Tatang Bisri
Departemen Anestesiologi dan Terapi Intensif Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

Published : 91 Documents
Articles

Apakah Epidural Preemtif Menghambat Stres Pembedahan dengan Sempurna?

Majalah Kedokteran Bandung Vol 45, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Analgesia preemtif adalah pemberian regimen analgesik sebelum onset stimulus noksius. Kerusakan jaringan akibat pembedahan menimbulkan rangsang noksius, melalui dua jalur input noksius ke susunan saraf pusat (SSP), melalui jalur neural dan jalur sirkulasi. Penelitian uji klinik tersamar ganda mengikutsertakan 48 pasien yang menjalani pembedahan orthopedi tungkai bawah. Dibagi 2 kelompok: kelompok I (n=24) diberikan bupivakain 0,25% 10 mL dan kelompok II (n=24) diberikan NaCl 0,9% melalui epidural sebagai kontrol sebelum dilakukan induksi. Kedua kelompok diberikan anestesi umum. Selama pembedahan pada kelompok I diberikan 5 mL bupivakain 0,25% selang 90 menit, sedangkan pada kelompok kontrol diberikan 5 mL NaCl 0,9% dengan selang waktu yang sama. Pascabedah kedua kelompok diberikan bupivakain 0,25% secara kontinu 4 mL/jam sampai 24 jam pascabedah. Pengukuran kadar sitokin: tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), IL-6 dan IL-10 dilakukan sebelum induksi anestesi, pascabedah dini, jam ke-4, 8, dan 24 pascabedah. Kelompok I memperlihatkan dinamika kadar proinflamasi lebih rendah dibandingkan dengan kelompok II namun secara statisik tidak bermakna (p>0,05). Sebaliknya, kadar sitokin antiinflamasi lebih tinggi pada kelompok epidural, namun tidak berbeda bermakna (p>0,05). Intensitas nyeri pada 4 jam, 8 jam, 24 jam pascabedah secara nyata lebih rendah pada kelompok I (p<0,05). Respons hemodinamik juga ditemukan lebih rendah pada kelompok I walaupun tidak berbeda nyata ( p>0,05) kecuali pada pascabedah dini namun tidak secara sempurna. Simpulan, pemberian analgetik epidural preemtif menghasilkan analgesia disertai hemodinamik yang stabil dibandingkan tanpa epidural preemtif, namun epidural premtif tidak dapat menekan produksi sitokin proinflamasi dan antiinflamasi. [MKB. 2013;45(3):147–54]Kata kunci: Epidural preemtif, hemodinamik, intensitas nyeri, sitokin Does Preemptive Epidural Analgesia Completely Blok Surgical Stress Responses?Preemptive analgesia is initiating an analgesic regimen before the onset of the noxious stimulus. Damages to the tissue caused by surgical trauma generate noxious response conveyed to the central nervous system (CNS) by two pathways, neural pathway and circulatory pathway. This study is a double- blinded clinical trial that included 48 patients undergoing lower extremity orthopedic surgery. The subjects were divided into two groups: group I (n=24) received 10 mL bupivacaine 0.25% from epidural route, and group II (n=24) received 10 mL NaCl 0.9% from epidural route as the control group before induction of anesthesia. Both groups were anesthetized under general anesthesia. Group I received 5 mL bupivacaine 0,5% every 90 minutes and group II received 5 mL NaCl 0,9 with similar time intraoperatively. Post-operatively, both groups received continuous bupivacaine 0,25% 4 mL/ hour until 24 hours after surgery. Measurements of cytokine levels: tumor necrosis factor-α (TNF-α), interleukin- 1β (IL-1β), IL-6 and IL-10 were done before induction of anesthesia, in the early post-operative period, at 4, 8, and 24 hours after surgery. Group I showed lower level proinflammatory cytokines level compared with group II but the difference was not statistically significant (p>0.05). The level of anti-inflammatory cytokine was higher in group I, but the difference was not statistically significant (p>0.05). Pain intensity at 4 hours, 8 hours, 24 jam hours post operative was lower significantly (p<0.05) Hemodynamic responses was lower in group I but not significant (p>0.05) excepst at early postoperative period (p<0.05). Generally, preemptive epidural analgesia was able to suppress the cytokine responses, but not completely. In conclusion, preemptive epidural analgesia is associated with better analgesia and better hemodynamic stability compared without preemptive epidural, but unable to suppress the production of proinflammatory and anti-inflammatory cytokines. [MKB. 2013;45(3):147–54]Key words: Cytokines, hemodynamic, pain intensity, preemptive epidural DOI: http://dx.doi.org/10.15395/mkb.v45n3.144

