Dewi Agustina
The Postgraduate Program in Clinical Dental Science with Special Interest in Oral Medicine, Oral Medicine Department, Faculty of Dentistry, Gadjah Mada University, Yogyakarta, Indonesia
Articles
27
Documents
Gambaran Manifestasi Klinis Dan Laboratorium Demam Berdarah Dengue (DBD) Di Bagian Anak RSUD DR. Abdul Moeloek

Juke Unila Vol 2, No 1 (2012)
Publisher : Juke Unila

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Abstract

Demam berdarah dengue (DBD) merupakan penyakit demam akut yang ditandai dengan demam akut selama 2 sampai dengan 7 hari, kadang-kadang bersifat bifasik, disertai dengan manifestasi perdarahan dan dapat menimbulkan syok serta kematian. Penelitian ini untuk mengetahui gambaran manifestasi klinis dan laboratorium demam berdarah dengue (DBD) di bagian Ilmu Kesehatan Anak RSUD dr. H. Abdul Moeloek bulan Juni 2007- Juni 2008. Penelitian menggunakan metode deskriptif retrospektif. Sample dalam penelitian ini menggunakan teknik total sampling, dimana semua populasi yang memenuhi kriteria inklusi yaitu anak yang didiagnosa DBD berdasarkan kriteria WHO 1997, usia diatas  1 bulan s/d 18 tahun dan adanya kelengkapan data rekam medik. Populasi penelitian sebanyak 85 orang, dimana hasil penelitian penderita DBD yang terbanyak pada umur 5 tahun - <12 tahun sebanyak 47 penderita (55<3%) dan terendah pada umur < 2 tahun sebanyak 2 penderita (2,3%). Lama demam penderita DBD selama 1 - 3 hari: 18 penderita (21,2%), 4 - 5 hari: 48 penderita (56,5%) dan selama 6 - 7 hari: 19 penderita (22,4%). Pada manifestasi perdarahan berupa uji tourniquet positip: 34 penderita (33,0%), petekie : 41 penderita (39,8%), epistaksis: 14 penderita (13,6%), perdarahan gusi: 2 penderita (1,9%), hematemesis: 4 penderita (3,9%) dan melena: 8 penderita (7,8%). Pada seorang penderita dapat dijumpai lebih dari satu macam gejala perdarahan. Hepatomegali: 15 penderita (17,6%), tidak hepatomegali: 70 penderita (82,4%). Trombosit 10 3/mm3 - 30 3/mm3 : 2 penderita (2,3%), >30 3/mm3 - 50 3/mm 3 : 23 orang (27,1%) dan >50 3/mm3 - 100 3/mm3  : 60 penderita (70,6%). Peningkatan hematokrit antara 20% - 29% : 32 penderita (37,7%), Ht. 30% - 39%: 44 penderita (51,8%) dan Ht. >39% : 9 penderita (10,6%). Uji serologis  IgM (+) dan IgG (+) : 65 penderita (76,5%),  IgM (+) dan IgG (-) : 18 penderita (21,2%) dan IgM (-) dan IgG (+) : 2 penderita (2,4%).  Penderita DBD derajat I :  21 penderita (24,7%), DBD derajat II : 50 penderita (58,8%), DBD derajat III : 11 penderita (12,9%) dan DBD derajat IV : 3 penderita (3,6%). Penderita DBD dengan manifestasi perdarahan yang terbanyak adalah petekie sebanyak 41 penderita yaitu pada   DBD derajat II dengan 33 penderita, sedangkan manifestasi perdarahan yang terendah adalah perdarahan gusi sebanyak 2 penderita. penderita DBD yang terbanyak tidak ada hepatomegali : 70 penderita, yaitu terbanyak pada DBD derajat II berjumlah 43 penderita. Jumlah trombosit yang terbanyak adalah   trombosit >503/mm3 - 1003/mm3: 60 penderita, yaitu terbanyak pada DBD derajat II : 38 penderita, sedangkan yang terendah dengan trombosit 103/mm3 - 303/mm3 pada DBD derajat I dan derajat IV. Peningkatan hematokrit yang terbanyak pada Ht. 30% - 39% : 44 penderita, yaitu terbanyak pada DBD derajat II sedangkan kadar peningkatan hematokrit yang terendah pada Ht. >39% : 9 penderita. Uji serologis yang terbanyak pada serologis IgM(+)/IgG (+) : 65 penderita yaitu terbanyak pada DBD derajat II : 40 penderita, dan terendah uji serologis IgM (-)/IgG (+) : 2 penderita. Kesimpulan bahwa untuk menegakkan diagnosis penyakit DBD berdasarkan kriteria WHO (1997) dan dikonfermasikan dengan pemeriksaan serologik hemaglutinasi atau IgM dan IgG

