy for 40-49, 50-59, ≥60 years age groups: p=0,095, p=0,267, p=0,287 respectively. The Chi–Square test for sex show that the value of p=0,006 (p<0,05), with OR: 3,641 (95% CI=1,4-9,468).Conclusion: serum triglycrides levels and age are negative risk factor colorectal carcinoma. Sex is significantly associated with the increased risk of colorectal carcinoma.Keywords: Serum triglycerides levels, age, sex, colorectal carcinoma
PERBEDAAN DERAJAT DIFERENSIASI ADENOKARSINOMA KOLOREKTAL PADA GOLONGAN USIA MUDA, BAYA, DAN TUA DI RSUP DR.KARIADI SEMARANG Ratnasari, Dian; Mughni, Abdul; Yudhanto, Eko; Budijitno, Selamat
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background : Nowadays, colorectal cancer was more oftenly found on patient in younger age which had worse prognosis than in older patient. Adenocarcinoma was a type of colorectal cancer which was oftenly found. Differentiation degree was a factor influenced colorectal cancer prognosis. The purpose of this study was to show that there was difference in differentiation degree of Adenocarcinoma colorectal between young, middle, and old age.Method : It was an observational analytic retrospective studies with cross sectional method. Patient’s medical records with diagnosis adenocarcinoma colorectal from Kariadi Hospital Semarang were classified into three groups, young age (≤40 years old), middle age(41-60 years old), and old age(>60 years old). Then, differentiation degree were noted . It was analyzed by chi-square test.Result : Analysis between age and differentiation degree shows that there is a significant difference with p=0,01. It also shows that the younger patient they are found the most in moderate-poorly differentiation degree, and the least they are found in well differentiation degree.Conclusion : There is a significant difference in differentiation degree of adenocarcinoma colorectal between young, middle, and old age in Dr Kariadi Hospital Semarang.Keyword: differentiation degree, adenocarcinoma colorectal, age
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KETERLAMBATAN BEROBAT PADA PASIEN PATAH TULANG YANG MENGGUNAKAN SISTEM PEMBIAYAAN JAMKESMAS (Studi Kasus di RS dr. Kariadi Semarang) Sari, Ayu Puspita; Priambodo, Agus; Pramono, Dodik; Yudhanto, Eka; Budijitno, Selamat
MEDIA MEDIKA MUDA 2012:MMM VOLUME 1 NUMBER 1 YEAR 2012
Publisher : MEDIA MEDIKA MUDA

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Background : Delayed treatments made bone fracture cases more difficult and required more intensive treatments. The Jamkesmas program was created to give the poor and the needy easy access to get health services.Aims : To analyze factors related to the delayed treatment on bone fracture patients who used Jamkesmas payment method in dr. Kariadi Hospital in Semarang.Methods : The type of this research is observational analysis with cross sectional design. The research was held from May 2012 until June 2012, at the Surgery in-patient installation of dr. Kariadi Hospital in Semarang. Interviews were conducted to patients by using questionnaires. Chi Square and Fischer exact test were used for the statistical test.Results : There are 90% of patients who do not have delayed treatment (< 72 hours) and 10% who have delayed treatment (> 72 hours). Most patients have low level of education (72%), sufficient level of knowledge about bone fracture (55,1%), good level of knowledge about Jamkesmas (69%), have good attitude toward bone fracture (96,6%), and have medical behaviors in searching for initial treatment of bone fracture (82,8%). Most of health facilities are affordable (96,9%). There is a significance between patient behaviors in searching for initial treatment of bone fracture (p<0.05) with the delayed treatment on patients who use Jamkesmas. There is no significance between the level of education (p>0.05), level of bone fracture knowledge (p>0.05), level of Jamkesmas knowledge (p>0.05), the affordable health facilities (p>0.05) and attitude toward bone fracture (p>0.05) with the delayed treatment on patients who used Jamkesmas.Conclusion : The patient behaviors in searching for initial treatment of bone fracture has a significant relationship with the delayed treatment on bone fracture patients who used Jamkesmas.Key words: delayed treatment, bone fracture, Jamkesmas
