Kamilah Budhi
Departemen Pediatri Fakultas Kedokteran Universitas Diponegoro/Rumah Sakit Umum Pusat Dr. Kariadi Semarang

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Hubungan Antara Derajat Asfiksia dengan Beratnya Hipokalsemia pada Bayi Baru Lahir Tohaga, Edwin; Budhi, Kamilah; Wijayahadi, Noor
Sari Pediatri Vol 16, No 1 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp16.1.2014.29-34.

Abstract

Latar belakang. Kalsium merupakan ion yang sangat penting untuk proses metabolisme biomolekular. Selama kehamilan, kalsium ditransfer secara aktif melalui kalsium transplasental yang diregulasi hormon parathyroid-related peptide (PTHrP). Hipokalsemia dapat menyebabkan gangguan neuromuskular, irama jantung apneu, dan gangguan gastrointestinal. Asfiksia dapat menurunkan kadar kalsium darah pada bayi baru lahir di bawah batas nadir. Pada asfiksia terjadi insufisiensi ginjal, metabolik asidosis, dan sekresi parathyroid hormon (PTH) kurang sehingga menurunkan kadar kalsium plasma.Tujuan. Mengetahui hubungan antara derajat asfiksia dengan beratnya hipokalsemia pada bayi baru lahirMetode. Desain penelitian observasional dengan pendekatan cross sectional pada bayi dengan asfiksia yang memenuhi kriteria inklusi dan eksklusi di bangsal perawatan bayi risiko tinggi Departemen Ilmu Kesehatan Anak RSUP Dr.Kariadi Semarang pada tahun 2012. Derajat asfiksia ditentukan berdasarkan nilai APGAR, yaitu asfiksia sedang dan berat, derajat hipokalsemia ditentukan berdasarkan nilai kadar kalsium serum. Analisis statistik dengan uji chi-square.Hasil. Subjek 66 bayi terdiri dari 29 bayi laki-laki dan 37 bayi perempuan, 20 bayi lahir kurang bulan dan 46 bayi lahir cukup bulan. Terdapat hubungan antara asfiksia dengan hipokalsemia (p=0,013). Hipokalsemia berat pada asfiksia berat PR 4,9, (IK95% 1,2-20,3; p=0,027), Hipokalsemia sedang pada asfiksia sedang PR 4,51(IK95% 1,3-14,6; p=0,009).Kesimpulan. Terdapat hubungan antara derajat asfiksia dengan beratnya hipokalsemia pada bayi baru lahir.
Factors That Related with Incomplete Children Immunization in Kuala Tungkal II Health Center yundri, yundri; Setiawati, Mexitalia; Suhartono, Suhartono; Setyawan, Henry; Budhi, Kamilah
Jurnal Berkala Epidemiologi Vol 5, No 3 (2017): Jurnal Berkala Epidemiologi
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V5I32017.361-370

Abstract

ABSTRACTImmunization is a program be done to protect a human body from diseases. In Tanjung Jabung Barat District, the completeness of mmunization has not reached in MDGs (> 93%). According to the health agency information, showed that the completeness of  immunization in West Tanjung Tabung regency (89%) and Kuala Tungkal II health Center (78%). The purpose of this research is to analyze factors that related with the status of basic Immunization. The type of research is qualitative method through indepth interview. This research uses cross sectional design. The research was be located on Kuala Tungkal II PHC in Tanjung Jabung Barat Regency. The population is all mothers who have children aged 12-24 months. Sampling is done by random sampling. The result showed that were a significant relationship between maternal education level (p = 0.007; OR 3.15; 95% CI 1.33-7.49), mother’s knowledge (p = 0.000; OR = 45.25; 95% CI 13.23-154.72), mothers attitude (p = 0.000; OR = 94.55; 95% CI 22.13-403.87), and mother’s motivate  (p = 0.000;  OR= 37.00 ; 95% CI 11.40-119.99) related to the child immunization status. It can be concluded that three variables have related to incomplete immunization. It is suggested that the health agency should improve the knowledge of health personnel in training that involves the basic immunization., so as to provide education to the public about the importance of complete basic immunization.Keywords: immunization, motivate, knowledge, attitude
Kadar Antioksidan Rendah Meningkatkan Risiko Hemolisis pada Sepsis Neonatus Budhi, Kamilah; Soemantri, Agustinus; Aminullah, Asril; Suhartono, Suhartono
Jurnal Kedokteran Brawijaya Vol 26, No 3 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2011.026.03.10