Multimodal Analgesic Effect on Proinflammatory and Anti-inflammatory Cytokines Serum

International Journal of Integrated Health Sciences VOL 2, NO 1, July (2014)
Publisher : International Journal of Integrated Health Sciences

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Abstract

Objective: To investigate the effect of combination epidural bupivacaine and intravenous parecoxib analgesia on  immune response in patients who underwent open reduction and internal fixation of the lower limb under epidural anesthesia.  Methods: This research was conducted using the randomized, placebo-controlled double blind trial method on 52 patients who were randomly divided into 2 groups: the Parecoxib group which received 40 mg intravenous parecoxib for 30 minutes before incision and the control group which received an equal volume of 0.9% normal saline. Both groups received epidural anesthesia and postoperative epidural 0.125% bupivacaine analgesia continously. Venous blood samples were obtained before parecoxib administration, 2 and 24 hours after the surgery. The data were analyzed using Mann Whitney U and Independent t tests (p<0.05).     Results: There was a significant difference between the two groups (p<0.05) in IL-1β, IL-6, IL-10 levels and proinflammatory to anti-inflammatory ratio, 2 hours after surgery.    Conclusions: Multimodal analgesic combination of 40 mg IV parecoxib and 0.125% bupivacaine epidural analgesia have the effect to alter and stabilize the  systemic immune response.    Keywords: Cytokines, epidural analgesia, interleukins, immune response, parecoxib, tissue damage DOI: 10.15850/ijihs.v2n1.272

Korelasi Antara Kadar Laktat, Base Deficit Dan Saturasi Vena Sentral Dengan Skor Multiple Organ Dysfunction Hari Ke-3 Pada Pasien Pascabedah Dengan Hemodinamik Stabil Di Ruang Perawatan Intensif Rumah Sakit Dr. Hasan Sadikin Bandung

Jurnal Anestesi Perioperatif Vol 1, No 1 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Hingga kini belum ada indikator yang untuk menilai perfusi global yang adekuat. Pasien dengan hemodinamik stabil masih mungkin terjadi perubahan kadar laktat, base deficit, dan saturasi vena sentral, yang dapat digunakan untuk menilai adanya suatu hipoksia jaringan. Penelitian ini bertujuan mencari korelasi yang paling baik diantara ketiga parameter tersebut terhadap skor MOD hari ke-3 pada pasien pascabedah dengan hemodinamik stabil yang dirawat di Ruang Perawatan Intensif (RPI). Penelitian ini suatu penelitian observasional dengan desain potong lintang. Penelitian ini dilakukan pada 50 orang pasien risiko tinggi yang dirawat di RPI, laki-laki dan wanita, usia 18 – 65 tahun yang telah menjalani laparotomi eksplorasi dengan anestesi umum. Semua pasien dilakukan pemeriksaan kadar laktat darah, gas darah arterial dan gas darah vena sentral ketika pasien masuk, dan jam  ke-24. Selanjutnya pada hari ke-3 dilakukan skoring MOD yang mencakup fungsi neurologis, kardiovaskular, respirasi, ginjal, hematologis, dan hepar. Pada penelitian ini didapatkan koefisien korelasi rank Spearman antara laktat 1 dan skor MOD hari ke-3 adalah 0,579 dengan p<0,001,  base deficit 1 dengan skor MOD hari ke-3 adalah 0,811 dengan p<0,001,  sedangkan yang tidak bermakna adalah antara saturasi vena sentral 1 dengan skor MOD hari ke-3, dan antara saturasi vena sentral 2 dengan skor MOD hari ke-3, dengan koefisien koreasi rank Spearman masing-masing adalah 0,328 dan 0,260. Koefisien korelasi yang baik terdapat pada laktat dan base deficit dengan skor MOD hari ke-3, sedangkan saturasi vena sentral memiliki koefisien korelasi yang lemah. Laktat dan base deficit dapat digunakan untuk mendeteksi secara dini adanya gangguan perfusi jaringan pada pasien risiko tinggi pascabedah dengan hemodinamik stabil.Kata kunci: laktat, base deficit, saturasi vena sentral, hipoksia jaringan, disfungsi organ.Correlation Between Lactate Level, Base Deficit, And Central Vein Saturation With Third-Day Multiple Organ Dysfunction Score On Haemodynamically Stable Postoperative Patient In Intensive Care Unit  Dr. Hasan Sadikin Bandung HospitalUntil now, there is no precise indicator to evaluate adequate global perfussion yet. On haemodynamically stable patient is possible to experience change in lactate value, base deficit, and central vein saturation, which can be used to assess tissue hypoxia. The aim of this study is to find the best parameter among those three parameters toward day-third-MOD (Multiple organ dysfunction) score on hemodinamically stable post surgery patients whose been hospitalized in ICU (Intensive care unit).This is a cross-sectional observational study. The subject of this study were 50 high-risk patients whose hospitalized in RPI, male and female between 18 – 65 years old who had been done explorative laparatomy procedures under general anesthesia. Blood lactate, arterial blood gas analysis and central vein blood gas analysis had been analysis on all subjects on admissions and on the 24th hours. On the third day, MOD score that covered neurologic, cardiovascular, respiration, renal, hematologic and liver function had been assessed. This study yielded rank Spearmen coeffisien correlation between blood lactate 1 and day-third-MOD score 0,572 (p<0,001), and base deficit 1 and day-third-MOD score was 0,811 (p<0,001). The value between central vein saturation  1 and day-third-MOD score, and central vein saturation 2 and day-third-MOD score were unsignificant, with rank Spearmen coeffisien correlation were 0,328 and 0,260. Good coeffisien correlation was found between blood lactate and base deficit with MOD score on third day, whilst central vein saturation had  weak coeffisien correlation. Blood lactate level and base deficit can be used to evaluate early tissue perfusion disturbances on hemodinamically stable high risk post surgery patients.Key words: lactate, base deficit, central vein saturation, tissue hypoxia, MOD score. DOI: 10.15851/jap.v1n1.154

