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All Journal Journal of Tropical Life Science Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Medical Journal of Indonesia Makara Journal of Technology Indonesian Journal of Cancer Chemoprevention Jurnal Kimia Terapan Indonesia ANNALES BOGORIENSES JURNAL ILMU KEFARMASIAN INDONESIA

Nina Artanti

Research Center of Chemistry, Indonesian Institute of Scinces, Kawasan Puspiptek Serpong, Tangerang 15314, Indonesia

Author-ID : 233979

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Engineering Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

Published : 19 Documents

Articles

Title

Antibacterial and Antioxidant activities of Indonesian ginger (jahe emprit) essential oil extracted by hydrodistillation Azizah, Nurul; Filaila, Euis; Salahuddin, Salahuddin; Agustian, Egi; Sulaswatty, Anny; Artanti, Nina
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 20, No 2 (2018)
Publisher : Research Center for Chemistry - LIPI

The rhizome of ginger is commonly used as a spice, food, beverage as well as medicine. Plant essential oils including from ginger have been widely used for food preservation, pharmaceutical and alternative medicines. Currently there are growing interest of consumer for natural sources such as essential oils for natural antibacterial and antioxidant. Jahe emprit (Zingiber officinale var. Amarum) is one of Indonesian ginger variety used to obtain ginger essential oil. The objective of current study was to investigate the effect of solvent to feed (SF) ratio in hydrodistillation process on yield, chemicals content, antibacterial and antioxidant activities of ginger essential oils from jahe emprit. SF ratio used in this study is 0.7: 1, 1.7: 1, 2.7: 1. Chemicals content was conducted using GCMS analysis. Antibacterial assay was conducted using disc diffusion method against Escherichia coli and Staphylococcus aureus. Antioxidant assay was conducted using DPPH free radical scavenging assay. The results show that the highest essential oil yield was obtained from SF ratio 1.7:1 which gave yield of 3.7%. GCMS analysis shows that camphene was always the major compound present in those 3 SF ratio, although the amount present was differed. Besides, 4 other major compounds present were varied. Antibacterial assay using 1% concentration showed ginger oil obtained from SF 0.7:1 and 2.7:1 have the same activities for S. aureus, whereas SF ratio 1.7:1 has the lowest activities. However for E. coli, all SF ratio gave same results. For antioxidant activities at 1000 ppm concentration, the highest activity was obtained from SF ratio 2.7:1

CHEMICAL CATALYTIC AND BIOCATALYTIC PROCESS OF CLOVE OIL DERIVATIVES REVIEW Tursiloadi, Silvester; Artanti, Nina; Sulaswatty, Anny
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 17, No 1 (2015)
Publisher : Research Center for Chemistry - LIPI

In 2011, Indonesian clove oil supply reached about 75 % (4,500 of 6,000 tons) of the world market. Utilization of clove oil and clove oil derivatives in aromatic chemical industry primarily as a mixture or additive of fragrances in the daily consumed product, such as perfumes, skin care products, deodorant, soap, shampoo, detergent, besides it is also used as an ingredient in the production of synthetic vanilla. The content of eugenol as the main compound in the essential oil in the clove flower, flower stalk and leaf have a range of 90-95 %, 83-95 % and 82-87 % respectively. The compounds content in clove oil is divided into two categories, phenolics (eugenol) and non-phenolic (beta-caryophyllene) that can be derivatized with various chemocatalytic and biocatalytic processes. Separation of the compounds in clove oil can be conducted by adding NaOH with repeated distillation. This process produces two layers product, the first layer contains eugenol and NaOH, while the second layer contains beta-caryophyllene. Derivatization of eugenol are conducted to produce various products such as vanilla, eugenyl ether, methyl ether eugenyl, eugenyl ethyl ether, eugenyl acetate, eugenyl cinnamate, dimmer eugenol and eugenyl benzoate, whereas derivatization of beta-caryophyllene are conducted to produce products such as caryophyllene oxide, kobusan, glycols, alcohols caryophyllene, β-caryolanylformate and kovanilformate, klovanildiformate, caryophyllene ketol. Biocatalysis or biotransformation can be defined as the use of biological systems (intact cells, cell extracts or isolated enzymes) to catalyze the conversion of a compound into another. Besides the common chemocatalysis system for derivatization of clove oil and clove oil compound such as eugenol into other compounds some biocatalysis systems were also described in this paper.Keywords: Clove oil, eugenol, beta-caryophyllene, derivatization, chemical catalysis, biocatalysis

