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REVIEW ARTIKEL : Manajemen Terapi Demam Tifoid : Kajian Terapi Farmakologis dan Non Farmakologis Rahmasari, Vani; Lestari, Keri
Farmaka Vol 16, No 1 (2018): Farmaka Suplemen (Juni)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.558 KB) | DOI: 10.24198/jf.v16i1.17445

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Demam tifoid adalah penyakit demam akut yang disebabkan oleh infeksi bakteri Salmonella typhi. Penderita demam tifoid di Indonesia mencapai 81% per 100.000. Demam tifoid dapat diberikan terapi farmakologis maupun non farmakologis yang bertujuan untuk mempercepat penyembuhan, meminimalkan komplikasi sekaligus untuk mencegah penyebaran penyakit. Metode yang digunakan dalam pengerjaan literatur review ini adalah studi literatur yang bersumber dari jurnal, e-book, dan artikel ilmiah nasional maupun internasional dengan tahun terbit maksimal 5 tahun terakhir. Terapi farmakologis yang dapat diberikan pada penderita demam tifoid yaitu terapi antibiotik seperti penggunaan Ciprofloxacin, Cefixime, Kloramfenikol, Tiamfenikol, Azitromisin, Ceftriaxone dan terapi kortikosteroid seperti penggunaan Dexametasone. Namun, perlu diperhatikan dalam penggunaan antibiotik maupun kortikosteroid dalam pengobatan demam tifoid. Penggunaan secara sembarangan menyebabkan peningkatan kejadian demam tifoid yang resistensi terhadap antibiotik maupun timbulnya efek samping terhadap antibiotik maupun kortikosteroid yang justru memperburuk kondisi penderita demam tifoid.Terapi non farmakologis untuk demam tifoid yaitu tirah baring, diet lunak rendah serat serta menjaga kebersihan. Kajian terapi farmakologis diperlukan dalam pemilihan jenis obat  yang akan sangat menentukan kualitas penggunaan obat dalam pemilihan terapi dan kajian non farmakologis diperlukan untuk mendukung keberhasilan terapi.Kata Kunci : Demam tifoid, terapi farmakologis, terapi non farmakologis
Identifikasi Interaksi Antar Obat Pada Resep di Apotek Kimia Farma 58 Kota Bandung N.P., BERLIAN HANUTAMI; Lestari, Keri
Farmaka Vol 17, No 2 (2019): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2308.439 KB) | DOI: 10.24198/jf.v17i2.22956

Abstract

Penggunaan obat semakin hari semakin meningkat untuk itu diperlukan penggunaan obat yang rasional bagi setiap pasien. Polifarmasi merupakan salah satu bentuk penggunaan obat yang irasional. Polifarmasi dapat menyebabkan timbulnya interaksi antar obat yang dapat meningkatkan atau menurunkan efektifitas dari salah satu obat. Interaksi obat dapat menyebabkan penurunan efek obat sehingga hasil terapi tidak maksimal. Oleh karena itu dilakukan identifikasi interaksi obat mencegah timbulnya resiko morbiditas dan mortalitas dalam pengobatan pasien. Identifikasi interaksi obat dilakukan dengan memilih secara acak dua resep perharinya lalu ditentukan tingkat keparahannya.menggunakan situs www.drugs.com dan aplikasi Medscape. Hasil yang didapatkan yaitu terdapat 21 resep dari 60 resep yang terdapat interaksi antar obat. Potensi interaksi antar obat sebesar 35 %. Untuk interaksi minor 23,8 %, interaksi moderate 57,14 % dan interaksi mayor 19,04 %.Kata Kunci : Interaksi Obat, Mayor, Minor, Moderate, Polifarmasi
IDENTIFIKASI INTERAKSI ANTAR OBAT PADA RESEP SALAH SATU APOTEK DI BANDUNG TRIARINI, DILA; Lestari, Keri; Mulyanto, Sangkan
Farmaka Vol 17, No 2 (2019): Farmaka (Agustus)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (69.502 KB) | DOI: 10.24198/jf.v17i2.22977