PERBEDAAN KUANTITAS PENGGUNAAN ANTIBIOTIK PADA ANAK DENGAN DEMAM TIFOID DI KELAS III DAN NON KELAS III RSUP. Dr. KARIADI SEMARANG PADA TAHUN 2011 Putri, Prastikha Rahmasari Vania; Hapsari, MMDEAH; Budijitno, Selamat
MEDIA MEDIKA MUDA Vol 2, No 1 (2013): MEDIA MEDIKA MUDA
Publisher : MEDIA MEDIKA MUDA

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Latar belakang :  Angka kejadian demam tifoid pada anak yang dari tahun ke tahun semakin meningkat, akan meningkatkan potensi penggunaan antibiotik yang lebih banyak. Perbedaan karakteristik kelas perawatan dapat menyebabkan perbedaan kuantitas penggunaan antibiotik. Kuantitas penggunaan antibiotik di rumah sakit akan dinyatakan dalam Defined Daily Doses/100 pasien-hari.Tujuan  : Penelitian ini dilakukan untuk mengukur dan membedakan kuantitas penggunaan kloramfenikol, seftriakson dan sefotaksim pada anak dengan demam tifoid di kelas III dan non kelas III RSUP Dr. Kariadi Semarang pada tahun 2011.Metode : Merupakan penelitian observasional klinik dengan desain cross sectional. Pengambilan data dengan consecutive sampling. Analisa data dilakukan dengan uji independent t test. Uji Mann-whitney apabila persebaran data tidak normal.Hasil : Kuantitas penggunaan antibiotik Kloramfenikol sebesar 30,51 DDD/100 pasien-hari (26,53 DDD/100pasien-hari kelas III dan 3,98 DDD/100pasien-hari non kelas III), Kuantitas Seftriakson sebesar 31,92 DDD/100pasien-hari (5,65 DDD/100pasien-hari kelas III dan 26,27 DDD/100pasien-hari non kelas III). Terdapat perbedaan kuantitas yang bermakna penggunaan kloramfenikol ( p = 0,00) dan seftriakson (p = 0,001) antara kelas III dan non kelas III.Kesimpulan :  Kloramfenikol lebih sering digunakan di kelas III dan Seftriakson lebih sering digunakan di non kelas III pada pasien anak dengan demam tifoid di RSUP Dr. Kariadi Semarang pada tahun 2011.
PERBEDAAN KUALITAS PENGGUNAAN ANTIBIOTIK PADA ANAK DENGAN DEMAM TIFOID DI KELAS III DAN NON KELAS III (Penelitian Di RSUP Dr. Kariadi Semarang pada Tahun 2011) Soegijanto, Wilma Monica; Hapsari, MMDEAH; Budijitno, Selamat
MEDIA MEDIKA MUDA Vol 2, No 1 (2013): MEDIA MEDIKA MUDA
Publisher : MEDIA MEDIKA MUDA

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Latar Belakang: Demam tifoid masih merupakan masalah kesehatan yang penting di berbagai negara berkembang, terutama Indonesia. Penggunaan antibiotik yang tidak rasional dapat menyebabkan resistensi bakteri terhadap antibiotik sehingga diperlukan evaluasi perbedaan penggunaan antibiotik terutama di ruang perawatan kelas 3 dan non kelas 3 di Bagian Ilmu Kesehatan Anak.Tujuan:  Penelitian ini dilakukan untuk mengetahui rasionalitas penggunaan antibiotic secara kualitas pada demam tifoid di kelas 3 dan non kelas 3 bangsal anak RSUP Dr. Kariadi pada periode Januari – Desember 2011.Metode:  Penelitian ini merupakan studi observasional klinik dengan design cross sectional. Kualitas dinilai dengan menggunakan kategori Gyssens, 2011. Uji beda menggunakan uji chi-square.Hasil: Rasionalitas penggunaan antibiotik secara kualitas pada pasien anak dengan demam tifoid pada kelas 3 bangsal anak RSUP Dr. Kariadi sebesar 43,6% dan pada non kelas 3 sebesar 8,1%. Proporsi rasionalitas penggunaan antibiotik pada kelas 3 bangsal anak RSUP Dr. Kariadi lebih tinggi dibangdingkan dengan non kelas 3.Kesimpulan: Terdapat ketidaktepatan penggunaan antibiotik terutama di non kelas 3 Bangsal Anak RSUP Dr. Kariadi.
