Samuel Arifin
Faculty of Medicine, Maranatha Christian University

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The Comparison Effect of Aloe vera L., Psidium guajava Linn, Curcuma domestica Val to Colitis Ulcerative Mice Models Histopatology Kurniawati, Dewi; Jasaputra, Diana Krisanti; Ratnawati, Hana; Tiono, Hartini; Sujatno, Muchtan; Dewi, Aprilin Krista; Mayestica S., Putu; Arifin, Samuel
Jurnal Medika Planta Vol 1, No 2 (2010)
Publisher : Jurnal Medika Planta

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Abstract

Introduction: Ulcerative colitis (UC) is an inflammatory disease limited to the mucosal and submucosal layers of the colon. UC treatments was aimed to decrease inflammation and oxidation process on colon. Nowadays people start using hermal medicine to attentuate inflammation and oxidation process in ulcerative colitis, e.g. Aloe vera, Psidium guajava Linn, Curcuma domestica Val.Objective: to compare the effect of Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract on histopatology of ulcerative colitis.Methods: experimental comparative research with completely randomized design. Mice were divided on 5 groups (n=6) which were given Aloe vera ethanol extract 700 mg/kgBB and DSS 2,5%; Psidium guajava Linn ethanol extract 1.591,2 mg/kgBB and DSS 2,5%; Curcuma domestica Val ethanol extract 180.816 mg/kgBB and DSS 2,5%; aquadest and DSS 2,5% (positive control); aquadest (negative control). Data were analyze with ANOVA followed by Tukey HSD test with a=0.05.Results: there were a decrement percentage of crypt loss on Aloe vera ethanol extract group (10.5 +- 4,64681%), Psidium guajava Linn ethanol extract group (11 +- 2,09762%), Curcuma domestica Val ethanol extract group (9 +- 3,09839%) compared with positive control group (26.8 +- 1,72240%)(p<0.05). Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract had same effectivity (p>0.05).Conclusion: Aloe vera ethanol extract, Psidium guajava Linn ethanol extract, Curcuma domestica Val ethanol extract had same effectivity on decreasing percentage of crypt loss on colitis ulcerative histopatology of mice induced by DSS 2.5%.