Hadi Ashar
Balai Litbang GAKI

Published : 3 Documents
Articles

Found 3 Documents
Search

HAMBATAN PERKEMBANGAN ANAK BALiTA Di DAERAH ENDEMIK GAKI

Media Gizi Mikro Indonesia Vol 1, No 3 Des (2010)
Publisher : Media Gizi Mikro Indonesia

Show Abstract | Original Source | Check in Google Scholar

Abstract

Background: First five years is an important period in child development, because in this period is the golden period that will determine subsequent child developmenr. Children in endemic areas iodine deficicncy disorders (IDD) has a risk of iodine deficiency will result in berkurangan IQ points, and disturbing development.Objective: This study aims to obtain constraints on the development ofchildren under live endemic iodine deficiency disorder by age group and type ofbarriers cxperienced growth.Method: The study was descriptive research. The population in this study were children underjive who experience barriers to progress in Magelang District, ages 3 to 60 months were divided in 13 groups according to age development DDTK guidelines.Conclusion: As many as 46.8% of children under .five experiencing barriers to development in less than 12 months of age, and young children in areas of endemic iodine deficiency disorder average experiencing barriers to development almost even lyon thefour aspects of thefive aspects of development.Key words: Development, Firstfive years, Endemic iodine deficiency disorder Background: First five years is an important period in child development, because in this period is the golden period that will determine subsequent child developmenr. Children in endemic areas iodine deficicncy disorders (IDD) has a risk of iodine deficiency will result in berkurangan IQ points, and disturbing development. Objective: This study aims to obtain constraints on the development ofchildren under live endemic iodine deficiency disorder by age group and type ofbarriers cxperienced growth. Method: The study was descriptive research. The population in this study were children underjive who experience barriers to progress in Magelang District, ages 3 to 60 months were divided in 13 groups according to age development DDTK guidelines. Conclusion: As many as 46.8% of children under .five experiencing barriers to development in less than 12 months of age, and young children in areas of endemic iodine deficiency disorder average experiencing barriers to development almost even lyon thefour aspects of thefive aspects of development. Key words: Development, Firstfive years, Endemic iodine deficiency disorder

Suplementasi Besi Mampu Memperbaiki Kadar Hormon TSH Anak Sekolah di Daerah Endemik GAKI

Media Gizi Mikro Indonesia Vol 5, No 2 (2014)
Publisher : Media Gizi Mikro Indonesia

Show Abstract | Original Source | Check in Google Scholar

Abstract

ABSTRACT Multiple nutritional and environmental influences contribute to the prevalence and severity of IDDs in iodine deficient areas, including iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. Iron deficiency adversely affects thyroid metabolism and may reduce the efficacy of iodized salt. The aim of this study was to investigate whether iron supplementation can improve thyrothrophin hormone in school children in iodine deficient areas. A trial of iron supplementation was carried out in an area of endemic goiter in Kertek Wonosobo (n = 35), another group given placebo (n = 35). At baseline, anthropometri, TSH, ferritin, urinary iodine excretion and level of iodized salt were measured. After 13 weeks supplementation, the same data collecting was conducted. Supplement’s compliance during the study reached 100%. Two subject were excluded from from the analysis because they have extreme bio chemical data than the overall average. Statistical test showed no differences in age and gender proportion between groups. There were no significant difference in nutritional status, level of EIU, and level of iodine in salt between groups after the intervention, but there was a significant increase in ferritin level in the iron group (31.0 vs 44.8 μg/l, p<0.05). There were a significant difference in protein and iron intake, but no significant different in energy intake.These two group did not differ in TSH level change. After taking into account the modification variable effect of adequate protein > 70% RDA, the effect of iron supplementation was proved to be effective in changing TSH level (p <0.05). Our result indicate that increase in iron status can improve TSH hormone after considering adequate protein intake (RDA). Keywords : IDD, iron supplementation, thyroid function.   ABSTRAK Di daerah yang kekurangan iodium, pengaruh gizi dan lingkungan berkontribusi pada prevalensi dan tingkat keparahan GAKI, termasuk defisiensi mikronutrien lain diantaranya zat besi. Di negara berkembang, banyak anak-anak menderita GAKI dan defisiensi besi secara bersamaan. Defisiensi besi dapat mengganggu metabolisme tiroid dan mengurangi efektivitas garam beriodum. Penelitian ini bertujuan mempelajari pengaruh suplementasi besi dosis 60 mg/minggu terhadap hormon tiroid pada anak sekolah di daerah endemik GAKI. Suplementasi besi diberikan pada anak sekolah dasar umur 9-12 tahun di daerah dengan kasus kretin, di Kertek Wonosobo (n = 35) dan kelompok lainnya mendapatkan plasebo (n = 35). Awal penelitian dilakukan pengukuran antropometri, kadar TSH, ferritin, UIE dan kadar garam. Setelah 13 minggu suplementasi dilakukan pengukuran yang sama. Tingkat kepatuhan subyek mengonsumsi bahan intervensi 100%, tetapi 2 orang dikeluarkan dari analisis karena data biokimia yang ekstrim dibandingkan rerata keseluruhan. Umur dan jenis kelamin subyek tidak berbeda secara statistik. Setelah suplementasi, status gizi, kadar UIE dan kadar iodium dalam garam tidak berbeda nyata, tetapi ada peningkatan kadar ferritin yang signifikan pada kelompok Fe (31.0 menjadi 44.8 μg/l, p <0.05). Ada perbedaan asupan protein dan zat besi yang signifikan (p <0.05) antara kelompok Fe dan plasebo, tetapi tidak pada asupan energi. Tidak ada perbedaan perubahan kadar TSH yang signifikan antara kelompok Fe dan plasebo. Setelah memperhitungkan efek modifikasi (kecukupan protein >70% AKG), terbukti suplementasi besi berpengaruh terhadap perubahan TSH (p <0.05). Peningkatan status besi dapat memperbaiki hormon TSH setelah memperhitungkan tingkat kecukupan protein (AKG). Kata kunci: GAKI, suplementasi besi, fungsi tiroid.

