Adnil Basha
Faculty of Medicine, University of Indonesia/ Harapan Kita National Cardiovascular Center

Published : 3 Documents
Articles

Found 3 Documents
Search

Factors Affecting Heart Rate Recovery After Symptom-limited Exercise Stress Testing Pakpahan, Henry AP; Priyana, Andria; Basha, Adnil; Radi, Basuni
Jurnal Kardiologi Indonesia VOL. 28 NO. 4 September 2007
Publisher : Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background. Heart rate recovery (HRR) has been recognized as an independent predictor of mortality.Objective. To identify factors that may affect HRR in patient with unknown coronary artery disease (CAD).Methods. This cross sectional study was performed in National Cardiac Center Harapan Kita. We reviewed the chart of patients with unknown CAD who underwent symptom-limited exercise stress testing for medical check up between January – December 2006. Factors that may influence HRR were recorded including current medications, peak exercise heart rate (HR), HR after 3-minute recovery, and the ischemic response to exercise. HRR was defined as the change in HR from peak exercise to 3-minute recovery. We further categorized patients to normal or abnormal HRR by using mean HRR as cut off value. All factors related to HRR and normal/abnormal categories were analyzed.Results. There were 188 patients aged 48 + 11 years. HRR significantly influenced by male sex (p=0.003), hypertension (p=0.028), â-blocker (p=0.03), calcium channel blocker (p=0.008), aspirin (p<0.001), and provoked ischemia (p=0.005). Using mean HRR (57x) as cut off, patients were classified as having normal (HRR <57x) or abnormal (HRR>57x). On further analysis, there was significant association between age (p=0.003), male sex (p=0.02), hypertension (p=0.02), use of â-blocker (p=0.026) and aspirin (p<0.005).Conclusion. In patients with unknown CAD who underwent symptomlimited exercise stress testing, HRR was influenced by age, male sex, hypertension, the presence of provoked ischemia, use of â-blocker, calcium channel blocker, and aspirin.
Effect of Green Tea on Endothelial Function Assessed by the Flow Mediated Dilatation among Coronary Artery Disease Patients Basalamah, Faris; Basha, Adnil; Kusmana, Dede
Jurnal Kardiologi Indonesia Vol.28 No.2 Mar 2007
Publisher : Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background. Endothelial dysfunction begins when atherosclerosis developed as what go through on hypertension, diabetes, hyperhomocysteinemia,and also what go through among smoker who hasn’thave CAD until end phase of atherosclerosis. Impairment of endothelial function depends on vasodilatation due to the decreasing of eNOS activity.Green tea has been proved to have positive effect in reversing endothelial dysfunction among healthy smoker. This study aim to prove that the shortterm green tea consumption improved flow mediated dilatation among coronary artery disease patients, thus reversed endothelial dysfunction.Methods and results. Twenty three coronary artery disease patients which had been confirmed by coronary angiography joined the study. The sample was divided into two groups, first was the group who took green tea, and the second was the group who took placebo (mineral water). Before treatment, the FMD of both two groups were measured and one hour and half after treatment. After 3-7 days of treatment, both groups were crossover. FMD among healthy group of age less than 25 years old was also measured as control group. There was no significant differences in baseline characteristic between the first and the second group (both received green tea but in different time). FMD after treatment was increased among group who took green tea (4.80±5.37 vs 8.68±6.00, p=0.026), while FMD among placebo group was decreased (5.87±3.89 vs 3.34±3.66 p=0.026). There was significant differences of FMD after treatment with green tea and after treatment with placebo (8.68±6.00 vs 3.35±3.66 p =0.002). There was no differences of brachial artery diameter in both groups (4.60±0.36 vs 4.57±0.41, p=0.8 and 4.57±0.41 vs 4.61±0.36, p=0.601). There was no significant differences on systolic and diastolic blood pressure as well as heart rate in both groups.Conclusions. Green tea had positive effect in reversing endothelial dysfunction among coronary artery disease patient by assessing flow mediated dilatation in short time. The group who took placebo showed the paradoxical effect.
Efficacy and tolerability of 12-weeks treatment with lipanthyl supra or trichol in Indonesian patients with dyslipidemia Supari, Siti F.; Raharjo, Sunu B.; Liastuti, Lies D.; Basha, Adnil
Medical Journal of Indonesia Vol 16, No 3 (2007): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.183 KB) | DOI: 10.13181/mji.v16i3.273

Abstract

The relation of dyslipidemia with the development and progression of atherosclerosis and coronary artery diseases has been demonstrated. This study compared the lipid modifying effects of locally-manufactured fenofibrate (trichol) versus lipanthyl supra in a randomized double-blind controlled study. A total of sixty-eight patients with levels of HDL cholesterol ≤40 mg/dL; triglyceride of 200–600 mg/dL; or LDL of ≥130 mg/dL were recruited to this study and were randomized to either receive trichol 300 mg once daily or lipanthyl 160 mg once daily. Sixty one patients completed the study. Lipid levels before and 4, 8, and 12 weeks after the treatments were measured and analyzed. Compared to baseline values, 12-weeks treatment with either lipanthyl or trichol significantly increased plasma HDL by 18.8% and 14.3% respectively (P<0.001), decreased triglyceride by 38.2% and 37.2% (P<0.001), but with no significant change in LDL levels. Furthermore, we observed a decreased in total cholesterol levels compare to baseline by 8.4% (P<0.05) and 3.1% (P=0.114), in total cholesterol/ HDL ratio by 17.6% and 18.4% (P<0.001), in fibrinogen level by 13.8% and 6.4% and an increase in ApoA-1 by 15.0% and 9.7% for lipanthyl and trichol, respectively. Interestingly, the decrease in total cholesterol level is significantly higher in trichol than lipanthyl groups (P<0.05).The adverse events of both treatments were comparable. The lipid-modifying effects of 300 mg daily dose of trichol is comparable to that of 160 mg daily dose of lipanthyl. Both drugs efficiently increased the plasma HDL levels and decreased plasma triglycerides concentration. Besides, a significant reduction of total cholesterol was achieved after 12 weeks treatment with trichol, but not lipanthyl. (Med J Indones 2007; 16:159-67) Keywords: dyslipidemia, fenofibrate