Abstract

Hemolisis  pada  neonatus  sepsis  terjadi  akibat  aktivasi  komplemen  yang  dipicu  oleh  reaksi  inflamasi  sebagai  respons terhadap  invasi  mikroba.  Penyebab  lain  meliputi:  proses    fisiologis,  kelainan  eritrosit  kongenital,  proses  imun,  stres oksidatif ,  obat  dan  enzim  hemolisin.  Penelitian  ini  bertujuan  untuk  membuktikan  hubungan  antara  kadar  antioksidan dengan kejadian hemolisis pada neonatus  sepsis. Penelitian dilakukan dengan desain observasional prospektif ,  nested case-control  pada  94  neonatus  sepsis  yang  terdiri  47  kelompok  kasus  (hemolisis  positif)  dan  47  kelompok  kontrol (hemolisis negatif). Hemolisis ditegakkan dengan kriteria indeks retikulosit > 3 pada hari ke 1 dan hari ke 3. Variabel yang diukur  meliputi: antioksidan  (GPx,  vitamin  E,  vitamin  C)  dan  oksidan  (MDA),  hemolisin.  Pemeriksaan  kadar  MDA,  GPx dengan  metode  spektrofotometri,  vitamin  C    metode  colorimetric  assay,  vitamin  E  metode  ELISA,  hemolisin  dengan media  agar  darah.  Data  dianalisis  dengan  Chi-square,  uji  t  tidak  berpasangan,  Mantel-Haenszel  dilanjutkan    regresi logistik. Hasil penelitian menunjukkan kadar GPx rendah (75µ/gHb), vitamin E rendah ((<17,8 µg/mL) merupakan faktor risiko signifikan terjadinya hemolisis dengan OR berturut-turut 6,14 ,  3,12. Kadar antioksidan rendah (GPx  dan vitamin E) merupakan  prediktor  kuat  terjadinya  hemolisis  pada  neonatus  sepsis.
RISK FACTORS FOR OROFACIAL CONGENITAL ANOMALIES IN NEONATES Radityo, Adhie Nur; Kosim, Muhammad Sholeh; Budhi, Kamilah; Santosa, Gatot Irawan; Rini, Arsirta Eka
Media Medika Muda Vol 1, No 1 (2016)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACTBackground. Orofacialanomalies are anatomical and physiological abnormalities in the structure of organs in the face which are present since birth. Previous studies found that 40-60% the cause of birth defects was unclear.Objective. To determine the risk factors for orofacial congenital anomalies in neonates.Methods. Retrospective observational study using case-control design based on medical records within January 2009-June 2013 in Kariadi Hospital was done. Subjects were selected by purposive sampling and simple randomize sampling. Risk factors studied were risky maternal age, intrauterine infection, lack of folic acid supplementation, low antenatal care and family history of orofacial anomalies. Statistical analysis were using Chi-square test, Mann-Whitney test, Kolmogorov-Smirnov test and unpaired t-test.Results. Subjects were 48 neonates, which 24 of them with orofacial anomalies. We found that significant factors of orofacialanomalies occurrence are risky maternal age (p = 0.000; OR = 11.667, 95% CI = 2.696-50.490), intrauterine infection (p = 0.000; OR = 15.400, 95% CI = 2.930-80.951), lack of folic acid supplementation (p = 0.003; OR = 7.000, 95% CI = 1.822-26.887) and low antenatal care (p = 0.000; OR = 38.333, 95% CI = 4.395-334.382) and they become not significant after had multivariate analysis.Conclusion. Maternal age, intrauterine infection, lack of folic acid supplementation and low antenatal care are risk factors for orofacial anomalies in neonates Keywords:orofacialanomalies, risk factor
Faktor-Faktor Risiko Status Imunisasi Dasar Tidak Lengkap pada Anak (Studi di Wilayah Kerja Puskesmas II Kuala Tungkal) Yundri, Yundri; Setiawati, Mexitalia; Suhartono, Suhartono; Setyawan, Henry; Budhi, Kamilah
Jurnal Epidemiologi Kesehatan Komunitas Vol 2, No 2: Agustus 2017
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.366 KB) | DOI: 10.14710/jekk.v2i2.4000