Abstract

Interaksi antar obat merupakan penyebab utama morbiditas dan mortalitas. Terjadinya interaksi obat yang tidak diinginkan dipengaruhi oleh banyak faktor, salah satunya polifarmasi. Identifikasi interaksi antar obat dilakukan pada resep yang masuk di salah satu Apotek di Bandung pada bulan April 2019. Dari 61 resep yang diambil secara acak, terdapat 18 interaksi obat pada 15 resep yang berbeda. Interaksi antar obat yang teridentifikasi terdiri dari 5 interaksi kategori major (27,7%), 9 interaksi kategori moderate (50%), dan 4 interaksi kategori minor (22,2%). Pengaruh dari interaksi antar obat dapat diminimalisir melalui peningkatan kewaspadaan oleh tenaga kesehatan professional, terutama farmasis.Kata kunci: interaksi obat, apotek, interaksi antar obat
PENETAPAN KADAR DEHIDRODIISOEUGENOL DALAM TABLET EKSTRAK PALA DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Sulistyaningsih, Dwi Lestari; Mutakin, Mutakin; Lestari, Keri; Levita, Jutti
Indonesian Journal of Applied Sciences Vol 4, No 2 (2014)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2143.441 KB) | DOI: 10.24198/.v4i2.16802

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AbstrakPenetapan kadar dehidrodiisoeugenol dalam tablet ekstrak pala dapat menggunakan KCKT fase terbalik dengan kolom C18, fase gerak metanol dan air dengan perbandingan 73:27 menggunakan detektor ultraviolet pada panjang gelombang 282 nm dan waktu retensi dehidrodiisoeugenol 13,79 menit. Perolehan kembali dehidrodiisoeugenol 100,14%±0,55% Batas deteksi 0,892 ?g/ml dan batas kuantisasi 2,97 ?g/ml. Kadar tablet ekstrak pala 300 mg mengandung dehidrodiisoeugenol sebanyak 0,818 mg.Kata kunci : dehidrodiisoeugenol, validasi, KCKT
Monitoring Terapi Warfarin pada Pasien Pelayanan Jantung pada Rumah Sakit di Bandung Putri, Norisca A.; Lestari, Keri; Diantini, Ajeng; Rusdiana, Taofik
Indonesian Journal of Clinical Pharmacy Vol 1, No 3 (2012)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (655.259 KB)

Abstract

Penelitian ini bertujuan untuk mengetahui monitoring terapi warfarin untuk menjamin ketepatan dosis,keamanan terapi, dan mengetahui apakah dosis terapi warfarin yang digunakan telah memenuhi kriteria  penggunaan obat warfarin yang rasional. Derajat antikogulasi setiap pasien diukur dengan parameter waktu protrombin yang dinyatakan dengan International Normalized Ratio (INR). Metode Penelitian meliputi monitoring terapi warfarin terhadap 80 pasien di pelayanan jantung melalui PT-INR, pendataanklinis pasien meliputi, usia, jenis kelamin, berat badan, tinggi badan, jenis penyakit, dosis yang digunakan dan obat lain yang dikonsumsi secara bersamaan. Hasil monitoring menunjukkan rata-rata INR pasien yaitu 1,38± 0,42 hasil ANAVA (? = 0,05) menunjukkan tidak ada pengaruh dosis terhadap INR(p=0,13) tetapi ada pengaruh pada umur (p =0,014), hasil uji beda (? = 0,05) menunjukkan tidak ada perbedaan terhadap rata-rata INR berdasarkan jenis kelamin (p =0,051), umur (p =0,397), dan variasi dosis (p = 0,057). Hasil tersebut menunjukkan bahwa dosis warfarin belum mencapai target terapi INR (2?3).Kata kunci: Warfarin, penyakit trombotik, PT-INR Warfarin Therapy Monitoring of Cardiac Care Patients in Hospital in BandungAbstractThe aims of this study were to identify the rational warfarin monitoring therapy to guarantee the rightdose, therapy security, and whether the dose of warfarin therapy has completed the rational criteria ornot. Degree of antikoagulasi for each patient is measured with protombin time as International Normalized Ratio (INR). The methods consist of warfarin monitoring therapy towards 80 patients at the heart service through the PT-INR constant, medical data, such as age, gender, weight, height, type of the disease, dose usage and another medicine which is used together, and statistical test of the average of INR. The monitoring result shows that patient?s INR average is 1,38 ±0,42, the result of ANAVA (?=0,05)shows that there?s no impact of dose towards INR (p=0,13) but there?s an INR average impact basedon gender (p=0,051), age (p=0,397) and dose variation (p=0,057). The results shown that warfarin dose which used is not bleeding risk.Key words: Warfarin, trombotic disease, PT-INR
Pengaruh Pelayanan Informasi Obat terhadap Keberhasilan Terapi Pasien Diabetes Melitus Tipe 2 Insani, Widya N.; Lestari, Keri; Abdulah, Rizky; Ghassani, Salma K.
Indonesian Journal of Clinical Pharmacy Vol 2, No 4 (2013)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.955 KB)