Efek Lidokain Intravena terhadap Nilai Numeric Rating Scale dan Kebutuhan Fentanil Pascaoperasi dengan Anestesi Umum

Jurnal Anestesi Perioperatif Vol 1, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Lidokain intravena mempunyai efek analgesia, antihiperalgesia, dan antiinflamasi. Penelitian ini bertujuan untuk mengetahui efek pemberian lidokain intravena terhadap nilai numeric rating scale (NRS) dan kebutuhan fentanil pascaoperasi eksisi fibroadenoma mammae. Penelitian ini merupakan uji klinis acak terkontrol buta ganda terhadap 40 orang pasien wanita usia 18–60 tahun dengan status fisik ASA I–II yang dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung periode September 2011–Februari 2012. Sampel dikelompokkan random menjadi kelompok lidokain dan kontrol. Penilaian nyeri menggunakan numeric rating scale. Data dianalisis menggunakan uji chi-kuadrat, uji-t, dan Mann Whitney dengan tingkat kepercayaan 95% dan dianggap bermakna bila p<0,05. Hasil penelitian menunjukkan nilai NRS kelompok lidokain lebih rendah dan berbeda bermakna pada 30 menit (p<0,001), 60 menit (p<0,001), 90 menit (p=0,003), dan 120 menit (p=0,011) pascaoperasi, penggunaan fentanil pertolongan pada kelompok lidokain adalah 0–25 µg dan pada kelompok kontrol 25–75 µg selama 3 jam pascaoperasi. Simpulan penelitian adalah lidokain intravena 1,5 mg/kgBB bolus sebelum induksi dilanjutkan dosis rumatan 1 mg/kgBB/jam sampai 1 jam pascaoperasi mampu menurunkan nilai numeric rating scale dan mengurangi kebutuhan fentanil pascaoperasi.Kata kunci: Kebutuhan fentanil pascaoperasi, lidokain intravena, numeric rating scaleThe Effect of Intravenous Lidocaine on Numeric Rating Scale Value and Postoperative Fentanyl Requirement in General AnesthesiaAbstractLidocain has analgesic, antihyperalgesic and antiinflamatory properties. This was a double blind randomized controlled trial study on 40 female patients, aged 18–60 years old with ASA physical status I–II who underwent excisional biopsy for fibroadenoma mammae at Dr. Hasan Sadikin General Hospital Bandung between September 2011–February 2012. The samples randomly divided into the lidocaine and the control group. Quality of postoperative pain was assessed using the numeric rating scale (NRS). The result were analyzed with chi-square test, t-test, and Mann Whitney Test with 95% confidence interval and considered significant if the p value <0.05. The result showed that in comparison to the control group, the NRS values obtained from the lidocaine group was significantly different in postoperative measurement time, 30 minutes (p<0.001), 60 minutes (p<0.001), 90 minutes (p=0.003) and 120 minutes (p=0.011) and the dose range of fentanyl as a rescue analgesic in 3 hours postoperative period for the lidocaine group was 0–25 µg and 25–75 µg for the control group. This study concluded that administration of 1,5 mg/kgBW lidocaine intravenous before induction and continued with 1 mg/kgBW/hour as maintenance dose until 1 hour postoperative is able to reduce the NRS score and the requirement of postoperative fentanyl.Key words: Intravenous lidocaine, numeric rating scale, post operative fentanyl requierement DOI: 10.15851/jap.v1n3.195