AKTIVITAS ANTIOKSIDAN DAN TOKSISITAS EKSTRAK AIR DAN ETANOL DAUN BENALU (Dendrophthoe pentandra L. Miq) YANG TUMBUH PADA BERBAGAI INANG Artanti, Nina; Widayati, Retno; Fajriah, Sofa
Jurnal Kimia Terapan Indonesia Vol 11, No 1 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v11i1.175

Mistletoes are used traditionally in Indonesiaas medicinal plant, one of this as anticancer. Cancer isone of degenerative diseases could be triggered by toomuch free radicals in the body, whereas antioxidantcould reduced the risk of degenerative diseases.Mistletoes reposted content flavonoids which known have antioxidant activity. Mistletoe potency as drugmaterial should be studied sa the utilization ofmistletoe could be developed. Antioxidant activitytest using "DPPH free radical scavenger" methodand toxicity test using BSLT (Brine Shrimp LethalityTest) method had been conducted on water andethanol extracts of mistletoe Dendropthoe pentandra(L.) Miq.) that grown on various trees (star fruit,mango, cananga, duku, sour-sop, kepel, mahkotadewa, and tea). The result showed that ethanol andwater extracte-ofD, petandra on all host plants haveantioxidant activity (IC50 value between 6.4 - 51.8ug/mL). The result of toxicity test showed that ethanolextract of mistletoe on cananga, starfruit, kepel andmahkota dewa host plants have toxicity effect againstA. salina larvae with LCso value below 1000 ug/mL,nevertheless ethanol extract on others host plants andwater extract didn It give toxicity effect against A.salina larvae (LC50 > 1000 ug/mL).Key words: mistletoe, D. petandra, DPPH, antioxidant,toxicity, degenerative disea.

AKTIVITAS ANTIOKSIDAN DAN BIOAKTIVITAS IN VITRO EKSTRAK AIR DAN EKSTRAK ETANOL DAUN DAN RANTING BENALU Macrosolen cochinchinensis (Lour.) van Tiegh. PADA INANG NANGKA ( Artocarpus heterophyllus) Artanti, Nina; Darmawan, Akhmad
Jurnal Kimia Terapan Indonesia Vol 11, No 2 (2009)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jkti.v11i2.160

Study on antioxidant activity and bioactivity of water and ethanol extracts from the leaves and twigs of mistletoe (Macrosolen cochinchinensis (Lour.) Van Tiegh) that grew on jackfruit (Artocarpus heterophyllus) tree as the host have been conducted. Water extracts of the M. cochinchinensis leaves andtwigs were active as antioxidant with IC50 23.08 ug/mL dan 21.56 ug/mL respectively. Whereas the ethanol extracts of both leaves and twigs was not active because the ICso higher than 100 ug/mL (not active as antioxidant against DPPH). Both water and ethanol extracts of M. cochinchinensis leaves and twigs did not showed bioactivity against Artemia salina Leach brine shrimp with each extracts has LCso higher than 1000 pg/mL.Key words Antioxidant, Bioactivity, Macrosolen cochinchinensi (Lour.) van Tiegh., Artocarpus heterophyllus. Artemiasalina Leach.