Abstract

pemahaman mengenai instruksi pengobatan merupakan permasalahan utama dalam pengobatan DMT2. Ketidakpatuhan pasien terhadap regimen obat hipoglikemik oral yang kompleks serta ketidaktepatan dalam cara dan waktu pengonsumsiannya merupakan barrier tercapainya keberhasilan terapi DMT2. Hal ini sangat berkaitan dengan kualitas pelayanan kefarmasian yang diberikan kepada pasien, khususnya pelayanan informasi obat. Penelitian ini bertujuan untuk mengevaluasi pengaruh intervensi pelayanan informasi obat terhadap parameter keberhasilan terapi diabetes yaitu glukosa 2 jam postprandial, HDL dan trigliserida. Penelitian ini merupakan nonrandomized concurrent control trial secara prospektif. 14 subjek uji direkrut selama 4 bulan selama Mei?Agustus 2013 kemudian dibagi menjadi dua grup. Kedua grup mendapat terapi pengobatan diabetes berupa hipoglikemik oral. Grup intervensi mendapatkan pelayanan informasi obat dan edukasi mengenai diabetes, sedangkan grup kontrol tidak mendapatkannya. Data dianalisis menggunakan uji t independen dengan ? 0,05. Walau belum berbeda signifikan, nilai keberhasilan terapi dengan intervensi pelayanan informasi obat pada parameter glukosa 2 jam postprandial, HDL dan trigliserida memberikan hasil yang lebih tinggi 17,01%; 6,73%; dan 6,31% untuk masing-masing parameter dibandingkan terapi tanpa pelayanan kefarmasian tersebut.Kata kunci: Pelayanan informasi obat, diabetes, obat hipoglikemik oral Effect of Pharmaceutical Information Care on Clinical Outcomes of Patients With Type 2 Diabetes MellitusPoor adherence to medication and lack of understanding about medication instructions are the main problems in the treatment of type 2 diabetes mellitus. Poor adherence to oral hypoglicemic drugs which have complex regiment and unappropriate consumption of them are the obstacles to reach good clinical outcomes. These problems are highly related to the quality of pharmaceutical care given to patients. The aim of this study was to evaluate the effect of pharmaceutical information care towards the outcome of type 2 diabetes mellitus including 2 hours postprandial glucose, HDL and tryglicerides. This study used nonrandomized concurrent control trial prospectively. 14 subjects were recruited during 4 months from May?August 2013 and were divided into two groups. Both of group were given oral hypoglycemic drugs. The intervention group received pharmaceutical information care and diabetes education, whilecontrol group did not receive these. Data were then analysed with independent t test using ? 0,005. Although the difference were not significant yet, pharmaceutical information care intervention on diabetes treatment gave higher improvement by 17,01%; 6,73%; and 6,31% respectively in 2 hours postprandial glucose, HDL and tryglicerides parameters, compared with the treatment without pharmaceutical care.Key words: Pharmaceutical information care, diabetes, oral hypoglicemic drugs
Stevia rebaudiana Bertoni Leaves Extract as a Nutraceutical with Hypoglycemic Activity in Diabetic Rats Lestari, Keri; Ridho, Abdurahman; Nurcayani, Nuning; Ramadhania, Zelika Mega; Barliana, Melisa Intan
The Indonesian Biomedical Journal Vol 11, No 2 (2019)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v11i2.686

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BACKGROUND: The prevalence of diabetes mellitus is growing every year, including in Indonesia. Medicinal herbs were used empirically for lowering blood glucose. One of potential herb to have hypoglycemic activity is Stevia. Stevia rebaudiana Bertoni leaves contain stevoside, a natural, low-calorie sweetener that is 300 times sweeter than saccharose. In this study, we aimed to explore the hypoglycemic activity of S. rebaudiana Bertoni leaves extract in a rat model of type 2 diabetes mellitus (T2DM). METHODS: Male Wistar rats were feed high-fat, high-carbohydrate feed and sugar solution for 74 days to induce a diabetic rat model. The animals were then divided into five groups consisting of a negative control group treated with 2% Pulvis Gom Arabicum; a positive control group treated with Metformin 45 mg/kg body weight (BW); and three test groups treated with aqueous extract of S. rebaudiana Bertoni leaves at doses of 3.125, 6.25 and 12.5 mg/kg BW for 36 days. Blood glucose was measured on days 14, 28 and 36.RESULTS: The results showed that blood glucose levels over 36 days were significantly (p=0.043) lower in the group treated with S. rebaudiana Bertoni leaves extract. Further Newman-Keuls analysis suggested that the hypoglycemic activity of S. rebaudiana Bertoni leaves extract was dose-dependent. CONCLUSION: Our results indicate that S. rebaudiana Bertoni leaves extract has a potential role as a hypoglycemic agent in the treatment of T2DM.KEYWORDS: Stevia rebaudiana Bertoni, nutraceuticals, hypoglycemic, diabetic rats
Consumption Time of Captopril Influenced the Outcomes of Patients with Stage 1 Hypertension Herdaningsih, Sulastri; Muhtadi, Ahmad; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 2, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (276.853 KB) | DOI: 10.15416/pcpr.v2i1.16213