ANALISIS ARUS KAS TERHADAP LIKUIDITAS PT. HOTEL MANDARINE REGENCY TBK PERIODE 2008-2012

JURNAL AKUNTANSI UNESA Vol 2, No 1 (2013): Volume 2 Nomer 1 September 2013
Publisher : JURNAL AKUNTANSI UNESA

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Abstract

Statements of cashflows can provide information to the management about the liquidity of companies. The research aims to determine the cash flow on liquidity of  the registered hospitality company in Indonesian Stock Exchange (IDX), especially PT. Hotel Mandarine Regency Tbk. The research method using descriptive method with cash flows from operating, investing and financing activities and liquidity (current ratio) as the variable. The results of this research showed the company’s cash flow surplus, except in 2009 anda 2011. The liquidity of PT. Hotel Mandarine Regency Tbk was liquid that judged from current ratio. Keywords : cash flows, liquidity, current ratio

Incidental Abnormalities in Oral Mucosal Carcinogenesis of v-H-ras Transgenic Mice OF v-H-ras TRANSGENIC MICE

Journal of Dentistry Indonesia Vol 16, No 1 (2009): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

The effect of individual oncogene on diverse cell types could be studied by using transgenic mice. The expression of transgene is mainly determined by the regulatory sequences chosen. Fifty four v-H-ras transgenic FVB/N mice and 54 parental FVB/N mice were used as the experimental and the control groups respectively. Each group was divided into nine subgroups with three different treatments i.e. 4-nitroquinoline 1-oxide (4NQO)-treated, phorbol 12,13-didecanoate (PDD)-treated and propane-1,2-diol (PD)-treated palatal of mice for 6, 16 or 24 weeks. Other four mice of parental mice were used as the untreated group. Two weeks after the last painting, all animals were sacrificed and the intra- or extra-oral tissues were removed and fixed in 4% m/v paraformaldehyde for 24 hours. Hard tissue were then decalcified after the fixation was completed. Subsequently, standard procedure for H&E staining was performed. The results of this study showed that 47 out of 54 transgenic mice produced spontaneous odontogenic, epidermal or mesenchymal neoplasms. After 24 weeks of painting with 4NQO there was minimal evidence of palatal epithelial dysplasia in both transgenic and parental strain groups and neither the PDD nor PD groups showed evidence of dysplasia. From these results it was apparent that the effect of 4NQO and PDD was slower than reported for other strain of mice and that activated v-H-ras did not increase the rate of palatal mucosal carcinogenesis in the model used. On the other hand, incidental abnormalities were much detected especially in the experimental group.DOI: 10.14693/jdi.v16i1.11

Unstimulated Salivary Flow Rate Corresponds with Severity of Xerostomia: Evaluation using Xerostomia Questionnaire and Groningen Radiotherapy- Induced Xerostomia Questionnaire

Journal of Dentistry Indonesia Vol 21, No 1 (2014): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