PENGARUH LOKASI DAN PELARUT PENGEKSTRAKSI TERHADAP KANDUNGAN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK PEGAGAN (Centella asiatica L. Urb) Artanti, Nina; Dewi, Rizna Triana; Maryani, Faiza
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 16, No 2 (2014)
Publisher : Research Center for Chemistry - LIPI

Pegagan (Centella asiatica Linn Urb.) merupakan jenis tanaman yang biasa digunakan dalam industry farmasi dan kosmetik.Penelitian ini ditujukan untuk mengevaluasi pengaruh tiga lokasi asal sampel dan tiga jenis larutan pengekstraksi (methanol, etanol 96% (v/v), dan etanol 70% (v/v)) terhadap aktivitas antioksidan herbal pegagan (Centella asiaticaLinn Urb).Sampel pegagan yang digunakan pada peneltian ini berasal dari Lembang, Bandung, dan Solo. Pada ekstrak yang diperoleh dilakukan penentuan kadar fenol total, flavonoid total, dan triterpenoid total. Aktivitas antioksidan dari ekstrak dievaluasi berdasarkan metoda peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH). Hasil yang diperoleh menunjukkan bahwa simplisia pegagan asal Lembang yang diekstrak dengan etanol 70% mempunyai aktivitas antioksidan tertinggi serta kandungan fenol total dan flavonoid total tertinggi. Sedangkan simplisia pegagan asal Bandung yang diekstrak dengan pelarut metanol memiliki kandungan triterpenoid total tertinggi tetapi memiliki kandungan fenol total dan flavonoid total serta aktivitas antioksidan yang terendah. Hasil analisa statistik menunjukkan bahwa lokasi asal simplisia pegagan dan polaritas pelarut yang digunakan untuk ekstraksi secara signifikan (p<0,05) mempengaruhi kandungan fenol total, flavonoid total dan triterpenoid total serta aktivitas antioksidan dari ekstrak pegagan.Kata kunci: ekstrak pegagan, antioksidan, polaritas pelarut Pegagan (Centella asiatica Linn Urb.) is a plant species that commonly used in the pharmaceutical and cosmetic industry. Objective of this study is to evaluate the effect of different source location and solvent polarity for the extraction to the content of total phenolic, total flavonoid total triterpenoids as well as antioxidanti activity of pegagan ((Centella asiatica (Linn.) Urb.)extracts. Pegagan materials for this study are from three different locations: Bandung, Lembang and Solo. Based on polarity differences methanol, ethanol 96% and ethanol 70% were used as solvent for extraction. Antioxidant activity of the extract was evaluated based on the method of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity. Results showed that the highest total phenolic content and flavonoid content and antioxidant activity were from 70% ethanol extract from Lembang. Materials from Bandung extracted with methanol gave the highest content of total triterpenoid, however has the lowest content of total phenolic, total flavonoid and antioxidant activity. Statistic analysis showed that there is significant differences (p<0,05) of results of total phenolic, total flavonoid, total triterpenoid and antioxidant activity due to source location and solvent polarity. Keywords:Centella asiatica (Linn.) Urb extract, antioxidant, polarity solvent

Effect of initial inoculum on growth and fatty acid content as an α-glucosidase inhibitor in Colletotrichum sp. TSC13 mycelium that cultures under shake and static conditions Artanti, Nina; Kardono, Leonardus B.S.; Tachibana, Sanro
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 19, No 2 (2017)
Publisher : Research Center for Chemistry - LIPI

Colletotrichum species were reported producing various bioactive compounds that may potentially be used in the development of anti-microbial, antioxidant, anticancer and anti-diabetes drugs. Our previous studies showed that the methanol extracts of mycelia from Colletotrichum sp. TSC13, an endophytic fungus isolated from Taxus sumatrana (Miq.) de Laub., were found to have α-glucosidase inhibitory activities. The aim of present study was to examine the effects of initial inoculum on growth and the content of fatty acids as an α-glucosidase inhibitor in Colletotrichum sp. TSC13 that grew under shake and static condition. The results showed that shake and static conditions had more effect compared to the initial inocculum on growth and glucose consumption in growth and glucose consumption. However in terms of fatty acids contents and α-glucosidase inhibitor activities the initial inoculum showed more effect than shake and static conditions

