Nur Illiyyin Akib
Jurusan Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Haluoleo, Kendari

Published : 7 Documents
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Journal : Pharmauho

Study of Physical Characteristic and Equivalence between Generic and Branded Name of Phenylbutazone Tablet

Pharmauho Vol 3, No 2 (2017): Pharmauho
Publisher : Pharmauho

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Abstract

Physical characterization and equivalence testing of generic and branded names of phenylbutazone tablets have been done. The information about quality of generic drugs is expected to increase the use of generic drugs by health practitioners and public. Dissolution test carried out by in vitro had correlation with bioequivalence by in vivo test. Sample of dissolution testing were generic (G) and branded (A and B) names of 200 mg phenylbutazone tablets. Physical characteristic test performed by uniformity weight test, hardness and disintegration time. Dissolution test were conducted by using basket and spectrophotometry ultra violet method in 200-400 nm wavelength. The result of uniformity weight of generic drug and branded drug was 352,02 mg and 352,82 mg, the hardness of generic was 9,58 kgf and branded was 9,50 kgf, and disintegration test result of generic was 16,1 minutes and branded was 3 minutes. The result of dissolution testing were dissolution profile and dissolved concentration at 30 minutes that compared to qualify of USP XXXII. Relative bioavailability testing of generic to A brand was 101.580 and generic to B brand was 105.275. Based on statistical test, there was no significant different or pharmaceutical equivalent. The generic tablets were equivalent to A and B branded names tablets with similar factors 82.120 and 74.271.Keywords: Equivalence, Dissolution, Salbutamol tablet; generic name, branded name

Uji Aktivitas Antimalaria Ekstrak Air Bunga Carthamus tinctorius L. pada Biakan In Vitro Plasmodium falciparum

Pharmauho Vol 1, No 1 (2015): Pharmauho
Publisher : Pharmauho

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Abstract

Pengujian aktivitas antimalaria dengan menggunakan ekstrak air bunga Carthamus tinctorius L. pada biakan in vitro plasmodium falciparum strain 3D7 yang sensitif terhadap klorokuin telah dilakukan. Uji aktivitas dilakukan dengan cara melarutkan bahan uji dalam DMSO kemudian dibuat serial pengenceran dalam media RPMI sampai diperoleh konsentrasi akhir sebesar 100 µg/ml, 10 µg/ml, 1 µg/ml, 0,1 µg/ml dan 0,01 µg/ml. Pada larutan uji ditambahkan suspensi parasit dengan kadar parasitemia ±1% dan hematokrit 5%. Kultur diinkubasi selama 48 jam pada suhu 37oC. Hasil menunjukkan pengujian aktivitas antimalaria dari ekstrak air bunga Carthamus tinctorius L. memiliki daya hambat terhadap pertumbuhan Plasmodium falciparum strain 3D7 sebesar 52,68%.Kata Kunci : Bunga Carthamus tinctorius L, Antimalaria, Plasmodium falciparum 3D7, dan Ekstrak air

Profil Fitokimia Ekstrak Etanol Bunga Kasumba Turate (Carthamus tinctorius L.) yang Berpotensi Sebagai Antimalaria

Pharmauho Vol 4, No 2 (2018): Pharmauho
Publisher : Universitas Halu Oleo

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Abstract

Bunga Kasumba turate (Carthamus tinctorius Linn) dari suku Asteraceae merupakan tumbuhan obat tradisional etnis Sulawesi Selatan yang secara empiris digunakan dalam pengobatan campak. Ekstrak etanol dari kasumba turate memberikan peningkatan aktivitas imunoglobulin G (IgG) dan  aktivitas imunoglobulin A (IgA) yang sangat signifikan. Penelitian menunjukkan ekstrak etanol bunga C. Tinctorius L memiliki potensi sebagai antimalaria secara in vitro dengan nilai IC50 sebesar 1,06 µg/ml. Sampel bunga C. tinctorius L. kering sebanyak 3 Kg dicacah hingga menjadi serbuk sebanyak 870 gram kemudian diekstraksi secara maserasi dengan menggunakan pelarut etanol 80%. Hasil maserasi dipekatkan dengan vacuum rotary evaporator pada suhu 50°C sehingga diperoleh ekstrak kental sebanyak 178,7gram. Profil fitokimia menunjukkan ekstrak etanol bunga C. tinctorius L. mengandung senyawa metabolit antara lain saponin, terpenoid, flavonoid, tanin dan antrakuinon.Kata kunci: Skrining, ekstrak, kasumba turate, obat tradisional, antimalaria