Perbandingan Gabapentin 600 mg dengan 1.200 mg per Oral Preoperatif terhadap Nilai Visual Analogue Scale dan Pengurangan Kebutuhan Petidin Pascaoperasi pada Modifikasi Mastektomi Radikal

Jurnal Anestesi Perioperatif Vol 1, No 3 (2013)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Gabapentin mempunyai efek antihiperalgesia, antialodinia, dan antinosiseptif. Penelitian ini bertujuan untuk menilai efek gabapentin 600 mg dan 1.200 mg per oral preoperatif terhadap nilai visual analogue scale (VAS) dan pengurangan kebutuhan petidin pascaoperatif. Penelitian dilakukan secara uji acak terkontrol buta ganda terhadap 38 orang pasien di Rumah Sakit Dr. Hasan Sadikin Bandung pada Mei–September 2010. Pasien dibagi menjadi dua kelompok yaitu kelompok gabapentin 600 mg dan gabapentin 1.200 mg. Penilaian skala nyeri dilakukan dengan menggunakan nilai VAS. Data hasil penelitian dianalisis menggunakan Uji Mann-Whitney dengan tingkat kepercayaan 95% dan dianggap bermakna bila nilai p<0,05. Hasil penelitian didapatkan nilai VAS saat diam dan saat mobilisasi berbeda bermakna (p<0,05). Kelompok gabapentin 1.200 mg lebih sedikit diberikan analgetik petidin tambahan (10,5% vs 15,8%), tetapi perbedaan tersebut tidak bermakna (p=0,631). Simpulan penelitian ini adalah gabapentin 1.200 mg per oral preoperatif lebih baik bila dibandingkan dengan 600 mg dalam mengurangi nilai VAS pasca operatif pada operasi modifikasi radikal mastektomi, namun tidak mengurangi kebutuhan petidin.Kata kunci: Gabapentin 600 mg, Gabapentin 1.200 mg, visual analogue scale, kebutuhan petidin The Comparison between 600 mg and 1,200 mg Gabapentin per Oral Preoperatively on Visual Analog Scale and Reduction of Postoperative Pethidine Requirement on Modified Radical MastectomyAbstract Gabapentin is a GABA analog which has the effect of anti hyperalgesia, anti allodynia, and anti nociceptive. This research was conducted in order to assess the effect of 600mg and 1,200 mg gabapentin given preoperatively to assess visual analogue scale (VAS) score and reduction of pethidine requirement. The study was done by conducting a double blind randomized controlled trial on 38 patients, aged 18–65 years, with ASA physical status I–II. Patients were divided into two groups: 600 mg gabapentin and 1,200 mg gabapentin group. The quality of pain was assessed using VAS score. The results were statistically analyzed using Mann-Whitney Test with 95% confidence interval and considered significant if p value <0.05. From the results, the VAS values obtained at rest and during mobilization were significantly different (p<0.05). The 1,200 mg gabapentin group received less additional pethidine (10.5% vs 15.8%), although no significant difference was shown (p=0.631). The conclusion of this study is that administration of 1,200 mg gabapentin per oral pre operatively is better when compared to 600 mg in reducing post operative visual analog scale score in modified radical mastectomy. However, it do not reduce the need for analgesic significantly.Key words: 600 mg Gabapentin, 1.200 mg Gabapentin, post operative pethidine requirement, visual analog scale DOI: 10.15851/jap.v1n3.196

Efek Penggunaan Leg Wrapping terhadap Kejadian Hipotensi Selama Anestesi Spinal pada Pasien Seksio Sesarea