Abstract

Background : Basic immunization is a program conducted to protect the body from disease. Mother behavior, health care and environmental factor serve as a benchmark in the basic immunization status. This study aimed to analyze the risk factors of incomplete basic immunization in children.Methods : The research used observational analytic and cross sectional studynsupported by qualitative approach of in-depth interview method. The research population was all mothers with children aged 12 to 24 months with sample size of 92 respondents. Sampling method was conducted by purposive random sampling. Data collection was done by interviewing and the measuring instrument used is an questionaire. Data was analyzed by univariate, bivariate and multivariate.Results : Multivariate analysis showed poor maternal knowledge (p=0.0001) and lack of supportive attitudes of mothers toward immunization (p=0.0001), is a risk factor for incomplete basic immunization status in children. While mother's age, mother's education, mother's occupation, mother's perception of health facility condition, mother's perception on immunization staff role, number of child in the household and information media are not the risk factors of incomplete basic immunization status in children. A qualitative approach with in-depth interviews indicates that poor knowledge of immunization and the lack of supportive attitude of mothers toward immunization resulting in an incomplete basic immunization status.Conclusion : Risk factors for incomplete basic immunization status in children are poor mother's knowledge and lack of supportive attitudes of mothers toward immunization
Beberapa Faktor Risiko Kejadian Campak Pada Balita di Kabupaten Sarolangun Arianto, Mostang; Setiawati, Mexitalia; Adi, Mateus Sakundarno; Hadisaputro, Suharyo; Budhi, Kamilah
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 1: Februari 2018
Publisher : Sekolah Pascasarjana Universitas Diponegoro Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.32 KB)

Abstract

Background: Measles is a highly infectious disease caused by the measles virus and is still a health problem in Indonesia. Based on data the communicable disease surveillance system from 2014 to January 2016 have been reported cases of measles as many as 200 cases. This study aims to explain host and environment factors as risk factors for occurrence of measles in children under five years old.Method: A case control study, involving 56 cases children under five years old suffer from measles were registered in form C1 of health center, with 56 sex matched neighborhood controls. Studied variables were analyzed by multivariate.Result: Risk factors for measles occurrence were living at unhealthy house (OR=7.5; 95 % CI=2.64 to 21.19), low of mother’s knowledge (OR=5.7; 95 % CI=2.22 to 14.85), and never received immunization (OR=3.7; 95 % CI=1.45 to 9.39). Risk factors not proved with measles occurrence were malnutrition, lack of vitamin A, never had measles, contact history, breast-fed < 2 years, maternal age < 20 years, low of socio-economic, number of children under five years old at home > 1 and less parenting.Conclusion: Risk factors associated with measles were living at unhealthy house, low ofmother’s knowledge and never received vaccination. For elimination, measles vaccination, home inspection, communication, information and education of measles is required.
Berbagai Faktor Risiko Kejadian Bayi Berat Lahir Rendah (BBLR) (Studi di Beberapa Puskesmas Kota Makassar) Hasriyani, Hasriyani; Hadisaputro, Suharyo; Budhi, Kamilah; Setiawati, Mexitalia; Setyawan, Henry
Jurnal Epidemiologi Kesehatan Komunitas Vol 3, No 2: Agustus 2018
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v3i2.4027

Abstract

Background: Low-birth-weight (LBW) as community health problem have remained as the main cause of prenatal morbidity and mortality. In Indonesia, the occurrence rate of LBW has reached 10,2%. LBW has caused by multifactors such as maternal factor, fetus factor, and environmental factor. The aim of the study was to elaborate if maternal factor and environmental factor are the risk factors contributing to LBW occurrence.Method: The study was based on case control design. The number of samples was 138 respondents who were categorized into 69 cases and 69 controls fulfilling the criteria of inclusion and exclusion. The cases were mothers with babies having birth weight <2500 grams regarding the gestational age, and the controls were mothers with babies having birth weight ≥2500 grams regarding the gestational age. Sampling method to the cases was conducted by consecutive sampling while sampling to the controls was conducted by simple random sampling with matching to sex and location.Results: Maternal factors observed as risk factors contributing to LBW are low nutritional status (OR=5.357; 95%CI=1.985-14.457), illness pregnancy (OR=3.976; 95%CI=1.669-9.476). Maternal factors and environmental factors observed as non-risk factors to LBWN are age < 20 years old or age > 35 years, the spacing of pregnancy < 2 years, the of family members smoking at home, the of a food taboos culture, ANC status < 4x , low social economy status.Conclusion: Low nutritional status, illness pregnancy are risk factors contributing to LBW occurrence. The probability of LBW occurrence when those risk factors observed are 68,87%.
Faktor Risiko Kejadian Diare Akut pada Anak Balita (Studi Epidemiologis di Puskesmas Baamang Unit I Kabupaten Kotawaringin Timur) Poernomo, Herry; Setiawati, Mexitalia; Hadisaputro, Suharyo; Budhi, Kamilah; Adi, Mateus Sakundarno
Jurnal Epidemiologi Kesehatan Komunitas Vol 1, No 2: Agustus 2016
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.972 KB) | DOI: 10.14710/j.e.k.k.v1i2.3946

