Nugroho Abikusno
InResAge, Center for Commmunity Health & Population Studies, Universitas Trisakti

Published : 3 Documents
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Systematic Review of the Effect of Vitamin D Supplementation on Immune Response Indrawati, Lili; Purwantyastuti, Purwantyastuti; Abikusno, Nugroho
Journal of the Indonesian Medical Association Vol. 61 No. 8 August 2011
Publisher : Journal of the Indonesian Medical Association

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Abstract

The potential role for vitamin D and its active metabolite 1, 25-hydroxyvitamin D (1.25(OH)2D) in modulating the immune response was first recognized 25 years ago. The presence of adequate levels of vitamin D is required for the proper functioning of the bodys defense system such as barrier integrity, the production of antimicrobials, chemotaxis of other immune cells and regulation of inflammation in the innate and adaptive immune system. Sixty two studies on vitamin D and immune respons from 2000-2011 were identified. A total of 33 studies were excluded because it was not clinical trials, of the remaining 29, 21 were excluded because clinical trials were not randomized controlled trials and one was excluded because of using combined vitamin D and calcium, so the remaining seven clinical trials were reviewed to evaluate the clinical evidence for the role of vitamin D in the immune system. From the seven Randomized Controlled Trials (RCTs) reviewed in this paper, it is concluded that more research is needed to determine the beneficial effects of daily vitamin D in improving low level chronic inflammation and immune response. Side effects recognized in these studies were minimal and rare. J Indon Med Assoc. 2011;61:310-5.Keywords: Vitamin D, immune response modulator.
STATUS KESEHATAN LANJUT USIA GEREJA RAWAMANGUN JAKARTA TIMUR Mawi, Martiem; Tandean, Reza; Abikusno, Nugroho
E-Journal Widya Kesehatan dan Lingkungan 2005
Publisher : E-Journal Widya Kesehatan dan Lingkungan

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Abstract

To determine the health status of older persons living in the community. A cross-sectional observational study was done of 59 older persons of a Catholic church in Rawamangun, east Jakarta, who volunteered in the study through informed consent. Data collected were physical, blood pressure, lipid profile, ECG, VEP1, weight, height knee height and food frequency. Older persons with hypertension (>140/90) were 14 (23.7%). The lipid profile of older persons were 31 (52.5%) subject had hypercholesterolemia (200 mg/L), 5 (8.5%) subject had hypertriglyceridemia (200>mg/L) 13 (22.0%) subjects had hypo-high-density-lipoproteinemia (<45 mg/L), and 12 (20.3%) subjects had hyper-low-density-lipoproteinemia (>150 mg/L). Older persons with abnormal ECG were 16 (27.1%), 2 (3.4%) subjects had less than normal VEP1 and 37 (62.7%) subjects exercised >= 3 times weekly. Body Mass Index of older persons were 12 (20.3%) subjects BMI below 20.27 (45.8%) BMI between 20-25, 18 (30.5%) between 25-30, and 2 (3.3%) subjects BMI above 30(obesity).
Ageing, longevity and fitness: towards new paradigms in healthy ageing Abikusno, Nugroho
Universa Medicina Vol 37, No 3 (2018)
Publisher : Faculty of Medicine, Trisakti University

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Abstract

We have nearly reached the end of the second decade of the Millennium. Within 5 years we hope the Third Ageing Summit will be held to discuss lessons learned and future directions in the field of Ageing and Longevity. 1) I mention the word Longevity since many countries especially in the Asia Pacific region, the second Hub of Ageing after the Western world countries, have experienced this phenomenon since the early years of this Millennium.