Jurnal Anestesi Perioperatif Vol 4, No 3 (2016)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Hipotensi merupakan komplikasi tersering selama anestesi spinal dengan insidensi >80% meskipun telah diberikan cairan preloading, posisi ibu left lateral tilt, dan penggunaan vasopresor. Terdapat teknik lain untuk mencegah terjadi hipotensi, yaitu penggunaan leg wrapping yang dapat memperbaiki aliran balik vena dengan meningkatkan volume darah sentral. Penelitian ini bertujuan menilai efek penggunaan leg wrapping terhadap kejadian hipotensi selama anestesi spinal pada pasien seksio sesarea. Penelitian bersifat eksperimental acak terkontrol buta tunggal dengan randomisasi secara acak sederhana yang melibatkan 40 ibu hamil American Society of Anesthesiologists (ASA) II yang menjalani seksio sesarea dengan anestesi spinal di Central Operating Theatre (COT) lantai 3, Rumah Sakit Dr. Hasan Sadikin Bandung pada bulan Juni–Juli 2015. Subjek penelitian dikelompokkan menjadi dua, yaitu 20 subjek dengan leg wrapping dan 20 subjek tanpa leg wrapping. Tekanan darah dan laju nadi diperiksa setiap dua menit sampai bayi lahir. Data dianalisis dengan uji-t tidak berpasangan dan chi-kuadrat, nilai p<0,05 dianggap bermakna. Analisis statistik menunjukkan kejadian hipotensi pada kelompok tanpa leg wrapping 95% (19 orang) dan 0% pada kelompok dengan leg wrapping dengan perbedaan bermakna (p<0,05). Secara keseluruhan, hemodinamik kelompok dengan leg wrapping lebih stabil dibanding dengan kelompok tanpa leg wrapping. Simpulan, penggunaan leg wrapping sebelum dilakukan anestesi spinal pada pasien yang menjalani seksio sesarea menurunkan angka kejadian hipotensi.Kata kunci: Anestesi spinal, hipotensi, leg wrapping, seksio sesareaEffect of Leg Wrapping on Hypotension Incidence in Cesarean Section with Spinal AnesthesiaAbstractHypotension is the most common complication of spinal anesthesia. The incidence remains high despite adequate fluid preloading, left lateral tilt positioning, and vasopressors use. There is a technique that can be used to prevent hypotension, which is referred as leg wrapping. Leg wrapping can improve venous return by increasing central blood volume. This study aimed to compare the hypotension incidence between with and without leg wrapping during spinal anesthesia for caesarean section. The method used was single blind randomized controlled trial with simple randomization, involving 40 pregnant women ASA II, who underwent cesarean section with spinal anesthesia in COT 3rd floor Dr. Hasan Sadikin General Hospital Bandung during the period of June–July 2015. Subjects were grouped into with leg wrapping and without leg wrapping groups with 20 subjects in each group. Blood pressure and heart rate were recorded every two minutes until the baby was born. Data were then analyzed using t-test and chi-square test with p values <0.05 considered significant. The statistical analysis showed that there were significant differences in the incidence of hypotension (p<0.05) in the group without leg wrapping , i.e. 95% (19 people), and the group with leg wrapping, i.e. 0%. Overall, hemodynamics of the leg wrapping group was more stable than the group without leg wrapping. In conclusion, leg wrapping prior to spinal anesthesia in patients undergoing cesarean section will reduce incidence of hypotension.Key words: Cesarean section, hypotension, leg wrapping, spinal anesthesia DOI: 10.15851/jap.v4n3.903

Penatalaksanaan Anestesi Pada Shaken Baby Syndrome

Jurnal Neuroanestesi Indonesia Vol 1, No 4 (2012)
Publisher : Departement of Anesthesiology and Intensive Care Dr. Hasan Sadikin Hospital Bandung

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Shaken Baby Syndrom adalah suatu kondisi perdarahan intraserebral atau intraokuler tanpa atau dengan hanya minimal trauma pada kepala, leher atau wajah. Kasus ini sering disebut kasus kekerasan anak- orang tua. Jumlah kejadian ini cukup banyak terjadi di US, sekitar 50.000 kasus pertahun, sepertiganya meninggal dunia dan setengah dari kasus yang bertahan hidup mengalami defisit neurologis yang berat. Umumnya prognosa penderita buruk. Di Indonesia sendiri data mengenai hal ini belum ada. Tapi mempunyai kecenderungan untuk meningkat.Gejala yang sering didapat adalah hematom subdural, perdarahan retina dan edema otak. Sering diikuti juga dengan multipel fraktur, trauma cervical dan jaringan leher lainnya. Peneliti lain melaporkan banyaknya kasus Diffuse Axonal Injury (DAI) pada kasus ini. Penanganan neuroanestesinya secara umum sama dengan neuroanestesi cedera otak traumatika pada pediatrik, karena terjadi peningkatan ICP sehingga mempengaruhi CBF, CMRO2 dan autoregulasi otak. Obat, tehnik anestesi yang digunakan dan perhitungan cairan selama operasi diusahakan tidak memperburuk keadaan . Pasca operasi penderita dirawat dan diobservasi di PICU. Anesthesia Management For Shaken Baby SyndromeShaken Baby Syndrome is a condition of intracerebral hemorrhage or intraocular without or with only minimal trauma to the head, neck or face. This case is often referred to cases of child-parent violence. This cases in the U.S, approximately 50,000 cases per year. From all event, one third died and half of the cases that survive with severe neurological deficit. Generally, prognosis of patients is poor. In Indonesia data on this subject does not exist. But it has a tendency to increase. Symptoms of a subdural hematoma is often obtained, retinal hemorrhages and brain edema.This case often followed by multiple fractures, cervical and other neck trauma tissues. Diffuse axonal injury researchers often reported for this case. Generally neuroanestesi technique for pediatric equal with pediatric trauma neuroanesthesia. Anesthesi challenges for this case was ICP, because increased ICP could influence for CBF, CMRO2 and cerebral autoregulation. Avoid anesthesi drugs , technique and the calculation of fluid during surgery to damaged this condition. Postoperative patients were treated and observed in the PICU.

