Safruddin Amin
Dept, of Dermato-Venereology, Hasanuddin Medical Faculty, Makassar

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COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB)

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
COMPARATIVE STUDY ON THE INTENSITY OF Mycobacterium leprae EXPOSURE TO CHILDREN WHO LIVE IN LOW AND HIGH ALTITUDE IN LOW LEPROSY ENDEMIC AREA OF SOUTH SULAWESI Rachmawati, Rachmawati; Mataallo, Timurleng Tonang; Adam, Safruddin; Adam, A. M.; Amin, Safruddin; Tabri, Farida; Adriaty, Dinar; Wahyuni, Ratna; Iswahyudi, Iswahyudi; Agusni, Indropo
Indonesian Journal of Tropical and Infectious Disease Vol 4, No 4 (2013)
Publisher : Institute of Topical Disease

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.847 KB) | DOI: 10.20473/ijtid.v4i4.220

Abstract

Background: The intensity of Mycobacterium leprae exposure to people who live in leprosy endemic area could be measured by serological study and detection of the bacilli in the nose cavity. Different geographical altitude might have some influences to this exposure since the bacilli prefer to live in warm areas. Aim: A combined serological and PCR study of leprosy was conducted in Selayar island, South Sulawesi to 80 school children (40 from low land and 40 from highland altitudes) in order to compare the exposure intensity between the two areas. Method: Anti PGL-1 IgM antibody (ELISA) and PCR study to detect M.leprae in the nasal cavity were performed simultaneously from each person. Result: Seropositive cases were found in 23/40 children from low land compared to 16/40 children from high land, but statistically no significant difference (p>0.05). PCR positive for M.leprae in the nasal cavity only found in 1/40 children, both in low and high altitude. Conclusion: It is concluded that although the existence of M.leprae in nasal cavity is minimal, the intensity of exposure to this bacilli still high as indicated by serological study.
Infeksi Cacing Tidak Berpengaruh terhadap Kadar Transforming Growth Factor (TGF)-β dan Kejadian Dermatitis Atopik pada Anak Mukhasin, Nadiah Soleman; Wahyuni, Sitti; Ilyas, Faridha S; Amin, Safruddin; Satriono, R; Tabri, Farida
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2015.028.03.10

Abstract

Infeksi cacing melalui kemampuannya memacu proliferasi sel T regulator dilaporkan dapat mempengaruhi manifestasi klinik dari alergi. Selain Interleukin (IL)-10, Transforming Growth Factor (TGF)-β merupakan sitokin yang di lepaskan oleh sel T regulator. Penelitian ini bertujuan untuk melihat pengaruh infeksi cacing terhadap kejadian dermatitis atopik (DA) melalui TGF-β. Penelitian ini dilakukan di beberapa rumah sakit pendidikan Fakultas Kedokteran Universitas Hasanuddin. Dermatitis atopik (DA) didiagnosis dengan menggunakan kriteria William, ada dan beratnya infeksi cacing diperiksa dengan metode Kato Katz dan kadar TGF-β serum diukur menggunakan metode ELISA.  Sebanyak 80 anak usia 2-7 tahun berpartisipasi pada penelitian ini. Partisipan dibagi menjadi kelompok DA (30 anak) dan non-DA (50 anak). Persentasi infeksi cacing adalah 21,2% (17/80) dengan intensitas infeksi yang ringan. Infeksi cacing tidak mempengaruhi kadar TGF-β, demikian juga infeksi cacing serta kadar TGF-β tidak mempengaruhi kejadian DA. Penelitian ini menyimpulkan bahwa infeksi cacing dengan intensitas ringan tidak mempengaruhi kadar TGF-β maupun kejadian DA pada anak di Makassar.Kata Kunci: Dermatitis atopik, infeksicacing, TGF-β