Pengaruh Suplementasi Ganda Iodium dan Zat Besi (Fe) terhadap Kadar Tsh, Ft4, T3 dan Ferritin Anak Sekolah Dasar

Media Gizi Mikro Indonesia Vol 6, No 2 (2015)
Publisher : Balai Penelitian dan Pengembangan Gangguan Akibat Kekurangan Iodium

Show Abstract | Original Source | Check in Google Scholar

Abstract

PENGARUH SUPLEMENTASI GANDA IODIUM DAN ZAT BESI (Fe) TERHADAP KADAR TSH, fT4, T3 DAN FERRITIN ANAK SEKOLAH DASAR   Effect of Iodine and Iron (Fe) Dual Supplementation on The Levels of TSH, fT4, T3 and Ferritin in Primary School Children ABSTRACT Background. Intercorrelations between iodine and iron (Fe) on the function of the thyroid gland and the status of iron (Fe) affects the effectiveness of Iodine deficiency disorders (IDD) prevention and anemia programs. Communities group prone to nutritional problems are school age children who are in growth period. Objective. This study aims to compare the effect of iodine iron (I+Fe) double supplementation with single supplementation of iodine (I) and single supplementation of iron (Fe) on the function of the thyroid gland and the status of iron (Fe). Method. The study was a randomized double-blind controlled trial. Provision of interventions done by randomization with block permutations dividing study subjects into four groups: Iodine+iron (I+Fe) dual supplement group, iodine (I) only supplement group, iron (Fe) only suplement group and placebo group. Subjects were primary school children aged 9-12 years. Interventions conducted for 13 weeks and thyroid function measured by serum levels of TSH, fT4 and T3, while the iron status based on ferritin levels. Results. Supplementation of Iodine and Iron can increase ferritin and T3 levels, while supplementation of I+FeI, I or Fe can increase levels of fT4 although it is not statistically significant. Ancova showed there is a mechanism of mutual influence between ferritin, fT4 and T3. Conclusion. There is no differences between dual supplementation of iodine and iron with single supplementation of iodine or iron in alteration of ferritin, TSH, fT4, and T3 serum. Keywords: iodine, iron, supplementation.   ABSTRAK Latar belakang. Interkorelasi antara iodium dan zat besi (Fe) terhadap fungsi kelenjar tiroid dan status zat besi (Fe) mempengaruhi efektifitas program penanggulangan Gangguan Akibat Kekurangan Iodium (GAKI) dan anemia. Kelompok masyarakat yang rawan terhadap kedua masalah gizi tersebut adalah anak usia sekolah yang sedang dalam masa pertumbuhan. Tujuan. Analisis ini bertujuan untuk membandingkan pengaruh suplementasi ganda iodium zat besi (Fe) dengan suplementasi tunggal iodium dan suplementasi tunggal zat besi (Fe) terhadap fungsi kelenjar tiroid dan status zat besi (Fe). Metode. Desain penelitian adalah randomized double blind contolled trial. Pemberian intervensi dilakukan dengan cara randomisasi dengan blok permutasi yang membagi partisipan penelitian ke dalam 4 kelompok yaitu kelompok suplementasi ganda iodium+zat besi (I+Fe), kelompok suplementasi tunggal iodium (I), kelompok suplementasi tunggal zat besi (Fe) dan kelompok placebo. Partisipan penelitian adalah anak sekolah dasar umur 9 – 12 tahun. Intervensi dilakukan selama 13 minggu dan fungsi tiroid diukur berdasarkan kadar TSH, fT4 dan T3 serum, sedangkan status besi berdasarkan kadar feritin serum. Hasil. Pemberian suplementasi Iodium dan Fe (I+Fe) dapat meningkatkan kadar feritin dan T3. Pemberian suplementasi Fe+I, I atau Fe dapat meningkatkan kadar fT4 walaupun secara statistik tidak bermakna. Uji ancova menunjukkan adamekanisme saling mempengaruhi antara feritin, fT4 dan T3. Kesimpulan. Tidak ada perbedaan nyata antara suplementasi ganda iodium zat besi (Fe) dengan suplementasi tunggal iodium atau zat besi (Fe) terhadap perubahan ferritin, TSH, fT4, dan T3 serum. Kata kunci: iodium, zat besi, suplementasi.