Supine Hypotension Syndrome pada Kehamilan

Majalah Kedokteran Bandung Vol 47, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Supine hypotension syndrome (SHS) dapat terjadi mulai kehamilan trimester 2 dan didefinisikan sebagai penurunan tekanan sistol ≥30% pada posisi supine dibanding dengan lateral. Tujuan penelitian mengetahui insidensi SHS pada wanita hamil aterm di Indonesia. Penelitian observasional pada 200 wanita hamil aterm, kehamilan pertama dan kedua, usia 18–40 tahun, tidak memiliki penyakit sertaan, dan akan dilakukan seksio sesarea elektif di Rumah Sakit Ibu dan Anak Melinda dalam periode Maret–Juli 2012. Pasien diberikan 500 cc cairan kristaloid Ringer laktat sebagai pengganti puasa, kemudian dilakukan pemeriksaan tekanan sistol, diastol, rata-rata, laju nadi, dan saturasi oksigen selama 5 menit dengan jarak 1 menit pada posisi supine dan miring kiri 45O. Hasil pengukuran tekanan sistol supine 113,49 (13,20) mmHg, miring 105,20 (12,08) mmHg dengan nilai p=0,93. Tekanan diastol supine  69,05 (7,31) mmHg dan miring 58,58 (7,73) mmHg (p=0,51). Tekanan darah rata-rata supine 84,59 (8,38) mmHg dan miring 75,87 (8,82) mmHg (p=0,62). Laju nadi supine 88,95 (12,19) x/menit, dan miring 86,26 (11,47) x/menit, (p=0,86). SpO2 supine 99,95 (1,11)% dan miring 99,64 (0,67)% (p=0,07). Simpulan, tidak ada perbedaan tekanan sistol, diastol, rata-rata, laju nadi, dan SpO2 wanita hamil aterm pada posisi berbaring dengan posisi miring kiri 450. [MKB. 2015;47(2):102–8]Kata kunci: Posisi supine, posisi miring kekiri, supine hypotension syndrome, wanita hamil atermSupine Hypotension Syndrome in PregnanciesAbstractSupine hypotension syndrome (SHS) can occur starting from the second trimester of pregnancy and is defined as a reduction of systolic blood pressure of ≥30% in the supine position compared to lateral position. The purpose of this study was to determine the incidence of SHS in full term pregnant women in Indonesia. An observational study on 200 full term pregnant women, first and second pregnancy, aged 18−40 years, no coexisting diseases, and was going to have an elective cesarean section in Melinda Woman and Child Hospital in the period of March–July 2012. Patients were given 500 cc of Ringer’s lactate crystalloid fluid instead of fasting. Systolic and diastolic blood pressure, mean blood pressure, pulse rate, and oxygen saturation for 5 minutes were then examined every  minute. The examination was conducted in the supine and left lateral position of 45O. The results show a systolic blood pressure in supine position of 113.49 (13.20) mmHg and in lateral position of 105.20 (12.08) mmHg (p=0.93). Meanwhile, the supine diastolic blood pressure was  69.05 (7.31) mmHg and lateral position was 58.58 (7.73) mmHg (p=0.51). The mean blood pressure in supine position was 84.59 (8.38) mmHg and 75.87 (8.82) mmHg (p=0.62) in lateral position . The pulse rates for supine and lateral position were 88.95 (12.19)x/min and 86.26 (11.47) x/min (p=0.86), respectively. Supine SpO­2 was 99.95 (1.11) % and lateral SpO2 was 99.64 (0.67) % (p=0.07). In conclusion, there is no differences in systolic, diastolic, mean blood pressure, pulse rate and SpO2 of full term pregnant women in supine or left lateral position of 45O. [MKB. 2015;47(2):102–8]Key words: Full term pregnant women, left lateral decubitus, supine hypotension syndrome, supine DOI: 10.15395/mkb.v47n2.461

Efek Penambahan Deksametason 5 mg pada Bupivakain 0,5% terhadap Mula dan Lama Kerja Blokade Sensorik Anestesia Epidural untuk Operasi Ortopedi Ekstremitas Bawah

