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Ardian Arif
Laboratorium Fisika Komputasi Departemen Fisika, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Jalan Meranti, Gedung Wing S, Lantai 2, Kampus IPB Darmaga, Bogor 16680

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Studi Awal Pemodelan Perlakuan Virotherapy yang Menggunakan Virus Campak pada Tumor Paru-paru Tikus

BERKALA FISIKA Vol 13, No 4 (2010): Berkala Fisika
Publisher : BERKALA FISIKA

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Abstract

The interaction model dynamics between tumor and viruses based on the interaction phenomenon between the three populations, namely: population of uninfected tumor cells, tumor cell population infected with the virus and the virus population. This study aimed to see the interaction between non-infected tumor cells, tumor cells infected with viruses and viruses, so it can be modeled using virotherapy treatment of measles virus in mouse lung tumors. Model parameters obtained from experimental data. Numerical Solution of the models suggest that the dose of the virus play an important role in determining the outcome of tumor therapy. Tumor growth can be slowed by using this virotherapy, but the tumor can not be killed as a whole. Keywords: model dynamics, virotherapy, measles virus, mouse lung tumors t; mu � ni�o� P� :IN> viscosity, indeks of refraction, transparent liquid 

Solusi Numerik Model Dinamik Perlakuan Immunotherapy pada Infeksi HIV-1

BERKALA FISIKA Vol 13, No 1 (2010): Berkala Fisika
Publisher : BERKALA FISIKA

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Abstract

There are several types of treatment options that can slow the progression of HIV that can be offered if the number of CD4 + cells has been known for certain, one treatment is by immunotherapy with interleukin-2 (IL-2). This type of treatment is to increase the immune system that can help the body fight against the infection itself. Efforts to raise an immune response would be appropriate to reduce the amount of virus. This brings new hope for treatment of HIV infection and the type of treatment is being researched. Interleukin-2 (IL-2) is most of the cytokines which are proteins made by the body. T-helper cells, a type of white blood cells, produce IL-2 when they were stimulated by infection. In this study, a model of HIV disease progression than individuals not treated can be expressed in a mathematical model, and also expressed immunotherapy model to see the dynamics of viral populations and the population of CD4 + T cells from HIV disease based on ordinary differential equation (ODE). This study aims to calculate the numerical solution immunotherapy mathematical model in HIV infection and a mathematical model to predict the outcome of immunotherapy treatment strategies in HIV infection. Keywords: HIV, CD4 + T cells, immunotherapy, mathematical modeling

Studi Awal Pemodelan Perlakuan Virotherapy Yang Menggunakan Virus Campak Pada Tumor Paru-Paru Tikus

BERKALA FISIKA Vol 13, No 2 (2010): Berkala Fisika, Edisi Khusus
Publisher : BERKALA FISIKA

Show Abstract | Original Source | Check in Google Scholar | Full PDF (268.876 KB)

Abstract

The interaction model dynamics between tumor and viruses based on the interaction phenomenon between the three populations, namely: population of uninfected tumor cells, tumor cell population infected with the virus and the virus population. This study aimed to see the interaction between non-infected tumor cells, tumor cells infected with viruses and viruses, so it can be modeled using virotherapy treatment of measles virus in mouse lung tumors. Model parameters obtained from experimental data. Numerical Solution of the models suggest that the dose of the virus play an important role in determining the outcome of tumor therapy. Tumor growth can be slowed by using this virotherapy, but the tumor can not be killed as a whole. Keywords: model dynamics, virotherapy, measles virus, mouse lung tumors