STANDARDISASI EKSTRAK PEGAGAN, CENTELLA ASIATICA SEBAGAI OBAT HERBAL TERSTANDAR HEPATOPROTEKTOR Lotulung, Puspa Dewi N; Handayani, Sri; Ernawati, Teni; Yuliani, Tri; Artanti, Nina; Mozef, Tjandrawati
Jurnal Kimia Terapan Indonesia (Indonesian Journal of Applied Chemistry) Vol 17, No 2 (2015)
Publisher : Research Center for Chemistry - LIPI

Herbal medicinal products would be affected by the quality of raw materials. In turn, the quality of raw material will also be influenced by various factors such as soil conditions, cultivation, post-harvest processing, and the processing of raw materials into crude drug or extract. Therefore, in order to make good herbal medicines, it is necessary to make standardization of herbal extracts that produced herbal medicines that have the same quality and functions of effectiveness in each process. From preliminary studies that have been done, Centella asiatica is one of the potential plants as a source of hepatoprotective compounds. Test in vivo and in vitro against Centella asiatica extracts have shown very good results. Ethyl acetate extract with 17.5 mg/kg of doses body weight and butanol 228.8 mg/kgof doses body weight has been applied for in vivo test using mice induced by CCl4; theydemonstrated hepatoprotective effects. Ethyl acetate extracts were able to reduce levels of the enzyme alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by 56 % and 44 % respectively while butanol extract can reduce the enzymes AST levels by 3%. Standardizationof Centella asiatica extract performed in this study was the characterization of the extract in the form of non-specific and specific parameters corresponding to the reference of PPOMN (Ministry of health Republic of Indonesia, 2000) such as levels of drying shrinkage, ash content, total plate count microbial contamination, levels of water-soluble compounds, levels of compounds that are soluble in ethanol, phytochemical test, total phenolic content, total flavonoid content and the determination of Pb and Cd weight.The results showed that non-specific parameters for the ethanol extract of Centella asiatica were requirements based on Herbal Pharmacopoeia in 2008 which includes parameters such as determination of shrinkage on drying ≤ 10%, ash content ≤ 16.6% and negative microbial contamination. Specific parameters for the ethanol extract of Centella asiatica have met the requirements of Herbal pharmacopeia in 2008.Keywords: Centellaasiatica, hepatoprotective, standardized herbal medicine, specificparameters, and non-specific parameters

Co-Authors . Djamilah Akhmad Darmawan Andini Sundowo Anny Sulaswatty, Anny Asih, Puji Budi Setia Dewijanti, Indah Dwiatmi Egi Agustian Euis Filaila Hani Mulyani, Hani Ira Djajanegara ISKANDAR, YETI MULYATI Jamilah Abbas Jamilah Abbas Abbas Kardono, Leonardus Broto Sugeng Ken Ichi Fujita, Ken Ichi L., MEILYAWATI Leonardus B.S. Kardono Lia Meilawati LIANDHAJANI, LIANDHAJANI Linar Zalinar Udin, Linar Zalinar Lotulung, Puspa Dewi N M. Hanafi Maryani, Faiza Mcfarlane, Ian James Megawati Megawati Minarti Minarti Muhammad Hanafi NURUL AZIZAH Pambudi, Sabar Pratiwi, Rosa Dewi Puspa D Lotulung, Puspa D Puspa Lotulung, Puspa Retno Lestari Retno Widayati Rina Andriyani Rina Hidayati Pratiwi Rizna Dewi Rizna Triana Dewi Salahuddin Salahuddin Sanro Tachibana Saraswati, Vienna Silvester Tursiloadi Sofa Fajriah Sofna D.S. Banjarnahor Sri Handayani Sri Hartati SUTARYO, SITI MASRURAH BROTO Syafrudin, Din Teni Ernawati Tjandrawati Mozef Tri Yuliani, Tri Tutik Murniasih Vienna Saraswaty, Vienna Yoshinosuke Usuki, Yoshinosuke

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