Jurnal Anestesi Perioperatif Vol 3, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Operasi ortopedi ekstremitas bawah dengan anestesia regional epidural memiliki kelemahan yaitu mula kerja yang lama. Penelitian ini bertujuan melihat efek penambahan 5 mg deksametason pada bupivakain 0,5% terhadap mula kerja dan lama kerja blokade sensoris. Penelitian prospektif eksperimental menggunakan uji klinis acak buta ganda pada 32 pasien dengan American Society of Anesthesiologist (ASA) I–II yang menjalani operasi ortopedi ekstremitas bawah dengan anestesi epidural di RSUP Dr. Hasan Sadikin Bandung pada Februari–Mei 2014. Pengambilan sampel dilakukan secara consecutive sampling dan random blok permutasi. Kelompok I, deksametason 5 mg ditambahkan ke dalam bupivakain 0,5% 15 mL. Kelompok II, bupivakain 0,5% ditambah NaCl 0,9% 15 mL. Hasil penelitian diuji secara statistika menggunakan uji-t dan Uji Mann-Whitney. Hasil penelitian menunjukkan mula kerja blokade sensorik kelompok I tidak lebih cepat, yaitu 13,56 menit dibanding dengan kelompok II, yaitu 14,31 menit (p=0,27). Lama kerja blokade sensorik kelompok I lebih lama, yaitu 399,81 menit dibanding dengan kelompok II, yaitu 227,43 menit (p=0,00). Simpulan, penambahan deksametason 5 mg pada bupivakain 0,5% 15 mL tidak mempercepat mula kerja blokade sensorik tetapi memperpanjang lama kerja blokade sensorik bupivakain 0,5% yang diberikan secara epidural.Kata kunci: Anestesi epidural, blokade sensorik, bupivakain, deksametason, lama kerja, mula kerjaEffect of Dexamethasone 5 mg Addition to Bupivacaine 0.5% on Onset and Duration of Sensory Blockade in Epidural Anesthesia for Lower Extremity Orthopedic SurgeryLower extremity orthopedic surgery performed with regional epidural anesthesia was still have weakness which is long onset of time. This study was conducted to determine the onset time and duration time of sensory blockade epidural anesthesia  between the use of dexamethasone 5 mg addition to 0.5% bupivacaine for lower limb orthophedic surgery. The study was using randomized controlled blind method on 32 ASA I–II patients undergoing lower limb orthopedic surgery under epidural anesthesia. Consecutive sampling and random allocation of block of permutation groups was applied. In group I, dexamethasone 5 mg was added to bupivacaine 0.5% 15 mL while in group II NaCl 1 mL was added to bupivacaine 0.5% 15 mL. The results were statistically tested using t-test and Mann-Whitney test. It was shown that the onset time of sensory blockade was not significantly faster when dexamethasone was added in bupivacaine 0.5%, 13.56 minutes versus 14.31 minutes (p=0.27). The duration time of sensory blockade in dexamethasone in bupivacaine 0.5% group was longer 399.81 minutes, compared to the bupivacaine 0.5% group, 227.43 minutes (p=0.00). In conclusions, the addition of dexamethasone 5 mg to bupivacaine 0.5% 15 mL does not produced faster onset time. However, the duration sensory blockade time is longer than bupivacaine 0,5% 15 mL is usedKey words: Bupivacaine, dexamethasone, duration time, epidural anesthesia, onset, sensory blockade DOI: 10.15851/jap.v3n2.577

Perbandingan Parasetamol dengan Ketorolak Intravena Sebagai Analgesia Pre-emtif terhadap Skala Nyeri Pascabedah Labioplasti pada Pasien Pediatrik

Jurnal Anestesi Perioperatif Vol 3, No 2 (2015)
Publisher : Faculty of Medicine, Universitas Padjadjaran