One of the oral complications in head and neck radiotherapy is xerostomia. The severity of xerostomia can be observed using objective examination (unstimulated salivary flow rate measurement) and subjective examination (assessment using xerostomia questionnaires). There are two questionnaires used in assessment of xerostomia in head and neck cancer radiotherapy namely Xerostomia Questionnaire (XQ) and Groningen Radiotherapy-Induced Xerostomia Questionnaire (GRIX). Objective: To know the correlation between unstimulated salivary flow rate and severity of xerostomia assessment using two questionnaires. Methods: 30 head and neck cancer patients undergoing radiotherapy at Radiotherapy Department of RSUP Dr. Sardjito Yogyakarta between January-April 2013 were involved in this study. The assessment of xerostomia used xerostomia questionnaires (XQ and GRIX). Unstimulated salivary flow rate was measured in ml/minutes. Data was analyzed using Spearman Rank Correlation. Results: There is a negative significant correlation between salivary flow rate and severity of xerostomia with correlation coefficient -0.452 (p<0.05) and -0.511 (p<0.05). Conclusions: There is a correlation between unstimulated salivary flow rate and severity of xerostomia assessment using XQ and GRIX for head and neck cancer patients undergoing radiotherapy at RSUP Dr. Sardjito Yogyakarta.

KOMPETENSI GURU DALAM PEMANFAATAN SUMBER BELAJAR GEOGRAFI SMA NEGERI

GEOGRAFI Vol 2, No 1 (2014)
Publisher : GEOGRAFI

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Abstract

Penelitian ini bertujuan untuk mengetahui (1) ketersediaan sumber belajar geografi, (2) pengetahuan guru tentang sumber belajar geografi, (3). kompetensi guru dalam pemanfaatan sumber belajar geografi, (4) upaya guru geografi dalam meningkatkan kompetensinya untuk memanfaatkan sumber belajar. Penelitian ini bersifat deskriptif dengan pendekatan kualitatif. Instrumen yang digunakan adalah kuesioner/angket, dokumentasi, dan observasi. Sampel penelitiannya menggunakan sampel penuh, yaitu seluruh guru SMA Negeri di Kabupaten Semarang yaitu sebanyak 16 orang. Analisis data yang digunakan adalah prosentase. Berdasarkan hasil penelitian menunjukan: 1) ketersedian sumber belajar di SMA Negeri di Kabupaten Semarang khususnya meliputi benda, karya ilmiah, manusia dan lingkungan menunjang kegiatan pembelajaran, hanya saja sedikit kurang tersedianya jurnal, koran, maket, dan hasil penelitian. 2) pengetahuan guru geografi terhadap sumber belajar meliputi jenis, fungsi, manfaat, cara penggunaan sumber belajar. Berdasarkan hasil penelitian, lebih dari setengah guru 57% atau 9 guru mmengetahui tentang jenis, fungsi, manfaat, dan cara penggunaan sumber belajar. Sisanya tidak mengetahui keseluruhan tetapi hanya sebagian saja. 3) Kompetensi guru dalam pemanfaatan sumber belajar sebagian besar guru 88% atau 13 guru menggunakan media, kecuali maket. 4) upaya pengembangan kompetensi guru untuk memanfaattkan sumber belajar diperoleh angka lebih dari setengah guru 88% atau 12 guru sering mengembangkan keprofesionalan. Berdasarkan penelitian ini penulis merekomendasikan agar guru geografi dan sekolah bekerjasama untuk meningkatkan ketersediaan jurnal, hasil penelitian dan koran. Meningkatkan kemampuannya dalam hal Guru geografi melakukan kerjasama dengan ssekolah untuk meningkatkan ketersediaan jurnal, hassil penelitian, dan koran. Guru geografi SMA Negeri di Kabupaten Semarang diharapkan dapat meningkatkan kemampuaanya dalam hal mendayagunakan lingkungan, langkah awalnya seperti mengakrabkan siswa dengan lingkungan sekitar, yaitu lingkungan sekolah dan mengakrabkan siswa dengan lingkungan di luar sekolah. Dikarenakan guru geografi SMA Negeri di Kabupaten Semarang jarang melakukan penelitian secara mandiri, disarankan untuk lebih giat melakukan penelitian secara mandiri untuk menunjang kemampuan dalam pemanfaatan dan pengembangan sumber belajar geografi. Kata Kunci : Kompetensi Guru, Pemanfaatan Sumber Belajar.

