Jan S. Purba*
Neurona Majalah Kedokteran Neuro Sains

Published : 3 Documents
Articles

Found 3 Documents
Search

PERAN KALSIUM MITOCHONDRIAL DAN STRES OKSIDATIF TERHADAP APOPTOSIS PADA PENYAKIT NEURODEGENERATIF Jan S. Purba*
NEURONA Vol 27 No. 4 Juli 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.929 KB)

Abstract

INTRODUCTION IT HAS LONG BEEN KNOWN THAT CALCIUM CA2 SIGNALS GOVERN A HOST OF VITAL CELL FUNCTIONS AND SO ARE NECESSARY FOR CELL SURVIVAL HOWEVER MORE RECENTLY IT HAS BECOME CLEAR THAT CELLULAR CA2 OVERLOAD OR PERTURBATION OF INTRACELLULAR CA2 COMPARTMENTALIZATION CAN CAUSE CYTOTOXICITY AND TRIGGER EITHER APOPTOTIC OR NECROTIC CELL DEATH NEURONAL DEATH UNDERLIES THE SYMPTOMS OF MANY HUMAN NEUROLOGICAL DISORDERS INCLUDING MULTIPLE SCLEROSIS MS ALZHEIMERS DISEASE AD PARKINSONS DISEASE PD AND HUNTINGTONS DISEASES HD STROKE AND AMYOTROPHIC LATERAL SCLEROSIS ALS THE IDENTIFICATION OF SPECIFIC GENETIC AND ENVIRONMENTAL FACTORS RESPONSIBLE FOR THESE DISEASES HAS BOLSTERED EVIDENCE FOR A SHARED PATHWAY OF NEURONAL DEATH INVOLVING OXIDATIVE STRESS PERTURBED CALCIUM HOMEOSTASIS MITOCHONDRIAL DYSFUNCTION AND ACTIVATION OF CYSTEINE PROTEASES CALLED CASPASES WITH THE IDENTIFICATION OF MECHANISMS THAT EITHER PROMOTE OR PREVENT NEURONAL APOPTOSIS COME NEW APPROACHES FOR PREVENTING AND TREATING NEURODEGENERATIVE DISORDERS
NYERI FIBROMIALGIA NYERI PATOLOGI ATAU NYERI IDIOPATIK Jan S. Purba*
NEURONA Vol 27 No. 3 April 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.59 KB)

Abstract

INTRODUCTION FIBROMYALGIA FM IS A CHRONIC MULTIDIMENSIONAL IDIOPATHIC PAIN SYNDROME DEFINED BY WIDESPREAD MUSCULOSKELETAL PAIN THE FM REFERS TO A COLLECTION OF SYMPTOMS WITH NO CLEAR PATHOLOGIC CAUSE BUT THE SYMPTOMS TOGETHER CONSTITUTE A CLEARLY RECOGNIZABLE AND DISTINCT PATHOLOGIC ENTITY
PERAN INFLAMASI DAN AMILOIDBETA PADA PATOLOGI PENYAKIT ALZHEIMER Jan S. Purba*
NEURONA Vol 28 No. 4 Juli 2011
Publisher : Neurona Majalah Kedokteran Neuro Sains

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

WORLDWIDE PREVALENCE OF ALZHEIMERS DISEASE AD IN YEAR 2006 WAS ESTIMATED TO BE 266 MILLION AND BY 2050 IS EXPECTED TO QUADRUPLE BECAUSE OF THE INCREASING LIFE EXPECTANCY IN MANY COUNTRIES THE MAIN CAUSE OF AD IS GENERALLY ATTRIBUTED TO INCREASED PRODUCTION AND ACCUMULATION OF AMYLOIDBETA A IN ASSOCIATION WITH NEUROFIBRILLARY TANGLES NFT FORMATION AND SYNAPTIC DEGENERATION