Faktor Risiko Penyakit Ginjal Kronik Diabetes (PGK-DM) pada Diabetes Mellitus Tipe-2 (Studi di RSUD DR Soedarso Kota Pontianak Provinsi Kalimantan Barat) Rini, Sulistio; Hadisaputro, Suharyo; Lestariningsih, Lestariningsih; Nugroho, Heri; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

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Background: Prevalence of type-2 diabetes mellitus have increased significantly. The increasing number of people with diabetes has a major impact on the development of chronic diabetic kidney disease. The research was aimed to clarify several risk factors of chronic diabetic kidney disease on type-2 diabetes mellitus (CDK-DM).Method: The research was based on case control study design. The number of respondents was 140 respondents consisting 70 cases and 70 controls that met the criteria of inclusion and exclusion. The cases were patients with type-2 chronic diabetic kidney disease stadium 2-5. The controls were patients with type-2 chronic diabetic kidney disease with blood sugar levels ≥ 200 mg / dL. The data were then analyzed using logistic regression.Results: The result shows that risk factors of chronic diabetic kidney disease in type-2 diabetes mellitus are diabetes in family (OR = 6,732; 95% CI = 2,623- 17,276), high blood pressure (OR = 6,760; 95% CI = 2,190- 20,867), lack of physical activities (OR = 4,367 95% CI = 1,823-10,462) and lack of family support (OR = 4,203; 95% CI = 1,437-12,295). The probability of chronic diabetic kidney disease occurrence in type-2 diabetes mellitus when four risk factors exist are 96,71%.Conclusion: The host factors have important role of chronic diabetic kidney disease in type 2 diabetes mellitus . The factors proven to be risk factors for occurrence of chronic diabetic kidney disease in type 2 diabetes mellitus were diabetic in the family, Hipertension, poor physical exercise and family Support. 
Perbandingan Kadar Estrogen Serum dan TGF β-1 Plasma pada Penderita BPH-Non BPH di Atas 50 Tahun dan Usia Muda Nugroho, Eriawan Agung; Budijitno, Selamat
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACT Comparison of estrogen serum and TGF β-1 plasma levels in benign prostate hyperplasia (BPH) and non BPH patients, among 50-years old and young patients.Background: Benign prostatic hyperplasia (BPH) is often found in older men. This disease affects an estimated 70% of men over 60 years, increased by 90% in men over 80 years age. Many scientists tried explores the hypothesis of the mechanism of occurrence of BPH. The purpose of study compared the levels of estrogen and transforming growth factor (TGF) ß-1 in plasma related to the development of BPH, in BPH patients and non-BPH over 50 years and young age.Methods: A clinical analysis study was carried out on subjects who were divided into 3 groups: patients with BPH >50 years, non-BPH >50 years and younger non-BPH aged 30-40 years. T-test was used to analyze the data. Serum estrogen and plasma TGF β-1 were assessed using ELISA method.Results: There was no significant difference (p=0.129) between the level of estrogen in BPH patients >50 years (140.091±43.649) and non BPH patients >50 years (63.69±18.757) but there was a significant difference (p=0.015) between level of plasma TGF ß-1 BPH patients >50 years (10.47±4.507) and non BPH patients >50 years of age (25.8±16.1103). No significant differences (p=0.348) were found between serum estrogen level of non-BPH >50 years (63.69±18.757) and the young age (57.17±10.2748), and between plasma TGF ß-1 non-BPH group >50 years (25.80±16.1103) and the younger age group (31.4±17,576)(p=0.496).Conclusion: There is difference in the level of TGF ß-1 between younger and older age groups. Elderly men are recommended for early prostate examination, because at the age of 50 years there is already a tendency