Abstract

Background : Report from UNICEF, WHO data in 2010, there was 801.000 children aged under five was died because of diarrhea. Diarrhea cases in children aged under five in East Kotawaringin District in 3 years ago (2010-2012) increased significantly: 14,6% (2010),17,0% (2011) and 18,6% (2012), while diarrhea in 2013 decreased about 9,3%, but causing 6 deaths in children aged under five with Crude Fatality Rate (CFR) about 0,17%. Host and environment factors (age of children, exclusive breastfeeding, nutritional status, caregiver education level, caregiver knowledge level, personal hygiene, types of water facilities, types of drinking water, physical condition of latrine, chewing the food, the level of family income) are closely related to acute diarrhea. Covered: healthy house 37,32%, use of clean water facilities 65,12%, family latrine 41,3%. The purpose of this research is to explain some of hostand environment factors which is risk factors to acute diarrhea in children aged under five. Methods : This research was an observational study using case control design. Sample case are 43 children aged under five who seek treatment suffer from acute diarrhea in Public Health Centre of Baamang Unit I in East Kotawaringin District. Sample control are 43 children aged under five who seek treatment do not suffer from acute diarrhea in PublicHealth Centre of Baamang Unit I in East Kotawaringin District with consecutive sampling.Results : Age of children < 2 years (aOR=2,617; 95%CI=1,063-6,444; p=0,036); types of water facilities was not from PDAM (aOR=2,892; 95%CI=1,173-7,127; p=0,021) was risk factors to acute diarrhea with probability event together amounted was 73,6%.Conclusion : The risk factors to acute diarrhea in children aged under five was aged < 2 years and type of water facilities was not from PDAM. 
Intensive Lactation Counseling for The Success of Giving Exclusive Breastfeeding until 2 Months Old Nurdiana, Nurdiana; Budhi, Kamilah; Sakundarno, Mateus; Mexitalia, Maria; Widjanarko, Bagoes
Health Notions Vol 2, No 12 (2018): December
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (178.132 KB) | DOI: 10.33846/hn.v2i12.260

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Background: In Semarang in 2016, giving exclusive breastfeeding by mother to her baby was 67.16% and in work area of Candi Lama Public Health Center only reached 43.52%. So far, it had not been known the influence of intensive lactation counseling against the success of giving exclusive breastfeeding. Purpose: to know the influence of intensive lactation counseling against the success of giving exclusive breastfeeding until 2 months old. Methods: This research utilized quasi experimental design. Population in this research was mothers who had gestational age in 37-42 weeks. Total of the subjects was 32 mothers who were divided by 2 groups, experiment group (n = 16) and control group (n = 16). Experiment group was given intensive lactation counseling in 6 times for 3 months. Meanwhile, control group was not given any lactation counseling, but was given leaflet of exclusive breastfeeding. Results: Proportion of mothers who were successful in giving exclusive breastfeeding until 2 months old in experiment group was higher (93.75%) rather than in control group (31.25%). The difference in this proportion was quite significant (p= 0.001). The comparison result of proportion for mothers who were successful in giving exclusive breastfeeding until 2 months old between the group that was given intensive lactation counseling (experiment group) and control group showed RR = 3.0 (95% CI: 1.435-6.273). Conclusion: Giving intensive lactation counseling increased the proportion for the mothers who were successful in giving exclusive breastfeeding until 2 months old. Keywords: Intensive lactation counseling, Exclusive breastfeeding