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Abstract

Parasetamol dan ketorolak merupakan analgetik yang biasa digunakan pada tatalaksana nyeri ringan hingga sedang. Penelitian ini bertujuan membandingkan efek analgesi pre-emtif parasetamol 20 mg/kgBB dengan ketorolak 0,5 mg/kgBB pada pasien pediatrik pascabedah labioplasti yang diukur menggunakan skala nyeri face, legs, activity, crying, consolability (FLACC). Penelitian eksperimental secara uji acak tersamar buta ganda terhadap 66 pasien pediatrik usia 6 bulan–12 tahun dengan status fisik American Society of Anesthesiology (ASA) I–II. Penelitian dilakukan di Rumah Sakit Dr. Hasan Sadikin Bandung periode Oktober 2013–Mei 2014. Pasien dibagi menjadi dua kelompok perlakuan, yaitu kelompok parasetamol (P) dan ketorolak (K) yang diberikan 15 menit prabedah. Analisis statistika diuji menggunakan uji-t independen, Mann-Whitney, dan Eksak Fisher. Hasil penelitian menunjukkan bahwa skala FLACC pada kelompok ketorolak pada jam ke-1, 2, 4, 6, dan 24 lebih rendah secara bermakna (p<0,05) dibanding dengan kelompok parasetamol. Simpulan, skala FLACC pemberian ketorolak 0,5 mg/kgBB prabedah pada pasien labioplasti lebih rendah dibanding dengan parasetamol 20 mg/kgBB.Kata kunci: Analgetik, analgesia pre-emtif, ketorolak, labioplasti, parasetamol, skala FLACCComparison between Intravenous Paracetamol and Ketorolac as Preemptive Analgesia on Postoperative Pain Scale in Pediatric Patients Undergo LabioplastyKetorolac and paracetamol are common analgetics used to treat mild to moderate pain. This study compared the efficacy of preemptive analgesia measured using face, legs, activity, crying, consolability (FLACC) scale between groups receiving 20 mg/kgBW paracetamol (P) and 0.5 mg/kgBW ketorolac (K) for pediatric labioplasty procedure. This experimental study is a are double-blind randomized trial against 66 pediatric patients aged 6 months–12 years with the physical status of the American Society of Anesthesiology (ASA) I–II. The study was conducted in Dr. Hasan Sadikin General Hospital Bandung during the period of October 2013–May 2014. The P and K groups received 20 mg/kgBW paracetamol and 0.5 mg/kgBW ketorolac, respectively, 15 minutes preoperatively. Data were analyzed statistically using independent-t, Mann-Whitney, and Fischer’s Exact Test. Results showed that the difference between FLACC scale in P and K groups  was statistically significant (p<0.05). In conclution, FLACC scale in patients who received ketorolac 0.5 mg/kgBW is lower than patients who received paracetamol 20 mg/kgBW.Key words: Analgetics, FLACC scale, ketorolac, labioplasty, paracetamol, preemptive analgesia DOI: 10.15851/jap.v3n1.573

Co-Authors , Rizki , Suwarman - Irwan, - A. Himendra Wargahadibrata A. Muthalib Nawawi Agus Junaidi Akbar, Ieva B Andie Muhari Barzah, Andie Muhari Ardi Zulfariansyah Bambang Suryono, Bambang Christanto, Sandhi christiana, monica Dedi Fitri Yadi Dewi Yulianti Bisri, Dewi Yulianti Diana C. Lalenoh, Diana C. Diana Lalenoh Erias, Muhammad Erwin Pradian Ezra Oktaliansah Firdaus, Riyadh Fithrah, Bona Akhmad Fitri Sepviyanti Sumardi Giovanni, Cindy Hamzah, Hanzah I Putu Pramana Suarjaya Ida Bagus Krisna Jaya Sutawan, Ida Bagus Krisna Jaya Ike Sri Redjeki Iman Muhammad Yusup Mansur Iwan Abdul Rachman, Iwan Abdul Iwan Fuadi Krisna J. Sutawan, Ida Bagus Kusuma Harimin, Kusuma Laksono, Buyung Hartiyo Lalenoh, Diana Christine M. Dwi Satriyanto M. Erias Erlangga, M. Erias M. Sofyan Harahap Mariko Gunadi Martinus, Fardian MM Rudi Prihatno, MM Rudi Mohammad Sofyan Harahap Muh. Rumli Ahmad Muhamad Adli Boesoirie, Muhamad Adli Muhammad Ramli Ahmad Nancy M Rehatta, Nancy M Ningsih, Diana Fitria Nugraha, Ade Aria Oetoro, Bambang J. Okatria, Ahmado Putri, Andika C. Radian Ahmad Halimi Rahmadsyah, Teuku Rahordjo, Sri Rasman, Marsudi Reza Widianto Sudjud Rose Mafiana Rovina Ruslami, Rovina RR. Pramada Resvita Ruby Satria Nugraha Ruli Herman Sitanggang Saleh, Siti Chasnak Saputra, Tengku Addi Sri Rahardjo Subekti, Bambang Eko Suryaningrat, IGB Susanto, Bahtiar Sutanto, Sigit Suwarman Suwarman, Suwarman Suwarman, S Syafruddin Gaus Thayeb, Srilina Theresia C. Sipahutar Theresia Monica Rahardjo Wirawijaya, Dear Mohtar Wirawijaya Wullur, Caroline Yunita Susanto Putri