of enlarged prostate gland. Levels of transforming growth factor β-1 can predict prostate enlargement.Keywords: Estrogen, TGF ß-1, benign prostate hyperplasia (BPH)ABSTRAKLatar belakang: Benign prostate hyperplasia (BPH) sering ditemukan pada pria usia lanjut. Penyakit ini terjadi pada 70% pria di atas 60 tahun, dan meningkat hingga 90% pada pria di atas 80 tahun. Banyak ilmuwan mencoba mengetengahkan hipotesis faktor yang berpengaruh terjadinya BPH. Tujuan penelitian ini membandingkan tingkat estrogen dan transforming growth factor (TGF) ß-1 dalam plasma terkait pembentukan BPH.Metode: Penelitian klinik analitik dilakukan pada subyek yang dibagi 3 kelompok, pasien dengan BPH >50 tahun, pasien non-BPH berusia >50 tahun dan muda non-BPH berusia 30-40 tahun. Analisis data dengan uji beda kadar estrogen serum dan TGF β-1 plasma ketiga kelompok. Kadar TGF ß-1 dan estrogen diukur dengan metoda ELISA.Hasil: Serum estrogen pasien BPH usia >50 tahun (140,091±43,649) lebih tinggi tetapi tidak berbeda bermakna (p=0,129) dibandingkan non BPH usia >50 tahun (63,69±18,757). Estrogen serum non-BPH usia >50 tahun (63,69±18,757) dibandingkan usia muda (57,17±10,2748) tidak berbeda bermakna (p=0,348). TGF ß-1 plasma pasien BPH usia >50 tahun (10,47±4,507) lebih rendah (p=0,015) dibandingkan pasien non BPH usia >50 tahun (25,8±16,1103). TGF ß-1 plasma kelompok non-BPH >50 tahun (25,80±16,1103) dibandingkan kelompok usia muda (31.04±17,576) tidak berbeda bermakna (p=0,496).Simpulan: Ada perbedaan antara tingkat TGF β-1 pada kelompok yang lebih tua. Laki-laki usia tua disarankan lebih dini melakukan pemeriksaan prostat, usia >50 tahun cenderung didapatkan pembesaran kelenjar prostat. Pemeriksaan kadar TGF -1 dapat memprediksi risiko pembesaran kelenjar prostat.
Efektivitas Ekstrak Artemisia vulgaris sebagai Suplementasi terhadap Kemoterapi Adenokarsinoma Mammae dalam Meningkatkan IL-12 dan Indeks Apoptosis Sel Kanker (Studi pada Mencit C3H yang Diberi Regimen Kemoterapi Adriamycin-Cyclophosphamide) Paulus, Antonio; Budijitno, Selamat; Issakh, Benny
Jurnal Kedokteran Brawijaya Vol 30, No 2 (2018)
Publisher : Fakultas Kedokteran Universitas Brawijaya

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Insiden kanker payudara di seluruh dunia masih tinggi. Pembedahan tetap merupakan pilihan utama dengan modalitas lain berupa kemoterapi, radiasi, dan imunoterapi antara lain Artemisia vulgaris (AV). Penelitian dilakukan untuk membuktikan efek pemberian ekstrak AV terhadap kadar IL-12 dan indeks apoptosis sel kanker pada adenokarsinoma mammae. Penelitian ini menggunakan desain post test only control group design menggunakan 24 ekor mencit C3H betina yang dibagi secara acak menjadi empat kelompok, yaitu: K (kontrol), P1 (kemoterapi), P2 (ekstrak AV), dan P3 (kombinasi kemoterapi dan ekstrak AV). Adriamycin 0,18mg dan Cyclophosphamide 1,8mg diberikan sebanyak 2 siklus. Ekstrak AV diberikan 13mg (0,2ml) perhari. Kadar IL-12 dinilai dengan pengecatan imunohistokimia sedangkan indeks apoptosis dengan hematoxilin eosin. Rerata kadar IL-12 dan indeks apoptosis didapatkan K, P1, P2, P3 berturut-turut 60,28+1,54, 50,40+1,56, 75,40+1,46, 53,48+1,35 dan 2,18+0,80, 18,00+1,58, 3,34+0,51, 20,32+1,39. Analisis statistik menunjukkan terdapat perbedaan bermakna pada kadar IL-12 antara kelompok K vs P1, P2, P3 (p=0,001), P1 vs P2 (p=0,001), P1 vs P3 (p=0,028), P2 vs P3 (p=0,001) dan indeks apoptosis antara kelompok K vs P1, P3 (p=0,001), P1 vs P2 (p=0,001), P1 vs P3 (p=0,035), P2 vs P3 (p=0,001). Terdapat hubungan positif kuat yang signifikan antara kadar IL-12 dengan indeks apoptosis (p=0,041 dan r=0,893). Pemberian ekstrak Artemisia vulgaris dapat meningkatkan kadar IL-12 dan indeks apoptosis sel kanker pada mencit C3H dengan adenokarsinoma mammae yang diberi regimen kemoterapi Adriamycin-Cyclophosphamide.
