Nurul Afriana
Medical Faculty of Indonesia University/ Dr. Cipto Mangunkusumo Hospital Jakarta

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IL-10 Serum Concentration was Observed Higher in Threatened Preterm Labor Afriana, Nurul; Hestiantoro, Andon; Sungkar, Ali
Indonesian Journal of Obstetrics and Gynecology Vol. 34. No. 4. October 2010
Publisher : Indonesian Journal of Obstetrics and Gynecology

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Abstract

Objective: To determine the serum concentration of Th-1 and Th-2 cytokine in threatened preterm labor compared to that in normal pregnancy.Method: The design was analytical cross-sectional, comparing the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor and 29 normal pregnant women. The cytokine concentration was measured with ELISA. T test and Mann-Whitney U test was used for statistical analysis.Results: The mean concentration of TNF-α and IL-2 in both groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor (PTL) group was observed higher than that observed in the normal pregnancy group (p = 0.001). Compared to normal pregnancy group, the TNF-α to IL-10 ratio in the PTL group was observed lower (p = 0.009). Both groups did not show any difference in the IL-2 to IL-10 ratio (p = 0.057).Conclusion: The IL-10 serum concentration was increased in threatened preterm labor. There was no difference observed in the Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as compared to normal pregnancy.[Indones J Obstet Gynecol 2010; 34-4: 191-4]Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokinesTujuan: Untuk menilai kadar sitokin Th-1 dan Th-2 dalam serum perempuan hamil dengan ancaman persalinan preterm dan dibandingkan dengan kadar tersebut pada perempuan hamil normal.Metode: Kajian potong lintang, yang membandingkan kadar TNF-α, IL-2, IL-10, nisbah TNF-α dengan IL-10 dan nisbah IL-2 dengan IL-10, pada 29 subjek penelitian perempuan hamil dengan ancaman persalinan preterm dan pada 29 perempuan hamil normal. Kadar sitokin diukur dengan teknik ELISA. Uji statistik dilakukan dengan menggunakan uji T dan uji Mann-Whitney.Hasil: Tidak dijumpai perbedaan yang bermakna dari rerata TNF-α dan IL-2 dari kedua grup (p = 0,188 dan p = 0,493). Konsentrasi median dari IL-10 serum perempuan hamil dengan ancaman preterm dijumpai lebih tinggi dibandingkan dengan kadar tersebut pada kehamilan normal. (p = 0,001). Dibandingkan dengan kehamilan normal, maka kehamilan dengan ancaman persalinan preterm menunjukkan nisbah TNF-α dengan IL-10 yang lebih rendah. Tidak terdapat perbedaan pada nisbah IL-2 dan IL-10 antara kedua grup.Kesimpulan: Kehamilan dengan ancaman persalinan preterm menunjukkan kadar IL-10 yang lebih tinggi dibandingkan dengan kehamilan normal. Tidak terdapat perbedaan nisbah sitokin Th-1 dan Th-2 pada kedua group.[Maj Obstet Ginekol Indones 2010; 34-4: 191-4]Kata kunci: IL-10, persalinan preterm, sitokin Th-1 dan Th-2
IL-10 Serum Concentration was Observed Higher in Threatened Preterm Labor Afriana, Nurul
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.827 KB)

Abstract

Objective: To determine the serum concentration of Th-1 and Th-2 cytokine in threatened preterm labor compared to that in normal pregnancy. Method: The design was analytical cross-sectional, comparing the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor and 29 normal pregnant women. The cytokine concentration was measured with ELISA. T test and Mann-Whitney U test was used for statistical analysis. Results: The mean concentration of TNF-α and IL-2 in both groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor (PTL) group was observed higher than that observed in the normal pregnancy group (p = 0.001). Compared to normal pregnancy group, the TNF-α to IL-10 ratio in the PTL group was observed lower (p = 0.009). Both groups did not show any difference in the IL-2 to IL-10 ratio (p = 0.057). Conclusion: The IL-10 serum concentration was increased in threatened preterm labor. There was no difference observed in the Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as compared to normal pregnancy. [Indones J Obstet Gynecol 2010; 34-4: 191-4] Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokines
IL-10 Serum Concentration was Observed Higher in Threatened Preterm Labor Afriana, Nurul
Indonesian Journal of Obstetrics and Gynecology Volume. 34, No. 4, October 2010
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.827 KB)

Abstract

Objective: To determine the serum concentration of Th-1 and Th-2 cytokine in threatened preterm labor compared to that in normal pregnancy. Method: The design was analytical cross-sectional, comparing the serum levels of TNF-α, IL-2, IL-10, TNF-α to IL-10 ratio and IL-2 to IL-10 ratio between 29 subjects with threatened preterm labor and 29 normal pregnant women. The cytokine concentration was measured with ELISA. T test and Mann-Whitney U test was used for statistical analysis. Results: The mean concentration of TNF-α and IL-2 in both groups did not reveal any difference (p = 0.188 and p = 0.493). Median of IL-10 serum concentration in the threatened preterm labor (PTL) group was observed higher than that observed in the normal pregnancy group (p = 0.001). Compared to normal pregnancy group, the TNF-α to IL-10 ratio in the PTL group was observed lower (p = 0.009). Both groups did not show any difference in the IL-2 to IL-10 ratio (p = 0.057). Conclusion: The IL-10 serum concentration was increased in threatened preterm labor. There was no difference observed in the Th-1 to Th-2 cytokines serum ratio in threatened preterm labor as compared to normal pregnancy. [Indones J Obstet Gynecol 2010; 34-4: 191-4] Keywords: IL-10, preterm labor, Th-1 and Th-2 cytokines