THE INFLUENCE OF NIFEDIPINE INDUCTION TO GINGIVAL EPITHELIAL CELL PROLIFERATION (in vivo study in rat)

Journal of Dentistry Indonesia Vol 11, No 1 (2004): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

It is well known that nifedipine administration in hypertensive patients results in gingival hyperplasia. The aim of this study was to study the pattern of nifedipine-induced gingival hyperplasia, based on morphometric and histogical changes as well as on PCNA (Proliferating Cell Nuclear Antigen) expression in the gingival epithelium. In total, 36 male Sprague Dawley rats at the age of 6-8 weeks were divided into nine experimental groups and three control groups. Each animal received daily DMSO (dimethyl sulfoxide) via oral intubation at a dosage of 0 (for control groups), 15, 30, or 60 mg/kg (experimental groups) of body weight for 7, 21 or 42 days. After the animals were sacrificed, impression of the lower gingival tissue was taken to measure mesio-distal distance, labio-lingual distance and papilla height. The number of blood vessels and the thickness of gingival epithelium were assessed from hematoxylin and eosin stained sections. Proliferative activity of the epithelial cells was determined by immunohistochemical analysis using PCNA monoclonal antibody. Significant increase in the mesio-distal and labio-lingual distance of the lower gingival tissue was detected morphometrically (p<0.05). There were more blood vessels in the experimental groups than in the control groups, however there was no specific pattern based on the dosage or duration of nifedipine administration. On the other hand, significant differences were found in the gingival epithelial thickness and proliferative activity between the experimental and the control groups. PCNA-positive cells were observed in basal and suprabasal layers, but nearly none in lamina propria.

Efek Pemberian Ekstrak Etanol Daun Gynura Procumbens (Lour) Merr pada Lambung Tikus Sprague Dawley Jantan

Journal of Dentistry Indonesia Vol 12, No 1 (2005): April
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

This research was conducted to study the histopathological effect of ethanol extract of Gynuraprocumbens (Lour) Merr leaves in male Sprague Dawley rats. Ten rats were divided into an experimental group and a control group, each consisting of five rats. The test extract was administered to the experimental group for 36 weeks, twice weekly. The control group was untreated up to the end of the experiment. The rats were necropsized at the end of the 18th and 36th week. The gastrium was excised to be fixed in 10% buffered formalin for 24 hours. The H&E sections were then prepared for histological examination. The histological appearance in 4 of 5 experimental rats shows extensive mucus secretion and a mild mucosal epithelial erosion of gastrium. No histological changes were detected in the control group. It was concluded that the administered extract of G. procumbens for 36 weeks twice weekly did not result in significant pathological changes.

Dampak Pembuatan Model Karsinogenesis Oral Terhadap Esofagus Tikus Sprague Dawley

Journal of Dentistry Indonesia Vol 12, No 3 (2005): December
Publisher : Faculty of Dentistry, University of Indonesia

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Abstract

This study was carried out to investigate the effect of 4NQO oral induction in oesophagus of male rats. Sixteen male Sprague Dawley rats were divided into three experimental groups and one untreated group as control. The experimental groups were applied with 0.5% 4-nitroquinoline 1-oxide on the dorsal mucosa of tongue thrice weekly for 8,16 or 24 weeks, one brush stroke per application. At the end of the 36th week, all rats were sacrificed and the tongue and oesophagus were excised and fixed in 10% buffered formalin for 24 hours. The H&E sections were prepared for histological examination. The microscopical assessment showed that all rat tongues whether applied with 4NQO for 8, 16 or 24 weeks were identified having Squamous Cell Carcinoma (SCC). Microscopical examination of oesophagus indicated that 75% of the rats applied with 4NQO for 16 weeks showed hyperkeratosis, and 20% of the rats applied with 4NQO for 24 weeks showed malignancy changes and hyperkeratosis, respectively. No histological changes were detected either in the tongue or the oesophagus of the control rats. It was concluded that the effect of carcinogenic induction in oral mucosa caused malignant changes in oesophagus.