Kadar Kortisol, Transforming Growth Factor β, serta Derajat Adhesi Pasca Laparoskopi dan Laparotomi Pribadi, Agung; Riwanto, Ignatius; Budijitno, Selamat
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

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Adhesi intraperitoneal pasca bedah abdomen terjadi pada 50-97% kasus adhesi, dengan penyebab terbanyak adalah laparotomi. Penelitian ini bertujuan membuktikan perbedaan dampak laparoskopi dan laparotomi terhadap derajat adhesi peritoneal, kadar kortisol dan TGF-β. Desain randomized control trial post test only diterapkan pada dua kelompok, yaitu kelompok laparoskopi dan laparotomi dalam anestesi umum. Sampel darah diambil sesaat sebelum dan 6 jam paska operasi untuk pemeriksaan kadar kortisol. Tujuh hari pasca operasi dilakukan terminasi, dilanjutkan laparotomi untuk penilaian adhesi intraperitoneal, dan pengambilan cairan peritoneum untuk pemeriksaan kadar TGF-β. Hasil penelitian menunjukkan ada perbedaan bermakna pada kenaikan kadar kortisol (rerata 20,03±1,550ng/ml), TGF-β (rerata 6.772,50±414,77pg/ml), dan derajat adhesi antara kedua kelompok (p=0,021, p<0,001, p=0,002). Terdapat korelasi positif kuat antara kadar kortisol denganTGF-β (p=0,030, r=0,632) dan korelasi positif yang signifikan antara kadar TGF-β dengan derajat adhesi (p=0,001, r=0,941). Penelitian ini membuktikan bahwa bedah laparoskopi dapat mengurangi peningkatan kadar kortisol dan TGF-β, serta insidens adhesi.
Komponen Sindrom Metabolik sebagai Faktor Risiko Penyakit Ginjal Kronik Stadium Terminal (Studi di RSUP Dr.Kariadi dan RSUD Kota Semarang) Ikawati, Kartika; Chasani, Shofa; Suhartono, Suhartono; Hadisaputro, Suharyo; Budijitno, Selamat
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 1: Februari 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

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Background: End Stage Renal Disease (ESRD) has been among the top ten list of non infectious diseases frequently found at RSUP dr. Kariadi and RSUD Kota Semarang. Risk factors for ESRD are metabolic syndrome components, which are having an upward trend. This study had an objective to provided an evidence of metabolic syndrome factors that became risk factors for ESRD.Method: This study applied an analytical observational method with a case control study design. The study used 90 respondents as samples, divided into two different groups: 45 respondents as case samples and 45 respondents as control samples with consecutive sampling. Variables in this study ware the individual characteristics and history of suffering from metabolic syndrome components. Data were collected by interview, medical record, and indepth interview. These data were subject to analyses using univariat, bivariate, and multivariate tests.Results: The study found the risk factors for ESRD as the followings: hypertension term of> 5 years (OR=10,89 and 95% CI=3,08-38,59; p=0,000), diabetes mellitus term of > 5 years (OR=3,84; 95% CI=1,20-12,30; p=0,023), and low HDL-cholesterol history of < 35 mg/dL(men) and < 40 mg/dL(women) with (OR=3.123, 95% CI=1.08-9.04; p=0,04). The indepth interview resulted in adequate knowledge of the respondents about the risk factors for ESRD.Conclusion: Risk factors for ESRD found during the observation were hypertension term of >5 years, diabetes mellitus term of >5 years, and low cholesterol HDL. To prevent theprogression of chronik kidney disease required strict control of metabolic syndrome.