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Differences in drugs consumption time may affect its absorption and metabolism in the bodywhich could lead to differences in its efficacy. For hypertension patients, one of the mostfrequently used drugs for lowering blood is captopril. However, information regarding theinfluence of consumption time on captopril efficacy was limited. Therefore, this study wasconducted to compare the efficacy of captopril in lowering blood pressure when administeredbefore and after meal. This was an experimental study with two treatment groups,conducted at Dr. Soedarso General Hospital, Pontianak, Indonesia, during April-June 2015.Statistical analysis was performed using Mann-Whitney, Exact-Fisher, and T-test. We foundout that the reduction of systolic blood pressure in group who consumed captopril beforeand after meal was 30 mmHg and 25 mmHg, respectively (p<0.05). The similar reduction indiastolic bloos pressure was observed in both groups (10 mmHg, p>0.05). In conclusion, itis recommended to take captopril on an empty stomach since it showed better efficacy whenadministered before meal compared to after meal consumption.Keywords: hypertension, captopril, absorption
Pharmaceutical Counseling Has a Positive Impact on Quality of Life of Hypertension Patients Aulia, Gina; Halimah, Eli; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 3, No 1
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (17.6 KB) | DOI: 10.15416/pcpr.v3i1.16449

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Pharmacists play a major role in educating patients regarding drug therapy, in order to achieve optimal health outcomes. The aim of this study was to investigate the effect of pharmaceutical counseling on quality of life (QoL) of hypertensive patients with renal impairment at one of public hospital in Bandung, Indonesia. This study used a prospective experimental design with pretest-posttest design for 2 months. Inclusion criteria in this study were hypertensive patients with renal impairment who received antihypertensive drugs, aged >18 years, and signed the informed consent. Exclusion criteria were patients who were not able to fill in the questionnaire, patients with end stage renal diseases, diabetes, and pregnant or lactating patients. Pharmaceutical counseling was given during 2 months of the therapy. Pharmaceutical counseling consisted of education on the appropriate use of drugs and disease management. Schedule of their own medication and leaflet containing educational information were given to the subjects. QoL was assessed using a previously validated Mini-Questionnaire of QoL in Arterial Hypertension (MINICHAL). The questionnaire consisted of 16 two dimensions questions, i.e., mental health and somatic manifestation. We found that the mean increase in mental health status (49.5±5.3) was higher than that of somatic dimension (32.7±3.6). Both dimensions had statistically significant improvement (P value <0.05). In conclusion, pharmaceutical counseling is beneficial to improve QoL of hypertension patients.Keywords: hypertension, renal impairment, quality of life 
Efficacy and Side Effects of Deferasirox and Deferiprone for Thalasemia Major in Children Rindarwati, Asti Y.; Diantini, Ajeng; Lestari, Keri
Pharmacology and Clinical Pharmacy Research Vol 1, No 3
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.813 KB) | DOI: 10.15416/pcpr.v1i3.15218

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Thalassemia major (TM) is an inherited disease caused by defective or absent of hemoglobin chain synthesis. Regular chelation therapy is necessary to reduce excess iron in several organs of TM patients. The most commonly used chelating agents are deferasirox and deferiprone. However, information regarding their effectiveness and side effects in Indonesian children population with TM were limited. This study was conducted to assess the effectiveness and side effects of deferasirox and deferiprone in pediatric patients with TM. This was an observational study with prospective analysis which was conducted during April-August 2015. We included pediatric patients with TM who visited a hospital in Bandung, Indonesia, using consecutive sampling method. Thirty two subjects were divided into two groups, i.e., deferasirox and deferiprone group. Review of medical records and interview were performed for each participants. Effectiveness was defined as reduction in ferritin level. Side effects were assessed using Naranjo scale. Data were analyzed using Mann-Whitney test, Wiloxon test and Chi square test. P value < 0.05 defined statistical significance. We found that deferasirox was more effective than deferiprone for the treatment of TM in pediatric patiens, with less side effects. The use of deferasirox as iron chelating agent is recommended for patients with TM.Keywords: deferasirox, deferiprone, ferritin, thalassemia major