The Noteworthy Case: Atypical Palatal Ulcer Which is Progressivelly Develop to Oral Squamous Cell Carcinoma in Diabetic Elderly

The Indonesian Journal of Dental Research Proceeding Book
Publisher : The Indonesian Journal of Dental Research

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Abstract

Background: Oral ulcers are commonly painful lesions that are associated with numerous etiologies. Palatal ulcer could be referred as atypical oral ulcer due to unusual site predilection. The correct differential diagnosis is necessary to establish the appropriate treatment, with regards to all possible causes. Purposes: This report was intended to explain Oral Squamous Cell Carcinoma [OSCC] which is presented as atypical palatal ulcer resembling Necrotizing Sialometaplasia [NS]. Case and management: A 65 year old male, edentulous with history of uncontrolled type 2 Diabetes mellitus and experienced a gradually enlarging palatal ulcer. According to the patient, a fish bone pricked his hard palate just before the complaint. There was no lymphadenopathy, and intraoral examination revealed a solitary shallow ulcer on the right side of hard palate, covered by white pseudomembranous layer without erythematous halo. The margin of the ulcer was distinctive without induration. A month later, the lesion was progressively painful and interfere the oral function. The differential diagnoses were traumatic ulcer suspected to Eosinophilic Ulcer, Necrotizing Sialometaplasia [NS], and OSCC. Treatment plans included palliative measures and medical consultation regarding the need of biopsy. The biopsy was performed two months later. At that time, the ulcers were enlarged with indurated margin and necrotic center. A biopsy confirmed the diagnosis as OSCC with moderate differentiation. For proper treatment, the patient was referred to Oncology Department, Sardjito General Hospital. Conclusion: An atypical persistent solitary oral ulcer, especially in elderly, should prompt urgent investigation, since an oral malignancy must be foremost on the differential diagnoses list. This case report showed a progressively development of OSCC, even without preceding premalignant lesion. It is the dentists responsibility to identify any suspicion of oral premalignancy, so that proper referral can be performed earlier for reducing the mortality.

PENERAPAN MODEL PEMBELAJARAN TWO STAY TWO STRAY (TSTS) UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA PADA MATA PELAJARAN ILMU PENGETAHUAN SOSIAL KELAS VIII DI MTS AL-KHOLIDIYAH SEDINGINAN KABUPATEN ROKAN HILIR

Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Vol 3, No 2 (2016): Wisuda Oktober 2016
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan

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Abstract

Abstrack: The learning model of Two Stay Two Stray technique or method two only two guests. Learning is a learning models that begins with the division of the group, and provide opportunities for groups to share results and information. The purpose of this study is to Determine the Increase in student motivation on the subjects of social sciences through a learning model of Two Stay Two Stray (TSTS) Class VIII at MTs Al-Kholidiyah Sedinginan Rokan Hilir. Place of research conducted at MTs Al-Kholidiyah Sedinginan Rokan Hilir class. The sample used is a class VIII student number 32, composed of 20 women and 12 men. Data Obtained using techniques obserpasi and observation for two weeks. While the data analysis techniques used are: analysis of the activity of teachers and students and the analysis of the motivation to learn. From the results of the data analysis that has been done shows. application of learning models Two Stay Two Stray (TSTS) can Increase students motivation on the subjects of Social Sciences Class VIII at MTs Al-Kholidiyah Sedinginan Rokan Hilir. From Reviews These results it is expected that the teacher suggested MTs Al-Kholidiyah Sedinginan, learning TSTS can use as an alternative model of learning to improve students motivation. However, this method should be Able to use the time as possible.Keywords: PPD Learning Method , Motivation